BGDA Lecture - Development of the Nervous System: Difference between revisions
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===Neuropores=== | ===Neuropores=== | ||
Cranial neuropore (cephalic, rostral or anterior) closes 24 days post-fertilization | '''Cranial neuropore''' (cephalic, rostral or anterior) closes about 24 days post-fertilization. | ||
<gallery> | <gallery> | ||
File:Stage11_sem9a.jpg|Anterior Neuropore | File:Stage11_sem9a.jpg|{{CS11}} Anterior Neuropore | ||
File:Stage11_sem7a.jpg|Posterior Neuropore | File:Stage11_sem7a.jpg|{{CS11}} Posterior Neuropore | ||
</gallery> | </gallery> | ||
'''Caudal neuropore''' (posterior) closes about 28 days post-fertilization. | |||
<gallery> | <gallery> | ||
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</gallery> | </gallery> | ||
* Common sites of neural tube defects. | |||
===Neural Crest=== | ===Neural Crest=== | ||
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* Cells staying dorsal to neural tube - dorsal root ganglia (DRG) | * Cells staying dorsal to neural tube - dorsal root ganglia (DRG) | ||
* Cells migrating ventral to neural tube - sympathetic ganglia | * Cells migrating ventral to neural tube - sympathetic ganglia | ||
* Cells migrating peritoneal cavity wall - adrenal medulla | * Cells migrating peritoneal cavity wall - {{adrenal}} medulla | ||
* Cells migrate into GIT wall - enteric nervous system | * Cells migrate into GIT wall - {{enteric nervous system}} | ||
<br> | <br> | ||
{{Adrenal movie}} | {{Adrenal movie}} |
Revision as of 18:15, 26 May 2018
Embryology - 3 Jun 2024 Expand to Translate |
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Introduction
Aim
To develop an understanding of the development of the nervous system and the consequences of abnormal development.
Textbooks
Week 3
<html5media height="520" width="320">File:Neuralplate_001.mp4</html5media> |
Week 3 Movies | |||
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Ectoderm
- neural plate - midline (columnar cells)
- neural crest - outside lateral edges of neural plate
- surface ectoderm - lateral (cuboidal cells)
- head - sensory and anterior pituitary (placodes)
- integument - epidermis of skin, hair, glands, teeth enamel
Neural Plate
- extends from buccopharyngeal membrane (oral membrane) to primitive node (Hensen's node)
- forms above notochord and paraxial mesoderm
- neuroectodermal cells - neural plate, neural crest
- rostrocaudal width
- broad - brain plate
- narrow - spinal cord
Week 4
Neural Tube
neural groove | neural tube and neural crest |
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<html5media height="480" width="480">File:Neuraltube_001.mp4</html5media> | <html5media height="440" width="380">File:Mouse neural tube 01.mp4</html5media> |
Week 4 Movies | |||||||
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Neuropores
Cranial neuropore (cephalic, rostral or anterior) closes about 24 days post-fertilization.
Caudal neuropore (posterior) closes about 28 days post-fertilization.
- Common sites of neural tube defects.
Neural Crest
Human embryo neural crest cells (Week 4, Stage 11) Neural crest (acoustico-facial primordium) |
<html5media height="380" width="410">File:Chicken-neural crest migration 01.mp4</html5media>
Chicken neural crest cell migration into pharyngeal arches.
<html5media height="500" width="560">File:Adrenal medulla.mp4</html5media> | Cartoon shows example of some neural crest medial migration and structures formed at the level of the body.
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System | Cell Type |
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Peripheral Nervous System (PNS) | Neurons - sensory ganglia, sympathetic and parasympathetic ganglia, enteric nervous system, and plexuses
Glia (neuroglial cells) - Schwann cells[1], satellite cells, olfactory ensheathing cells[2] |
endocrine | Adrenal medulla Calcitonin-secreting cells Carotid body type I cells |
integumentary | Epidermal pigment cells melanocyte |
Facial cartilage and bone | Facial and anterior ventral skull cartilage and bones |
Sensory | inner ear, cornea endothelium and stroma |
Connective tissue | tooth odontoblast
smooth muscle, and adipose tissue of skin in head and neck Connective tissue of meninges, salivary, lachrymal, thymus, thyroid, and pituitary glands Connective tissue and smooth muscle in arteries of aortic arch origin |
Links: neural crest | Category:Neural Crest | Neural Crest collapsible table |
Primary Brain Vesicles
Traditional vesicle description (simplified name and alternate neuromere description in brackets)
Brain
- Prosencephalon (forebrain, prosomeres)
- Mesencephalon (midbrain, mesomeres)
- Rhombencephalon (hindbrain, rhombomeres)
Spinal Cord
Neural Tube Regions | |||||||||||||||||||||
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Table above shows the future transient regions that develop from the early neural tube. |
Links: Spinal Cord
Week 5
Secondary Brain Vesicles
Brain Flexures
Rapid growth folds the neural tube forming 3 brain flexures (cranial to caudal)
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Ventricles
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CSF-filled spaces in adult brain. |
Week 6
<html5media height="600" width="520">File:Human embryo tomography Carnegie stage 17.mp4</html5media> |
Note the shape and size of the different regions of the brain and spinal cord.
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Week 8
The human MRI movie below (head, sagittal plane, left to right) shows the central nervous system (CNS) development at the end of the embryonic period (week 8; GA week 10).
<html5media height="500" width="550">File:Stage23 MRI S01.mp4</html5media>
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Cortex
Week 8 Developing Cortex |
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Human embryo, Week 8, (GA week 10) Carnegie stage 22 section from the neural tube at the level of the developing cortex. Inset (upper right) shows whole section overview and approximate level of section (red line). Grey box shows detailed image region of developing cerebrum layer thicknesses are shown in microns.
Developing Cortex will form from the thin outer layer called the cortical plate. The underlying layers transient structures that continue to supply cells to the cortex through fetal period, most of these layers will eventually be lost, except for a thin ventricular layer. Cells migrate out along radial glia that establish the initial columnar and layered structure of the cortex. Layers are named according to the nervous system revised terminology (1970)[3] Developing Vascular blood vessels can also be seen spanning the developing layers. In the adult, these vessels will be lined with non-fenestrated endothelial cells that together with other vascular cells (pericytes and vascular smooth muscle cells), glial cells (astrocytes and microglia) and neurons will form the "blood-brain barrier". Developing Ventricular Space is cerebrospinal fluid (CSF) filled and the lateral ventricles form within the cortical region. The inset image shows lying within the lateral ventricles, the choroid plexus the modified vascular structure that forms and secretes the CSF. Developing Meninges layers lie outside the neural tube. The thin pia mater that closely covers the entire brain. The mesh-like arachnoid mater and the sub-arachnoid space that will also be CSF filled. The dense dura mater lies outside these 2 layers and under the skull, it cannot be seen in the enlarged image. |
Spinal Cord
Week 8 Developing Spinal Cord (virtual slide) | |||||
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These listed features link to zoomed views of the virtual slide with the named feature generally in the centre of the view.
Use the (-) at the top left of the screen to see where this feature is located. | ||||
Spinal Cord Features | Other Features
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Fetal
Second Trimester
Human week 10 fetus
Brain and Ventricular Development[4] | Brain Fissure Development[4] |
Sylvian Fissure Development | |
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<html5media height="600" width="600">File:Neural_-_Sylvian_fissure.mp4</html5media> |
Third Trimester
The brain goes from a smooth surface to begin to fold.
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Human Fetus (CRL 240mm) Brain |
Human Brain Growth | ||||||||||||||||||||||||||
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Embryonic | ||||||||||||||||||||||||||
Table below shows a direct comparison of brain growth in size between week 4 to 8 (GA 6-10)
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Fetal | ||||||||||||||||||||||||||
Adult | ||||||||||||||||||||||||||
Adult CNS Structures | ||||||||||||||||||||||||||
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Fetal Timeline
Electrical Activity | Myelination |
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Myelination process occurs both in the CNS (from neural tube glia) and also in peripheral nerves (from neural crest Schwann cells). |
Postnatal
Movies
All Neural Movies | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Abnormalities
There are a large number of different neural abnormalities associated with genetic, environmental and unknown causes. These can also involve several different systems including: neural tube, neural crest, sensory development, ventricular and vascular system development.
It would be difficult to cover all in this current lecture so a few examples are given and students should explore the topic more widely themselves. |
Environmental
The long time course of neural development (week 3 through to postnatal) also means that a large number of different environmental factors, including dietary deficiency, can impact upon its development and also have a range of different effects.
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Postnatal Neural Assessment - there are several basic clinical motor assessments that can identify normal and abnormal development.
Abnormality Links | ||||
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Terms
Neural Terms |
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Neural Development
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Other Terms Lists |
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Terms Lists: ART | Birth | Bone | Cardiovascular | Cell Division | Endocrine | Gastrointestinal | Genital | Genetic | Head | Hearing | Heart | Immune | Integumentary | Neonatal | Neural | Oocyte | Palate | Placenta | Radiation | Renal | Respiratory | Spermatozoa | Statistics | Tooth | Ultrasound | Vision | Historic | Drugs | Glossary |
- ↑ Woodhoo A & Sommer L. (2008). Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. Glia , 56, 1481-90. PMID: 18803317 DOI.
- ↑ Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ & Baker CV. (2010). Neural crest origin of olfactory ensheathing glia. Proc. Natl. Acad. Sci. U.S.A. , 107, 21040-5. PMID: 21078992 DOI.
- ↑ . (1970). Embryonic vertebrate central nervous system: revised terminology. The Boulder Committee. Anat. Rec. , 166, 257-61. PMID: 5414696 DOI.
- ↑ 4.0 4.1 Huang H, Xue R, Zhang J, Ren T, Richards LJ, Yarowsky P, Miller MI & Mori S. (2009). Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging. J. Neurosci. , 29, 4263-73. PMID: 19339620 DOI.
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Cite this page: Hill, M.A. (2024, June 3) Embryology BGDA Lecture - Development of the Nervous System. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDA_Lecture_-_Development_of_the_Nervous_System
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G