Carnegie stage 13

Embryology - 1 Dec 2023        Expand to Translate
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Introduction

	Facts week 4 to week 5, 28 - 32 days. The embryos have a crown rump length (CRL) of 4 - 6 mm and somite number 30 pairs. Gestational Age GA - end week 6 beginning week 7 Summary ectoderm: Neural tube continues to close, Caudal neuropore closes, forebrain mesoderm: continued segmentation of paraxial mesoderm (21 - 29 somite pairs), heart prominence head: 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum Body: heart, liver, umbilical, early upper limb bulge See also Carnegie stage 13 Events
Features 30 somites, forebrain, site of lens placode, site of otic placode , stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somites Identify: forebrain, site of lens placode, site of otic placode, stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somite
Stage 13 - Left Ventrolateral View  ‎‎Mobile | Desktop | Original Stage 13 | Embryo Slides	Stage 13 Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Movies | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 13 | Next Stage 14   Historic Papers: 1905 Embryo 148 | 1926 Precervical Sinus | 1945 | 1955 Carnegie Stage 13 Movies: Gastrointestinal Tract | Cardiovascular | Central Nervous System | Carnegie Stage 13 | Stage 22 Movies | Movies The original animations were part of the UNSW Independent Learning Project (ILP) prepared by Aashish Kumar (2006).

Week:	1	2	3	4	5	6	7	8
Carnegie stage:	1 2 3 4	5 6	7 8 9	10 11 12 13	14 15	16 17	18 19	20 21 22 23

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Bright Field

Embryo and placenta

Embryo Links: Embryo and Placenta | Embryo | Embryo (label) | Embryo (animated) | Embryo (animated large) | Head region | Head region (label) | Body region | Body region (label) | Carnegie stage 13

Embryo Virtual Slide

Stage 13 - Left Ventrolateral View

‎‎Mobile | Desktop | Original

Stage 13 | Embryo Slides

Scanning EM

Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Kyoto Collection

Upper half of embryo shown in median sagittal plane. Scale bar 1 mm.
Upper half of embryo shown in ventral view. Scale bar 0.5 mm.	Oral cavity floor. Scale bar 0.5 mm.

Movies

‎‎Embryo Stage 13 Page | Play

‎‎Embryo CNS Page | Play

‎‎Heart Sag MRI Page | Play

‎‎Sagittal EFIC Page | Play

Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Carnegie stage 13: 6473 left | 6473 dorsal | 6473 right | 6469 right | 8066 dorsal | 8066 left | 8119 left | 7433 right | 7433 ventral

Carnegie Collection Embryos - Stage 13
Serial No.	Size (mm)	Grade	Fixative	Embedding Medium	Plane	Thinness (µm)	Stain	Year	Notes
1	E.,4.5 Ch., 30x30	Poor	Salicylic acid	P	Transverse	10	Hemat.	1887	Obtained by Mall while student
19	E., 5.5 Ch., 18x14	Poor	p	?	Transverse	20	Al. coch.	1895
98	E., 4 Ch., 24x16x9	Poor	p	P	Transverse	20	Al. coch.	1896
76	E., 4.5 Ch., 22x20	Poor	Alc.	P	Transverse	20	Al. coch.	1897
112	E., 4	Poor	p	P	Sagittal	10	Al. coch.	p
116	E., 5	Poor	p	?	Sagittal	10	Al. coch.	1898
148	E.,4.3 Ch., 17x14x10	Poor	Alc.	P	Coronal	10	(Stain - Haematoxylin Eosin)	1899	Abnormal. Nasal discs fused
186	E.,3.5 Ch., 25x20x15	Poor	Alc.	P	Transverse	20	Al. coch.	1901
239	E., 3.0	Poor	Formalin	P	Transverse	10	(Stain - Haematoxylin Eosin)	1903
248	E., 4.5 Ch., 30x23x15	Poor	p	?	Coronal	50	Al. coch.	1904
407	E.,4 Ch., 14x13X7	Poor	Formalin	?	Transverse	40	Al. coch.	1907
463	E., 3.9 Ch., 17x12x7	Good	Formalin	P	Coronal	10	Al. coch.	1910
523	E., 5 Ch., 25x25x15	Fair	Formalin	P	Transverse	p	Al. coch.	1911
588	E., 4.0 Ch., 19x15x8	Good	Corros. acetic	P	Coronal	15	(Stain - Haematoxylin Eosin)	1912	Advanced
786	E., 4.5 Ch., 19x10x10	Poor	Alc.	P	Sagittal	15	Al. coch.	1913
800	E., 6.0	Good	Corros. acetic	P	Transverse	10	H	1913	Curettage. Anencephaly
808	E.,4.0	Poor	Corros. acetic	P	Transverse	15	Al. coch.	1914	Tubal Incomplete
826	E., 5.0 Ch., 13x13x9	Good	Formalin	P	Transverse	20	Al. coch.	1914	Shrunken
836	E.,4.0 Ch., 22x18x11	Exc.	Corros. acetic	P	Transverse	15	Al. coch.	1914	Less advanced
963	E.,4.0 Ch., 23x18x16	Good	Formalin	P	Coronal	20	Al. coch.	1914
1075	E.,6.0 Ch., 46x32x20	Exc.	Corros. acetic	P	Coronal	20	(Stain - Haematoxylin Eosin) or. G.	1915	Most advanced in group
3956	E., 4.0	Poor	Formalin	P	Transverse	20	Al. coch.	1922	Tubal Incomplete
4046	E.,5 Ch., 22x20x20	Poor	Formalin	P	Transverse	50	Al. coch.	1922
5541	E., 6.0 Ch., 35x30x20	Good	Formalin	P	Transverse	10	Al. coch., eosin	1927
5682	E., 5.3 Ch., 29x25x13	Poor	Formalin	P	Coronal	20	Al. coch.	1928
5874	E., 4.8	Exc.	Bouin	P	Transverse	10	(Stain - Haematoxylin Eosin)	1929	Hysterotomy. Bromides only
6032	E., 5.8 Ch., 30x24x13	Poor	Formalin	P	P	?	p	1929	Not good enough to cut
6469	E., 5.0 Ch., 25x18x18	Poor	Formalin	P	P	P	P	1932	Fragmented on cutting. Not saved
6473	E., 5.0 Ch, 30x30x15	Exc.	Formalin	C-P	Coronal	6	Al. coch.	1932	Less advanced. Ag added
7433	E., 5.2 Ch., 15x13x13	Exc.	Formalin	C-P	Coronal	8	(Stain - Haematoxylin Eosin)	1937	Tubal
7618	E, 48 Ch, 18x15x15	Exc.	Bouin	C-P	Coronal	10	(Stain - Haematoxylin Eosin)	1939	Hystereaomy. Advanced. Ag added
7669	E, 5.0 Ch., 23x16x14	Good	Formalin	C-P	Coronal	6	(Stain - Haematoxylin Eosin)	1939	Hysterectomy. Least advanced in group, Ag added
7889	E, 4.2	Exc.	Bouin	C-P	Coronal	6	(Stain - Haematoxylin Eosin)	1941	Hysterectomy
8066	E,53 Ch , 20x18xI8	Exc.	Bouin	C-P	Transverse	8	(Stain - Haematoxylin Eosin)	1942	Hysterectomy. Ag added to slide 2
8119	E., 5.3 Ch., 32x28x6.5	Exc.	Bouin	C-P	Transverse	8	(Stain - Haematoxylin Eosin)	1943	Hysterectomy
8147	E., 5.2 Ch., 27x21x19	Poor	Formalin	?	?	p	p	1943	Tubal Not cut
8239	E., 4.3	Exc.	Bouin	C-P	Sagittal	8	H. phlox.	1944
8372	E., 5.6	Exc.	Alc.& Bouin	P	Transverse	10	Azan	1946
8581	E., 4.8	Good	Kaiserling	C-P	Sagittal	8	Azan	1948	Most-advanced third
8967	E., 5.7	Exc.	Acetic Zenker	C-P	Transverse	6	(Stain - Haematoxylin Eosin)	1931	Head injured. Univ. Chicago No. H1426
9296	E,4.5	Exc.	C-P	Coronal	8	Azan	1955
9297	E., 4.5	Exc.	C-P	Sagittal	8	Azan	1955
9697	E., 5.5	Bouin	1956	not cut
Abbreviations Size - E. is the greatest length of the embryo and Ch. is the mean diameter of the chorion. Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections. Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P). Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution) Stain - ? - unknown or not determined.

iBook - Carnegie Embryos

iTunes link | iBook Store Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology. Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English. PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning). The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Hill Collection

Hill HH145

Links: Hill Collection

Hinrichsen Collection

Hinrichsen collection Human Embryo ME18 (stage13).

Note the developing pharyngeal arches in this ventral view of the embryo head.

Image source: The Hinrichsen Collection images are reproduced with the permission of Prof. Beate Brand-Saberi, Head, Department of Anatomy and Molecular Embryology, Ruhr-Universität Bochum. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Perry-Arey-Milligan Collection

Count	Rec.	Cat Number	Stage (est)	Age (days)	Cat Number	Size (CRL mm)	Sex	Section	Quality	Comment
1		1246-2	13	23 est	1246-2	5		entire	fair
2		25	13	23 est	25	5				29-24 all in
3		26	13	23 est	26	5				25-26 one box
4		51	13	23 est	51	5		Sagittal	fair
5		14	13	23 est	14	5			good	1 of 2 @ 5mm
		14	13	23 est	14	5			good	2 of 2 @ 5mm

Perry-Arey-Milligan Collection
Count	Rec.	Cat Number	Stage (est)	Age (days)	Cat Number	Size (CRL mm)	Sex	Section	Quality	Comment
1		1246-2	13	23 est	1246-2	5		entire	fair
2		25	13	23 est	25	5				29-24 all in
3		26	13	23 est	26	5				25-26 one box
4		51	13	23 est	51	5		Sagittal	fair
5		14	13	23 est	14	5			good	1 of 2 @ 5mm
		14	13	23 est	14	5			good	2 of 2 @ 5mm
6		K	15	37 est	K	7		Coronal	poor
7		29	15	37 est	29	7				#36 & #37 in 1 box
8		24	15	24	7
9		14	15	37 est	14	7			good	1 of 2 @ 7mm
		14	15	37 est	14	7			good	2 of 2 @ 7mm
10		8	15	37 est	8	8		longt.sec	Fair-good	entire embryo
11		60	16	38 est	60	10		Coronal	good
12		87	16	38 est	87	11	Male	Coronal	good
13		85	17	39 est	85	12	Male	Coronal	good
14		A	17	39 est	A	13		entire	good
15		6	17	39 est	6	15		Coronal	good
16		6C	17	39 est	6C	13		Transverse	good	pollack
17		65	18	41 est	65	18		Coronal	good
18		36	18	41 est	36	17			good
19		10	18	41 est	10	18			good
20		1	18	41 est	1	18		Sagittal	good
		1(2)	18	41 est	1(2)	70		Sagittal	good	18mm head
21		37	18	41 est	37	70			good	18mm head
22		88	18	41 est	88	18	Male	Coronal	good
23		2	19	45 est	2	20			good
24		5	19	45 est	5	20		Coronal	fair
25		56	19	45 est	56	20		Coronal	good
26		86	19	45 est	86	20	Male	Coronal	good
27		67	19	45 est	67	20	Male	Coronal	good
28		A-3	19	45 est	A-3	20	Male	Coronal	good
			21	48 est		25			fair
29		62	21	48 est	62	25		Coronal	fair
30		78(1)	21	48 est	78(1)	25	Male	Coronal	good
		78(2)			78(2)	25	Male	Coronal	good
31		103	22	50	103	28	Male		good
32		97	22	50	97	28	Male	Coronal	good
??		B-3 (Box 2)	23		B-3 (Box 2)	30		Coronal	good
33		98	23		98	30	Female	Coronal	good
1		B(1)	8 wk		B(1)	32	Female	Coronal	good
		B(1)	8 wk		B(1)	32	Female	Coronal	good
2		101	8 wk		101	33	Male		good
3		D-3 (Box 2)	8 wk		D-3 (Box 2)	33		Coronal	good
4		94	8 wk		94	35	Female	Coronal	good
5		E-3(1)	8 wk		E-3(1)	35	Male	Coronal	good
		E-3(2)	8 wk		E-3(2)	35	Male	Coronal	good
6		127	8 wk		127	36		Sagittal	good
7		38	8 wk		38	38		Sagittal	good
8		126.1	8 wk		126.1	38		Sagittal	good
		126.2	8 wk		126.2	38		Sagittal	good
9		A5(1)	9 wk		A5(1)	45		Coronal	good
		A5(2)	9 wk		A5(2)	45		Coronal	good
10		68	9 wk		68	45		Coronal	good
11		73	9 wk		73	45		Sagittal	good
12		55A(1)	9 wk		55A(1)	47		Coronal	good
		55A(2)	9 wk		55A(2)	47		Coronal	good
13		89A	10 wk		89A	59	Male	Coronal	good
		89B(1)	10 wk		89B(1)	59	Male	Coronal	good
		89B(2)	10 wk		89B(2)	59	Male	Coronal	good
14		83A	10 wk		83A	60	Male	Coronal	good
		83B	10 wk		83B	60	Male	Sagittal	good
15		17(1)	10 wk		17(1)	60		Sagittal	good
		17(2)	10 wk		17(2)	60		Coronal	good
16		1372(1)	10 wk		1372(1)	64		Sagittal	good
		1372(2)	10 wk		1372(2)	64		Coronal	good
17		58A(1)	10 wk		58A(1)	65		Coronal	good
		58A(2)	10 wk		58A(2)	65		Coronal	good
18		52	10 wk		52	65	Female	Sagittal	good
19		19	10 wk		19	66		Sagittal	good
20		15(1)	10 wk	73	15(1)	67		Coronal	good
		15(2)	10 wk	73	15(2)	67		Coronal	good
21		90B	11 wk	75	90B	70	Male	Sagittal	good
22		14(1)	11 wk	75	14(1)	70		Coronal	good
22		14(2)	11 wk	75	14(2)	70		Coronal	good
22		14(3)	11 wk	75	14(3)	70		Sagittal	good
23	2001Dec	39.2	11 wk	75	39	70		Coronal	good	39 box 1= Sagittal
24	2001Dec	90A(1)	11 wk	75	90A(1)	70	Male	Coronal	good
24	2001Dec	90A(2)	11 wk	75	90A(2)	70	Male	Coronal	good
25		54A(1)	11 wk	77	54A(1)	72	Male
25		54A(2)	11 wk	77	54A(2)	72	Male
26		91#1	11 wk	77	91#1	75	Male	Coronal	good
26		91#2	11 wk	77	91#2	75	Male	Coronal	good
28		66B{1}	11 wk	77	66B{1}	75	Male	Coronal	good
28		66B{2}	11 wk	77	66B{2}	75	Male	Coronal	good
29		69B{1}	11 wk	77	69B{1}	75	Male	Sagittal	good
29		69B{2}	11 wk	77	69B{2}	75	Male	Sagittal	good
30		79A{1)	11 wk	77	79A{1)	75	Male	Coronal	good
30		79A{2)	11 wk	77	79A{2)	75	Male	Sagittal	good
30		79B	11 wk	77	79B	75	Male	Sagittal	good
31		1246(1)	11 wk	79	1246(1)	78		Coronal	good
31		1246(2)	11 wk	79	1246(2)	78		Coronal	good
32	2001Dec	80A(1)	11 wk	79	80A(1)	78	Male	Coronal	good
32	2001Dec	80A(2)	11 wk	79	80A(2)	78	Male	Coronal	good
32	2001Dec	80B	11 wk	79	80B	78	Male	Sagittal	good
33		22	11 wk	79	22	78			Sagittal	good
34		20{1}	11 wk	80	20{1}		Coronal	good
34		20{2}	11 wk	80	20{2}		Coronal	good
35	2001Dec	74(1)	11 wk	80	74(1)	80	Male	Coronal	good
35	2001Dec	74(1)	11 wk	80	74(1)	80	Male	Coronal	good
36	2001Dec	57B(1}	11 wk	80	57B(1}	80	Male	Sagittal	good
36	2001Dec	57B(2}	11 wk	80	57B(2}	80	Male	Sagittal	good
36	2001Dec	57A(1}	11 wk	80	57A(1}	80	Male	Coronal	good
36	2001Dec	57A(2}	11 wk	80	57A(2}	80	Male	Coronal	good
36	2001Dec	57A(3}	11 wk	80	57A(3}	80	Male	Coronal	good
37	2001Dec	53A(1}	11 wk	80	53A(1}	80	Male	Coronal	good
37	2001Dec	53A(2}	11 wk	80	53A(2}	80	Male	Coronal	good
37	2001Dec	53B(1}	11 wk	80	53B(1}	80	Male	Sagittal	good
37	2001Dec	53B(2}	11 wk	80	53B(2}	80	Male	Sagittal	good
38	2001Dec	74B(1}	11 wk	80	74B(1}	80	Male	Sagittal	good
38	2001Dec	74B(2}	11 wk	80	74B(2}	80	Male	Sagittal	good
39	2001Dec	1819(1}	11 wk	81	1819(1}	81		Transverse	good
39	2001Dec	1819(2}	11 wk	81	1819(2}	81		Transverse	good
40	2001Dec	77B{1}	11 wk	82	77B{1}	82	Male	Sagittal	good
40	2001Dec	77B{2}	11 wk	82	77B{2}	82	Male	Sagittal	good
41	2001Dec	81B{1}	11 wk	82	81B{1}	82	Male	Sagittal	good
41	2001Dec	81B{2}	11 wk	82	81B{2}	82	Male	Sagittal	good
41	2001Dec	81A{1}	11 wk	82	81A{1}	82	Male	Coronal	good
41	2001Dec	81A{2}	11 wk	82	81A{2}	82	Male	Coronal	good
42	2001Dec	75A	11 wk	82	75A	82.5	Male	Coronal	good
43		16	11 wk	83	16	85		Coronal
44	2001Dec	93A (1)	11 wk	83	93A (1)	85	Male	Coronal	good
44	2001Dec	93A (2)	11 wk	83	93A (2)	85	Male	Coronal	good
45	2001Dec	12 (1)	11 wk	83	12 (1)	85	Male	Coronal	good
45	2001Dec	12 (2)	11 wk	83	12 (2)	85	Male	Coronal	good
45	2001Dec	12 (3)	11 wk	83	12 (3)	85	Male	Coronal	good
45	2001Dec	12 (4)	11 wk	83	12 (4)	85	Male	Coronal	good
46	2001Dec	92 (1)	11 wk	83	92 (1)	85	Male	Sagittal	good
46	2001Dec	92 (2)	11 wk	83	92 (2)	85	Male	Sagittal	good
47	2001Dec	82B (1)	12 wk	84	82B (1)	90	Female	Sagittal	good
47	2001Dec	82B (2)	12 wk	84	82B (2)	90	Female	Sagittal	good
48	2001Dec	8	12 wk	84	8	90		Coronal
48	2001Dec	8	12 wk	84	8	90		Coronal
49	2001Dec	82A(1)	12 wk	84	82A(1)	90	Female	Coronal	good
49	2001Dec	82A(2)	12 wk	84	82A(2)	90	Female	Coronal	good
50	2001Dec	49	12 wk	88	49	96		coronal	fair
51	2001Dec	14151.1	12 wk	88	14151.1	97
51	2001Dec	14151.2	12 wk	88	14151.2	97
51	2001Dec	14151.3	12 wk	88	14151.3	97
52	2001Nov	11.1	12 wk	90	11.1	100	Male	Coronal	Exc	whole head-MTC
52	2001Nov	11.2	12 wk	90	11.2	100	Male	Coronal	Exc	whole head-MTC
52	2001Nov	11.3	12 wk	90	11.3	100	Male	Coronal	good	whole head-MTC
53	2001Nov	4C	13 wk	96	4C	112		Coronal		pollack sta
54	2001Nov	1862	13 wk	97	1862	113
55	2001Nov	1741	13 wk	100	1741	120		Coronal	good
56	2001Nov	5C(1)	14 wk	103	5C(1)	124		Coronal	good
56	2001Nov	5C(2)	14 wk	103	5C(2)	124		Coronal	good	pollack sta
57	2001Nov	6C	15 wk	106	6C	130		Transverse	good	pollack sta
58	2001Nov	7C(1)	17 wk	122	7C(1)	160		Transverse	good	pollack
58	2001Nov	7C(2)	17 wk	122	7C(2)	160		Transverse	good	pollack
59	2001Nov	1123	21 wk		1123	206		Coronal	good	pollack
60	2001Nov	1683	wk		1683	227		Transverse	good
61	2001Nov	1731	wk		1731	246		Coronal	good	pollack
62	2001Nov	1777	26 wk		1777	255		Coronal	good	pollack
		1A(2)			1A(2)	no CRL		Coronal	good
		1A(3)			1A(3)	no CRL		Coronal	good
		13			13				good	4 different embryos
		28			28	10mm ?			good	label on box says 4.5 mm
		5.1			5.1	10mm ?		Coronal	good	head = 7mm
		5.2			5.2				good	head = 7mm
		23			23		Female	Coronal	good	head measure to 13
		18			18			Coronal	good	head measure to 19
		70	11 wk est		70	head 27mm		Coronal	good
	2001Nov	100(1)			100(1)	head 27mm		Sagittal	good	No CR notes
	2001Nov	100(2)			100(2)	head 27mm		Sagittal	good	No CR notes
		75A			75A	?	Male	Coronal	good	No CR notes

Stage 13 Serial Section Images

These are the original serial images prepared from embryo sections for Embryology practical classes and transferred online in 1996. This embryo shows some features present on the later Stage 14 embryo.

Links: Carnegie stage 13 - serial sections | Carnegie stage 22 - serial sections | Carnegie stage 22

Labeled Sections

Stage 13 serial labeled images

A1L	A2L	A3L	A4L	A5L	A6L	A7L
B1L	B2L	B3L	B4L	B5L	B6L	B7L
C1L	C2L	C3L	C4L	C5L	C6L	C7L
D1L	D2L	D3L	D4L	D5L	D6L	D7L
E1L	E2L	E3L	E4L	E5L	E6L	E7L
F1L	F2L	F3L	F4L	F5L	F6L	F7L
G1L	G2L	G3L	G4L	G5L	G6L	G7L

Unlabeled Sections

Stage 13 serial unlabeled images

A1	A2	A3	A4	A5	A6	A7
B1	B2	B3	B4	B5	B6	B7
C1	C2	C3	C4	C5	C6	C7
D1	D2	D3	D4	D5	D6	D7
E1	E2	E3	E4	E5	E6	E7
F1	F2	F3	F4	F5	F6	F7
G1	G2	G3	G4	G5	G6	G7

Stage 13 Reconstruction Movies

‎‎Systems Page | Play

‎‎GIT Stage 13 Page | Play

‎‎Cardiovascular Page | Play

‎‎Stage 13 Neural Page | Play

Events

• hearing - otic vesicle closes from surface and endolymphatic appendage apparent. A capillary network forms around the otic vesicle with esoderm becomes condensed as the otic capsule.
  • inner ear
    • Vestibulocochlear ganglion (vestibular part) and vestibular nerve fibres present.
    • miR-183 MicroRNA family are differentially expressed in cochleovestibular ganglion in the human inner ear
• vision
  • By the end of the fourth week the optic vesicle lies close to the surface ectoderm. Optic evagination differentiation allows identification of optic part of retina, future pigmented layer of retina, and optic stalk. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.
• cardiovascular
  • Cerebral Artery - hindbrain (i.e., future posterior fossa) is supplied by two parallel neural arteries (or channels). These arteries obtain their blood supply from carotid-vertebrobasilar anastomoses given by the trigeminal artery, the otic artery, hypoglossal artery, and the pre-atlantal artery.
• endocrine
  • pituitary - basement membranes of the craniopharyngeal pouch and the brain are clearly in contact (O'Rahilly 1973).
  • thymus - Weller (1933) recognized already a thymic primordium "of considerable size" on the ventral part of the third pharyngeal pouch, whereas Norris (1938) considered this stage to be "preprimordial"
  • thyroid - median thyroid is now bilobed and is connected to the pharynx by a hollow pedicle. The telopharyngeal body has been regarded by some as a "lateral thyroid component".
  • pancreas - ventral pancreas may perhaps be distinguishable.
• Meninges (spinal cord) - xiii and xiv (embryos of 4 to 8 mm), advances are particularly evident in the vertebral rudiments and in the spinal ganglia, with the latter starting their migration ventrad. The vascularization of the tissues directly adjacent to the neural tube has continued, and endothelium-lined channels are beginning to form in the older embryos.
• genital -primordial germ cells are migrating into the mesonephric ridges.

• limb - neural upper limb nerves (C5-T1) extended from the spinal cord.

Additional Images

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  Stage 13 crown rump length

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  Stage 13 surface bulges

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  Stage 13 Optical Projection Tomography

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  Stage 13 otocyst

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  Stage 13 caudal trunk

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  Cross-section showing neural tube, notochord, limb bud

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  Selected image of above cross-section showing neural tube, notochord, limb bud

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  Fig. 37. Human Heart Reconstruction

Historic

Historic Disclaimer - information about historic embryology pages

Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding.     (More? Embryology History | Historic Embryology Papers)

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  Historic - Human embryo with twenty-seven primitive segments (7 mm., 26 days)

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  Historic - Human embryo with 28 primitive segments (7.5 mm)

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  1911 Cloaca model Carnegie Embryo 186

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  Arch arteries Carnegie Embryo 836

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Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Embryonic Development

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Cite this page: Hill, M.A. (2023, December 1) Embryology Carnegie stage 13. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_13

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© Dr Mark Hill 2023, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G