Musculoskeletal System Development
|Embryology - 4 Jul 2015 Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Textbooks
- 4 Objectives
- 5 Development Overview
- 6 Shoulder and Pelvis
- 7 References
- 8 Additional Images
- 9 External Links
- 10 Glossary Links
The mesoderm forms nearly all the connective tissues of the musculoskeletal system. Each tissue (cartilage, bone, and muscle) goes through many different mechanisms of differentiation.
The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.
The intraembryonic mesoderm can be broken into paraxial, intermediate and lateral mesoderm relative to its midline position. During the 3rd week the paraxial mesoderm forms into "balls" of mesoderm paired either side of the neural groove, called somites.
Somites appear bilaterally as pairs at the same time and form earliest at the cranial (rostral,brain) end of the neural groove and add sequentially at the caudal end. This addition occurs so regularly that embryos are staged according to the number of somites that are present. Different regions of the somite differentiate into dermomyotome (dermal and muscle component) and sclerotome (forms vertebral column). An example of a specialized musculoskeletal structure can be seen in the development of the limbs.
Skeletal muscle forms by fusion of mononucleated myoblasts to form mutinucleated myotubes. Bone is formed through a lengthy process involving ossification of a cartilage formed from mesenchyme. Two main forms of ossification occur in different bones, intramembranous (eg skull) and endochondrial (eg limb long bones) ossification. Ossification continues postnatally, through puberty until mid 20s. Early ossification occurs at the ends of long bones.
Musculoskeletal and limb abnormalities are one of the largest groups of congenital abnormalities.
- Musculoskeletal Links: Introduction | Mesoderm | Somitogenesis | Limb | Cartilage | Bone | Bone Timeline | Axial Skeleton | Skull | Joint | Muscle | Muscle Timeline | Tendon | Diaphragm | Lecture - Musculoskeletal Development | Abnormalities | Limb Abnormalities | Cartilage Histology | Bone Histology | Skeletal Muscle Histology | Category:Musculoskeletal
Some Recent Findings
|More recent papers|
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Malte Haupt, Vivien Kauschke, Jonas Sender, Marian Kampschulte, Anna Kovtun, Lutz Dürselen, Christian Heiss, Katrin Susanne Lips Bone status of adult female butyrylcholinesterase gene-deficient mice. Int. Immunopharmacol.: 2015; PMID: 26138460 Jacob L Jaremko, Meaghan Pitts, Walter P Maksymowych, Robert G Lambert Development of Image Overlay and Knowledge Transfer Module Technologies Aimed at Enhancing Feasibility and External Validation of Magnetic Resonance Imaging-based Scoring Systems. J. Rheumatol.: 2015; PMID: 26136486 Regina Ebert, Peggy Benisch, Melanie Krug, Sabine Zeck, Jutta Meißner-Weigl, Andre Steinert, Martina Rauner, Lorenz Hofbauer, Franz Jakob Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells. Stem Cell Res: 2015, 15(1);231-239 PMID: 26135899 Corrie Myburgh, Eleanor Boyle, Henrik H Lauridsen, Lise Hestbaek, Alice Kongsted What influences retrospective self-appraised recovery status among danes with low-back problems? A comparative qualitative investigation. J Rehabil Med: 2015; PMID: 26132377 Peter K Joshi, Tonu Esko, Hannele Mattsson, Niina Eklund, Ilaria Gandin, Teresa Nutile, Anne U Jackson, Claudia Schurmann, Albert V Smith, Weihua Zhang, Yukinori Okada, Alena Stančáková, Jessica D Faul, Wei Zhao, Traci M Bartz, Maria Pina Concas, Nora Franceschini, Stefan Enroth, Veronique Vitart, Stella Trompet, Xiuqing Guo, Daniel I Chasman, Jeffrey R O'Connel, Tanguy Corre, Suraj S Nongmaithem, Yuning Chen, Massimo Mangino, Daniela Ruggiero, Michela Traglia, Aliki-Eleni Farmaki, Tim Kacprowski, Andrew Bjonnes, Ashley van der Spek, Ying Wu, Anil K Giri, Lisa R Yanek, Lihua Wang, Edith Hofer, Cornelius A Rietveld, Olga McLeod, Marilyn C Cornelis, Cristian Pattaro, Niek Verweij, Clemens Baumbach, Abdel Abdellaoui, Helen R Warren, Dragana Vuckovic, Hao Mei, Claude Bouchard, John R B Perry, Stefania Cappellani, Saira S Mirza, Miles C Benton, Ulrich Broeckel, Sarah E Medland, Penelope A Lind, Giovanni Malerba, Alexander Drong, Loic Yengo, Lawrence F Bielak, Degui Zhi, Peter J van der Most, Daniel Shriner, Reedik Mägi, Gibran Hemani, Tugce Karaderi, Zhaoming Wang, Tian Liu, Ilja Demuth, Jing Hua Zhao, Weihua Meng, Lazaros Lataniotis, Sander W van der Laan, Jonathan P Bradfield, Andrew R Wood, Amelie Bonnefond, Tarunveer S Ahluwalia, Leanne M Hall, Erika Salvi, Seyhan Yazar, Lisbeth Carstensen, Hugoline G de Haan, Mark Abney, Uzma Afzal, Matthew A Allison, Najaf Amin, Folkert W Asselbergs, Stephan J L Bakker, R Graham Barr, Sebastian E Baumeister, Daniel J Benjamin, Sven Bergmann, Eric Boerwinkle, Erwin P Bottinger, Archie Campbell, Aravinda Chakravarti, Yingleong Chan, Stephen J Chanock, Constance Chen, Y-D Ida Chen, Francis S Collins, John Connell, Adolfo Correa, L Adrienne Cupples, George Davey Smith, Gail Davies, Marcus Dörr, Georg Ehret, Stephen B Ellis, Bjarke Feenstra, Mary F Feitosa, Ian Ford, Caroline S Fox, Timothy M Frayling, Nele Friedrich, Frank Geller, Generation Scotland, Irina Gillham-Nasenya, Omri Gottesman, Misa Graff, Francine Grodstein, Charles Gu, Chris Haley, Christopher J Hammond, Sarah E Harris, Tamara B Harris, Nicholas D Hastie, Nancy L Heard-Costa, Kauko Heikkilä, Lynne J Hocking, Georg Homuth, Jouke-Jan Hottenga, Jinyan Huang, Jennifer E Huffman, Pirro G Hysi, M Arfan Ikram, Erik Ingelsson, Anni Joensuu, Åsa Johansson, Pekka Jousilahti, J Wouter Jukema, Mika Kähönen, Yoichiro Kamatani, Stavroula Kanoni, Shona M Kerr, Nazir M Khan, Philipp Koellinger, Heikki A Koistinen, Manraj K Kooner, Michiaki Kubo, Johanna Kuusisto, Jari Lahti, Lenore J Launer, Rodney A Lea, Benjamin Lehne, Terho Lehtimäki, David C M Liewald, Lars Lind, Marie Loh, Marja-Liisa Lokki, Stephanie J London, Stephanie J Loomis, Anu Loukola, Yingchang Lu, Thomas Lumley, Annamari Lundqvist, Satu Männistö, Pedro Marques-Vidal, Corrado Masciullo, Angela Matchan, Rasika A Mathias, Koichi Matsuda, James B Meigs, Christa Meisinger, Thomas Meitinger, Cristina Menni, Frank D Mentch, Evelin Mihailov, Lili Milani, May E Montasser, Grant W Montgomery, Alanna Morrison, Richard H Myers, Rajiv Nadukuru, Pau Navarro, Mari Nelis, Markku S Nieminen, Ilja M Nolte, George T O'Connor, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R Palmas, James S Pankow, Inga Patarcic, Francesca Pavani, Patricia A Peyser, Kirsi Pietilainen, Neil Poulter, Inga Prokopenko, Sarju Ralhan, Paul Redmond, Stephen S Rich, Harri Rissanen, Antonietta Robino, Lynda M Rose, Richard Rose, Cinzia Sala, Babatunde Salako, Veikko Salomaa, Antti-Pekka Sarin, Richa Saxena, Helena Schmidt, Laura J Scott, William R Scott, Bengt Sennblad, Sudha Seshadri, Peter Sever, Smeeta Shrestha, Blair H Smith, Jennifer A Smith, Nicole Soranzo, Nona Sotoodehnia, Lorraine Southam, Alice V Stanton, Maria G Stathopoulou, Konstantin Strauch, Rona J Strawbridge, Matthew J Suderman, Nikhil Tandon, Sian-Tsun Tang, Kent D Taylor, Bamidele O Tayo, Anna Maria Töglhofer, Maciej Tomaszewski, Natalia Tšernikova, Jaakko Tuomilehto, Andre G Uitterlinden, Dhananjay Vaidya, Astrid van Hylckama Vlieg, Jessica van Setten, Tuula Vasankari, Sailaja Vedantam, Efthymia Vlachopoulou, Diego Vozzi, Eero Vuoksimaa, Melanie Waldenberger, Erin B Ware, William Wentworth-Shields, John B Whitfield, Sarah Wild, Gonneke Willemsen, Chittaranjan S Yajnik, Jie Yao, Gianluigi Zaza, Xiaofeng Zhu, BioBank Japan Project, Rany M Salem, Mads Melbye, Hans Bisgaard, Nilesh J Samani, Daniele Cusi, David A Mackey, Richard S Cooper, Philippe Froguel, Gerard Pasterkamp, Struan F A Grant, Hakon Hakonarson, Luigi Ferrucci, Robert A Scott, Andrew D Morris, Colin N A Palmer, George Dedoussis, Panos Deloukas, Lars Bertram, Ulman Lindenberger, Sonja I Berndt, Cecilia M Lindgren, Nicholas J Timpson, Anke Tönjes, Patricia B Munroe, Thorkild I A Sørensen, Charles N Rotimi, Donna K Arnett, Albertine J Oldehinkel, Sharon L R Kardia, Beverley Balkau, Giovanni Gambaro, Andrew P Morris, Johan G Eriksson, Margie J Wright, Nicholas G Martin, Steven C Hunt, John M Starr, Ian J Deary, Lyn R Griffiths, Henning Tiemeier, Nicola Pirastu, Jaakko Kaprio, Nicholas J Wareham, Louis Pérusse, James G Wilson, Giorgia Girotto, Mark J Caulfield, Olli Raitakari, Dorret I Boomsma, Christian Gieger, Pim van der Harst, Andrew A Hicks, Peter Kraft, Juha Sinisalo, Paul Knekt, Magnus Johannesson, Patrik K E Magnusson, Anders Hamsten, Reinhold Schmidt, Ingrid B Borecki, Erkki Vartiainen, Diane M Becker, Dwaipayan Bharadwaj, Karen L Mohlke, Michael Boehnke, Cornelia M van Duijn, Dharambir K Sanghera, Alexander Teumer, Eleftheria Zeggini, Andres Metspalu, Paolo Gasparini, Sheila Ulivi, Carole Ober, Daniela Toniolo, Igor Rudan, David J Porteous, Marina Ciullo, Tim D Spector, Caroline Hayward, Josée Dupuis, Ruth J F Loos, Alan F Wright, Giriraj R Chandak, Peter Vollenweider, Alan R Shuldiner, Paul M Ridker, Jerome I Rotter, Naveed Sattar, Ulf Gyllensten, Kari E North, Mario Pirastu, Bruce M Psaty, David R Weir, Markku Laakso, Vilmundur Gudnason, Atsushi Takahashi, John C Chambers, Jaspal S Kooner, David P Strachan, Harry Campbell, Joel N Hirschhorn, Markus Perola, Ozren Polašek, James F Wilson Directional dominance on stature and cognition in diverse human populations. Nature: 2015; PMID: 26131930
| Hill, M.A. (2015). UNSW Embryology (15th ed.) Retrieved July 4, 2015, from https://embryology.med.unsw.edu.au
|Moore, K.L. & Persuad, T.V.N. (2008). The Developing Human: clinically oriented embryology (8th ed.). Philadelphia: Saunders.|
| Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H. (2009). Larsen’s Human Embryology (4th ed.). New York; Edinburgh: Churchill Livingstone.
- Identify the components of a somite and the adult derivatives of each component.
- Give examples of sites of endochondral and intramembranous ossification and to compare these two processes.
- Identify the general times of formation of primary and of formation of secondary ossification centres, and of fusion of such centres with each other.
- Briefly summarise the development of the limbs.
- Describe the developmental abnormalities responsible for the following malformations: selected growth plate disorders; congenital dislocation of the hip; scoliosis; arthrogryposis; and limb reduction deformities.
Bone is a connective tissue and develops from mesoderm except in the head where neural crest also contributes. Below is a very brief cartoon overview using simple figures of 3 aspects of early musculoskeletal development. More detailed overviews are shown on other notes pages Mesoderm and Somite, Vertebral Column, Limb in combination with serial sections and Carnegie images.
|Mesoderm beside the notochord (axial mesoderm, blue) thickens, forming the paraxial mesoderm as a pair of strips along the rostro-caudal axis.|
|Paraxial mesoderm towards the rostral end, begins to segment forming the first somite. Somites are then sequentially added caudally. The somitocoel, is a cavity forming in early somites, which is lost as the somite matures.|
|Cells in the somite differentiate medially to form the sclerotome (forms vertebral column) and dorsolaterally to form the dermomyotome.|
| The dermomyotome then forms the dermotome (forms dermis) and myotome (forms muscle).
Neural crest cells migrate beside and through somite.
|The myotome differentiates to form 2 components dorsally the epimere and ventrally the hypomere, which in turn form epaxial and hypaxial muscles respectively. The bulk of the trunk and limb muscle coming from the Hypaxial mesoderm. Different structures will be contributed depending upon the somite level.|
Somite Links: 1 paraxial | 2 early somite | 3 sclerotome and dermomyotome | 4 dermatome and myotome | 5 somite spreading | SEM image - Human Embryo (week 4) showing somites | Movie - somitogenesis Hes expression
Shoulder and Pelvis
The skeletal shoulder consists of: the clavicle (collarbone), the scapula (shoulder blade), and the humerus. Development of his region occurs through both forms of ossification processes.
The skeletal pelvis consists of: the sacrum and coccyx (axial skeleton), and pelvic girdle formed by a pair of hip bones (appendicular skeleton). Before puberty, he pelvic girdle also consists of three unfused bones: the ilium, ischium, and pubis. In chicken, the entire pelvic girdle originates from the somatopleure mesoderm (somite levels 26 to 35) and the ilium, but not of the pubis and ischium, depends on somitic and ectodermal signals.
- Olivier Pourquié Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell: 2011, 145(5);650-63 PMID: 21620133
- Yegor Malashichev, Bodo Christ, Felicitas Pröls Avian pelvis originates from lateral plate mesoderm and its development requires signals from both ectoderm and paraxial mesoderm. Cell Tissue Res.: 2008, 331(3);595-604 PMID: 18087724
- Developmental Biology by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000 Paraxial and intermediate mesoderm | Myogenesis: The Development of Muscle | Osteogenesis: The Development of Bones | Figure 14.10. Conversion of myoblasts into muscles in culture
- Molecular Biology of the Cell Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 Search Molecular Biology of the CellBone Is Continually Remodeled by the Cells Within ItImage: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.
Olivier Pourquié Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell: 2011, 145(5);650-63 PMID: 21620133
Katarzyna A Piróg, Michael D Briggs Skeletal dysplasias associated with mild myopathy-a clinical and molecular review. J. Biomed. Biotechnol.: 2010, 2010;686457 PMID: 20508815
Avan Aihie Sayer, Cyrus Cooper Fetal programming of body composition and musculoskeletal development. Early Hum. Dev.: 2005, 81(9);735-44 PMID: 16081228
J M Walker Musculoskeletal development: a review. Phys Ther: 1991, 71(12);878-89 PMID: 1946622
Kimberly E Applegate Can MR imaging be used to characterize fetal musculoskeletal development? Radiology: 2004, 233(2);305-6 PMID: 15516609
Jung Kyu Ryu, Jeong Yeon Cho, Jong Sun Choi Prenatal sonographic diagnosis of focal musculoskeletal anomalies. Korean J Radiol: 2004, 4(4);243-51 PMID: 14726642
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Cite this page: Hill, M.A. (2015) Embryology Musculoskeletal System Development. Retrieved July 4, 2015, from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_Development
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