Neural Crest - Peripheral Nervous System
|Embryology - 18 Aug 2017 Expand to Translate|
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The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, teeth, head, face, heart, adrenal glands, gastrointestinal tract) will also have a contribution fron the neural crest cells.
In the body region, neural crest cells also contribute the peripheral nervous system (both neurons and glia) consisting of sensory ganglia (dorsal root ganglia), sympathetic and parasympathetic ganglia and neural plexuses within specific tissues/organs.
In the head region, neural crest cells migrate into the pharyngeal arches (as shown in movie below) forming ectomesenchyme contributing tissues which in the body region are typically derived from mesoderm (cartilage, bone, and connective tissue).General neural development is also covered in Neural Notes.
|Neural Crest Links: Introduction | Lecture - Early Neural | Lecture - Neural Crest Development | Schwann | Adrenal Gland | Melanocyte | Peripheral Nervous System | Enteric Nervous System | Cornea | Cranial Nerves | Cardiac | Nicole Le Douarin | Neural Crest Movies | Abnormalities | Category:Neural Crest|
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Nima Ghitani, Arnab Barik, Marcin Szczot, James H Thompson, Chia Li, Claire E Le Pichon, Michael J Krashes, Alexander T Chesler Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull. Neuron: 2017, 95(4);944-954.e4 PubMed 28817806
Annabel J Sorby-Adams, Amanda M Marcoionni, Eden R Dempsey, Joshua A Woenig, Renée J Turner The Role of Neurogenic Inflammation in Blood-Brain Barrier Disruption and Development of Cerebral Oedema Following Acute Central Nervous System (CNS) Injury. Int J Mol Sci: 2017, 18(8); PubMed 28817088
Eduardo Bondan, Carolina Cardoso, Maria de Fátima Martins Curcumin decreases astrocytic reaction after gliotoxic injury in the rat brainstem. Arq Neuropsiquiatr: 2017, 75(8);546-552 PubMed 28813085
Konstantin Rosich, Bishoy Hanna, Rami K Ibrahim, Daniel Joseph Hellenbrand, Amgad Hanna The Effects of Glial Cell Line-Derived Neurotrophic Factor After Spinal Cord Injury. J. Neurotrauma: 2017; PubMed 28795616
Marco Puthenparampil, Alberto Terrin, Lisa Federle, Matteo Gizzi, Paola Perini, Paolo Gallo Acute simultaneous development of brain tumour-like lesion and demyelinating polyneuropathy in a patient with chronic relapsing myelitis. Mult. Scler.: 2017;1352458517714610 PubMed 28795610
Chang-Ning Liu, Edwin Berryman, David Zakur, Ahmed M Shoieb, Ingrid D Pardo, Magalie Boucher, Chris J Somps, Chedo M Bagi, Jon C Cook A novel endpoint for the assessment of chemotherapy-induced peripheral neuropathy in rodents: biomechanical properties of peripheral nerve. J Appl Toxicol: 2017; PubMed 28815646
Regina Hanstein, David C Spray The role of pannexin 1 in chemotherapy-induced peripheral neuropathy (CIPN). J. Clin. Oncol.: 2015, 33(29_suppl);6 PubMed 28148146
Mohamad-Reza Aghanoori, Darrell R Smith, Subir Roy Chowdhury, Mohammad Golam Sabbir, Nigel A Calcutt, Paul Fernyhough Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats. Exp. Neurol.: 2017; PubMed 28803751
Feifei Wang, Qianghua Wang, Chen Li, Panpan Yu, Yibo Qu, Libing Zhou The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia. Neuroscience: 2017; PubMed 28754314
Estrela Neto, Cecília J Alves, Luís Leitão, Daniela M Sousa, Inês S Alencastre, Francisco Conceição, Meriem Lamghari Axonal outgrowth, neuropeptides expression and receptors tyrosine kinase phosphorylation in 3D organotypic cultures of adult dorsal root ganglia. PLoS ONE: 2017, 12(7);e0181612 PubMed 28742111
Julia J Müller, Matthias Schwab, Charles R Rosenfeld, Iwa Antonow-Schlorke, Peter W Nathanielsz, Florian Rakers, Harald Schubert, Otto W Witte, Sven Rupprecht Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation. J. Vasc. Res.: 2017, 54(5);259-271 PubMed 28810262
Lisa Klingelhoefer, Heinz Reichmann The Gut and Nonmotor Symptoms in Parkinson's Disease. Int. Rev. Neurobiol.: 2017, 134;787-809 PubMed 28805583
Christopher T Leffler, Stephen G Schwartz, Ricardo D Wainsztein, Adam Pflugrath, Eric Peterson Ophthalmology in North America: Early Stories (1491-1801). Ophthalmol Eye Dis: 2017, 9;1179172117721902 PubMed 28804247
Riccardo Liga, Alessia Gimelli, Paolo Marzullo, Giuseppe Ambrosio, Matteo Cameli, Elisabetta Cerbai, Stefano Coiro, Michele Emdin, Rossella Marcucci, Doralisa Morrone, Alberto Palazzuoli, Anna Sonia Petronio, Ketty Savino, Luigi Padeletti, Roberto Pedrinelli, Società Italiana di Cardiologia, Sezione Regionale Tosco-Umbra Myocardial (123)I-metaiodobenzylguanidine imaging in hypertension and left ventricular hypertrophy. J Nucl Cardiol: 2017; PubMed 28798990
Zifeng Xu, Tao Xu, Puwen Zhao, Rui Ma, Mazhong Zhang, Jijian Zheng Differential Roles of the Right and Left Toe Perfusion Index in Predicting the Incidence of Postspinal Hypotension During Cesarean Delivery. Anesth. Analg.: 2017; PubMed 28795968
Neural Crest Migration
Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.
The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.
Cranial Neural Crest
- stage 9 - an indication of mesencephalic neural crest
- stage 10 - trigeminal, facial, and postotic components
- stage 11 - crest-free zones are soon observable in rhombomere 1, 3, and 5
- stage 12 - rhombomeres 6 and 7 neural crest migrate to pharyngeal arch 3 and then rostrad to the truncus arteriosus
- stage 13 - nasal crest and the terminalis-vomeronasal complex are last of the cranial crest to appear
stages 9-14 - otic vesicle primordium descends
Trunk Neural Crest
Spinal ganglia increase in number over time and are in phase with the somites, though not their centre. There are 3 migratory pathways: ventrolateral between dermatomyotome and sclerotome, ventromedial between neural tube and sclerotomes, and lateral between surface ectoderm and dermatomyotome.
- stage 13 - about 19 present
- stage 14 - about 33 present
- stage 15-23 - 30–35 ganglia
- Katarina Vukojevic, Natalija Filipovic, Ivana Tica Sedlar, Ivana Restovic, Ivana Bocina, Irena Pintaric, Mirna Saraga-Babic Neuronal differentiation in the developing human spinal ganglia. Anat Rec (Hoboken): 2016; PubMed 27225905
- Ze-Lan Hu, Ming Shi, Ying Huang, Min-Hua Zheng, Zhe Pei, Jia-Yin Chen, Hua Han, Yu-Qiang Ding The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev: 2011, 6;14 PubMed 21510873
- Paul M Kulesa, Caleb M Bailey, Jennifer C Kasemeier-Kulesa, Rebecca McLennan Cranial neural crest migration: new rules for an old road. Dev. Biol.: 2010, 344(2);543-54 PubMed 20399765
- P M Kulesa, S E Fraser In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches. Development: 2000, 127(6);1161-72 PubMed 10683170
- Ronan O'Rahilly, Fabiola Müller The development of the neural crest in the human. J. Anat.: 2007, 211(3);335-51 PubMed 17848161 | PMC2375817 | J Anat.
Shlomo Krispin, Erez Nitzan, Chaya Kalcheim The dorsal neural tube: a dynamic setting for cell fate decisions. Dev Neurobiol: 2010, 70(12);796-812 PubMed 20683859
Uwe Ernsberger Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. Cell Tissue Res.: 2009, 336(3);349-84 PubMed 19387688
Harvey B Sarnat, Laura Flores-Sarnat Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J. Child Neurol.: 2005, 20(8);637-43 PubMed 16225807
Hsiao-Huei Chen, Simon Hippenmeyer, Silvia Arber, Eric Frank Development of the monosynaptic stretch reflex circuit. Curr. Opin. Neurobiol.: 2003, 13(1);96-102 PubMed 12593987
A Schober, K Unsicker Growth and neurotrophic factors regulating development and maintenance of sympathetic preganglionic neurons. Int. Rev. Cytol.: 2001, 205;37-76 PubMed 11336393
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Cite this page: Hill, M.A. 2017 Embryology Neural Crest - Peripheral Nervous System. Retrieved August 18, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Peripheral_Nervous_System
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