Neural Crest - Peripheral Nervous System
|Embryology - 1 Apr 2015 Translate|
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The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, teeth, head, face, heart, adrenal glands, gastrointestinal tract) will also have a contribution fron the neural crest cells.
In the body region, neural crest cells also contribute the peripheral nervous system (both neurons and glia) consisting of sensory ganglia (dorsal root ganglia), sympathetic and parasympathetic ganglia and neural plexuses within specific tissues/organs.
In the head region, neural crest cells migrate into the pharyngeal arches (as shown in movie below) forming ectomesenchyme contributing tissues which in the body region are typically derived from mesoderm (cartilage, bone, and connective tissue).General neural development is also covered in Neural Notes.
- Neural Crest Links: Introduction | Lecture - Early Neural | Lecture - Neural Crest Development | Schwann | Adrenal Gland | Melanocyte | Peripheral Nervous System | Enteric Nervous System | Cornea | Nicole Le Douarin | Neural Crest Movies | Abnormalities | Category:Neural Crest
Some Recent Findings
Neural Crest Migration
Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.
The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.
Cranial Neural Crest
- stage 9 - an indication of mesencephalic neural crest
- stage 10 - trigeminal, facial, and postotic components
- stage 11 - crest-free zones are soon observable in rhombomere 1, 3, and 5
- stage 12 - rhombomeres 6 and 7 neural crest migrate to pharyngeal arch 3 and then rostrad to the truncus arteriosus
- stage 13 - nasal crest and the terminalis-vomeronasal complex are last of the cranial crest to appear
stages 9-14 - otic vesicle primordium descends
Trunk Neural Crest
Spinal ganglia increase in number over time and are in phase with the somites, though not their centre. There are 3 migratory pathways: ventrolateral between dermatomyotome and sclerotome, ventromedial between neural tube and sclerotomes, and lateral between surface ectoderm and dermatomyotome.
- stage 13 - about 19 present
- stage 14 - about 33 present
- stage 15-23 - 30–35 ganglia
- Ze-Lan Hu, Ming Shi, Ying Huang, Min-Hua Zheng, Zhe Pei, Jia-Yin Chen, Hua Han, Yu-Qiang Ding The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev: 2011, 6;14 PMID: 21510873
- Paul M Kulesa, Caleb M Bailey, Jennifer C Kasemeier-Kulesa, Rebecca McLennan Cranial neural crest migration: new rules for an old road. Dev. Biol.: 2010, 344(2);543-54 PMID: 20399765
- P M Kulesa, S E Fraser In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches. Development: 2000, 127(6);1161-72 PMID: 10683170
- Ronan O'Rahilly, Fabiola Müller The development of the neural crest in the human. J. Anat.: 2007, 211(3);335-51 PMID: 17848161 | PMC2375817 | J Anat.
Shlomo Krispin, Erez Nitzan, Chaya Kalcheim The dorsal neural tube: a dynamic setting for cell fate decisions. Dev Neurobiol: 2010, 70(12);796-812 PMID: 20683859
Uwe Ernsberger Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. Cell Tissue Res.: 2009, 336(3);349-84 PMID: 19387688
Harvey B Sarnat, Laura Flores-Sarnat Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J. Child Neurol.: 2005, 20(8);637-43 PMID: 16225807
Hsiao-Huei Chen, Simon Hippenmeyer, Silvia Arber, Eric Frank Development of the monosynaptic stretch reflex circuit. Curr. Opin. Neurobiol.: 2003, 13(1);96-102 PMID: 12593987
A Schober, K Unsicker Growth and neurotrophic factors regulating development and maintenance of sympathetic preganglionic neurons. Int. Rev. Cytol.: 2001, 205;37-76 PMID: 11336393
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Cite this page: Hill, M.A. (2015) Embryology Neural Crest - Peripheral Nervous System. Retrieved April 1, 2015, from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Peripheral_Nervous_System
- © Dr Mark Hill 2015, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G