Neural System Development
|Embryology - 26 Sep 2017 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Objectives
- 4 Reading
- 5 Neural Movies
- 6 Human Early Neural Development
- 7 Week 4 to Week 8
- 8 Development Overview
- 9 Early Brain Structure
- 10 Ventricles
- 11 Neural Layers
- 12 Fetal Development
- 13 Thyroid System and Neural Development
- 14 Gliogenesis and Myelination
- 15 References
- 16 Terms
- 17 Additional Images
- 18 Glossary Links
Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.
The early central nervous system begins as a simple neural plate that folds to form a groove then tube, open initially at each end. Failure of these opening to close contributes a major class of neural abnormalities (neural tube defects).
Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord.
- Neural development beginnings quite early, therefore also look at notes covering Week 3 - neural tube and Week 4 - early nervous system.
- Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in detail in other notes sections.
|Neural Links: Introduction | Ventricular System | Stage 22 | Gliogenesis | Fetal | Medicine Lecture - Neural | Lecture - Ectoderm | Lecture - Neural Crest | Lab - Early Neural | Neural Crest | Sensory | Abnormalities | Folic Acid | Iodine Deficiency | Fetal Alcohol Syndrome | Postnatal | Postnatal - Neural Examination | Histology | Historic Neural | Category:Neural|
- Neural Parts: Introduction | Prosencephalon | Telencephalon | Amygdala | Hippocampus | Basal Ganglia | lateral ventricles | Diencephalon | Epithalamus | Thalamus | Hypothalamus | Pituitary | Pineal | third ventricle | Mesencephalon | Mesencephalon | Tectum | cerebral aqueduct | Rhombencephalon | Metencephalon | Pons | Cerebellum | Myelencephalon | Medulla Oblongata | Spinal Cord | Vascular | Meninges | Category:Neural
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Ai-Lan Pang, Liu-Lin Xiong, Qing-Jie Xia, Fen Liu, You-Cui Wang, Fei Liu, Piao Zhang, Bu-Liang Meng, Sheng Tan, Ting-Hua Wang Neural Stem Cell Transplantation Is Associated with Inhibition of Apoptosis, Bcl-xL Upregulation, and Recovery of Neurological Function in a Rat Model of Traumatic Brain Injury. Cell Transplant: 2017, 26(7);1262-1275 PubMed 28933221
Cheryl S Rosenfeld, Nancy D Denslow, Edward F Orlando, Juan Manuel Gutierrez-Villagomez, Vance L Trudeau Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates. J Toxicol Environ Health B Crit Rev: 2017, 20(5);276-304 PubMed 28895797
Eiki Kimura, Ken-Ichiro Kubo, Toshihiro Endo, Wenting Ling, Kazunori Nakajima, Masaki Kakeyama, Chiharu Tohyama Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse. PLoS ONE: 2017, 12(8);e0183497 PubMed 28820910
Shin Hayashi, Daniela Tiaki Uehara, Kousuke Tanimoto, Seiji Mizuno, Yasutsugu Chinen, Shinobu Fukumura, Jun-Ichi Takanashi, Hitoshi Osaka, Nobuhiko Okamoto, Johji Inazawa Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE: 2017, 12(8);e0181791 PubMed 28783747
Valentina Boeva, Caroline Louis-Brennetot, Agathe Peltier, Simon Durand, Cécile Pierre-Eugène, Virginie Raynal, Heather C Etchevers, Sophie Thomas, Alban Lermine, Estelle Daudigeos-Dubus, Birgit Geoerger, Martin F Orth, Thomas G P Grünewald, Elise Diaz, Bertrand Ducos, Didier Surdez, Angel M Carcaboso, Irina Medvedeva, Thomas Deller, Valérie Combaret, Eve Lapouble, Gaelle Pierron, Sandrine Grossetête-Lalami, Sylvain Baulande, Gudrun Schleiermacher, Emmanuel Barillot, Hermann Rohrer, Olivier Delattre, Isabelle Janoueix-Lerosey Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. Nat. Genet.: 2017; PubMed 28740262
| These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
- Understand early neural development.
- Understand the formation of spinal cord.
- Understand the formation of the brain; grey and white matter from the neural tube.
- Understand the role of migration of neurons during neural development.
- To know the main derivatives of the brain vesicles and their walls.
- To know how the nervous system is modelled, cell death etc.
- To understand the contribution of the neural crest.
- Understand the developmental basis of certain congenital anomalies of the nervous system, including hydrocephalus, spina bifida, anencephaly and encephalocele.
| Citation: Hill, M.A. (2017). UNSW Embryology (17th ed.) Retrieved September 26, 2017, from https://embryology.med.unsw.edu.au
The Developing Human: Clinically oriented embryology
Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2015). The developing human: clinically oriented embryology (10th ed.). Philadelphia: Saunders. (links only function with UNSW connection)
Larsen's human embryology
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone. (links only function with UNSW connection)
Human Early Neural Development
The stages below refer to specific Carneigie stages of development (modified from O'Rahilly and Müller 1994).
- stage 8 - (about 18 postovulatory days) neural groove and folds are first seen
- stage 9 - the three main divisions of the brain, which are not cerebral vesicles, can be distinguished while the neural groove is still completely open.
- stage 10 - (two days later) neural folds begin to fuse near the junction between brain and spinal cord, when neural crest cells are arising mainly from the neural ectoderm
- stage 11 - (about 24 days) the rostral (or cephalic) neuropore closes within a few hours; closure is bidirectional, it takes place from the dorsal and terminal lips and may occur in several areas simultaneously. The two lips, however, behave differently.
- stage 12 - (about 26 days) The caudal neuropore takes a day to close.
- the level of final closure is approximately at future somitic pair 31.
- corresponds to the level of sacral vertebra 2.
- stage 13 - (4 weeks) the neural tube is normally completely closed.
Secondary neurulation begins at stage 12 - is the differentiation of the caudal part of the neural tube from the caudal eminence (or end-bud) without the intermediate phase of a neural plate.
Week 4 to Week 8
|Embryonic Central Nervous System|
|Stage 13||Stage 14||Stage 16||Stage 21|
scale bar = 1 mm
|Week 4||Week 5||Week 6||Week 8|
Week 4 - Stage 13
Week 4 - Stage 16
Week 8 - Stage 23
The above MRI scan movie shows the structure of the central nervous system at the end of the embryonic period. Note the relative size and position of the CNS parts, the flexures, the size of the ventricular spaces and chord plexus within this space. There are additional Stage 23 movies available in the links below.
|Stage 23 MRI Movies: Surface | Central Nervous System | CNS (labeled) | Sagittal | Sagittal (labeled) | Transverse | Transverse (labeled) | Coronal | Sagittal Head (labeled) | Sagittal GIT (labeled) | Carnegie stage 23|
|Carnegie stage:||1 2 3 4||5 6||7 8 9||10 11 12 13||14 15||16 17||18 19||20 21 22 23|
|Stage 23 Links: Week 8 | System Development | Lecture - Limb | Lecture - Head Development | Lecture - Sensory | Science Practical - Head | Science Practical - Sensory | Science Practical - Urogenital | Historic - Skull Development | Carnegie Embryos | Madrid Embryos | Category:Carnegie Stage 23 | Next Fetal Development|
|Historic Papers: 1954 Stage 19-23|
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Neuralation begins at the trilaminar embryo with formation of the notochord and somites, both of which underly the ectoderm and do not contribute to the nervous system, but are involved with patterning its initial formation. The central portion of the ectoderm then forms the neural plate that folds to form the neural tube, that will eventually form the entire central nervous system.
- Early developmental sequence: Epiblast - Ectoderm - Neural Plate - Neural groove and Neural Crest - Neural Tube and Neural Crest
|Neural Tube||Primary Vesicles||Secondary Vesicles||Adult Structures|
|week 3||week 4||week 5||adult|
|Prosencephalon||Telencephalon||Rhinencephalon, Amygdala, Hippocampus, Cerebrum (Cortex), Hypothalamus, Pituitary | Basal Ganglia, lateral ventricles|
|Diencephalon||Epithalamus, Thalamus, Subthalamus, Pineal, third ventricle|
|Mesencephalon||Mesencephalon||Tectum, Cerebral peduncle, Pretectum, cerebral aqueduct|
Does not contribute to the final nervous system, but is critical to patterning the development.
- forms initially as the Axial Process, a hollow tube which extends from the primitive pit , cranially to the oral membrane
- the axial process then allow transient communication between the amnion and the yolk sac through the neuroenteric canal.
- the axial process then merges with the Endodermal layer to form the Notochordal Plate.
- the notochordal plate then rises back into the Mesodermal layer as a solid column of cells which is the Notochord.
- Links: Notochord
Two main parts with different morphology
- columnar - midline neural plate forming neural tube and neural crest
- cuboidal - lateral surface ectoderm forming epidermis and sensory placodes
- epidermis of skin, hair, glands, anterior pituitary, teeth enamel
- sensory placodes
- Links: Ectoderm
| The neural plate forms above the notochord and paraxial mesoderm and extends from the buccopharyngeal membrane to primitive node. The cells are described as neuroectodermal and form initially two regions along the head to tail axis: a cranial broad plate region (brain plate) and caudally a narrower plate region (spinal cord).
Neuronal populations are thought to be specified before the plate folds by signals from underlying notochord and mesoderm, as well as signals spread laterally through teh plate.
There are two bending processes occurring in the formation of the neural groove and neural tube.
- occuring in the midline due to cells in this region having a basal nuclear localisation. This initial bending leads to formation of the neural groove.
- occuring at the dorsolateral hinge points by different mechanism involving "buckling". This later bending leads to formation of the neural tube.
Mouse neural tube bending model (see review)
Carnegie stage 10 Week 4
- fusion of neural groove extends rostrally and caudally
- begins at level of 4th somite, "zips up" neural groove
- leaves 2 openings at either end- Neuropores
- forms the brain and spinal cord
- Secondary Neuralation - caudal end of neural tube formed by secondary neuralation, develops from primitive streak region, solid cord canalized by extension of neural canal. mesodermal caudal eminence
|Cranial Neuropore||Caudal Neuropore|
|(stage 11)||(stage 12)|
- cranial (anterior) neuropore closes before caudal (posterior)
- failure to close - Neural Tube Defects (NTD), severity dependent upon level, spina bifida anancephaly (More? [neuron2.htm Neural Abnormalities])
- found that supplementation of maternal diet with folate reduces incidence of NTDs
- A randomised controlled trial conducted by the Medical Research Council of the United Kingdom demonstrated a 72% reduction in risk of recurrence by periconceptional (ie before and after conception) folic acid supplementation (4mg daily).
- Women who have one infant with a neural tube defect have a significantly increased risk of recurrence (40-50 per thousand compared with 2 per thousand for all births)
- a population of cells at the edge of the neural plate that lie dorsally when the neural tube fuses
- dorsal to the neural tube, as a pair of streaks
- cells migrate throughout the embryo
- studied by quail-chick chimeras - transplanted quail cells have obvious nucleoli compared with chicken Neural Crest Derivitives
- pluripotential, forms many different types of cells: dorsal root ganglia (neurons, sheath cells, glia), autonomic ganglia, adrenal medulla, pia-arachnoid sheath, skin melanocytes, connective tissue of cardiac outflow, thyroid parafollicular cells, craniofacial skeleton and teeth odontoblasts.
- Links: Neural Crest Development
Early Brain Structure
- rostral neural tube forms 3 primary brain vesicles (week 4)
- 3 primary vesicles: prosencephalon (forebrain), mesencephalon (midbrain), rhombencephalon (hindbrain)
See also the week 4 embryo movie.
From the 3 primary vesicles developing to form 5 secondary vesicles (week 5)
- prosencephalon- telencephalon (endbrain, forms cerebral hemispheres), diencephalon (betweenbrain, forms optic outgrowth)
- rhombencephalon- metencephalon (behindbrain), myelencephalon (medullabrain)
See also the week 6 embryo movie.
|Carnegie Stage 14 Secondary Vesicles (Week 5)|
|Lateral view of the central nervous system of embryo at Carnegie stage 14 (Scale bar is 1 mm).|
Week 8 - Stage 23
- cavity within tube will form the contiguious space of the ventricules of the brain and central canal of spinal cord
- this space is filled initially with amniotic fluid, later with CerebroSpinal Fluid (CSF)
- CSF is secreted by a modified vascular structure, the chorioid plexus, lying within the ventricles
Rapid growth folds the neural tube forming 3 brain flexures (cranial to caudal)
- cephalic flexure - (mesencephalic) pushes mesencephalon upwards
- pontine flexure - generates 4th ventricle
- cervical flexure - between brain stem and spinal cord
- neural stem cells lie in the layer closest to the ventricular space, the ventricular layer
- this layer generates both neuroblasts and glioblasts
Neuroblasts - neurons arise first as neuroblasts and migrate along radial gial, their migration stops at cortical plate. Glioblasts - glia arise later as glioblasts
Both neurons and glia undergo a complex process of growth, differentiation and interaction over a long developmental time period.
Spinal Cord Axes
- Experimental manipulation of interactions.
- Initial experiments looked at how isolated tissues may influence the development of the spinal cord.
- Repositionining of specific tissues both in vivo and in vitro
- specific markers of or alteration of differentiation.
- Ventral- Sonic Hedgehog
- notochord secretes sonic hedgehog
- Gene expression studies (ISH) showed shh gene expression occured in a subset of inducing tissues
- has a patterning role elsewhere (limb, sclerotome, lung)
- 2 signaling activities acting (locally and at a distance) Ventral- Sonic Hedgehog
- Binds to cell surface receptor patched
- without shh, patched (Ptc) binds smoothened (Smo)
- with shh shh-Ptc releases Smo activating G protein pathway
Early Development and Neural Derivatives
- bilaminar embryo- hyoblast
- trilaminar embryo then ectoderm layer, neural plate, neural groove, neural tube and neural crest
- cranial expansion of neural tube- central nervous system
- caudal remainder of neural tube- spinal cord
- neural crest
- dorsal root ganglia
- parasympathetic / sympathetic ganglia.
- ectodermal placodes- components of the special senses: otic placode (otocyst), nasal placode, lens placode
Neural tube and Genes: neural specification- Notch/Delta, patched receptor. Border- fibroblast growth factor (fgf), BMP (BMP4, msx1) Rostral border- Dlx5
Neural Tube Patterning
- segmented along its length- Hox/Lim gene expression
- ventral identity- sonic hedgehog, BMP7/chordin interaction
- dorsal identity- dorsalin
Human Fetus (CRL 240mm) Brain (left dorsolateral view)
For more details see Neural System - Fetal
Fetal - Second Trimester
|Brain and Ventricular Development||Brain Fissure Development|
Three-dimensional magnetic resonance imaging and image-processing algorithms have been used to quantitate between 29-41 weeks volumes of: total brain, cerebral gray matter, unmyelinated white matter, myelinated, and cerebrospinal fluid (grey matter- mainly neuronal cell bodies; white matter- mainly neural processes and glia). A study of 78 premature and mature newborns showed that total brain tissue volume increased linearly over this period at a rate of 22 ml/week. Total grey matter also showed a linear increase in relative intracranial volume of approximately 1.4% or 15 ml/week. The rapid increase in total grey matter is mainly due to a fourfold increase in cortical grey matter. Quantification of extracerebral and intraventricular CSF was found to change only minimally.
Thyroid System and Neural Development
Human thyroid system and neural development
Gliogenesis and Myelination
Glial cells have many different types and roles in central and peripheral neural development, though they are typically described as "supportive", and have the same early embryonic origins as neurons. (More? [neuron7.htm Gliogenesis and Myelination])
Early in neural development a special type of developmental glia, radial glia, provide pathway for developing neuron (neuroblasts) migration out from the proliferating ventricular layer and are involved in the subsequent lamination and columnar organization of the central nervous system.
Types of glia: radial glia, astroglia, oligodendroglia, microglia and Schwann cells.
Gene Diseases - Sonic Hedgehog
SHH Human mutation- holoprosencephaly 3
- characteristic facies of the severe form of HPE which included a single fused eye (cyclopia) and a nose-like structure (proboscis) above the eye
- Downstream targets of Sonic hedgehog signalling: transcription factors like Gli3 (responsible for Greigs polycephalosyndactyly in humans), d Hoxd13 (responsible for polysyndactyly)
- Hee-Jin Yang, Do-Hun Lee, Yun-Jin Lee, Je G Chi, Ji Yeoun Lee, Ji Hoon Phi, Seung-Ki Kim, Byung-Kyu Cho, Kyu-Chang Wang Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens. Childs Nerv Syst: 2014, 30(1);73-82 PubMed 23760472
- Mohammad Zeeshan Ozair, Chris Kintner, Ali H Brivanlou Neural induction and early patterning in vertebrates. Wiley Interdiscip Rev Dev Biol: 2013, 2(4);479-98 PubMed 24014419
- Giovanna Ponti, Kirsten Obernier, Cristina Guinto, Lingu Jose, Luca Bonfanti, Arturo Alvarez-Buylla Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice. Proc. Natl. Acad. Sci. U.S.A.: 2013, 110(11);E1045-54 PubMed 23431204
- Christina Pyrgaki, Paul Trainor, Anna-Katerina Hadjantonakis, Lee Niswander Dynamic imaging of mammalian neural tube closure. Dev. Biol.: 2010, 344(2);941-7 PubMed 20558153
- Valentina Massa, Dawn Savery, Patricia Ybot-Gonzalez, Elisabetta Ferraro, Anthony Rongvaux, Francesco Cecconi, Richard Flavell, Nicholas D E Greene, Andrew J Copp Apoptosis is not required for mammalian neural tube closure. Proc. Natl. Acad. Sci. U.S.A.: 2009, 106(20);8233-8 PubMed 19420217
- R O'Rahilly, F Müller Neurulation in the normal human embryo. Ciba Found. Symp.: 1994, 181;70-82; discussion 82-9 PubMed 8005032
- Suzanne G McShane, Matteo A Molè, Dawn Savery, Nicholas D E Greene, Patrick P L Tam, Andrew J Copp Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Dev. Biol.: 2015; PubMed 26079577 | PMC4528075 | Dev Biol.
- Hao Huang, Rong Xue, Jiangyang Zhang, Tianbo Ren, Linda J Richards, Paul Yarowsky, Michael I Miller, Susumu Mori Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging. J. Neurosci.: 2009, 29(13);4263-73 PubMed 19339620 | PMC2721010 | J Neurosci.
- P S Hüppi, S Warfield, R Kikinis, P D Barnes, G P Zientara, F A Jolesz, M K Tsuji, J J Volpe Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann. Neurol.: 1998, 43(2);224-35 PubMed 9485064
- Kembra L Howdeshell A model of the development of the brain as a construct of the thyroid system. Environ. Health Perspect.: 2002, 110 Suppl 3;337-48 PubMed 12060827
- S A Bayer, J Altman, R J Russo, X Zhang Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology: 1993, 14(1);83-144 PubMed 8361683
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Developmental Biology (6th ed) Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000. Formation of the Neural Tube | Differentiation of the Neural Tube | Tissue Architecture of the Central Nervous System | Neuronal Types | Snapshot Summary: Central Nervous System and Epidermis
Neuroscience Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark. Sunderland (MA): Sinauer Associates, Inc. ; c2001 Early Brain Development | Construction of Neural Circuits | Modification of Brain Circuits as a Result of Experience
Molecular Biology of the Cell (4th Edn) Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter. New York: Garland Publishing; 2002. Neural Development | The three phases of neural development
Health Services/Technology Assessment Text (HSTAT) Bethesda (MD): National Library of Medicine (US), 2003 Oct. Developmental Disorders Associated with Failure to Thrive
Magdalena Götz, Wieland B Huttner The cell biology of neurogenesis. Nat. Rev. Mol. Cell Biol.: 2005, 6(10);777-88 PubMed 16314867
Nicholas D E Greene, Andrew J Copp Development of the vertebrate central nervous system: formation of the neural tube. Prenat. Diagn.: 2009, 29(4);303-11 PubMed 19206138
Hirotomo Saitsu, Kohei Shiota Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development. Congenit Anom (Kyoto): 2008, 48(1);1-6 PubMed 18230116
Embryonic vertebrate central nervous system: revised terminology. The Boulder Committee. Anat. Rec.: 1970, 166(2);257-61 PubMed 5414696
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Bartelmez GW. The subdivisions of the neural folds in man. (1923) J. Comp. Neural., 35: 231-247.
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Cite this page: Hill, M.A. 2017 Embryology Neural System Development. Retrieved September 26, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_Development
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