Abnormal Development - Hypoxia
|Embryology - 2 Dec 2023 Expand to Translate|
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|Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.|
Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally, environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia (including birth) has been shown to have many detrimental effects for the growing fetus/neonate. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development. Exposure to altitude hypoxia normally results in physiological responses that act to preserve maternal and fetal oxygenation.
Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae. More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.|
- Links: axial skeleton
- Hunter C & Clegg EJ. (1973). The effects of hypoxia on the caudal vertebrae of growing mice and rats. J. Anat. , 116, 227-44. PMID: 4783417
- Ritchie HE, Oakes DJ, Kennedy D & Polson JW. (2017). Early Gestational Hypoxia and Adverse Developmental Outcomes. Birth Defects Res , 109, 1358-1376. PMID: 29105381 DOI.
- Giampietro PF, Raggio CL, Blank RD, McCarty C, Broeckel U & Pickart MA. (2013). Clinical, genetic and environmental factors associated with congenital vertebral malformations. Mol Syndromol , 4, 94-105. PMID: 23653580 DOI.
Herrera EA, Krause B, Ebensperger G, Reyes RV, Casanello P, Parra-Cordero M & Llanos AJ. (2014). The placental pursuit for an adequate oxidant balance between the mother and the fetus. Front Pharmacol , 5, 149. PMID: 25009498 DOI.
Search Pubmed: Maternal Hypoxia
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- Victor Chang Cardiac Research Institute - Dunwoodie Lab
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Cite this page: Hill, M.A. (2023, December 2) Embryology Abnormal Development - Hypoxia. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Hypoxia
- © Dr Mark Hill 2023, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G