Endocrine System - Abnormalities

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Introduction

Human adrenal gland (Week 10)

The endocrine system has an ongoing important role in embryonic, fetal and postnatal development as well as maintainance of homeostasis and reproductive function. There exists a complex interaction between the maternal and fetal endocrine system during development and failure for fetal endocrine development has a cascading effect on many other developing systems. There are additional pages covering abnormalities of specific endocrine organs.

The endocrine system resides within specific endocrine organs and both organs and tissues with other specific functions. Epithelia (ectoderm and endoderm) form the majority of the “ductless” endocrine glands like gastrointestinal and skin associated “ducted” glands. Differentiation of several also organs involves a epithelial/mesenchye interaction, seen in repeated in many differentiation of many different tissues. The endocrine glands produce hormones, which are distributed by the vascular system to the many body tissues, subsequently these organs are richly vascularized.

Hormones are recognised by either cell surface receptors (modified amino acids, peptides, proteins) or cytoplasmic/nuclear receptors (steroids). Hormones “orchestrate” responses in other tissues, including other endocrine organs, and these overall effects can be similar or different in different tissues. In addition, these hormone effects (like music) can be rapid, slow, brief, diurnal, or long-term. Hormone effects can be mimicked, stimulated, and blocked by therapeutic drugs, nutritional and environmental chemicals.

The human fetus is dependent upon endocrine development for hormones, which support normal development. Peripheral endocrine glands (thyroid, pancreas, adrenals, gonads) form early in the second month from epithelial/mesenchye interactions and differentiate into the third month. The fetus also has a unique hormonal system that combines not only its own developing endocrine system, but also that of the placenta and maternal hormones.

Abnormal endocrine development/function can impact on many different systems. For example, insufficient maternal dietary iodine impacts on fetal thyroid gland thyroid hormone production, which in turn can lead to abnormal neural development. Alternatively, we now know many environmental and therapeutic chemicals have a wide range of effects on the endocrine system.

Sex hormones from the gonads also have significant effects prenatally and postnatally, specifically at puberty with a role to play in male/female biological maturity and have wide actions throughout the body. Finally, each endocrine organ page listed below has additional abnormalities information specific to that organ.


Endocrine Links: Introduction | BGD Lecture | Science Lecture | Pineal | Hypothalamus‎ | Pituitary | Thyroid | Parathyroid | Thymus‎ | Pancreas‎ | Adrenal‎ | Gonad‎ | Placenta‎ | Other Tissues | Stage 22 | Abnormalities | Hormones | Category:Endocrine

Some Recent Findings

  • Transplacental passage of antimicrobial paraben preservatives[1] "Parabens are widely used preservatives suspected of being endocrine disruptors, with implications for human growth and development. The most common paraben found in consumer products is methylparaben. To date, no study has examined whether these substances cross the human placenta. A total of 100 study subjects (50 mother-child pairs) were enrolled at two medical institutions, serving primarily African-American and Caucasian women, respectively. A maternal blood sample was drawn on admission and a paired cord blood sample was obtained at delivery. Of the 50 mothers, 47 (94%) showed methylparaben in their blood (mean level 20.41 ng/l), and 47 in cords bloods (mean level 36.54 ng/l). There were 45 mother-child pairs where methylparaben was found in both samples. Of these, the fetal level was higher than the maternal level in 23 (51%). For butylparaben, only 4 mothers (8%) showed detectable levels (mean 40.54 ng/l), whereas 8 cord blood samples (16%) were positive (mean 32.5 ng/l). African-American mothers and infants showed higher prevalence of detectable levels (P=0.017). Methylparaben and butylparaben demonstrate transplacental passage. Additional studies are needed to examine potential differences in exposure by geography and demographics, what products are used by pregnant women that contain these preservatives, as well as any potential long-term effects in the growth and development of exposed children."
  • Effect-directed identification of endocrine disruptors in plastic baby teethers[2] "Concerns have been raised regarding the human health effects of endocrine disrupting chemicals (EDCs), many of which are associated with and leaching from plastics. As infants are particularly vulnerable to EDCs, we have investigated whether plastic teethers for babies represent a relevant source of exposure. Applying effect-directed analysis, we use bioassays to screen teethers, toys used to soothe a baby's teething ache, for endocrine activity and chemical analysis to identify the causative compounds. We detected significant endocrine activity in two of 10 plastic teethers. Those samples leached estrogenic and/or antiandrogenic activity as detected in the Yeast Estrogen Screen and Yeast Antiandrogen Screen. After sample fractionation, gas chromatography-mass spectrometry non-target screening revealed that methyl-, ethyl- and propylparaben were responsible for the observed estrogenic and antiandrogenic activity in one product. The second product is likely to contain at least six different antiandrogenic compounds that remain so far unidentified. This study demonstrates that plastic teethers can be a source of infant exposure to well-established and unknown EDCs. Because of their limited value to the product, but potential toxicity, manufacturers should critically revisit the use of parabens in plastic teethers and further toys. Moreover, plastic teethers might leach EDCs that escape routine analysis and, thus, toxicological evaluation. The resulting uncertainty in product safety poses a problem to consumers, producers and regulators that remain to be resolved."
  • Rare diseases in clinical endocrinology: a taxonomic classification system[3] "Rare endocrine-metabolic diseases (REMD) represent an important area in the field of medicine and pharmacology. The rare diseases of interest to endocrinologists involve all fields of endocrinology, including rare diseases of the pituitary, thyroid and adrenal glands, paraganglia, ovary and testis, disorders of bone and mineral metabolism, energy and lipid metabolism, water metabolism, and syndromes with possible involvement of multiple endocrine glands, and neuroendocrine tumors. Taking advantage of the constitution of a study group on REMD within the Italian Society of Endocrinology, consisting of basic and clinical scientists, a document on the taxonomy of REMD has been produced. METHODS AND RESULTS: This document has been designed to include mainly REMD manifesting or persisting into adulthood. The taxonomy of REMD of the adult comprises a total of 166 main disorders, 338 including all variants and subtypes, described into 11 tables. CONCLUSIONS: This report provides a complete taxonomy to classify REMD of the adult. In the future, the creation of registries of rare endocrine diseases to collect data on cohorts of patients and the development of common and standardized diagnostic and therapeutic pathways for each rare endocrine disease is advisable. This will help planning and performing intervention studies in larger groups of patients to prove the efficacy, effectiveness, and safety of a specific treatment."
More recent papers
Mark Hill.jpg
This table shows an automated computer PubMed search using the listed sub-heading term.
  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent


Search term: Endocrine Developmental Abnormalities

M A Angulo, M G Butler, M E Cataletto Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings. J. Endocrinol. Invest.: 2015; PMID: 26062517 Rieko Takatani, Masanori Minagawa, Angelo Molinaro, Monica Reyes, Kaori Kinoshita, Tomozumi Takatani, Itsuro Kazukawa, Misako Nagatsuma, Kenichi Kashimada, Kenichi Sato, Kazuyuki Matsushita, Fumio Nomura, Naoki Shimojo, Harald Jüppner Similar frequency of paternal uniparental disomy involving chromosome 20q (patUPD20q) in Japanese and Caucasian patients affected by sporadic pseudohypoparathyroidism type Ib (sporPHP1B). Bone: 2015; PMID: 25997889 Wen-Jing Li, Chun-Xiu Gong, Mei-Jie Guo, Jie Xing, Tang Li, Wen-Hui Song, Xiao-Ping Luo, Di Wu, Jian-Ping Liang, Bing-Yan Cao, Yi Gu, Chang Su, Xue-Jun Liang, Min Liu, Rui Wang, Feng-Ting Li Efficacy and Safety of Domestic Leuprorelin in Girls with Idiopathic Central Precocious Puberty: A Multicenter, Randomized, Parallel, Controlled Trial. Chin. Med. J.: 2015, 128(10);1314-1320 PMID: 25963350 Jakob Biran, Maayan Tahor, Einav Wircer, Gil Levkowitz Role of developmental factors in hypothalamic function. Front Neuroanat: 2015, 9;47 PMID: 25954163 Igor Pravdivyi, Klaus Ballanyi, William F Colmers, Rachel Wevrick Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in the Magel2-null mouse model of Prader-Willi Syndrome. Hum. Mol. Genet.: 2015; PMID: 25926624


Brenda J Mengeling, J David Furlow Pituitary Specific Retinoid-X Receptor Ligand Interactions With Thyroid Hormone Receptor Signaling Revealed By High Throughput Reporter And Endogenous Gene Responses. Toxicol In Vitro: 2015; PMID: 26096596 Hui-Bog Noh, Nanjanagudu Ganesh Gurudatt, Mi-Sook Won, Yoon-Bo Shim Analysis of Phthalate Esters in Mammalian Cell Culture Using a Microfluidic Channel Coupled with an Electrochemical Sensor. Anal. Chem.: 2015; PMID: 26088015 B Huerta, S Rodriguez-Mozaz, C Nannou, L Nakis, A Ruhí, V Acuña, S Sabater, D Barcelo Determination of a broad spectrum of pharmaceuticals and endocrine disruptors in biofilm from a waste water treatment plant-impacted river. Sci. Total Environ.: 2015; PMID: 26087856 Lisa Ann Marasco Unsolved Mysteries of the Human Mammary Gland: Defining and Redefining the Critical Questions from the Lactation Consultant's Perspective. J Mammary Gland Biol Neoplasia: 2015; PMID: 26084427 Yunhui Zhang, Yang Cao, Huijing Shi, Xiaoxiao Jiang, Yan Zhao, Xin Fang, Changming Xie Could exposure to phthalates speed up or delay pubertal onset and development? A 1.5-year follow-up of a school-based population. Environ Int: 2015, 83;41-49 PMID: 26073845

Pineal

  • Hypoplasia - associated with retinal disease.
  • Tumours - in children are associated with abnormal puberty development.


Links: Endocrine - Pineal Development‎ | PubMed - Pineal Hypoplasia

Pituitary

  • craniopharyngeal canal - Rathke's pouch abnormality, from the anterior part of the fossa hypophyseos of the sphenoid bone to the under surface of the skull.
  • pituitary tumours (adenomas) - several abnormalities associated with abnormal levels of the hormonal output of the pituitary.
    • Growth hormone (GH) adenomas - benign pituitary tumors lead to chronic high GH output levels, that may lead to acromegaly.
  • Cushing's disease - caused either by a pituitary adenoma produces excess adrenocorticotropic hormone (ACTH, corticotropin) or due to ectopic tumors secreting ACTH or corticotropin-releasing hormone (CRH).


Links: Endocrine - Pituitary Development‎

Thyroid

Thyroid pyramidal lobe
Thyroid uptake scans
  • Pyramidal lobe - from isthmus (50% of people) attached to hyoid bone distal end of thryoglossal duct.
  • Congenital hypothyroidism - approximately 1 in 3000 births, associated with neurological abnormalities.
  • Lingual thyroid gland - failure of thyroid descent.
  • Thyroglossal cyst - persistance of thyroglossal duct. Image - thyroglossal duct
  • Thyroglossal fistula - partial degeneration of the thyroglossal duct.
  • Abnormal development of the thyroid - incomplete or excessive descent.
  • Childhood hypothyroidism delays ossification and bone mineralization.

Iodine Deficiency

  • A teaspoon of iodine, total lifetime requirement, cannot be stored for long periods by our body, tiny amounts are needed regularly
  • Areas of endemic iodine deficiency, where soil and therefore crops and grazing animals do not provide sufficient dietary iodine to the populace
  • food fortification and supplementation - Iodized salt programs and iodized oil supplements are the most common tools in fight against IDD


Links: Endocrine - Thyroid Development‎

Parathyroid

  • Usually four glands are present (2 on each side), but three to six glands have been found in human.
  • Lower parathyroid glands arise from the third pharyngeal pouch and descend with the thymus. Variable descent can lead to a range of adult locations, from just beneath the mandible to the anterior mediastinum.


Links: Endocrine - Parathyroid Development‎

Pancreas

  • Type 1 Diabetes - juvenile onset diabetes, more severe form of illness, increases risk of blindness, heart disease, kidney failure, neurological disease, T-lymphocyte-dependent autoimmune disease, infiltration and destruction of the islets of Langerhans, Approx 16 million Americans
  • Type 2 Diabetes - loosely defined as "adult onset" diabetes, becoming more common cases of type 2 diabetes seen in younger people
  • Risk of developing diabetes - environmental factors (food intake and exercise play an important role, either overweight or obese), Inherited factors (genes involved remain poorly defined)


Links: Endocrine - Pancreas Development‎ | Abnormal Development - Maternal Diabetes

Adrenal

  • Congenital Adrenal Hyperplasia (CAH) - family of inherited disorders of adrenal steroidogenesis enzymes which impairs cortisol production by the adrenal cortex. Androgen excess leads newborn females with external genital ambiguity and postnatal progressive virilization in both sexes.
    • Enzymes most commonly affected: 21-hydroxylase (21-OH), 11beta-hydroxylase, 3beta-hydroxysteroid dehydrogenase.
    • Enzymes less commonly affected: 17alpha-hydroxylase/17,20-lyase and cholesterol desmolase.
  • Pheochromocytomas (PCC) - Catecholamine-producing (neuro)endocrine tumor located in the adrenal medulla. Similar catecholamine-producing tumors outside the adrenal gland are called paragangliomas (PGL).


Links: Endocrine - Adrenal Development

Endocrine Disruptors

Exogenous chemicals that interfere with the function of hormones. There are 3 main mechanisms: mimic, block or interfere.

Mimic

Replicate the effects of natural hormones by binding receptors.

Diethylstilbestrol
Diethylstilbestrol.jpg (DES or diethylstilbetrol) a drug prescribed to women from 1938-1971 to prevent miscarriage in high-risk pregnancies. Acts as a potent estrogen (mimics natural hormone) and therefore a potential endocrine disruptor.

Female fetus, increased risk abnormal reproductive tract and cancer. Male fetus, abnormal genitalia. Banned by USA FDA in 1979 as a teratogen, previously used as livestock growth promoter.

Block

Inhibit the binding of a hormone to receptor or hormone synthesis.

Finasteride Vinclozolin
Finasteride.jpg Vinclozoline.jpg
Chemical used to prevent male pattern baldness and enlargement of prostate glands. An anti-androgen (blocks synthesis of dihydrotestosterone) and therefore a potential endocrine disruptor, exposed pregnant women can impact on male fetus genetial development. Dicarboximide fungicide, perinatal exposure in rats inhibits morphological sex differentiation. In adult rats, shown to cause gonad tumours (Leydig cell) and atrophy. Chemical has androgen-antagonist (antiandrogenic) activity, metabolies compete with natural androgen

Interfere

Compromise with the hormone transport or elimination.

Polychlorinated biphenyl pollutants - (PCBs) Rats exposed to PCBs have low levels of thyroid hormone. Compete for binding sites of thyroid hormone transport protein. Without being bound to this protein, thyroid hormones are excreted from the body (McKinney et al. 1985; Morse et al. 1996)


International Classification of Diseases

XVI Perinatal Period

Transitory endocrine and metabolic disorders specific to fetus and newborn (P70-P74)

Incl.: transitory endocrine and metabolic disturbances caused by the infant's response to maternal endocrine and metabolic factors, or its adjustment to extrauterine existence

P70 Transitory disorders of carbohydrate metabolism specific to fetus and newborn

  • P70.0 Syndrome of infant of mother with gestational diabetes Fetus or newborn (with hypoglycaemia) affected by maternal gestational diabetes
  • P70.1 Syndrome of infant of a diabetic mother Fetus or newborn (with hypoglycemia) affected by maternal diabetes mellitus (pre-existing)
  • P70.2 Neonatal diabetes mellitus
  • P70.3 Iatrogenic neonatal hypoglycaemia
  • P70.4 Other neonatal hypoglycaemia Transitory neonatal hypoglycaemia
  • P70.8 Other transitory disorders of carbohydrate metabolism of fetus and newborn
  • P70.9 Transitory disorder of carbohydrate metabolism of fetus and newborn, unspecified

P71 Transitory neonatal disorders of calcium and magnesium metabolism

  • P71.0 Cow's milk hypocalcaemia in newborn
  • P71.1 Other neonatal hypocalcaemia Excl.: neonatal hypoparathyroidism (P71.4)
  • P71.2 Neonatal hypomagnesaemia
  • P71.3 Neonatal tetany without calcium or magnesium deficiency Neonatal tetany NOS
  • P71.4 Transitory neonatal hypoparathyroidism
  • P71.8 Other transitory neonatal disorders of calcium and magnesium metabolism
  • P71.9 Transitory neonatal disorder of calcium and magnesium metabolism, unspecified

P72 Other transitory neonatal endocrine disorders Excl.: congenital hypothyroidism with or without goitre (E03.0-E03.1) dyshormogenetic goitre (E07.1) Pendred's syndrome (E07.1)

  • P72.0 Neonatal goitre, not elsewhere classified Transitory congenital goitre with normal function
  • P72.1 Transitory neonatal hyperthyroidism Neonatal thyrotoxicosis
  • P72.2 Other transitory neonatal disorders of thyroid function, not elsewhere classified Transitory neonatal hypothyroidism
  • P72.8 Other specified transitory neonatal endocrine disorders
  • P72.9 Transitory neonatal endocrine disorder, unspecified

P74 Other transitory neonatal electrolyte and metabolic disturbances

  • P74.0 Late metabolic acidosis of newborn
  • P74.1 Dehydration of newborn
  • P74.2 Disturbances of sodium balance of newborn
  • P74.3 Disturbances of potassium balance of newborn
  • P74.4 Other transitory electrolyte disturbances of newborn
  • P74.5 Transitory tyrosinaemia of newborn
  • P74.8 Other transitory metabolic disturbances of newborn
  • P74.9 Transitory metabolic disturbance of newborn, unspecified


Links: ICD - XVI Perinatal Period | Neonatal Development

References

  1. Craig V Towers, Paul D Terry, David Lewis, Bobby Howard, Wesley Chambers, Casey Armistead, Beth Weitz, Stephanie Porter, Christopher J Borman, Rebekah C M Kennedy, Jiangang Chen Transplacental passage of antimicrobial paraben preservatives. J Expo Sci Environ Epidemiol: 2015; PMID: 25944699
  2. Elisabeth Berger, Theodoros Potouridis, Astrid Haeger, Wilhelm Püttmann, Martin Wagner Effect-directed identification of endocrine disruptors in plastic baby teethers. J Appl Toxicol: 2015; PMID: 25988240
  3. G Marcucci, L Cianferotti, P Beck-Peccoz, M Capezzone, F Cetani, A Colao, M V Davì, E Degli Uberti, S Del Prato, R Elisei, A Faggiano, D Ferone, C Foresta, L Fugazzola, E Ghigo, G Giacchetti, F Giorgino, A Lenzi, P Malandrino, M Mannelli, C Marcocci, L Masi, F Pacini, G Opocher, A Radicioni, M Tonacchera, R Vigneri, M C Zatelli, M L Brandi Rare diseases in clinical endocrinology: a taxonomic classification system. J. Endocrinol. Invest.: 2014; PMID: 25376364

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Cite this page: Hill, M.A. (2015) Embryology Endocrine System - Abnormalities. Retrieved June 29, 2015, from https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_System_-_Abnormalities

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© Dr Mark Hill 2015, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G