Template talk:Main Page News: Difference between revisions
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Revision as of 15:59, 8 September 2023
The following are earlier versions of the news panel that appears on the website Main Page.
2023
September
Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.
Complete human day 14 post-implantation embryo models from naïve ES cells
The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a).
2020
March
News - Novel coronavirus (COVID-19) |
Coronaviruses (Latin corona = crown or halo) name refers to the appearance of their virions, due to the presence of a "crown" of surface spikes. Several of the coronavirus infections in humans occur initially as respiratory infections that originated from animal contact as a zoonotic infection.
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January
News - Climate Change Abnormal Development - Environmental |
European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE, Nov 2019)
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2019
December
News - Abnormal Development - Air Pollution |
Prenatal and early life exposures to ambient air pollution and development[1]
See also [2]
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June
February
News - Rare Sesquizygotic Twinning | ||
(1697-1763)]]
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2018
November
News - French Ain babies missing limb births prompt national inquiry |
France has launched a national investigation into the number of babies being born with limb agenesis (entire missing upper limbs, missing forearms and hands, or fingers) just weeks after an initial inquiry closed. The cases were clustered in the Ain, Brittany and Loire-Atlantique regions. The cause is still unknown, but may relate to local developmental environmental abnormalies. More? BBC News | Environmental Abnormalies | Limb Abnormalities |
October
News - Australian Screening for Spinal Muscular Atrophy | |
SMA added to newborn heel prick (Guthrie test) "In an Australian first, newborn babies are now being routinely screened for the genetic condition SMA, or spinal muscular atrophy". SMA leads to a loss of motor neurons and progressive muscle wasting and has several different forms: Type 1, Type 2, and Type 3a SMA. ABC News
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The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation."
https://www.nobelprize.org/prizes/medicine/2018/summary
https://www.nobelprize.org/uploads/2018/10/press-medicine2018.pdf
June
News - Ronan O’Rahilly, Anatomist and Embryologist, Dies at 96 |
Ronan O'Rahilly (September 13, 1921 - June 24, 2018) Professor, School of Medicine, University of California, Davis, CA, USA.
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February
News - Australian 2018 Pregnancy Care Guidelines | ||||
Clinical Practice Guidelines - Pregnancy Care Guidelines released 5 Feb 2018.
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2017
November
News - World Diabetes Day - 14 November |
<html5media width="480" height="360">https://www.youtube.com/embed/Ds-FK_7G7sE</html5media>
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September
News - Zika Virus | ||||||||
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly Science 28 Sep 2017: eaam7120 DOI: 10.1126/science.aam7120
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July
News - CRISPR Gene Editing |
It has been reported (but not confirmed by publication) that USA scientists have gene-edited embryos using CRISPR This follows on from an earlier 2015 published work (PMID 25894090) from China using the same technique see Nature 22 April 2015 and a more recent 2017 paper (PMID 28251317).
The CRISPR/Cas9-mediated gene editing system was derived from the adaptive immune system evolved in bacteria to defend against invading plasmids and viruses. |
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February
Australia - Gestational Diabetes (2015) |
Proportion of insulin-treated diabetes by type (2015) The 2017 published AIHW fact sheet provides the latest available national data on new cases of insulin-treated diabetes in Australia. It shows that in 2015 there were 28,775 people who began using insulin to treat their diabetes in Australia
In 2015, 7,405 women began using insulin to manage gestational diabetes—130 cases per 100,000 women of reproductive age (15–49 years), or around 1 in every 800 women aged 15–49. This represents almost 1 in 4 (24%) women diagnosed with gestational diabetes aged 15–49 in 2015. Gestational diabetes occurs when higher than normal blood glucose is diagnosed for the first time during pregnancy. It generally occurs in the second or third trimester, among women who have not previously been diagnosed with other forms of diabetes. Reference: AIHW 2017. Incidence of insulin-treated diabetes in Australia, 2015. Diabetes series no. 27. Cat. no. CVD 78. Canberra: AIHW. Viewed 20 February 2017 http://www.aihw.gov.au/publication-detail/?id=60129558632.
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2016
September
News - Embryonic Development - Kyoto eBook |
The Kyoto embryo collection is the largest collection of human embryos in the world, it therefore provides a unique research and educational resource for studying all aspects of early human development. This iBook now allows you to observe selected embryos from the first 8 weeks after fertilization and explore for yourself the changes that occur in normal human development during this key period. This atlas of the Kyoto embryos from Carnegie Stage 7 to 23 provides a brief description of each stage, surface views, interactive images, histology, movies and a glossary.
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August
News - Dolly's sisters live on! |
PMID 27459299 This recent report showed that 13 cloned sheep generated from the same cell line that produced "Dolly" have now survived much longer, and appear to have health measurements within the normal ranges. |
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June
News - Thalidomide Molecular Mechanism shown in Zebrafish |
PMID 27294876 | Nat Med. Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of CD147 (also known as Basigin) a member of the immunoglobulin superfamily). Zebrafish knockdown of CD147 was shown to match the teratogenic effects of thalidomide exposure. |
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March
News - Human Pancreas Stem Cells show Glycemic control in Mice |
PMID 26808346 | Nat Med. Implanted in the intraperitoneal space of mice treated to chemically induce type 1 diabetes. Implants induced glycemic correction without any immunosuppression until their removal at 174 d after implantation. Human C-peptide concentrations and in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control and retrieved implants contained viable insulin-producing cells. |
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January
News - Oral Contraceptives and Abnormal Development |
Oral Contraceptives A recent 2016 Danish study births from Danish registries between 1997 and 2011 identified that:
PMID 26738512 | BMJ
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2015
September
News - Maternal Malaria Neurovascular Development Effects |
Malaria (plasmodium falciparum) - 125 million pregnancies worldwide are at risk of malaria infection every year. A recent mouse model of maternal infection, without embryo infection, has shown effects on neurovasular development in the exposed offspring. (More? PMID 26402732 | Abnormal Development - Malaria | Neural | Cardiovascular) |
June
Oocyte/Spermatozoa fate decision by Primordial Germ Cells | |
Medaka Sex determination is an essential step in the commitment of a germ cell to a spermatozoa or oocyte. The intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. "foxl3 is expressed in germ cells but not somatic cells in the gonad, and has been identified as involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment." (More? PMID 26067255 | Medaka Development | Oocyte Development | Spermatozoa Development) |
April
Americas region is declared the world’s first to eliminate endemic transmission of rubella | |
Rubella is a contagious viral disease that can cause multiple birth defects as well as fetal death when contracted by women during pregnancy. "This achievement culminates a 15-year effort that involved widespread administration of the vaccine against measles, mumps and rubella (MMR) throughout the Western Hemisphere. The announcement comes as 45 countries and territories of the Americas are participating in the 13th annual Vaccination Week in the Americas (April 25 to May 2)." This follows the regional eradication of smallpox in 1971 and the elimination of polio in 1994.
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February
Three-person embryos | |
UK government has voted to legalize a gene-therapy technique that could help women to avoid passing genetic defects onto their children.
The technique called either "mitochondrial replacement" or "three-person in vitro fertilization" intention is to prevent maternal mitochondrial mutations to be passed on to children. Its estimated that estimated 1 in 5,000 children are born with these type of diseases caused by such mutations. |
2014
October
Hippocampus Development | |
2014 Nobel Prize in Physiology or Medicine
John O´Keefe, May-Britt Moser and Edvard I. Moser - for their discoveries of cells that constitute a positioning system in the brain
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July
Embryo Epigenetics | |
Embryos Reprogram their Epigenetics
Two recent studies show that after fertilisation human embryos loose DNA methylation from most of the genome. This implies that there is an early "reprogramming" or "resetting" of the embryo's epigenetic status.
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June
Maternal Mortality | |
WHO - Trends in Maternal Mortality 1990 to 2013
An estimated 289,000 women died in 2013 due to complications in pregnancy and childbirth, down from 523,000 in 1990.
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May
The World Health Organization says polio has re-emerged as a public health emergency.
(More? Polio Virus | WHO - Polio) |
March
(More? Trisomy 21 | Trisomy 18 | Prenatal Diagnosis) Reference: <pubmed>24571752</pubmed>| N Engl J Med.
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January
News - Stimulus-triggered fate conversion of somatic cells into pluripotency | |
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Is STAP Real?
- RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers Science April 2014
- Japanese research institute has opened an investigation into this groundbreaking stem cell study after concerns were raised about its credibility. The RIKEN investigation follows allegations on blog sites about the use of duplicated images in Obokata’s papers, and numerous failed attempts to replicate her results. Nature
2013
2012 Nobel Prize for Stem Cells | |
Stem Cell Signaling
The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent"
(More? Yamanaka Factors | Induced Stem Cells | Stem Cells) |