Sheep Development

Embryology - 2 Dec 2023 Expand to Translate
Google Translate - select your language from the list shown below (this will open a new external page)
العربية \| català \| 中文 \| 中國傳統的 \| français \| Deutsche \| עִברִית \| हिंदी \| bahasa Indonesia \| italiano \| 日本語 \| 한국어 \| မြန်မာ \| Pilipino \| Polskie \| português \| ਪੰਜਾਬੀ ਦੇ \| Română \| русский \| Español \| Swahili \| Svensk \| ไทย \| Türkçe \| اردو \| ייִדיש \| Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)

Introduction

Sheep with lamb with second (twin) lamb being born.

The domestic sheep (Ovis aries) has been used as a mammalian model of development with a term gestational period of 145 - 150 days.

Category:Sheep
Historic Embryology: 1940 respiratory muscles nerve-endings

Animal Development Time

Animal	Average Days
Bear (Black)	210
Bison	270
Budgerigar	18
Camel	410
cat	65
cow	281
chicken	21
Chimpanzee	236
Chinchilla	111
Coyote	63
deer (Mule)	200
dog	63
Donkey	365
Duck	28
Duck (Muscovy)	35
elephant	660
Elk, Wapiti	255
Ferret	42
Finch	14
Fox	52
Giraffe	425
goat	150
Goose	28
Gorilla	270
Guinea fowl	28
guinea pig	68
Hare	36
Hippopotamus	240
horse	338
Human	274
Leopard	95
Lion	108
Llama	350
Marmoset	150
Mink (European)	41
monkey (Macaque)	180
Moose	240
mouse	20
Muskox	255
Muskrat	29
Nutria, Coypu	130
opossum	12
Otter	285
Panther	90
Parrot	26
Pheasant	24
Pig	114
Pigeon	18
Porcupine	210
Pronghorn	230
Quail	16
rabbit	31
Raccoon	63
rat	21
Reindeer	225
Rhinoceros (African)	480
Seal	330
sheep	150
Shrew	20
Skunk	63
Squirrel (Gray)	40
Swan	35
Tapir	390
Tarsier	182
Tiger	103
Turkey	28
Walrus	450
whale (Sperm)	450
Wolf	63
Woodchuck	31

Animal Notes and Table Data Sources

Each animal species has different variations +/- the average values shown in the table.
Gestation is the carrying of an animal embryo or fetus inside a female viviparous animal. Except in the case of human gestational age GA.
Incubation is the laying of an egg (birds, reptiles, monotremes) with development occurring outside the female animal.

Some Recent Findings

Healthy ageing of cloned sheep^[1] "The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental long-term health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7-9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5-and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals." Somatic Cell Nuclear Transfer

Development of morulae from the oocytes of cultured sheep preantral follicles^[2] "Sheep preantral follicles (PFs) measuring 250-400 microm in diameter were cultured for six days in serum-free media supplemented differently with growth factors and hormones. ...In combination with T4 and FSH, IGF-I+GH supported the best development of the PFs. Culture of PFs in micro drops or agar gel supported similarly high development. In vitro fertilization of the oocytes from the cultured sheep PFs resulted in the embryos developing to the morula stage for the first time."

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Sheep Development \| Sheep Embryology \| Ovine Development

Older papers
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table. See also the Discussion Page for other references listed by year and References on this current page. Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model^[3]

Development Overview

Sheep follicle in vitro^[4]

Day	Event
4	embryo enters the uterus at the morula stage
6	blastocyst stage
8	blastocyst hatches from zona pellucida
11-16	elongates to a filamentous form
14 - 16	binucleate cells begin to differentiate in the trophoblast
16	adplantation

See also Implantation mechanisms: insights from the sheep^[5]

Dolly

Dolly the sheep (5 July 1996 – 14 February 2003)

A female domestic sheep remarkable in being the first mammal to be cloned from an adult somatic cell, using the process of nuclear transfer.^[6]

Cloned by Ian Wilmut, Keith Campbell and colleagues at the Roslin Institute near Edinburgh in Scotland, born on 5 July 1996 and she lived until the age of six (5 July 1996 – 14 February 2003). The cell used as the donor for the cloning of Dolly was taken from a mammary gland, and the production of a healthy clone therefore proved that a cell taken from a specific part of the body could recreate a whole individual. As Dolly was cloned from part of a mammary gland, she was named after the famously curvaceous country western singer Dolly Parton.

Links: Roslin Institute, Edinburgh | Science Museum - Dolly the sheep, 1996-2003

Oocyte Development

Sheep follicle gene expression^[7]

red - genes expressed in granulose cells.
blue - genes expressed in oocytes.
black - genes expressed both in oocytes and granulosa cells.

Sheep Oocyte Distribution of Telomerase reverse transcriptase

The following oocyte images are from a recent study of sheep in vitro follicle development.^[4]


preantral	early antral

early antral	preovulatory follicle

TERT - Red (Cy3-conjugated secondary antibody) (telomerase reverse transcriptase, TERT)
DNA - Green (SYBR Green 14/I)

Respiratory

Phases of fetal lung development:^[8]

embryonic - 0 to 40 days.
pseudoglandular - 40 to 80 days.
canalicular - 80 to 120 days.
saccular - 120 to term 148 days gestation.

Links: Respiratory Development

Immune

Lymphocytes development has been characterised by an immunohistology study of T lymphocytes in the sheep fetal spleen.^[9]

Day (days of gestation)	Event
43 - 44	SBU-T1- and SBU-T8-positive lymphocytes were present in low numbers.
45 - 50	Surface immunoglobulin (sIg) was first detected on fetal spleen cells
50 - 55	SBU-T4, 20.96-, 25.69-, 38.38-, or 46.66-positive lymphocytes present.
57	SBU-T19 lymphocytes appeared.

Links: Immune Development

References

↑ Sinclair KD, Corr SA, Gutierrez CG, Fisher PA, Lee JH, Rathbone AJ, Choi I, Campbell KH & Gardner DS. (2016). Healthy ageing of cloned sheep. Nat Commun , 7, 12359. PMID: 27459299 DOI.
↑ Arunakumari G, Shanmugasundaram N & Rao VH. (2010). Development of morulae from the oocytes of cultured sheep preantral follicles. Theriogenology , 74, 884-94. PMID: 20615540 DOI.
↑ Black SG, Arnaud F, Burghardt RC, Satterfield MC, Fleming JA, Long CR, Hanna C, Murphy L, Biek R, Palmarini M & Spencer TE. (2010). Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model. J. Virol. , 84, 9078-85. PMID: 20610723 DOI.
↑ ^4.0 ^4.1 Barboni B, Russo V, Cecconi S, Curini V, Colosimo A, Garofalo ML, Capacchietti G, Di Giacinto O & Mattioli M. (2011). In vitro grown sheep preantral follicles yield oocytes with normal nuclear-epigenetic maturation. PLoS ONE , 6, e27550. PMID: 22132111 DOI.
↑ Spencer TE, Johnson GA, Bazer FW & Burghardt RC. (2004). Implantation mechanisms: insights from the sheep. Reproduction , 128, 657-68. PMID: 15579583 DOI.
↑ Wilmut I, Schnieke AE, McWhir J, Kind AJ & Campbell KH. (1997). Viable offspring derived from fetal and adult mammalian cells. Nature , 385, 810-3. PMID: 9039911 DOI.
↑ Bonnet A, Servin B, Mulsant P & Mandon-Pepin B. (2015). Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth. PLoS ONE , 10, e0141482. PMID: 26540452 DOI.
↑ Gnanalingham MG, Mostyn A, Dandrea J, Yakubu DP, Symonds ME & Stephenson T. (2005). Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung. J. Physiol. (Lond.) , 565, 159-69. PMID: 15774522 DOI.
↑ Maddox JF, Mackay CR & Brandon MR. (1987). Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen. Immunology , 62, 107-12. PMID: 3308689

Reviews

Thompson RP, Nilsson E & Skinner MK. (2020). Environmental epigenetics and epigenetic inheritance in domestic farm animals. Anim. Reprod. Sci. , , 106316. PMID: 32094003 DOI.

Gebreselassie G, Berihulay H, Jiang L & Ma Y. (2019). Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries). Animals (Basel) , 10, . PMID: 31877963 DOI.

Lazzari G, Colleoni S, Lagutina I, Crotti G, Turini P, Tessaro I, Brunetti D, Duchi R & Galli C. (2010). Short-term and long-term effects of embryo culture in the surrogate sheep oviduct versus in vitro culture for different domestic species. Theriogenology , 73, 748-57. PMID: 19726075 DOI.

Campbell KH, Alberio R, Choi I, Fisher P, Kelly RD, Lee JH & Maalouf W. (2005). Cloning: eight years after Dolly. Reprod. Domest. Anim. , 40, 256-68. PMID: 16008756 DOI.

Articles

Wang J, Guillomot M & Hue I. (2009). Cellular organization of the trophoblastic epithelium in elongating conceptuses of ruminants. C. R. Biol. , 332, 986-97. PMID: 19909921 DOI.

Guillomot M, Turbe A, Hue I & Renard JP. (2004). Staging of ovine embryos and expression of the T-box genes Brachyury and Eomesodermin around gastrulation. Reproduction , 127, 491-501. PMID: 15047940 DOI.

Search PubMed

Search Pubmed: sheep development | ovine development | ovine embryo development

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Oklahoma State University - breeds of sheep

Historic Embryology
1897 Pig \| 1900 Chicken \| 1901 Lungfish \| 1904 Sand Lizard \| 1905 Rabbit \| 1906 Deer \| 1907 Tarsiers \| 1908 Human \| 1909 Northern Lapwing \| 1909 South American and African Lungfish \| 1910 Salamander \| 1951 Frog \| Embryology History \| Historic Disclaimer

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2023, December 2) Embryology Sheep Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sheep_Development

What Links Here?

[PMID27459299-1] Sinclair KD, Corr SA, Gutierrez CG, Fisher PA, Lee JH, Rathbone AJ, Choi I, Campbell KH & Gardner DS. (2016). Healthy ageing of cloned sheep. Nat Commun , 7, 12359. PMID: 27459299 DOI.

[PMID20615540-2] Arunakumari G, Shanmugasundaram N & Rao VH. (2010). Development of morulae from the oocytes of cultured sheep preantral follicles. Theriogenology , 74, 884-94. PMID: 20615540 DOI.

[PMID20610723-3] Black SG, Arnaud F, Burghardt RC, Satterfield MC, Fleming JA, Long CR, Hanna C, Murphy L, Biek R, Palmarini M & Spencer TE. (2010). Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model. J. Virol. , 84, 9078-85. PMID: 20610723 DOI.

[PMID22132111-4] 4.0 ^4.1 Barboni B, Russo V, Cecconi S, Curini V, Colosimo A, Garofalo ML, Capacchietti G, Di Giacinto O & Mattioli M. (2011). In vitro grown sheep preantral follicles yield oocytes with normal nuclear-epigenetic maturation. PLoS ONE , 6, e27550. PMID: 22132111 DOI.

[PMID15579583-5] Spencer TE, Johnson GA, Bazer FW & Burghardt RC. (2004). Implantation mechanisms: insights from the sheep. Reproduction , 128, 657-68. PMID: 15579583 DOI.

[PMID9039911-6] Wilmut I, Schnieke AE, McWhir J, Kind AJ & Campbell KH. (1997). Viable offspring derived from fetal and adult mammalian cells. Nature , 385, 810-3. PMID: 9039911 DOI.

[PMID26540452-7] Bonnet A, Servin B, Mulsant P & Mandon-Pepin B. (2015). Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth. PLoS ONE , 10, e0141482. PMID: 26540452 DOI.

[PMID15774522-8] Gnanalingham MG, Mostyn A, Dandrea J, Yakubu DP, Symonds ME & Stephenson T. (2005). Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung. J. Physiol. (Lond.) , 565, 159-69. PMID: 15774522 DOI.

[PMID3308689-9] Maddox JF, Mackay CR & Brandon MR. (1987). Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen. Immunology , 62, 107-12. PMID: 3308689

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]