Template talk:Main Page News: Difference between revisions
mNo edit summary |
m (→September) |
||
(108 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
The following are earlier versions of the news panel that appears on the website [[Main Page]]. | The following are earlier versions of the news panel that appears on the website [[Main Page]]. | ||
==2023== | |||
===September=== | |||
{| width=800px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Stage6 bf03.jpg|thumb|150px|alt=Carnegie Stage 6 Embryo|Carnegie Stage 6 Embryo]] | |||
This recent Nature paper{{#pmid:37673118|PMID37673118}} describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development. | |||
"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)." | |||
:'''Links:''' {{stem cells}} | Carnegie stage {{CS6}} | |||
<references/> | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older News Articles | |||
|- | |||
| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#January|Climate Change Abnormal Development]] | [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]] | |||
|} | |||
|} | |||
==2020== | |||
===March=== | |||
{| width=800px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Novel coronavirus (COVID-19)'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:MERS-CoV EM1.jpg|thumb|150px|alt=Middle East Respiratory Syndrome coronavirus (MERS-CoV) electron micrograph|Middle East Respiratory Syndrome coronavirus electron micrograph (image CDC)]] | |||
First reported in Wuhan, {{China}} in 2019{{#pmid:31950516|PMID31950516}} and it is too soon to establish the possible fetal teratogenic effects of infection.{{#pmid:31953166|PMID31953166}} | |||
[[File:WHO coronavirus world data 1.jpg|600px]] | |||
Coronaviruses (Latin ''corona'' = crown or halo) name refers to the appearance of their virions, due to the presence of a "crown" of surface spikes. Several of the coronavirus infections in humans occur initially as respiratory infections that originated from animal contact as a zoonotic infection. | |||
:'''Links:''' {{Coronavirus}} | {{virus}} | {{abnormal environmental}} | {{zoonotic infection}} | [https://www.who.int/health-topics/coronavirus WHO coronavirus] | [https://www.cdc.gov/coronavirus/2019-ncov/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2Fnovel-coronavirus-2019.html CDC] | |||
<references/> | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older News Articles | |||
|- | |||
| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#January|Climate Change Abnormal Development]] | [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]] | |||
|} | |||
|} | |||
===January=== | |||
{| width=800px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Climate Change Abnormal Development - Environmental'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Malaria global limits 2007.jpg|thumb|link=Abnormal Development - Malaria|Global limits and endemicity of P. falciparum in 2007]] | |||
'''European Scientific Conference on Applied Infectious Disease Epidemiology''' ([https://www.escaide.eu/en ESCAIDE], Nov 2019) | |||
[https://blogs.plos.org/everyone/2020/01/21/escaide-2019/ PLOS Blog] | |||
:"On the impact of climate change on human disease epidemiology, Dr. Henriette De Valk and Prof. Ana Maria de Roda Husman presented informative and sobering overviews on changes in vector-borne, water-borne, and other diseases that have been observed and can be expected to occur in the future. Warming temperatures in Europe create opportunities for mosquitos and other disease vectors to spread further North, reaching new human populations, as has been the case with {{West Nile virus}}. The conclusion drawn from their talks is that time is running out and action is needed now to stop things becoming much worse later down the line." | |||
:'''Links:''' {{abnormal environmental}} | {{West Nile virus}} | {{Malaria}} | {{zoonotic infection}} | {{air pollution}} | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older News Articles | |||
|- | |||
| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
|} | |||
==2019== | |||
===December=== | |||
{| width=800px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Abnormal Development - Air Pollution'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Particulate matter.jpg|thumb|link=Abnormal Development - Air Pollution|Particulate matter comparative size]] | |||
'''Prenatal and early life exposures to ambient {{air pollution}} and development'''{{#pmid:30979514|PMID30979514}} | |||
<br>"Residential proximity to major roadways, and prenatal exposures to particulate matter <2.5 μm (PM2.5) and ozone (O3) are linked to poor fetal outcomes but their relationship with childhood development is unclear. We investigated whether proximity to major roadways, or prenatal and early-life exposures to PM2.5 and O3 increase the risk of early developmental delays. 4089 singletons and 1016 twins born between 2008 and 2010. Proximity to major roadway was calculated using road network data from the NY Department of Transportation. Concentrations of PM2.5 and O3 estimated by the Environmental Protection Agency Downscaler models were spatiotemporally linked to each child's prenatal and early-life addresses incorporating residential history, and locations of maternal work and day-care. In this prospective cohort study, proximity to major roadway and prenatal/early-life exposures to PM2.5 and O3 were associated with developmental delays. While awaiting larger studies with personal {{air pollution}} assessment, efforts to minimize {{air pollution}} exposures during critical developmental windows may be warranted." | |||
See also {{#pmid:30826615|PMID30826615}} | |||
<references/> | |||
:'''Links:''' {{air pollution}} | {{Neural postnatal}} | {{Neural examination}} | {{epigenetics}} | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older News Articles | |||
|- | |||
| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
|} | |||
===June=== | |||
{| width=800px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Australia's mothers and babies 2017'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| [[File:Australia's mothers and babies 2017.jpg|thumb|150px|alt=Australia's mothers and babies 2017|link=Australia’s mothers and babies 2017]] | |||
[https://www.aihw.gov.au/reports/mothers-babies/australias-mothers-and-babies-2017-in-brief/contents/table-of-contents Australia's mothers and babies 2017—in brief] (27 June 2019) | |||
* In 2017, 301,095 women gave birth in [[Australian Statistics|Australia]], an increase of 4.0% since 2007. | |||
* 30.6 was the average {{maternal age}} of all women who gave birth, compared with 29.9 in 2007. | |||
* 13% of women who gave birth in 2017 had {{gestational diabetes}} | |||
* 1 in 3 mothers had a {{caesarean}} section in 2017 | |||
* 6.7% of liveborn babies were low {{birthweight}} in 2017 | |||
[[File:Australian-maternal-age-2007-17.jpg|500px|link=Australia’s mothers and babies 2017]] | |||
{{Ref-AMB2017}} | |||
<br> | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older News Articles | |||
|- | |||
| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
|} | |||
===February=== | |||
{| width=800px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Rare Sesquizygotic Twinning'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Smellie1754_table_10_twins.jpg|thumb|150px|alt=Twinning historic drawing|link=Abnormal Development - Twinning|Twinning historic drawing by [[Embryology History - William Smellie|William Smellie]] (1697-1763)]] (1697-1763)]] | |||
<br>Sesquizygotic twinning is a rare intermediate form of twinning, lying between mono-zygotic and dizygotic twinning, the twins can be maternally identical but chimerical for their paternal genome. This rare twinning event has been recently identified by a twin {{amniocentesis}} genotyping study<ref name=Ref-Gabbett2019>{{Ref-Gabbett2019}}</ref> that showed twins that were maternally identical, but chimerically shared 78% of their paternal genome. | |||
<br> | |||
<references/> | |||
<br> | |||
'''Links:''' {{twinning}} | {{amniocentesis}} | [https://www.nejm.org/doi/full/10.1056/NEJMoa1701313 NEMJ] | [https://newsroom.unsw.edu.au/news/health/semi-identical-twins-identified-pregnancy-first-time?utm_source=medicine&utm_medium=social-team UNSW News 29Feb2019] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Sesquizygotic+Twinning Search Pubmed] | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older News Articles | |||
|- | |||
| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
<center><html5media width="480" height="360">https://www.youtube.com/embed/YH9yA3w6bSI</html5media></center> | |||
<center>[https://youtu.be/YH9yA3w6bSI YouTube video]</center> | |||
|} | |||
==2018== | |||
===November=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - French Ain babies missing limb births prompt national inquiry'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:France - Ain - Brittany - Loire-Atlantique.jpg|thumb|alt - French Map regions Ain, Brittany and Loire-Atlantique|link=Musculoskeletal System - Limb Abnormalities|French regions - Ain, Brittany and Loire-Atlantique]] | |||
France has launched a national investigation into the number of babies being born with [[Musculoskeletal System - Limb Abnormalities|limb agenesis]] (entire missing upper limbs, missing forearms and hands, or fingers) just weeks after an initial inquiry closed. The cases were clustered in the Ain, Brittany and Loire-Atlantique regions. The cause is still unknown, but may relate to local [[Abnormal_Development_-_Environmental|developmental environmental abnormalies]]. | |||
More? [https://www.bbc.com/news/world-europe-46043564 BBC News] | [[Abnormal_Development_-_Environmental|Environmental Abnormalies]] | [[Musculoskeletal System - Limb Abnormalities|Limb Abnormalities]] | |||
|} | |||
===October=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Australian Screening for Spinal Muscular Atrophy'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Guthrie card.jpg|thumb|link=Guthrie test|NSW Newborn Screening Programme]]SMA added to newborn heel prick ({{Guthrie test}}) "In an Australian first, newborn babies are now being routinely screened for the genetic condition SMA, or spinal muscular atrophy". SMA leads to a loss of motor neurons and progressive muscle wasting and has several different forms: Type 1, Type 2, and Type 3a SMA. [http://www.abc.net.au/news/2018-10-14/genetic-testing-sma-added-to-newborn-heel-prick-test/10359622 ABC News] | |||
<br><br> | |||
{{Neonatal Diagnosis links}} | |||
|} | |||
The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation." | |||
https://www.nobelprize.org/prizes/medicine/2018/summary | |||
https://www.nobelprize.org/uploads/2018/10/press-medicine2018.pdf | |||
===June=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Ronan O’Rahilly, Anatomist and Embryologist, Dies at 96'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Ronan O'Rahilly 1987.jpg|thumb|alt=Ronan O'Rahilly 1987|link=Embryology_History_-_Ronan_O%27Rahilly#Obituary|Ronan O'Rahilly (1987 Carnegie Labs)]] | |||
[[Embryology History - Ronan O'Rahilly|'''Ronan O'Rahilly''']] (September 13, 1921 - June 24, 2018) Professor, School of Medicine, University of California, Davis, CA, USA. | |||
[[Embryology_History_-_Ronan_O%27Rahilly#Obituary|Obituary excerpt]] | |||
:"Ronan O’Rahilly, MD, human anatomist and embryologist, scholar, scientist, and academic whose research produced insights into our understanding of the developing human at all stages, died on June 24, 2018 in Villars-sur-Glâne, Switzerland. He was 96 and had formerly lived in Ireland, England, the United States and most recently in Fribourg, Switzerland." | |||
<br> | |||
Search Pubmed - [http://www.ncbi.nlm.nih.gov/pubmed/?term=O'Rahilly+R%5BAuthor%5D O'Rahilly R] | |||
<br>[[Carnegie Collection]]<br><br> | |||
:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
===February=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Australian 2018 Pregnancy Care Guidelines</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| | |||
[[File:Pregnancy-care-guidelines-5Feb18-1.jpg|250px|right|alt=Pregnancy Care Guidelines|link=Australian Statistics]] | |||
[http://www.health.gov.au/internet/main/publishing.nsf/Content/pregnancycareguidelines Clinical Practice Guidelines - Pregnancy Care Guidelines] released 5 Feb 2018. | |||
<br> | |||
<br> | |||
{{Abnormality Links}} | |||
:'''Links:''' [[Fetal Development]] | [[Birth]] | |||
|- | |||
| | |||
:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
==2017== | |||
===November=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - World Diabetes Day - 14 November</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| | |||
<html5media width="480" height="360">https://www.youtube.com/embed/Ds-FK_7G7sE</html5media> | |||
:'''Links:''' [[Abnormal Development - Maternal Diabetes|Maternal Diabetes]] | [http://www.worlddiabetesday.org WDD 2017] | | |||
|- | |||
| | |||
:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
===September=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Zika Virus'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| | |||
[[File:Zika virus TEM02.jpg|250px|right|alt=Zika virus EM|link=Abnormal Development - Zika Virus]] | |||
'''A single mutation in the prM protein of Zika virus contributes to fetal microcephaly''' | |||
:"Here, we show that a single serine to asparagine substitution (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs), led to more significant microcephaly in the mouse fetus, and higher mortality in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. " | |||
[http://science.sciencemag.org/content/early/2017/09/27/science.aam7120 A single mutation in the prM protein of Zika virus contributes to fetal microcephaly] Science 28 Sep 2017: eaam7120 DOI: 10.1126/science.aam7120 | |||
{| | |||
| width=250px| '''Links:''' [[Abnormal Development - Zika Virus|'''Zika Virus''']] | |||
| {{Zika Virus translation collapsable}} | |||
|} | |||
{{Viral Links}} | |||
|} | |||
===July=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - CRISPR Gene Editing'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| [[File:CRISPR Cas9 interaction with target DNA.jpg|250px|right|alt=CRISPR Cas9 interaction with target DNA|link=]] | |||
It has been reported (but not confirmed by publication) that USA scientists have [https://www.technologyreview.com/s/608350/first-human-embryos-edited-in-us/amp/ gene-edited embryos using CRISPR] | |||
This follows on from an earlier 2015 published work ([https://www.ncbi.nlm.nih.gov/pubmed/25894090 PMID 25894090]) from China using the same technique [http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378 see Nature 22 April 2015] and a more recent 2017 paper ([https://www.ncbi.nlm.nih.gov/pubmed/?term=28251317 PMID 28251317]). | |||
'''About CRISPR''' | |||
The CRISPR/Cas9-mediated gene editing system was derived from the adaptive immune system evolved in bacteria to defend against invading plasmids and viruses. | |||
:'''Links:''' [[Molecular_Development_-_Genetics#CRISPR|CRISPR]] | [[Molecular_Development_-_Genetics|Genetics]] | |||
|- | |||
| | |||
:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#September|Zika Virus Mutation]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
===February=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''Australia - Gestational Diabetes (2015)'''</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| [[File:Australia - insulin-treated diabetes by type 2015.jpg|200px|right|alt=Australia - insulin-treated diabetes by type 2015|link=Australian_Statistics#Incidence_of_insulin-treated_diabetes_in_Australia_2015]] | |||
'''Proportion of insulin-treated diabetes by type (2015)''' The 2017 published AIHW fact sheet provides the latest available national data on new cases of insulin-treated diabetes in Australia. | |||
It shows that in 2015 there were 28,775 people who began using insulin to treat their diabetes in Australia | |||
* 63% had type 2 diabetes | |||
* '''26%''' (18,142) had [[Abnormal Development - Maternal Diabetes|gestational diabetes]] | |||
* 9% had type 1 diabetes | |||
* 2% had other forms of diabetes or their diabetes status was unknown. | |||
In 2015, 7,405 women began using insulin to manage gestational diabetes—130 cases per 100,000 women of reproductive age (15–49 years), or around 1 in every 800 women aged 15–49. This represents almost 1 in 4 (24%) women diagnosed with gestational diabetes aged 15–49 in 2015. Gestational diabetes occurs when higher than normal blood glucose is diagnosed for the first time during pregnancy. It generally occurs in the second or third trimester, among women who have not previously been diagnosed with other forms of diabetes. | |||
Reference: AIHW 2017. Incidence of insulin-treated diabetes in Australia, 2015. Diabetes series no. 27. Cat. no. CVD 78. Canberra: AIHW. Viewed 20 February 2017 http://www.aihw.gov.au/publication-detail/?id=60129558632. | |||
:'''Links:''' [[Abnormal Development - Maternal Diabetes|Maternal Diabetes]] | [http://www.aihw.gov.au/publication-detail/?id=60129558632 AIWH Factsheet] | |||
|- | |||
| | |||
:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
==2016== | ==2016== | ||
===September=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Embryonic Development - Kyoto eBook</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top| [[File:Kyoto Embryo Collection - cover.jpg|200px|left|alt=Kyoto Embryo Collection|link=http://itunes.apple.com/us/book/id1143922693]] | |||
[[File:AvailableBook.png|150px|right|link=https://itunes.apple.com/au/book/kyoto-embryo-collection/id1143922693?mt=11]] | |||
The Kyoto embryo collection is the largest collection of human embryos in the world, it therefore provides a unique research and educational resource for studying all aspects of early human development. | |||
This iBook now allows you to observe selected embryos from the first 8 weeks after fertilization and explore for yourself the changes that occur in normal human development during this key period. This atlas of the Kyoto embryos from Carnegie Stage 7 to 23 provides a brief description of each stage, surface views, interactive images, histology, movies and a glossary. | |||
:'''Links:''' [[Kyoto Collection]] | [[Embryology iBooks]] | |||
|- | |||
| | |||
:[[Template_talk:Main_Page_News|Older News Articles]] - [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | |||
|} | |||
===August=== | |||
{| width=700px| | |||
|-bgcolor="CEDFF2" | |||
| <span style="font-size:150%">'''News - Dolly's sisters live on!</span> | |||
|-bgcolor="F5FAFF" | |||
| valign=top|[[File:Sheep 8-year old clones.jpg|300px|left|alt=Four 8-year old Finn-Dorset clones|link=Somatic Cell Nuclear Transfer]] | |||
PMID 27459299 This recent report showed that 13 cloned sheep generated from the same cell line that produced "Dolly" have now survived much longer, and appear to have health measurements within the normal ranges. | |||
:'''Links:''' [[Somatic Cell Nuclear Transfer]] | [[Sheep Development]] | |||
|- | |||
| | |||
:[[Template_talk:Main_Page_News|Older News Articles]] - [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]] | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]] | 2014 Nobel Prize in Medicine - [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2014/press.html Neural Development] | [[Neural_-_Hippocampus_Development|Hippocampus Development]] | WHO - Trends in Maternal Mortality 1990 to 2013 - [[Statistics - Maternal Mortality]] | WHO polio - [[Abnormal Development - Polio Virus|Polio Virus]] | [[Template_talk:Main_Page_News#March|Trisomy 21 - Genome-wide Effects]] | |||
|} | |||
===June=== | ===June=== | ||
Line 12: | Line 343: | ||
PMID 27294876 | [http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4128.html Nat Med.] | PMID 27294876 | [http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4128.html Nat Med.] | ||
Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of | Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, [http://www.omim.org/entry/254500 multiple myeloma] (MM) and del(5q) [http://www.omim.org/entry/614286 myelodysplastic syndrome] (MDS). Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of CD147 ([[Abnormal Development - Thalidomide#CD147 (Basigin)|also known as Basigin]]) a member of the immunoglobulin superfamily). | ||
Zebrafish knockdown of CD147 was shown to match the teratogenic effects of thalidomide exposure. | |||
:'''Links:''' [[Abnormal Development - Thalidomide]] | [[Zebrafish Development]] | :'''Links:''' [[Abnormal Development - Thalidomide]] | [[Zebrafish Development]] |
Latest revision as of 16:09, 8 September 2023
The following are earlier versions of the news panel that appears on the website Main Page.
2023
September
News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells |
This recent Nature paper[1] describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development. "The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."
|
2020
March
News - Novel coronavirus (COVID-19) |
Coronaviruses (Latin corona = crown or halo) name refers to the appearance of their virions, due to the presence of a "crown" of surface spikes. Several of the coronavirus infections in humans occur initially as respiratory infections that originated from animal contact as a zoonotic infection.
|
January
News - Climate Change Abnormal Development - Environmental |
European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE, Nov 2019)
|
2019
December
News - Abnormal Development - Air Pollution |
Prenatal and early life exposures to ambient air pollution and development[1]
See also [2]
|
June
February
News - Rare Sesquizygotic Twinning | ||
(1697-1763)]]
|
2018
November
News - French Ain babies missing limb births prompt national inquiry |
France has launched a national investigation into the number of babies being born with limb agenesis (entire missing upper limbs, missing forearms and hands, or fingers) just weeks after an initial inquiry closed. The cases were clustered in the Ain, Brittany and Loire-Atlantique regions. The cause is still unknown, but may relate to local developmental environmental abnormalies. More? BBC News | Environmental Abnormalies | Limb Abnormalities |
October
News - Australian Screening for Spinal Muscular Atrophy | |
SMA added to newborn heel prick (Guthrie test) "In an Australian first, newborn babies are now being routinely screened for the genetic condition SMA, or spinal muscular atrophy". SMA leads to a loss of motor neurons and progressive muscle wasting and has several different forms: Type 1, Type 2, and Type 3a SMA. ABC News
|
The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation."
https://www.nobelprize.org/prizes/medicine/2018/summary
https://www.nobelprize.org/uploads/2018/10/press-medicine2018.pdf
June
News - Ronan O’Rahilly, Anatomist and Embryologist, Dies at 96 |
Ronan O'Rahilly (September 13, 1921 - June 24, 2018) Professor, School of Medicine, University of California, Davis, CA, USA.
|
February
News - Australian 2018 Pregnancy Care Guidelines | ||||
Clinical Practice Guidelines - Pregnancy Care Guidelines released 5 Feb 2018.
| ||||
|
2017
November
News - World Diabetes Day - 14 November |
<html5media width="480" height="360">https://www.youtube.com/embed/Ds-FK_7G7sE</html5media>
|
|
September
News - Zika Virus | ||||||||
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly Science 28 Sep 2017: eaam7120 DOI: 10.1126/science.aam7120
|
July
News - CRISPR Gene Editing |
It has been reported (but not confirmed by publication) that USA scientists have gene-edited embryos using CRISPR This follows on from an earlier 2015 published work (PMID 25894090) from China using the same technique see Nature 22 April 2015 and a more recent 2017 paper (PMID 28251317).
The CRISPR/Cas9-mediated gene editing system was derived from the adaptive immune system evolved in bacteria to defend against invading plasmids and viruses. |
|
February
Australia - Gestational Diabetes (2015) |
Proportion of insulin-treated diabetes by type (2015) The 2017 published AIHW fact sheet provides the latest available national data on new cases of insulin-treated diabetes in Australia. It shows that in 2015 there were 28,775 people who began using insulin to treat their diabetes in Australia
In 2015, 7,405 women began using insulin to manage gestational diabetes—130 cases per 100,000 women of reproductive age (15–49 years), or around 1 in every 800 women aged 15–49. This represents almost 1 in 4 (24%) women diagnosed with gestational diabetes aged 15–49 in 2015. Gestational diabetes occurs when higher than normal blood glucose is diagnosed for the first time during pregnancy. It generally occurs in the second or third trimester, among women who have not previously been diagnosed with other forms of diabetes. Reference: AIHW 2017. Incidence of insulin-treated diabetes in Australia, 2015. Diabetes series no. 27. Cat. no. CVD 78. Canberra: AIHW. Viewed 20 February 2017 http://www.aihw.gov.au/publication-detail/?id=60129558632.
|
|
2016
September
News - Embryonic Development - Kyoto eBook |
The Kyoto embryo collection is the largest collection of human embryos in the world, it therefore provides a unique research and educational resource for studying all aspects of early human development. This iBook now allows you to observe selected embryos from the first 8 weeks after fertilization and explore for yourself the changes that occur in normal human development during this key period. This atlas of the Kyoto embryos from Carnegie Stage 7 to 23 provides a brief description of each stage, surface views, interactive images, histology, movies and a glossary.
|
August
News - Dolly's sisters live on! |
PMID 27459299 This recent report showed that 13 cloned sheep generated from the same cell line that produced "Dolly" have now survived much longer, and appear to have health measurements within the normal ranges. |
|
June
News - Thalidomide Molecular Mechanism shown in Zebrafish |
PMID 27294876 | Nat Med. Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of CD147 (also known as Basigin) a member of the immunoglobulin superfamily). Zebrafish knockdown of CD147 was shown to match the teratogenic effects of thalidomide exposure. |
|
March
News - Human Pancreas Stem Cells show Glycemic control in Mice |
PMID 26808346 | Nat Med. Implanted in the intraperitoneal space of mice treated to chemically induce type 1 diabetes. Implants induced glycemic correction without any immunosuppression until their removal at 174 d after implantation. Human C-peptide concentrations and in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control and retrieved implants contained viable insulin-producing cells. |
|
January
News - Oral Contraceptives and Abnormal Development |
Oral Contraceptives A recent 2016 Danish study births from Danish registries between 1997 and 2011 identified that:
PMID 26738512 | BMJ
|
2015
September
News - Maternal Malaria Neurovascular Development Effects |
Malaria (plasmodium falciparum) - 125 million pregnancies worldwide are at risk of malaria infection every year. A recent mouse model of maternal infection, without embryo infection, has shown effects on neurovasular development in the exposed offspring. (More? PMID 26402732 | Abnormal Development - Malaria | Neural | Cardiovascular) |
June
Oocyte/Spermatozoa fate decision by Primordial Germ Cells | |
Medaka Sex determination is an essential step in the commitment of a germ cell to a spermatozoa or oocyte. The intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. "foxl3 is expressed in germ cells but not somatic cells in the gonad, and has been identified as involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment." (More? PMID 26067255 | Medaka Development | Oocyte Development | Spermatozoa Development) |
April
Americas region is declared the world’s first to eliminate endemic transmission of rubella | |
Rubella is a contagious viral disease that can cause multiple birth defects as well as fetal death when contracted by women during pregnancy. "This achievement culminates a 15-year effort that involved widespread administration of the vaccine against measles, mumps and rubella (MMR) throughout the Western Hemisphere. The announcement comes as 45 countries and territories of the Americas are participating in the 13th annual Vaccination Week in the Americas (April 25 to May 2)." This follows the regional eradication of smallpox in 1971 and the elimination of polio in 1994.
|
February
Three-person embryos | |
UK government has voted to legalize a gene-therapy technique that could help women to avoid passing genetic defects onto their children.
The technique called either "mitochondrial replacement" or "three-person in vitro fertilization" intention is to prevent maternal mitochondrial mutations to be passed on to children. Its estimated that estimated 1 in 5,000 children are born with these type of diseases caused by such mutations. |
2014
October
Hippocampus Development | |
2014 Nobel Prize in Physiology or Medicine
John O´Keefe, May-Britt Moser and Edvard I. Moser - for their discoveries of cells that constitute a positioning system in the brain
|
July
Embryo Epigenetics | |
Embryos Reprogram their Epigenetics
Two recent studies show that after fertilisation human embryos loose DNA methylation from most of the genome. This implies that there is an early "reprogramming" or "resetting" of the embryo's epigenetic status.
|
June
Maternal Mortality | |
WHO - Trends in Maternal Mortality 1990 to 2013
An estimated 289,000 women died in 2013 due to complications in pregnancy and childbirth, down from 523,000 in 1990.
|
May
The World Health Organization says polio has re-emerged as a public health emergency.
(More? Polio Virus | WHO - Polio) |
March
(More? Trisomy 21 | Trisomy 18 | Prenatal Diagnosis) Reference: <pubmed>24571752</pubmed>| N Engl J Med.
|
January
News - Stimulus-triggered fate conversion of somatic cells into pluripotency | |
|
Is STAP Real?
- RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers Science April 2014
- Japanese research institute has opened an investigation into this groundbreaking stem cell study after concerns were raised about its credibility. The RIKEN investigation follows allegations on blog sites about the use of duplicated images in Obokata’s papers, and numerous failed attempts to replicate her results. Nature
2013
2012 Nobel Prize for Stem Cells | |
Stem Cell Signaling
The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent"
(More? Yamanaka Factors | Induced Stem Cells | Stem Cells) |