|Embryology - 1 Apr 2015 Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Pharyngeal Arch Contributions
- 4 Week 4
- 5 Week 8
- 6 Tongue Muscles
- 7 Tongue Innervation
- 8 Lingual Frenulum
- 9 Histology
- 10 Abnormalities
- 11 Additional Images
- 12 References
- 13 External Links
- 14 Glossary Links
The tongue's embryonic orgin is derived from all pharyngeal arches contributing different components. As the tongue ((Latin, lingua; Greek, glossa) develops "inside" the floor of the oral cavity, it is not readily visible in the external views of the embryonic (Carnegie) stages of development. Tongue muscle cells originate from somites, while muscles of mastication derive from the unsegmented somitomeres. This current page gives a brief overview of early tongue development.
The dorsal tongue is covered by a stratified squamous epithelium, with numerous papillae and taste buds. There are also 8 to 12 circumvallate papillae arranged in an inverted V-shape towards the base of the tongue. These notes cover development of the muscular tongue, not the sense of taste.
- Taste Links: Introduction | Student project | Tongue Development | Category:Taste | Gastrointestinal Tract | Head Development | Category:Tongue
|1902 Tongue | 1921 Tongue|
Some Recent Findings
|More recent papers|
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Christos Savopoulos, Nikolaos Kakaletsis, Georgia Kaiafa, Fotios Iliadis, Anna Kalogera-Fountzila, Apostolos I Hatzitolios Riedel's lobe of the liver: a case report. Medicine (Baltimore): 2015, 94(3);e430 PMID: 25621695 Szilvia Kecskes, Clara Matesz, Botond Gaál, András Birinyi Neural circuits underlying tongue movements for the prey-catching behavior in frog: distribution of primary afferent terminals on motoneurons supplying the tongue. Brain Struct Funct: 2015; PMID: 25575900 Rosemary Dodds, Deborah Neiger Perspectives on tongue-tie. Pract Midwife: 2014, 17(9);23-6 PMID: 25571701 Chengsan Sun, Arjun Dayal, David L Hill Expanded terminal fields of gustatory nerves accompany embryonic BDNF overexpression in mouse oral epithelia. J. Neurosci.: 2015, 35(1);409-21 PMID: 25568132 Masatoshi Suzuki, Fuyuki Sato, Ujjal K Bhawal The basic helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates Twist1 through an E-box element. Biochem. Biophys. Res. Commun.: 2014; PMID: 25446074
Pharyngeal Arch Contributions
The tongue has contributions from all pharyngeal arches which changes with time. The tongue initially begins as swelling rostral to foramen cecum, the median tongue bud.
Animation shows the sequence of development of the tongue. The different colours represents the relative contribution from each pharyngeal arch.
The four images below are from the Carnegie Stage 22 human embryo during week 8 of development.
- Tongue muscles originate from the somites.
- Masticatory muscles (MM) originate from the somitomeres. These muscles develop late and are not complete even at birth.
- Tongue muscles develop before masticatory muscles and complete by birth.
Developing muscle fibers within the tongue. Note the multinucleated appearance of each muscle fiber and their overall organization. Muscle goes through the same developmental changes as other skeletal muscle.
See also: Embryonic and postnatal development of masticatory and tongue muscles.
- Links: Skeletal Muscle Histology
The hypoglossal nerve (CN XII) provides the motor innervation of the intrinsic and extrinsic tongue muscles allowing protrusion, retrusion, and changes in the shape of the tongue. Motor units within the hypoglossal motor system can be categorized as predominantly fast fatigue resistant.
The human tongue innervation has been recently analysed histologically and described as extremely dense and complex. The structure of the motor endplate junctions (neuromuscular junctions) was found to be of the multiple en grappe (grapelike cluster) form. The transverse muscle group that comprises the core of the tongue was found to have the most complex innervation. The pattern of innervation of the human tongue also has specializations not found in other mammalian tongues, this allows for fine motor control of tongue shape.
The pathway of the hypoglossal nerve can be imaged using magnetic imaging (MRI) while computer tomography (CT) can show the bony anatomy of the neurovascular foramina of the skull base. Clinically, the nerve pathway can be divided into three regions: intra-axial, cisternal, skull base and extracranial segments.
Frenulum is a general term for a small fold of integument (skin) or mucous membrane that limits the movements of an organ or part. There are several anatomical frenula associated with the genital system, while the lingual frenulum is associated with the inferior side of the tongue.
The lingual frenulum length (short) and position of insertion (anterior) can lead to speech disorders and may affect postnatal feeding. Interestingly, it is the prevalence of pain in mothers breastfeeding infants with ankyloglossia that presents many problems in breastfeeding.
Children with a frenulum length of more than 2 cm do not show these speech problems. Ankyloglossia (tongue-tie) is the general clinical term for the short frenulum which limits the range of movement of the tongue, there is still no accurate classification for this condition. Frenotomy, frenectomy, and frenuloplasty are the main surgical treatment options to release or remove an ankyloglossia.
Term means an abnormally large tongue. Macroglossia is more common than microglossia and can be associated with a number of genetic abnormalities including: trisomy 21 (Down syndrome), acromegaly, Beckwith-Wiedemann syndrome, mucopolysaccharidoses and primary amyloidosis. There is also an association with congenital hypothyroidism and diabetes.
Macroglossia associated with Beckwith-Wiedemann syndrome.
Term means an abnormally small tongue.
Ankyloglossia (tongue-tie) is the general clinical term for the short lingual frenulum (less than 2 cm), that limits the range of movement of the tongue, prevalence ranges between 4.2% and 10.7%. This is associated with speech development disorders and has been suggested as also associated with feeding disorders. There is still no accurate classification for this condition. Frenotomy, frenectomy, and frenuloplasty are the main surgical treatment options to release or remove an ankyloglossia, though there is still discussion about surgical intervention.
A short lingual frenulum is also associated with a number of genetic syndromes such as: ROR2-Related Robinow Syndrome, Dystrophic Epidermolysis Bullosa, Oral-Facial-Digital Syndrome Type I, Opitz Syndrome (X-Linked Opitz G/BBB Syndrome) and Van der Woude syndrome.
- Links: Medline Plus - Tongue tie | ROR2-Related Robinow Syndrome | Dystrophic Epidermolysis Bullosa | Oral-Facial-Digital Syndrome Type I | X-Linked Opitz G/BBB Syndrome
|Historic Disclaimer - information about historic embryology pages|
Human Embryology and Morphology. Keith, A. (1902) London: Edward Arnold.
Anatomy of the Human Gray, H. (1918) Philadelphia: Lea & Febiger.
- Jun-ichi Iwata, Akiko Suzuki, Richard C Pelikan, Thach-Vu Ho, Yang Chai Noncanonical transforming growth factor β (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects. J. Biol. Chem.: 2013, 288(41);29760-70 PMID: 23950180
- Zhongchen Song, Chao Liu, Junichi Iwata, Shuping Gu, Akiko Suzuki, Cheng Sun, Wei He, Rong Shu, Lu Li, Yang Chai, YiPing Chen Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J. Biol. Chem.: 2013, 288(15);10440-50 PMID: 23460641
- Kayoko Aoyama, Akira Yamane, Takeo Suga, Erika Suzuki, Tadayoshi Fukui, Yoshiki Nakamura Bone morphogenetic protein-2 functions as a negative regulator in the differentiation of myoblasts, but not as an inducer for the formations of cartilage and bone in mouse embryonic tongue. BMC Dev. Biol.: 2011, 11;44 PMID: 21736745
- Jae-Young Kim, Min-Jung Lee, Kyoung-Won Cho, Jong-Min Lee, Yeun-Jung Kim, Ji-Youn Kim, Hye-In Jung, Je-Yoel Cho, Sung-Won Cho, Han-Sung Jung Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development. Dev. Biol.: 2009, 325(1);273-80 PMID: 19014928
- A Yamane Embryonic and postnatal development of masticatory and tongue muscles. Cell Tissue Res.: 2005, 322(2);183-9 PMID: 16041600
- J Chadwick Smith, Stephen J Goldberg, Mary Snyder Shall Phenotype and contractile properties of mammalian tongue muscles innervated by the hypoglossal nerve. Respir Physiol Neurobiol: 2005, 147(2-3);253-62 PMID: 16087149
- Liancai Mu, Ira Sanders Human tongue neuroanatomy: Nerve supply and motor endplates. Clin Anat: 2010, 23(7);777-91 PMID: 20607833
- Pedro Alves Imaging the hypoglossal nerve. Eur J Radiol: 2010, 74(2);368-77 PMID: 20347541
- Irene Queiroz Marchesan Lingual frenulum: classification and speech interference. Int J Orofacial Myology: 2004, 30;31-8 PMID: 15832860
- Lauren M Segal, Randolph Stephenson, Martin Dawes, Perle Feldman Prevalence, diagnosis, and treatment of ankyloglossia: methodologic review. Can Fam Physician: 2007, 53(6);1027-33 PMID: 17872781
- Valérie G A Suter, Michael M Bornstein Ankyloglossia: facts and myths in diagnosis and treatment. J. Periodontol.: 2009, 80(8);1204-19 PMID: 19656020
R Achiron, A Ben Arie, U Gabbay, S Mashiach, Z Rotstein, S Lipitz Development of the fetal tongue between 14 and 26 weeks of gestation: in utero ultrasonographic measurements. Ultrasound Obstet Gynecol: 1997, 9(1);39-41 PMID: 9060129
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name.
- Clinical Methods The Tongue
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Cite this page: Hill, M.A. (2015) Embryology Tongue Development. Retrieved April 1, 2015, from https://embryology.med.unsw.edu.au/embryology/index.php/Tongue_Development
- © Dr Mark Hill 2015, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G