Embryonic Development: Difference between revisions
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{{Header}} | |||
== Introduction == | == Introduction == | ||
This page shows some key events of human development during the embryonic period of the first eight weeks (weeks 1 - 8) following fertilization. This period is also considered the organogenic period, when most organs within the embryo have begun to form. There are links to more detailed descriptions which can be viewed in a week by week format, by the | {| class="wikitable mw-collapsible mw-collapsed" | ||
! Author Comments | |||
|- | |||
| [[File:Mark_Hill.jpg|50px]] '''Start here''' by looking at the external appearance of embryos in sequence from [[#Carnegie_Stages|1 to 23]]. It is not so important to memorise the dates, as they are only approximate, but more important to understand '''growth''' (size changes) and the '''development''' (overall sequence of events) during this period. | |||
Clicking the Carnegie stage numbers opens a page dedicated to describing that single stage and the associated developmental events. | |||
|} | |||
{| | |||
| This page shows some key events of human development during the embryonic period of the first eight weeks (weeks 1 - 8) following fertilization. This period is also considered the organogenic period, when most organs within the embryo have begun to form. | |||
There are links to more detailed descriptions which can be viewed in a week by week format, by the Carnegie stages or integrated into a [[Timeline_human_development|'''Timeline of human development''']]. | |||
Online resources include: individual images of all Carnegie stages, scanning electron micrographs of the earlier stages, cross-sections showing internal structures at mid- and late-embryonic, 3D reconstructions of internal structures, animations of processes, ultrasound scans and information about abnormalites of development. | |||
Note that there is variability in the actual timing of specific events and at the end of this period [[Fetal_Development|fetal development]] begins. | Note that there is variability in the actual timing of specific events and at the end of this period [[Fetal_Development|fetal development]] begins. | ||
{{Human Embryo - Biological definition 2006}} | |||
{{ | {{Carnegie_stage_table_1}} | ||
{{ | | valign=top| [[File:Embryo stages 01.gif]] | ||
|} | |||
{| | |||
! Kyoto Collection | |||
! width=5px| | |||
! Carnegie Collection | |||
|- | |||
| [[File:Human Carnegie stage 1-23.jpg|alt=Kyoto Collection Embryos|link=Kyoto Collection|550px]] | |||
| | |||
| [[File:Human Carnegie stage 10-23.jpg|alt=Carnegie Collection Embryos|link=Carnegie Collection|420px]] | |||
|- | |||
| Human Embryo, Carnegie stages 1-23 | |||
| | |||
| Human Embryo, Carnegie stages 10-23 | |||
|} | |||
{| | |||
| width=380px|<html5media height="530" width="375">File:Embryo stages 003.mp4</html5media> | |||
| valign=top|Use the stage number links to images and information about each specific stage of human development over the first 8 weeks. The links below give a broad overview of developmental events during each week. | |||
[[File:Stage14compare23.jpg|200px]] | |||
Embryo sizes - stage 14 compared to 23 | |||
{{Embryo stage movie 1}} | |||
{{Week}} | |||
:'''Links:''' [[Embryo Virtual Slides]] | [[Human Embryo Collections]] | [[Carnegie stage 13 - serial sections]] | [[Carnegie stage 22 - serial sections]] | |||
|} | |||
== Week 1 == | == Week 1 == | ||
[[Image:Early_zygote.jpg|thumb|Week 1 - Early zygote]] | [[Image:Early_zygote.jpg|thumb|link=zygote|Week 1 - Early zygote]] | ||
* [[Week 1]] Carnegie stage [[Carnegie_stage_1 | * [[Week 1]] Carnegie stage - {{CS1}} | {{CS2}} | {{CS3}} | {{CS4}} | ||
* {{oocyte}} | {{spermatozoa}} | {{fertilization}} | |||
* {{zygote}} | |||
* {{morula}} | |||
* {{blastocyst}} | |||
<br> | |||
{{Week 1 Links}} | |||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Early_zygote_labelled.jpg|100px|link=Carnegie_stage_1]] | |||
| [[File:Stage2.jpg|100px|link=Carnegie_stage_2]] | |||
| [[File:CSt3.jpg|100px|link=Carnegie_stage_3]] | |||
| [[File:Human_embryo_day_5.jpg|100px|link=Carnegie_stage_4]] | |||
|- | |||
| [[Carnegie_stage_1|stage 1]] | |||
| [[Carnegie_stage_2|stage 2]] | |||
| [[Carnegie_stage_3|stage 3]] | |||
| [[Carnegie_stage_4|stage 4]] | |||
|} | |||
== Week 2 == | == Week 2 == | ||
* [[Week 2]] Carnegie stage [[Carnegie_stage_5|5]] | [[Carnegie_stage_6|6]] | |||
* | [[File:Week2_001 icon.jpg|thumb|link=Implantation|Week 2 Implantation]] | ||
* [[Week 2]] Carnegie stage - [[Carnegie_stage_5|5]] | [[Carnegie_stage_6|6]] | |||
* {{trophoblast}} - ({{trophectoderm}}) outer cell layer | |||
* [[Embryoblast]] - inner cell mass | * [[Embryoblast]] - inner cell mass | ||
* | * {{implantation}} | ||
* [[Bilaminar embryo]] | * [[Bilaminar embryo]] | ||
<br> | |||
{{Week 2 Links}} | |||
{| | |||
! Carnegie stages | |||
|- | |||
| [[File:HeuserStreeter1941 fig49.jpg|100px|link=Carnegie_stage_4]] | |||
| [[File:Stage5_bf11L.jpg|100px|link=Carnegie_stage_5]] | |||
| [[File:Stage6_bf03.jpg|100px|link=Carnegie_stage_6]] | |||
|- | |||
| [[Carnegie_stage_4|stage 4]] | |||
| [[Carnegie_stage_5|stage 5]] | |||
| [[Carnegie_stage_6|stage 6]] | |||
|} | |||
== Week 3 == | == Week 3 == | ||
[[Image:Stage7 features.jpg|thumb|Week 3 - Embryonic disc]] | [[Image:Stage7 features.jpg|thumb|link=Week 3|Week 3 - Embryonic disc]] | ||
* [[Week 3]] - Carnegie stage [[Carnegie_stage_7|7]] | [[Carnegie_stage_8|8]] | [[Carnegie_stage_9|9]] | * [[Week 3]] - Carnegie stage - [[Carnegie_stage_7|7]] | [[Carnegie_stage_8|8]] | [[Carnegie_stage_9|9]] | ||
* [[Gastrulation]] | * [[Gastrulation]] | ||
* [[Notochord]] | |||
* [[Trilaminar embryo]] | * [[Trilaminar embryo]] | ||
* [[Mesoderm]] | |||
* [[Somitogenesis]] | * [[Somitogenesis]] | ||
* [[Neurogenesis]] | * [[Neurogenesis]] | ||
<br> | |||
{{Week 3 Links}} | |||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Stage7-sem4.jpg|100px|link=Carnegie_stage_7]] | |||
| [[File:Stage8_SEM1.jpg|80px|link=Carnegie_stage_8]] | |||
| [[File:Stage9_sem1c.jpg|100px|link=Carnegie_stage_9]] | |||
|- | |||
| [[Carnegie_stage_7|stage 7]] | |||
| [[Carnegie_stage_8|stage 8]] | |||
| [[Carnegie_stage_9|stage 9]] | |||
|} | |||
== Week 4 == | == Week 4 == | ||
* [[Week 4]] - Carnegie stage [[Carnegie_stage_10|10]] | [[Carnegie_stage_11|11]] | [[Carnegie_stage_12|12]] | [[Carnegie_stage_13|13]] | [[File:Stage11_bf3b.jpg|thumb|120px|link=Week 4|Week 4 - The heart begins]] | ||
* [[Week 4]] - Carnegie stage - [[Carnegie_stage_10|10]] | [[Carnegie_stage_11|11]] | [[Carnegie_stage_12|12]] | [[Carnegie_stage_13|13]] | |||
* [[Heart]] | * [[Cardiovascular System - Heart Development|Heart]] | ||
* [[Placodes]] | * [[Placodes]] | ||
* [[Pharyngeal arches]] | * [[Pharyngeal arches]] | ||
<br> | |||
{{Week 4 Links}} | |||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Stage10_sem2.jpg|100px|link=Carnegie_stage_10]] | |||
| [[File:Stage11 sem13c.jpg|80px|link=Carnegie_stage_11]] | |||
| [[File:Stage12_sem1c.jpg|100px|link=Carnegie_stage_12]] | |||
| [[File:Stage13_sem1c.jpg|100px|link=Carnegie_stage_13]] | |||
|- | |||
| [[Carnegie_stage_10|stage 10]] | |||
| [[Carnegie_stage_11|stage 11]] | |||
| [[Carnegie_stage_12|stage 12]] | |||
| [[Carnegie_stage_13|stage 13]] | |||
|} | |||
== Week 5 == | == Week 5 == | ||
[[ | [[File:Stage14_bf2l.jpg|thumb|link=Week 5|Week 5 embryo]] | ||
* [[Week 5]] - Carnegie stage [[Carnegie_stage_14|14]] to [[Carnegie_stage_15|15]] | * [[Week 5]] - Carnegie stage - [[Carnegie_stage_14|14]] to [[Carnegie_stage_15|15]] | ||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Stage14_sem1c.jpg|100px|link=Carnegie_stage_14]] | |||
| [[File:Stage15_bf1c.jpg|100px|link=Carnegie_stage_15]] | |||
|- | |||
| [[Carnegie_stage_10|stage 14]] | |||
| [[Carnegie_stage_11|stage 15]] | |||
|} | |||
== Week 6 == | == Week 6 == | ||
[[File:Stage16-18_face.jpg|thumb||link=Week 6|Week 6 - Early face deevelopment]] | |||
* [[Week 6]] - Carnegie stage - [[Carnegie_stage_16|16]] to [[Carnegie_stage_17|17]] | |||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Stage16_bf1c.jpg|100px|link=Carnegie_stage_16]] | |||
| [[File:Stage17_bf1c.jpg|100px|link=Carnegie_stage_17]] | |||
|- | |||
| [[Carnegie_stage_10|stage 16]] | |||
| [[Carnegie_stage_11|stage 17]] | |||
|} | |||
== Week 7 == | == Week 7 == | ||
* [[Week 7]] - Carnegie stage [[Carnegie_stage_18|18]] to [[Carnegie_stage_19|19]] | [[File:Stage19_bf2b.jpg|thumb|150px||link=Week 7|Week 7 - Head and limb development]] | ||
* [[Week 7]] - Carnegie stage - [[Carnegie_stage_18|18]] to [[Carnegie_stage_19|19]] | |||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Stage18_bf1c.jpg|100px|link=Carnegie_stage_18]] | |||
| [[File:Stage19_bf1c.jpg|100px|link=Carnegie_stage_19]] | |||
|- | |||
| [[Carnegie_stage_18|stage 18]] | |||
| [[Carnegie_stage_19|stage 19]] | |||
|} | |||
== Week 8 == | == Week 8 == | ||
[[File:Stage23_bf1c.jpg|thumb||link=Week 8|Week 8 - Last embryonic stage 23]] | |||
* [[Week 8]] - Carnegie stage - [[Carnegie_stage_20|20]] | [[Carnegie_stage_21|21]] | [[Carnegie_stage_22|22]] | [[Carnegie_stage_23|23]] | |||
* Last week of embryonic development. | |||
{| border='0px' | |||
! Carnegie stages | |||
|- | |||
| [[File:Stage20_bf1c.jpg|100px|link=Carnegie_stage_20]] | |||
| [[File:Stage21_bf1c.jpg|100px|link=Carnegie_stage_21]] | |||
| [[File:Stage22_bf1c.jpg|100px|link=Carnegie_stage_22]] | |||
| [[File:Stage23_bf1c.jpg|100px|link=Carnegie_stage_23]] | |||
|- | |||
| [[Carnegie_stage_20|stage 20]] | |||
| [[Carnegie_stage_21|stage 21]] | |||
| [[Carnegie_stage_22|stage 22]] | |||
| [[Carnegie_stage_23|stage 23]] | |||
|} | |||
{{Carnegie stages}} | |||
{{Carnegie stage table}} | |||
==References== | |||
<references/> | |||
{{ | {{Glossary}} | ||
[[Category:Human Embryo]] | {{Footer}} | ||
[[Category:Human Embryo]][[Category:Human]] | |||
[[Category:Week 1]][[Category:Week 2]][[Category:Week 3]][[Category:Week 4]] | |||
[[Category:Week 5]][[Category:Week 6]][[Category:Week 7]][[Category:Week 8]] |
Latest revision as of 06:46, 13 December 2018
Embryology - 19 May 2024 Expand to Translate |
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Introduction
Author Comments |
---|
Start here by looking at the external appearance of embryos in sequence from 1 to 23. It is not so important to memorise the dates, as they are only approximate, but more important to understand growth (size changes) and the development (overall sequence of events) during this period.
Clicking the Carnegie stage numbers opens a page dedicated to describing that single stage and the associated developmental events. |
This page shows some key events of human development during the embryonic period of the first eight weeks (weeks 1 - 8) following fertilization. This period is also considered the organogenic period, when most organs within the embryo have begun to form.
|
Kyoto Collection | Carnegie Collection | |
---|---|---|
Human Embryo, Carnegie stages 1-23 | Human Embryo, Carnegie stages 10-23 |
<html5media height="530" width="375">File:Embryo stages 003.mp4</html5media> | Use the stage number links to images and information about each specific stage of human development over the first 8 weeks. The links below give a broad overview of developmental events during each week.
Embryo sizes - stage 14 compared to 23
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 |
Week 1
- Week 1 Carnegie stage - 1 | 2 | 3 | 4
- oocyte | spermatozoa | fertilization
- zygote
- morula
- blastocyst
Week 1 Links: stage 1 | stage 2 | stage 3 | menstrual cycle | fertilization | zygote | morula | blastocyst | Lecture - Fertilization | meiosis | mitosis | Lecture - Week 1 and 2 | menstrual cycle | oocyte | spermatozoa | twinning | Genetic risk maternal age | Trisomy 21 | Trisomy 18 | Trisomy 13 | hydatidiform mole | GA week 3 |
Carnegie stages | |||
---|---|---|---|
stage 1 | stage 2 | stage 3 | stage 4 |
Week 2
- Week 2 Carnegie stage - 5 | 6
- trophoblast - (trophectoderm) outer cell layer
- Embryoblast - inner cell mass
- implantation
- Bilaminar embryo
Week 2 Links: stage 4 | stage 5 | stage 6 | Lecture - Week 1 and 2 | implantation | trophoblast | human chorionic gonadotropin | pregnancy test | twinning | Category:Week 2 | GA week 4 |
Carnegie stages | ||
---|---|---|
stage 4 | stage 5 | stage 6 |
Week 3
Week 3 Links: stage 7 | stage 8 | stage 9 | Gastrulation | Endoderm | Mesoderm | Ectoderm | Placenta | Coelomic Cavity | Lecture | Category:Week 3 | GA week 5 |
Carnegie stages | ||
---|---|---|
stage 7 | stage 8 | stage 9 |
Week 4
Week 4 Links: stage 10 | stage 11 | stage 12 | 13 | Placodes | Pharyngeal arches | Lecture - Mesoderm | Lecture - Ectoderm | Lecture - Early Vascular | Category:Week 4 | GA week 6 |
Carnegie stages | |||
---|---|---|---|
stage 10 | stage 11 | stage 12 | stage 13 |
Week 5
Carnegie stages | |
---|---|
stage 14 | stage 15 |
Week 6
Carnegie stages | |
---|---|
stage 16 | stage 17 |
Week 7
Carnegie stages | |
---|---|
stage 18 | stage 19 |
Week 8
Carnegie stages | |||
---|---|---|---|
stage 20 | stage 21 | stage 22 | stage 23 |
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Carnegie Stage Table
Weeks shown in the table below are embryonic post ovulation age, for clinical Gestational Age (GA) measured from last menstrual period, add 2 weeks.
(not to scale) |
||||
fertilized oocyte, zygote, pronuclei | ||||
morula cell division with reduction in cytoplasmic volume, blastocyst formation of inner and outer cell mass | ||||
loss of zona pellucida, free blastocyst | ||||
attaching blastocyst | ||||
(week 2) |
implantation | |||
extraembryonic mesoderm, primitive streak, gastrulation | ||||
gastrulation, notochordal process | ||||
primitive pit, notochordal canal | ||||
Somitogenesis Somite Number 1 - 3 neural folds, cardiac primordium, head fold | ||||
Somite Number 4 - 12 neural fold fuses | ||||
Somite Number 13 - 20 rostral neuropore closes | ||||
Somite Number 21 - 29 caudal neuropore closes | ||||
Somite Number 30 leg buds, lens placode, pharyngeal arches | ||||
lens pit, optic cup | ||||
lens vesicle, nasal pit, hand plate | ||||
nasal pits moved ventrally, auricular hillocks, foot plate | ||||
finger rays | ||||
ossification commences | ||||
straightening of trunk | ||||
upper limbs longer and bent at elbow | ||||
hands and feet turned inward | ||||
eyelids, external ears | ||||
rounded head, body and limbs | ||||
The embryos shown in the table are from the Kyoto and Carnegie collection and other sources.
References
- ↑ Findlay JK, Gear ML, Illingworth PJ, Junk SM, Kay G, Mackerras AH, Pope A, Rothenfluh HS & Wilton L. (2007). Human embryo: a biological definition. Hum. Reprod. , 22, 905-11. PMID: 17178746 DOI.
- ↑ O'Rahilly R. 1979. Early human development and the chief sources of information on staged human embryos. Europ. J. Obstet. Gynec. Reprod. Biol., 9, 273-280. PMID 400868
- ↑ O'Rahilly R. and Müller F. Developmental Stages in Human Embryos. Contrib. Embryol., Carnegie Inst. Wash. 637 (1987).
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 19) Embryology Embryonic Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryonic_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G