Difference between revisions of "Embryology History - Franklin Mall"
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- 1 Introduction
- 2 Franklin Paine Mall 1862-1917 In Memoriam
- 3 Manual of Human Embryology
- 4 A Human Embryo Twenty-Six Days Old
- 5 Studies on abortuses: a survey of pathologic ova in the carnegie embryological collection
- 6 Report Upon the Collection of Human Embryos at the John Hopkins University
- 7 On The Frequency of Localized Anomalies in Human Embryos and Infants at Birth
- 8 Blood-Vessels of the Brain
- 9 References
- 10 External Links
- 11 Glossary Links
Franklin P. Mall (1862-1917) is most remembered for his work done at the Department of Embryology at the Carnegie Institute of Washington. Mall began collecting human embryos while a postgraduate student in Lepzig with Wilhelm His, but didn't receive the first Carnegie specimen until his position at Johns Hopkins University.
Surprizingly age and size proves a poor way to organize embryos. It is very difficult to accurately age an embryo, and it could shrink a full 50% in the preserving fluids. Mall took it upon himself to find a better way. He had more success basing his "staging" scheme on morphological characteristics. To that end, Mall and his colleagues not only prepared and preserved serial sections of the embryos, they also made hundreds of three-dimensional models at different stages of growth.
According to Adrianne Noe, who manages the collection at the National Museum of Health and Medicine, Mall gathered the most renowned scientists, scholars, artists, photographers, and craftspeople ever to apply their interests and skills to embryology.
One of the first to be hired, in 1913, was modeler Osborne O. Heard, who spent 42 years at the department and made over 700 wax-based reconstructions. The results of this team effort still stand as the international standard by which human embryos are described and classified.
(Above text and information about the collection is modifed from the original Carnegie Institute website)
The embryo collection is now held at the National Museum of Health and Medicine, located at the Walter Reed Army Medical Center in Washington, D.C. the Carnegie collection is still available for use by researchers.
- Franklin Mall Links: Franklin Mall | 1891 26 Day Human Embryo | 1905 Blood-Vessels of the Brain | 1906 Human Ossification | 1910 Manual of Human Embryology 1 | 1912 Manual of Human Embryology 2 | 1911 Mall Human Embryo Collection | 1912 Heart Development | 1915 Tubal Pregnancy | 1916 Human Magma in Normal and Pathological Development | 1917 Frequency Human Abnormalities | 1917 Human Embryo Cyclopia | 1918 Embryo Age | 1918 Appreciation | 1934 Franklin Mall biography PDF | Mall photograph | Mall painting | Mall painting | Carnegie Stages | Carnegie Embryos | Carnegie Collection | Category:Franklin Mall
|Embryologists: William Hunter | Wilhelm Roux | Caspar Wolff | Wilhelm His | Oscar Hertwig | Julius Kollmann | Hans Spemann | Francis Balfour | Charles Minot | Ambrosius Hubrecht | Charles Bardeen | Franz Keibel | Franklin Mall | Florence Sabin | George Streeter | George Corner | James Hill | Jan Florian | Thomas Bryce | Thomas Morgan | Ernest Frazer | Francisco Orts-Llorca | José Doménech Mateu | Frederic Lewis | Arthur Meyer | Robert Meyer | Erich Blechschmidt | Klaus Hinrichsen | Hideo Nishimura | Arthur Hertig | John Rock | Viktor Hamburger | Mary Lyon | Nicole Le Douarin | Robert Winston | Fabiola Müller | Ronan O'Rahilly | Robert Edwards | John Gurdon | Shinya Yamanaka | Embryology History | Category:People|
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline | Glossary Carnegie Collection
Franklin Paine Mall 1862-1917 In Memoriam
- An address, in memory of Franklin Paine Mall, presented at the thirty-fourth session of the American Association of Anatomists, convened at the University of Minnesota, December 27 to 29, 1917. (1918 Anat Rec. 14 (1): 9-17.)
This hour, of our busy session, has been set aside to enable us to voice our deep appreciation, our gratitude and affection of one who has been wont to meet with us, one of our members whose busy and eventful life, but recently and all too suddenly was brought to an end. On November 17 We were shocked and grieved to learn of the death of Franklin Paine Mall, Professor of Anatomy at Johns Hopkins University and Director of the Department of Embryology of the Carnegie Institution of Washington. We Who in thought lingered at his bedside during the final week of illness, though separated by boundaries of states, We who Were made hopeful or sorrowed as bulletins Were received, and were in a measure led to anticipate the end, were none the less unprepared to sustain the grief which came with the realization of the sudden ending of a career which has meant so much to the development of scientific Anatomy in America. On this 17th day of November there came to a close the lives of two notable personalities with international standing. The one, Auguste Rodin, with years numbering more than three score and ten, who labored more than half a century to reach fame, one whose molded clay and chiseled stone expressed structure and movement; the other, our departed member, who in the scarce more than half century of life, obtained a commanding position early in his career and of his brief span was for nearly a quarter of a century recognized at home and abroad as an able investigator, with wide sympathies, and keen and broad vision; one Who saw life in a dead section; one who has been teacher to many of us though we held not the formal relation of pupils.
We are at the moment too near to sorrow to sketch with full justice this life. I have been the more willing to give expression to our feelings, at this time, since I fully realize that no word of eulogy of mine is needed to bring him to your appreciation. We are all familiar with the results of his labor. To nearly all of us there has been a personal side, not revealed in printed page. To me, he has been a helpful friend of many years standing, one whose frank though kindly criticism as well as encouraging word, whether written or spoken, have been appreciated and have influenced my endeavors and will influence them to the end of my labors.
Franklin Paine Mall was born September 28, 1862, on a farm some two miles distant from Belle Plaine, Iowa, the son of Francis and Louise (Miller) Mall. His father came to America from Germany in 1848. His mother, born in this country, died during his early boyhood. His preliminary education was received largely at a boarding school situated near his home. He entered the Department of Medicine and Surgery of the University of Michigan, apparently on the advice of their family physician, who had graduated there, in the autumn of 1880, and received the degree of Doctor of Medicine from this institution on June 28, 1883; thus several months before attaining majority. This period of study fell to a time when “The Faculty recognizes what is evident in the experience of all medical students, that attendance upon lectures on the same subject a second time, is much more interesting and profitable than the first; hence they require students to attend lectures on all the leading subjects more than once.” Probably speaking from his own experience—Liberty in Medical Education~he states “When the third year course was introduced the second year was the first year taken over again, with a special third year course added. In this way the student heard each course of lectures twice in order to make him remember it.” Laboratory courses in anatomy and histology were required, though in later years while discussing the need of careful work in the dissecting room, with reference to the value of Barker’s Manual, he states that “Nowhere do we read that the 5000 questions which were placed before me while a medical student give the ‘royal road’ to knowledge.” It is stated that instead of taking lectures over again, yes a first time in certain courses, this medical student chose the alternative of study in the library. Of his then teachers he has spoken to me of two— Vaughan and Sewall — as having given inspiration and incentive to further work. To me, who approached this same course at about the same age and with essentially the same preliminary training and only a few years later, retrospect does not reveal much specific knowledge gained during undergraduate days; rather one had opportunity to acquire an attitude of mind. A ‘trieb’ within for knowing the unknown did find congenial environment in the quiet and stimulating University atmosphere, with approach to academic ideals.
The years immediately following graduation in medicine, Doctor Mall spent in study in Europe. The first year (1884) at Heidelberg, where he pursued various medical subjects, lived the life of a student and perfected himself in the German language. In his discussion of liberty in medical education, with special reference to sequence or courses, we read “If a student desires to take pathological histology without having had normal histology and the instructor did not object, the student would have to take the consequences. I myself did this as a student at Heidelberg and to this day I have not regretted it.” The years of 1885-86 were spent in Leipzig and the greater part of this time in Ludwig’s laboratory, and he was profoundly influenced by this teacher, one whom Minot has characterized “as the greatest teacher of the art of scientific research whom he had ever met.” The influence of Ludwig was the dominant one in molding his future scientific ideals as well as his attitude toward medical education. The happy relations existing in the laboratory between Ludwig and his pupils was one which impressed him greatly and was emulated by him in his own laboratory in later years. During his second year at Leipzig a part of the time was spent in study in the laboratory of His. This great teacher of anatomy was not so congenial and less approachable. In his account of the life of Wilhelm His he informs us that “When I knocked at his door at first I was turned away, but after appearing a number of times I was finally accepted.” Teacher and pupil became intimate friends in later years. Doctor Mall spent many summers in Leipzig working with His. Their intimacy was based on common interests in similar scientific problems. The clear reasoning and direct manner of formulat— ing and solving problems, characteristic of His, impressed and influenced his pupil and co—worker. The results of his two years of study at Leipzig are embodied in two publications, one from each of the two laboratories in which his special work was carried on—“Die Blut—und Lymphwege im Diinndarm des Hundes” and “Entwickelung der Branchialbogen und Spalten des Hunchens,” characteristic of the spirit of the two laboratories and in a measure foreshadowing the main lines of his future work.
On his return to America Doctor Mall was called to Baltimore, where he entered upon the duties of Fellow in Pathology, under Professor Welch (1886~88) in association with Doctors Halstead and Councilman. He was named Instructor in Pathology, 1888-89. These were further years of training, devoted to investigation, as attested by a number of publications. It is deemed fitting to emphasize here this long period of training devoted to research, and the breadth of the training—physiology, embryology and pathology. Doctor Mall has often, in spoken and written word, stressed the necessity of training in research as a preparation for an academic career and has pled for the opportunity for such training in our American Medical Schools. “In America,” he writes, “we frequently find recent graduates who tell us they would follow an academic career if their future were assured as far as salary is concerned. Little do they realize that this attitude of mind alone would exclude them absolutely from such a career.” With the opening of Clark University Doctor Mall became Adjunct Professor of Vertebrate Anatomy (1889-92), and with the foundation of Chicago University, Professor of Anatomy (1892-93). With the establishment of the School of Medicine at Johns Hopkins University, he returned to Baltimore to enter upon the duties'of Professor of Anatomy and Director of the Laboratory, which position he held at the time of his death, assuming in 1914, in conjunction, the directorship of the newly created Department of Embryology of the Carnegie Institution of Washington. The University of Michigan honored him and honored itself by conferring the degree of A.M., in 1900, and the degree of Sc.D., in 1908. He received the degree of LL.D., from the University of Wisconsin, in 1904. His sympathies in the sciences, more particularly in the Biological sciences were broad, and in an advisory capacity, as a member of committees or of boards, he did much to promote his chosen and allied sciences. He was sometime a trustee of the Woods Hole Biological Laboratory, member of the Advisory Board of The Wistar Institute, member of the committee of brain research of the International Association of Academies, member of the National Academy of Sciences, of the American Philosophical Association, Fellow of the College of Physicians of Philadelphia and member of many learned societies of America.
Doctor Mall’s publications number somewhat over one hundred. Time does not permit, nor is this the opportunity to present a bibliographic list and discuss critically these publications. This I am attempting for record elsewhere. However, a fleeting survey may here be permitted. His Leipzig teachers, Ludwig and His, were sometime teachers both of anatomy and physiology and many of Ludwig’s researches were of physiological problems studied chiefly on an anatomical basis, bringing structures and course of blood vessels in relation with function of organs. This functional or physiological anatomy is exemplified in his studies of the blood and lymph vessels of the dog’s small intestine and stomach, his studies of the spleen lobule, and of the structural unit of the liver. finished contributions of studies in which methods of vascular injection, corrosion injection, maceration and differential digestion where used to advantage in reaching definite conclusions. Of his more purely physiologic researches may be mentioned the studies of the vasomotor supply of the Portal System. His careful and illuminating studies of the histogenesis of the connective tissue from mesenchymal syncytium and of collagenous, yellow elastic and reticular fibrils have given us a new conception of the structure of connective tissue. However, from the time of his early studies in embryology in the His laboratory, resulting in his first publication, embryology and histogenesis have been the chief theme of his investigation, his real program for modern anatomy. The embryological studies contributed by himself, with many others emanating from his laboratory, have greatly extended the bounds of our knowledge of developmental processes, especially as concerns the human embryo, the development of which, except for earliest stages, is now better understood than that of any other mammal, and this largely through his labors, his cooperation or his incentive. Doctor Mall’s first embryological contribution dealt with the development of the branchial cleft region of the chick, followed in close succession by a series of studies of this region, both in chick and mammals. These were followed by a series of papers on the development of the coelomic cavity, culminating in his well known contribution to the development of the human coelom. His study of a human embryo 26 days old, falling to the early period of his work (1891) exemplifies a characteristic of the embryological work of His, namely, that he viewed the embryo as a whole and carried the investigation to its logical conclusion. This study has been the prototype for other investigations of human and other mammalian embryos. The contribution to the development of the human intestine and its position in the adult exemplifies another type of embryological work, one worthy of special commendation. Of it, His has stated in a private letter— “What is lacking in the majority of contributions to embryology is a fundamental conception of the transition phases from early developmental stages to fetal and adult stages. For the intestine you have now completed this chain, from beginning to end, and this I hold to be a great advance.” This broad conception of embryblogic investigation characterizes other of his contributions; his studies on the development of the heart, normal and pathological, and of the structure of the adult heart, his studies of the structural unit of the liver, of the blood vessels of the brain and other vessels, all bring to conclusion developmental stages and give the key to modern anatomic investigation. With the increase in the size of the human embryological collection at Johns Hopkins University, the need of determining more definitely the age relation to the size of the human embryo, the sequence of stages and a uniform and well authenticated designation of stages, became apparent, and much thought was given this phase of embryologic investigation. The results of these reflections have appeared in a number of publications which have proven essential and helpful in the correlation of investigations on the human embryo. The ever-growing collection of human embryos contained many specimens of pathologic ova and young embryos, which have formed the basis for a number of monographic contributions dealing with the pathology of early human embryos, the causes underlying the origin of human monsters, of cyclopia in the human embryo, the frequency of localized anomalies in human embryos and infants at birth, the causes of tubal pregnancy and the fate of the embryo in tubal pregnancy. Much of this later work was pioneer work and of the greatest value; of interest not only to the specialist but of a wide general interest. The “Manual of Human Embryology,” edited by Keibel and Mall, and published simultaneously in German and in English, marks a milestone in the progress of our knowledge of human development and embodies the crystallized thought of Doctor Mall and his co-workers.
Doctor Mall was for many years vitally interested in the question of medical education. From the time of his early Leipzig days, influenced by the attitude existing between Ludwig and his pupils, influenced also by this able investigator’s views on medical education and on university education in general, he agitated for more liberty in medical education. “How different is the study of medicine in Europe than in America. There freedom reigns and students wander from place to place, being controlled only by a fairly rational system of examinations in case they wish to graduate,” we hear him say. And againv “Liberty to the student should not mean license to him, but rather liberty also to the instructor.” He has argued for more liberal curricula, concentration of courses, opportunity for electives on the part of the student, but also for more freedom from routine and better facilities for research on the part of the teacher. “A medical department of a University must consist of a group of independent departments, each a complete organization in itself, existing primarily as a conservator of the branch it represents. Teaching beginners may become its chief work, but should never be its chief ideal.” I am not prepared to say just how much of the improvement in medical education witnessed during the past decade is due to his influence, direct or indirect, though I feel that he has been a potent factor; and may we come to a nearer realization of his ideals.
His chief concern was of necessity with departments of anatomy. On entering upon the real work of his life, at Johns Hopkins University, he was able to organize a department of anatomy unhampered by traditions, and in an environment of academic freedom, surrounded by departments devoted to scientific research, he was able, from the beginning, to realize certain of his ideals. The work of the department was placed on a broad basis. “To bring about desired reform it is necessary to have represented in an anatomical department, even in a medical school, all which naturally belongs to this science. The study of anatomy begins with the cell, ends with the entire individual, and includes man,” we were informed in his remarks to this association as president. And again — “A subject like anatomy, taught for many centuries, has recently been made a new science through the studies in embryology and histology.” His was the first department of anatomy i11 America in which all divisions of anatomy were thus correlated, not alone in printed announcement but in daily practice. Other medical schools have followed, but some have been tardy followers. From the beginning much needed reform was instituted in the dissecting room; his was not a ‘dissecting room’ but a laboratory. Consideration was given to adequate preservation of material. The aim from the beginning was to make the study of anatomy inductive, and a type of instruction in gross anatomy was inaugurated and carried on with eminent success, which if followed by many of us would inevitably have cost us our positions. The student was led to make a complete dissection, using atlases, text-books and manuals. Analyzing the object itself was thought to be of infinitely more value than watching the results exposed by another. Neat, careful and accurate dissection was insisted upon, for it was appreciated that “The thorough dissector is much more likely to become a fine and discriminating physician and an effective and progressive surgeon.” And further — “The importance of working out the finer structure lies not always so much in the actual knowledge gained by the student, as in the acquisition of the habits of thoroughness of observation and investigation.” Such a course in gross anatomy could only be carried on in a department the staff of which was actively engaged in scientific research and in contributing to the progress of anatomy. From the beginning and through these many years he has been able to associate with himself a corps of able assistants and co-workers, who have profited by his methods and acquired his ideals, and many of them have become able and independent investigators. It was fortunate that when reorganization of medical schools became imperative, and fulltime and trained.teachers were sought, this need for the departments of anatomy was met, and in a number of medical schools the departments of anatomy formed the nucleus around which reorganization was effected. May I be permitted to quote from the English periodical Nature (February 3, 1916) in which the reorganization of embryological research in America, and incidentally its departments of anatomy, are considered; and I quote with full accord- “five-and-twenty years ago anatomists in America were British in method and spirit; they were easygoing, each man following leisurely his own individual bent. Since that time a remarkable change has taken place; the number of laboratories in which the structure and development of the human body are taught and investigated have increased tenfold; the number of investigators has grown in a still greater ratio; in quantity and quality their anatomical proceedings and journals have come to rival those of any country in Europe. In effecting this transformation the chief credit must be assigned to one manFranklin P. Mall, for twenty—three years professor of anatomy at the Johns Hopkins University. He planted in Baltimore the methods and aims which he acquired when working in the laboratory of the late Professor His at Leipzig. By his personal influence and example, by pupils and disciples, and by reason of the inherent excellence of the Leipzig traditions, he has succeeded in Germanizing the majority of the dissecting rooms and anatomical laboratories throughout the length and breadth of North America.” I never entered the unpretentious little building, situated at the corner of Wolfe and Monument Streets, though admirably planned within, crowded to the doors, with Walls of halls covered with drawings of illustrations of contributions to all phases of anatomy, nor shared the simple noonhour lunch of staff, perhaps each contributing to my share, without realizing to the full, that not brick and mortar, not even chiseled stone adorned by marble, make an anatomic institute.
During the early period of the regeneration of anatomic departments in our medical schools, the need of a medium for publishing in America, contributions to anatomy emanating from American laboratories, was keenly felt by him. Scientific anatomy had been Wrested from the medical school by collegiate and University departments of Zoology; the scattered contributions to anatomy were being published abroad or in our own journal devoted primarily to Zoology or to general science. And, while he believed fully in the catholicity of the Biological Sciences, he did not like to have it said of our association that its prominent members were not anatomists but biologists or something else. To enable fuller expression of anatomic thought, to assist in developing and differentiating Work in the anatomic laboratories of our medical schools, and the creation of a science of anatomy in America, The American Journal of Anatomy was founded. The realization of the need was largely his. In the fruition of the plans, an editorial board drawn from workers in a number of laboratories was created. Members of this board, laboratories and others interested in the development of anatomy, subscribed a suflicient fund to assure the publication of the early volumes. The journal at once became the organ of this association; membership in it automatically giving subscription to the journal. The early volumes were edited and published from his laboratory. The high standard set for contributions accepted, the enthusiasm with which the work was carried on, the sacrifice of time given to the work by himself and associates in his laboratory, did much to insure the success of this journal. After the issuance of the first few volumes of The American Journal of Anatomy, a few pages were set aside in each number, under the heading of “Anatomical Record.” To these pages he contributed freely himself; and nearly always, whether in book review, in record of collection or brief note, the dominant theme pertains to development of anatomy. The Anatomical Record, which thus. had its anlage by budding, soon developed into an independent organ, which has differentiated with the development of anatomy. With the re-formulation of the aims of The Wistar Institute of Anatomy under the directorship of Doctor Greenman, who, with far—seeing policy, appreciated the opportunity of lending the aid of this Institute to the development of scientific anatomy in America, and with full approval of an Advisory Board of Anatomists for this Institute, created at his suggestion, the publication office of The American Journal of Anatomy and The Anatomical Record, and other prominent morphologic journals, was transferred to The Wistar Institute. To the wisdom of establishing and maintaining these relations we can all testify. It has seemed to me that there has been no one effort on the part of The Wistar Institute which has been so instrumental in developing scientific anatomy in America as the broad policy shown by its Director in furthering the interests of our anatomic publications. We anatomists acknowledge a debt to the Director of this Institute as well as to Doctor Mall; the realization of the need of an American journal of Anatomy, and the appreciation of its value in furthering the development of scientific anatomy in our medical schools, to a large measure its inception and an ever present help in earlier stages of development, we owe to the one; the other through material aid and broad policy has been instrumental in bringing to fuller fruition the earlier endeavors. It is peculiarly fitting and appropriate that an appreciation of the life and influence of Doctor Mall should be presented at a session of the American Association of Anatomists. Some time its President and for a large number of years member of its executive committee, ever interested in its wellfare and keenly appreciative of its growth in numbers and influence and ever appreciating character of papers and demonstrations presented at its yearly sessions; to him this expressed growth of anatomy in America. Three years ago, this association assembled in its thirty—first session recorded in resolution its profound sense of sorrow and deep feeling of the loss sustained by the death of Charles Sedgwick Minot, he having died the 19th of November preceding. We recorded in appropriate words our appreciation of his labors in furthering the affairs of this association. I recall distinctly a session of this society, held in New Haven some twenty years ago, one of the first I attended. This session marked the turning point in the growth and development of our association. Plans for reorganization were then instituted. At a subsequent meeting, Professor Huntington was elected to the presidency, which office he held for a period of four years, important years in our evolution. I became your secretary during this period and was permittedto come in closer oflicial connection, and to serve in this capacity, during the terms of presidency of three of our members who more than others were responsible for the reforming of the aims and ideals of our society: Huntington, Minot, Mall. I recall the many letters received from Doctor Mall during this period, full of discussion of plans for furthering our common interests and elevating our ideals, with ever—growing lists of names proposed for new members, with plans and suggestions for furthering the development of our journals and their relation to our membership. In all ever striving with unselfish devotion and sacrifice of time, for the furthering of the affairs of this association, and thus developing scientific anatomy in America.
Perhaps the crowning work of the career of Doctor Mall, though we judge it now only in its inception, is the work connected with the Department of Embryology of the Carnegie Institution of Washington. An institute of this kind, finally achieved, was in his mind years before it was realized. He was much impressed and influenced by a paper published by His as early as 1886, on the necessity of Research Institutes. Later when opportunity presented itself His made a plea. for a research institute in neurology and one for human embryology. In answer, the commission for brain research was sanctioned by the Associated Academies. Concerning the development of plans for the research in human embryology I abstract as follows from Doctor Mall’s plea for such an institute, published but a few years ago. The second project of His was referred by the Associated Academies to the Anatomic Societies for consideration, and in consequence, the German Anatomic Society, in the meeting of 1901, appointed a committee to arrange for cooperation in embryologic research; it developed no activities. Not until the time of the Brussels meeting of the Anatomic Congress in 1910, were further definite steps taken at that time, and as I recall at the suggestion of Doctor Minot, a committee was appointed to revise embryonic nomenclature. Shortly after this Brussels meeting a self appointed committee of three met at Utrecht to arrange for an international institute for comparative embryology. The object of the Brussels committee was to revise embryologic nomenclature and of the Utrecht conference, to make extensive collections of embryos of all vertebrates, neither committee purposed to confine its field especially to human development. Recognizing the fact that in the study of human development there are specific problems of great scientific and practical value, which cannot possibly be studied to best advantage without more concentration of energies than either the above committees had planned, and the further fact, that the science of anatomy, which in a great measure has been the mother of all biological sciences, needs a thorough revision and a new basis, to be obtained through the study of embryology, the original plan of His was again revised and ably and clearly put forth in “A Plea for an Institute of Human Embryology.” Through cooperation of those especially interested, and the hearty endorsement of the late Professor Minot, this oft expressed wish was realized through the generosity and foresight of the Director and the Trustees of the Carnegie Institution of Washington, and for this recognition of anatomy in America, on the part of this Institution, we anatomists are placed in a deep and lasting obligation. The new department of embryology was stationed at Baltimore with Doctor Mall as its director. The scope of the plans for the new Institute of Human Embryology, as outlined in the plea for its creation, and already in part realized, is broad and comprehensive. It calls for a large collection of embryos, a competent staff, the very best material equipment and an appreciation of all the problems which bear on anatomy~physical anthropology, comparative embryology, physiology of gestation, pathology and teratology. The larger questions to be given consideration are—curve of growth; anatomy of various stages; morphology of the brain; histogcnesis; causes of abortion; the study of monsters and of moles ;_ comparative and experimental embryology to elucidate human. Nearly twenty subdivisions of these larger questions are enumerated and discussed. I gather from a recent report that the collection of human embryos consists of about 2000 specimens, many of which have been prepared in permanent serial sections. The collection is already unique, both in magnitude and importance, and vigorous efforts are being made to increase it, but I note also, that the chief function of an institute of human embryology is not the making of a collection, but the formulation and solution of problems. That this new institute was already at work, and the manner in which it was to fulfil its destiny, is attested by the “Contributions to Embryology,” published by the Carnegie Institution, some twenty of which have appeared in monographic form, with a goodly number of smaller publications which have appeared in our Anatomic journals. May the personality and strength and the high scientific ideals of the late Director of this new Institute for the study of human embryology serve as an example and stimulus to such as follow in his footsteps; we conceive of no surer avenue to success.
Such has been his life; here briefly, all too briefly and I realize inadequately told. I cannot leave its appreciation without referring to the loving care and affectionate solicitude with which it has been watched over by his trusted wife. Who, trained in anatomy, was fully appreciative of his endeavors and ever interested in the development and realization of his ideals. We who have been permitted to partake of the kindly and sincere hospitality of their home, will cherish pleasant memories. To her and to the family, We as individuals and collectively as an association, extend our most sincere and heartfelt sympathy. May the knowledge that this profound sorrow is mutually borne, lighten their grief.
In closing I make use of the opening paragraph of his account of the life and influence of Wilhelm His, his teacher and his friend - “The ancient science of anatomy has been perpetuated and extended during the many centuries of its existence by great men who have dedicated their lives to it. The list is a long one for the development of the science has been slow and progressive from the earliest ages to the present time; we find in it on the one hand, some of the greatest who have ever lived—Aristotle, Vesalius~on the other, the names of those who rank as leaders of a generation, Bichat, His.” To the names of Bichat and His, I would add, with your accord, the name of Mall.
G. Carl Huber.
Nature - Obituary Notice
Prof. Franklin P. Mall
- "ALL who are interested in the progress of biology will learn with deep regret of the sudden death of Dr. Franklin P. Mall, of Johns Hopkins University, at the age of fifty-five. It was chiefly owing to his precepts and example that, in little more than a score of years, a complete revolution was wrought in the anatomical departments attached to medical schools throughout the length and breadth of the United States. Dissecting-rooms were changed from places in which routine teaching and perfunctory investigation were carried on to laboratories where exact methods were applied to the elucidation of definite problems. Prof. Mall was thirty-one years of age when he returned in 1893 from a long course of study under the late Prof. His, of Leipzig, to become the first professor of anatomy in Johns Hopkins University, Baltimore. He designed his own department, selecting a slimly built, cheap, brick construction, and settled down with his students to combine study with research. He devoted himself to embryological and microscopic investigations, reconstructing his results in the exact model methods practised by Prof. His. His writings cover the whole field of embryology, every contribution representing a permanent addition to knowledge. His pupils left him to fill the various chairs of anatomy as they fell vacant, and carried to their new departments the methods and spirit they had imbibed from Franklin Mall. He took a leading-part in the foundation of the excellent journals which have been established in the United States for the publication of anatomical investigations the American Journal of Anatomy, the Anatomical Record, and the Journal of Morphology. He pursued the study of human embryology in a more systematic manner than has ever been accomplished by any other man."
- Links: Nature (27 December 1917)
|Historic Disclaimer - information about historic embryology pages|
|Embryology History | Historic Embryology Papers)|
Manual of Human Embryology
A Human Embryo Twenty-Six Days Old
A Human Embryo Twenty-Six Days Old Journal of Morphology (1891) vol. 5. pp459-480.
Studies on abortuses: a survey of pathologic ova in the carnegie embryological collection
Contributions to Embryology VOLUME XII (1921)
By Franklin Paine Mall and Arthur William Meyer. (24 plates, 5 text-figures, and 1 chart)
- In this historic 1921 pathology paper, figures and plates of abnormal embryos are not suitable for young students.
Contributions Vol.12 No.56 (1921): Preface | 1 Collection origin | 2 Care and utilization | 3 Classification | 4 Pathologic analysis | 5 Size | 6 Sex incidence | 7 Localized anomalies | 8 Hydatiform uterine | 9 Hydatiform tubal | Chapter 10 Alleged superfetation | 11 Ovarian Pregnancy | 12 Lysis and resorption | 13 Postmortem intrauterine | 14 Hofbauer cells | 15 Villi | 16 Villous nodules | 17 Syphilitic changes | 18 Aspects | Bibliography | Figures | Contribution No.56 | Contributions Series | Embryology History
Report Upon the Collection of Human Embryos at the John Hopkins University
Mall FP. Report upon the collection of human embryos at the Johns Hopkins University. (1911) Anat. Rec., 5(7): 343–357.
Mall, F.P. The Anatomical Record Volume 5, Issue 7, pages 343–357, July 1911
- 533 specimens recorded under 500 numbers
- 335 normal specimens
- 198 pathological
- under 8 mm in length, under six weeks old
- 50 normal embryos
- 105 pathological
- 9 and 25 mm
- 133 normal embryos
- 66 pathological
- 68% first six weeks of pregnancy
- 34% sixth to the end of the eighth week
- 18% remaining seven months
- i - obtain complete vascular injection in embryos less than 20 mm long
- k - clarified in caustic potash and glycerine to show the extent of ossification
On The Frequency of Localized Anomalies in Human Embryos and Infants at Birth
On the Frequency of Localized Anomalies in Human Embryos and Infants at Birth Amer. Jour. Anat., (1917) vol. 22, p. 49-72.
- In this historic 1921 pathology paper, figures and plates of abnormal embryos are not suitable for young students.
Blood-Vessels of the Brain
Mall FP. On the Development of the Blood-Vessels of the Brain in the Human Embryo. (1905) Amer. J. of Anat. 4; 1–18.
Mall FP. Development of the lesser peritoneal cavity in birds and mammals. (1891) J of Morphology 5: 165-179.
Mall FP. A human embryo of the second week. (1893) Anat. Anz. 8: 630-633.
Mall FP. Early human embryos and the mode of their preservation. (1893) Johns Hopkins Hospital Bulletin 4: 115-121.
Mall FP. Human embryos. (1893) Ref. Handb. Med. Sci. Supplement, 9: 268-269.
Mall FP. Coelom. (1893) Ref. Handb. Med. Sci. Supplement, 9: 184-189.
Mall FP. The heart. (1893) Ref. Handb. Med. Sci. Supplement, 9: 391-395.
Mall FP. Development of the thyroid. (1893) Ref. Handb. Med. Sci. Supplement, 9: 879-881.
Mall FP. Development of the thymus. (1893) Ref. Handb. Med. Sci. Supplement, 9: 875-877.
Mall FP. Development of the human coelom. (1893) Jour. Morph. 12: 395-453.
Mall FP. Development of the internal mammary and deep epigastric arteries in man. (1898) Johns Hopkins Hospital Bulletin 5: 232-235.
Mall FP. Development of the human intestine and its position in the adult. (1898) Johns Hopkins Hospital Bulletin 5: 197-208.
Mall FP. A contribution to the study of the pathology of early human embryos, (1900) Johns Hopkins Hosp. Rep., 9: 1-68.
Mall FP. Age of human embryos. (1901) Ref. Handb. Med. Sci., 2d ed. 3: 794-797
Mall FP. Development of the human coelom. (1901) Ref. Handb. Med. Sci., 2d ed. 3: 171-189.
Mall FP. Hosp. Bull., XIV, 1903. Catalogue of the collection of human embryos in the Anatomical Laboratory of the Johns Hopkins University. Johns Hopkins Hopkins University. Baltimore, 1904.
Mall FP. A study of the causes underlying the origin of human monsters. (1908) Jour, of Morphol., 19:
Mall FP. A list of normal human embryos which have been cut into serial sections. (1910) Anat. Rec. 4(10): 355-367.
Mall FP. Report upon the collection of human embryos at the Johns Hopkins University. (1911) Anat. Rec., 5(7): 343–357.
Mall FP. A plea for an institute of human embryology. (1913) J. Amer. Med. Ass., 60: 1599-1601.
Mall FP. On stages in the development of human embryos from 2 to 25 mm long. (1914) Anat. Anz., 46: 78-84.
Mall FP. On the fate of the human embryo in tubal pregnancy. (1915) Contrib. Embryol., Carnegie Inst. Wash. Publ. 221, 1: 1-104.
Mall FP. The human magma reticule in normal and in pathological development. (1916) Contrib. Embryol., Carnegie Inst. Wash. Publ. 224, 4:5-26.
Mall FP. and Meyer AW. Studies on abortuses: a survey of pathologic ova in the Carnegie Embryological Collection. (1921) Contrib. Embryol., Carnegie Inst. Wash. Publ. 275, 12: 1-364.
Search PubMed: Mall FP
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- Johns Hopkins Medical Institutions The Franklin P. Mall Collection (1885-1918)
- Nature Prof. Franklin P. Mall obituary notice (27 December 1917)
- National Museum of Health and Medicine | Human Developmental Anatomy Center | Franklin P. Mall - Biography
- Carnegie Institution Department of Embryology
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Cite this page: Hill, M.A. (2019, August 20) Embryology Embryology History - Franklin Mall. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryology_History_-_Franklin_Mall
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