Embryology History - Nicole Le Douarin

Embryology - 9 Dec 2023        Expand to Translate
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Introduction

Nicole Le Douarin

Nicole Le Douarin has a long research career, her research area has been mainly on the development of neural crest cells using originally a Chicken-Quail chimera model she had developed. See her recent review paper on the "beginnings" of the neural crest.

A 2005 paper was dedicated to her original PhD work on the development of the gastrointestinal tract. Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis. "This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf.", see also.

Links: neural crest | chicken

Developmental hematopoiesis: historical background and perspectives. An interview with Nicole le Douarin. Interview by Charles Durand and Thierry Jaffredo.

"Nicole le Douarin has shown a long lasting interest for developmental hematopoiesis. Starting from her early research experience, we travel along the main discoveries and concepts that have shaped the modern view of developmental hematopoiesis. All through, we survey the seminal contribution of the "Ecole de Nogent" about lymphocyte homing and the discovery of endothelial-specific tyrosine kinases. This interview is a promenade through the past and present of developmental hematopoiesis narrated by an exceptional personality and an outstanding scientist."

Some Recent Findings

Review - The neural crest, a multifaceted structure of the vertebrates "In this review, several features of the cells originating from the lateral borders of the primitive neural anlagen, the neural crest (NC) are considered. Among them, their multipotentiality, which together with their migratory properties, leads them to colonize the developing body and to participate in the development of many tissues and organs. The in vitro analysis of the developmental capacities of single NC cells (NCC) showed that they present several analogies with the hematopoietic cells whose differentiation involves the activity of stem cells endowed with different arrays of developmental potentialities. The permanence of such NC stem cells in the adult organism raises the problem of their role at that stage of life. The NC has appeared during evolution in the vertebrate phylum and is absent in their Protocordates ancestors. The major role of the NCC in the development of the vertebrate head points to a critical role for this structure in the remarkable diversification and radiation of this group of animals." Sonic Hedgehog promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch developmentPubmedParser error: The PubmedParser extension received invalid XML data. () "Cell-adhesion molecule-related/Downregulated by Oncogenes (CDO or CDON) was identified as a receptor for the classic morphogen Sonic Hedgehog (SHH). It has been shown that, in cell culture, CDO also behaves as a SHH dependence receptor: CDO actively triggers apoptosis in absence of SHH via a proteolytic cleavage in CDO intracellular domain. We present evidence that CDO is also pro-apoptotic in the developing neural tube where SHH is known to act as a survival factor. SHH, produced by the ventral foregut endoderm, was shown to promote survival of facial neural crest cells (NCCs) that colonize the first branchial arch (BA1). We show here that the survival activity of SHH on neural crest cells is due to SHH-mediated inhibition of CDO pro-apoptotic activity. Silencing of CDO rescued NCCs from apoptosis observed upon SHH inhibition in the ventral foregut endoderm. Thus, the pair SHH/dependence receptor CDO may play an important role in neural crest cell survival during the formation of the first branchial arch."

References

Reviews

Etchevers HC, Dupin E & Le Douarin NM. (2019). The diverse neural crest: from embryology to human pathology. Development , 146, . PMID: 30858200 DOI.

Le Douarin NM & Dupin E. (2018). The "beginnings" of the neural crest. Dev. Biol. , 444 Suppl 1, S3-S13. PMID: 30048640 DOI.

Dupin E, Calloni GW, Coelho-Aguiar JM & Le Douarin NM. (2018). The issue of the multipotency of the neural crest cells. Dev. Biol. , 444 Suppl 1, S47-S59. PMID: 29614271 DOI.

Le Douarin NM & Dupin E. (2016). The Pluripotency of Neural Crest Cells and Their Role in Brain Development. Curr. Top. Dev. Biol. , 116, 659-78. PMID: 26970647 DOI.

Creuzet S, Couly G & Le Douarin NM. (2005). Patterning the neural crest derivatives during development of the vertebrate head: insights from avian studies. J. Anat. , 207, 447-59. PMID: 16313387 DOI.

Charrier JB, Catala M, Lapointe F, Le-Douarin N & Teillet MA. (2005). Cellular dynamics and molecular control of the development of organizer-derived cells in quail-chick chimeras. Int. J. Dev. Biol. , 49, 181-91. PMID: 15906231 DOI.

Salaün J, Corbel C & Le-Douarin NM. (2005). Regulatory T cells in the establishment and maintenance of self-tolerance: role of the thymic epithelium. Int. J. Dev. Biol. , 49, 137-42. PMID: 15906226 DOI.

Le Douarin N. (2005). The Nogent Institute--50 years of embryology. Int. J. Dev. Biol. , 49, 85-103. PMID: 15906221 DOI.

Le Douarin NM, Creuzet S, Couly G & Dupin E. (2004). Neural crest cell plasticity and its limits. Development , 131, 4637-50. PMID: 15358668 DOI.

Dieterlen-Lièvre F & Le Douarin NM. (2004). From the hemangioblast to self-tolerance: a series of innovations gained from studies on the avian embryo. Mech. Dev. , 121, 1117-28. PMID: 15358008 DOI.

Le Douarin NM. (2004). The avian embryo as a model to study the development of the neural crest: a long and still ongoing story. Mech. Dev. , 121, 1089-102. PMID: 15296974 DOI.

Le Douarin NM & Dupin E. (2003). Multipotentiality of the neural crest. Curr. Opin. Genet. Dev. , 13, 529-36. PMID: 14550420

Dupin E & Le Douarin NM. (2003). Development of melanocyte precursors from the vertebrate neural crest. Oncogene , 22, 3016-23. PMID: 12789276 DOI.

Etchevers HC, Couly G & Le Douarin NM. (2002). Morphogenesis of the branchial vascular sector. Trends Cardiovasc. Med. , 12, 299-304. PMID: 12458092

Monsoro-Burq AH & Le Douarin N. (2000). Duality of molecular signaling involved in vertebral chondrogenesis. Curr. Top. Dev. Biol. , 48, 43-75. PMID: 10635457

Monsoro-Burq AH & Le Douarin N. (1999). [Molecular aspects of vertebral chondrogenesis]. J. Soc. Biol. , 193, 263-8. PMID: 10542956

Teillet MA, Ziller C & Le Douarin NM. (1999). Quail-chick chimeras. Methods Mol. Biol. , 97, 305-18. PMID: 10443376 DOI.

Eichmann A, Corbel C & Le Douarin NM. (1998). Segregation of the embryonic vascular and hemopoietic systems. Biochem. Cell Biol. , 76, 939-46. PMID: 10392707

Le Douarin NM, Teillet MA & Catala M. (1998). Neurulation in amniote vertebrates: a novel view deduced from the use of quail-chick chimeras. Int. J. Dev. Biol. , 42, 909-16. PMID: 9853821

Dupin E, Ziller C & Le Douarin NM. (1998). The avian embryo as a model in developmental studies: chimeras and in vitro clonal analysis. Curr. Top. Dev. Biol. , 36, 1-35. PMID: 9342519

Le Douarin NM, Catala M & Batini C. (1997). Embryonic neural chimeras in the study of vertebrate brain and head development. Int. Rev. Cytol. , 175, 241-309. PMID: 9203359

Le Douarin N, Corbel C, Bandeira A, Thomas-Vaslin V, Modigliani Y, Coutinho A & Salaün J. (1996). Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. Immunol. Rev. , 149, 35-53. PMID: 9005218

Le Douarin N, Dieterlen-Lièvre F & Teillet MA. (1996). Quail-chick transplantations. Methods Cell Biol. , 51, 23-59. PMID: 8722469

Le Douarin NM, Dupin E & Ziller C. (1994). Genetic and epigenetic control in neural crest development. Curr. Opin. Genet. Dev. , 4, 685-95. PMID: 7849508

Le Douarin NM, Hallonet ME & Pourquié O. (1994). Cell migrations and establishment of neuronal connections in the developing brain: a study using the quail-chick chimera system. Prog. Brain Res. , 100, 3-18. PMID: 7938530

Le Douarin NM & Ziller C. (1993). Plasticity in neural crest cell differentiation. Curr. Opin. Cell Biol. , 5, 1036-43. PMID: 8129941

Le Douarin NM, Ziller C & Couly GF. (1993). Patterning of neural crest derivatives in the avian embryo: in vivo and in vitro studies. Dev. Biol. , 159, 24-49. PMID: 8365563 DOI.

Coutinho A, Salaün J, Corbel C, Bandeira A & Le Douarin N. (1993). The role of thymic epithelium in the establishment of transplantation tolerance. Immunol. Rev. , 133, 225-40. PMID: 8225369

Le Douarin NM & Dupin E. (1993). Cell lineage analysis in neural crest ontogeny. J. Neurobiol. , 24, 146-61. PMID: 8445384 DOI.

Le Douarin NM. (1993). Embryonic neural chimaeras in the study of brain development. Trends Neurosci. , 16, 64-72. PMID: 7680502

Le Douarin NM, Cameron-Curry P & Dulac C. (1992). Cellular interactions during the ontogeny of neural crest derivatives. C. R. Acad. Sci. III, Sci. Vie , 314, 55-8. PMID: 1422907

Le Douarin NM, Dupin E, Baroffio A & Dulac C. (1992). New insights into the development of neural crest derivatives. Int. Rev. Cytol. , 138, 269-314. PMID: 1360467

Le Douarin N. (1991). Studies on the ontogeny of the immune function in birds. Adv. Exp. Med. Biol. , 292, 19-30. PMID: 1950770

Le Douarin N, Dulac C, Dupin E & Cameron-Curry P. (1991). Glial cell lineages in the neural crest. Glia , 4, 175-84. PMID: 1827777 DOI.

Baroffio A, Dupin E & Le Douarin NM. (1990). Cell lineage studies in avian neural crest ontogeny. Adv. Exp. Med. Biol. , 265, 53-62. PMID: 2198780

Le Douarin NM. (1988). The Claude Bernard lecture, 1987. Embryonic chimeras: a tool for studying the development of the nervous and immune systems. Proc. R. Soc. Lond., B, Biol. Sci. , 235, 1-17. PMID: 2907137

Le Douarin NM. (1988). On the origin of pancreatic endocrine cells. Cell , 53, 169-71. PMID: 3282672

Le Douarin NM. (1988). [Differentiation of the neural crest. Influence of growth factors]. Ann. Endocrinol. (Paris) , 49, 256-69. PMID: 3059967

Le Douarin NM & Smith J. (1988). Development of the peripheral nervous system from the neural crest. Annu. Rev. Cell Biol. , 4, 375-404. PMID: 3058162 DOI.

Le Douarin N. (1986). The microenvironment of T and B lymphocyte differentiation in avian embryos. Curr. Top. Dev. Biol. , 20, 291-313. PMID: 3082601

Le Douarin NM, Dieterlen-Lièvre F & Oliver PD. (1984). Ontogeny of primary lymphoid organs and lymphoid stem cells. Am. J. Anat. , 170, 261-99. PMID: 6383002 DOI.

Le Douarin NM. (1984). Ontogeny of the peripheral nervous system from the neural crest and the placodes. A developmental model studied on the basis of the quail-chick chimaera system. Harvey Lect. , 80, 137-86. PMID: 6400655

Le Douarin NM, Smith J & Le Lièvre CS. (1981). From the neural crest to the ganglia of the peripheral nervous system. Annu. Rev. Physiol. , 43, 653-71. PMID: 7011203 DOI.

Le Douarin N. (1980). Migration and differentiation of neural crest cells. Curr. Top. Dev. Biol. , 16, 31-85. PMID: 6110513

Le Douarin NM. (1974). Cell recognition based on natural morphological nuclear markers. Med. Biol. , 52, 281-319. PMID: 4139393

Dupin E, Creuzet S, Le Douarin NM. The Contribution of the Neural Crest to the Vertebrate Body. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK6098/

Search PubMed

Search April 2006 "Le Douarin N" 322 reference articles of which 42 were reviews.

Search PubMed: term = Le Douarin N

External Links

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• Collège de France Chaire d'Embryologie cellulaire et moléculaire
• Society for Neuroscience - History of Neuroscience - Nicole M. Le Douarin Biography

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