Embryology History - John Gurdon
|Embryology - 3 Dec 2023 Expand to Translate|
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Sir John Gurdon (born 1933) in 1962 used nuclear transplantation and cloning to show that the nucleus of a differentiated somatic cell retains the totipotency necessary to form a whole organism.
Some Recent Findings
The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka
- 2012 - The Nobel Prize in Physiology or Medicine 2012 awarded jointly with Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent".
Methods of transplanting nuclei from single cultured cells to unfertilized frogs' eggs
- "Two methods of transplanting single nuclei from monolayers of cultured cells to unfertilized eggs of Xenopus laevis are described, illustrated, and tested.
The detached-cell method is simpler and quicker to operate and is suitable for homogeneous populations of cells which are easily removed from the substrate on which they are growing. The other, attached-cell, method is technically more elaborate, but is applicable to cells whose properties can be individually determined under the phase-contrast microscope and to cells which are not readily dissociated from other cells or from their substrate."
Genetic content of adult somatic cells tested by nuclear transplantation from cultured cells
- "It has yet to be proved that somatic cells of an adult animal possess genes other than those necessary for their own growth and differentiation. A particularly stringent test of the genetic content of the nucleus of a somatic cell is provided by transplanting it to an enucleated egg. The development of the egg tests the capacity of the genes in the transplanted nucleus to elicit normal early development and differentiation. Although this method has been applied to certain cells of embryos, larvae, and newly metamorphosed froglets, it has not been possible, until now, to transfer nuclei successfully from the cells of normal adult animals."
|Embryologists: William Hunter | Wilhelm Roux | Caspar Wolff | Wilhelm His | Oscar Hertwig | Julius Kollmann | Hans Spemann | Francis Balfour | Charles Minot | Ambrosius Hubrecht | Charles Bardeen | Franz Keibel | Franklin Mall | Florence Sabin | George Streeter | George Corner | James Hill | Jan Florian | Thomas Bryce | Thomas Morgan | Ernest Frazer | Francisco Orts-Llorca | José Doménech Mateu | Frederic Lewis | Arthur Meyer | Robert Meyer | Erich Blechschmidt | Klaus Hinrichsen | Hideo Nishimura | Arthur Hertig | John Rock | Viktor Hamburger | Mary Lyon | Nicole Le Douarin | Robert Winston | Fabiola Müller | Ronan O'Rahilly | Robert Edwards | John Gurdon | Shinya Yamanaka | Embryology History | Category:People|
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- Wellcome Trust/Cancer Research UK Gurdon Institute is part of Cambridge University with funding from the listed two main sponsors, and other sources, supports research into the complementary areas of Cancer and Developmental Biology.
- John Gurdon - Research Lab
- Berkeley interview March 16, 2006 | YouTube
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Cite this page: Hill, M.A. (2023, December 3) Embryology Embryology History - John Gurdon. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryology_History_-_John_Gurdon
- © Dr Mark Hill 2023, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G