Lecture - Heart Development

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Introduction

Human embryo stage 10 heart tube

Heart1 atrium.gif


Lecture Resources

Movies and Virtual Slides
Week3 folding icon.jpg
 ‎‎Week 3
Page | Play
Heart1 looping icon.jpg
 ‎‎Heart Looping
Page | Play
Heart1 realign icon.jpg
 ‎‎Heart Realign
Page | Play
Heart1 atrium icon.jpg
 ‎‎Atrial Septation
Page | Play
Heart1 ventricle icon.jpg
 ‎‎Outflow Septation
Page | Play
Heart Cartoons
Heart fields 001 icon.jpg
 ‎‎Heart Fields
Page | Play
Heart folding 002 icon.jpg
 ‎‎Primitive Heart Tube
Page | Play
Heart folding 001 icon.jpg
 ‎‎Heart Tubes
Page | Play
Heart looping 006 icon.jpg
 ‎‎Cardiac Looping
Page | Play
Heart septation 003 icon.jpg
 ‎‎Cardiac Septation
Page | Play
Heart septation 001 icon.jpg
 ‎‎Cardiac Septation
Page | Play
Outflow tract 001 icon.jpg
 ‎‎Outflow Tract
Page | Play
Heart-ventricular-septum-01.jpg
 ‎‎Ventricular Septum 1
Page | Play
Heart-ventricular-septum-02.jpg
 ‎‎Ventricular Septum 2
Page | Play
Heart-ventricular-septum-03.jpg
 ‎‎Ventricular Septum 3
Page | Play
Historic Animations
Heart historic 001 icon.jpg
 ‎‎Anatomy
Page | Play
Heart historic 002 icon.jpg
 ‎‎Week 3
Page | Play
Heart historic 003 icon.jpg
 ‎‎Week 3-5
Page | Play
Heart historic 004 icon.jpg
 ‎‎Week 4-11
Page | Play
Heart historic 005 icon.jpg
 ‎‎Embryo overview
Page | Play
Heart historic 006 icon.jpg
 ‎‎AV Septation
Page | Play
Heart historic 007 icon.jpg
 ‎‎Outflow Septation
Page | Play
Heart historic 008 icon.jpg
 ‎‎Valve+Overview
Page | Play
About Historic Animations
Mark Hill.jpg
Animations are modified and converted from a historic film (circa 1960's, copyright unknown) demonstrating aspects of human heart development.

The sound quality is quite poor and some of the information is now out of date, most general concepts are still correct.

Please note the relatively large size (Mb) of each excerpt will effect download and viewing.

March 2013

Cardiovascular Links: Introduction | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | Heart | Coronary Circulation | Heart Valve | Heart Rate | Circulation | Blood | Blood Vessel | Blood Vessel Histology | Cardiac Muscle Histology | Lymphatic | Ductus Venosus | Spleen | Stage 22 | Abnormalities | OMIM | 2012 ECHO Meeting | 2016 Cardiac Review | Category:Cardiovascular
Historic Embryology - Cardiovascular 
1902 Vena cava inferior | 1905 Brain Blood Vessels | 1909 Cervical Veins | 1912 Heart | 1912 Human Heart | 1914 Earliest Blood-Vessels | 1915 Congenital Cardiac Disease | 1915 Dura Venous Sinuses | 1916 Pars Membranacea Septi | 1919 Lower Limb Arteries | 1921 Human Brain Vascular | 1921 Spleen | 1922 Aortic-Arch System | 1922 Pig Forelimb Arteries | 1922 Chicken Pulmonary | 1923 Head Subcutaneous Plexus | 1925 Venous Development | 1928 Heart Blood Flow | 1935 Aorta | 1935 Venous valves | 1938 Pars Membranacea Septi | 1938 Foramen Ovale | 1939 Atrio-Ventricular Valves | 1940 Vena cava inferior | 1940 Early Hematopoiesis | 1942 Truncus and Conus Partitioning | Ziegler Heart Models | 1951 Heart Movie | 1954 Week 9 Heart | 1957 Cranial venous system | 1959 Brain Arterial Anastomoses | Historic Embryology Papers | 2012 ECHO Meeting | 2016 Cardiac Review | Historic Disclaimer
References
UNSW Embryology logo
Hill, M.A. (2017). UNSW Embryology (17th ed.) Retrieved September 24, 2017, from https://embryology.med.unsw.edu.au
Cardiovascular Links: Introduction | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | Heart | Coronary Circulation | Heart Valve | Heart Rate | Circulation | Blood | Blood Vessel | Blood Vessel Histology | Cardiac Muscle Histology | Lymphatic | Ductus Venosus | Spleen | Stage 22 | Abnormalities | OMIM | 2012 ECHO Meeting | 2016 Cardiac Review | Category:Cardiovascular
Historic Embryology - Cardiovascular 
1902 Vena cava inferior | 1905 Brain Blood Vessels | 1909 Cervical Veins | 1912 Heart | 1912 Human Heart | 1914 Earliest Blood-Vessels | 1915 Congenital Cardiac Disease | 1915 Dura Venous Sinuses | 1916 Pars Membranacea Septi | 1919 Lower Limb Arteries | 1921 Human Brain Vascular | 1921 Spleen | 1922 Aortic-Arch System | 1922 Pig Forelimb Arteries | 1922 Chicken Pulmonary | 1923 Head Subcutaneous Plexus | 1925 Venous Development | 1928 Heart Blood Flow | 1935 Aorta | 1935 Venous valves | 1938 Pars Membranacea Septi | 1938 Foramen Ovale | 1939 Atrio-Ventricular Valves | 1940 Vena cava inferior | 1940 Early Hematopoiesis | 1942 Truncus and Conus Partitioning | Ziegler Heart Models | 1951 Heart Movie | 1954 Week 9 Heart | 1957 Cranial venous system | 1959 Brain Arterial Anastomoses | Historic Embryology Papers | 2012 ECHO Meeting | 2016 Cardiac Review | Historic Disclaimer
Heart Tutorial | 2014 Lecture | 2013 Lecture Slides

Sean M Wu, Kenneth R Chien, Christine Mummery Origins and fates of cardiovascular progenitor cells. Cell: 2008, 132(4);537-43 PubMed 18295570

| PMC2507768

Textbook cover The Developing Human, 9th edn.
Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2011). The developing human: clinically oriented embryology (9th ed.). Philadelphia: Saunders.
The following chapter links only work with a UNSW connection.
Textbook cover Larsen's human embryology 4th edn.
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. & Francis-West, P.H. (2009). Larsen's human embryology (4th ed.). New York; Edinburgh: Churchill Livingstone.

UNSW students have full access to this textbook edition through UNSW Library subscription (with student Zpass log-in).

  • Chapter 12 - Development of the Heart

Heart Development

Intermediateicon.jpg
Begin Intermediate: Primordial Heart Tube  Heart Tube Looping  Atrial Ventricular Septation  Outflow Tract  Heart Valves  Cardiac Abnormalities  Vascular Overview
Intermediate Heart Development Timeline.jpg

The cardiovascular system is the first major system to function within the embryo, with the heart beginning to function during the fourth week. Congenital heart defects affect 8-10 of every 1000 births in the United States. Hence in both embryological and clinical contexts it is important to consider heart development.

The intermediate section of this module on cardiac embryology is directed at university level students with some previous study of embryology but minimal previous study of cardiac development specifically. This unit takes approximately 30-40 minutes to complete. The intermediate cardiac module contains 7 pages which should be worked through in order.

  1. Primordial Heart Tube
  2. Looping of the Heart Tube
  3. Atrial and Ventricular Septation
  4. Development of the Outflow Tract
  5. Development of Heart Valves
  6. Abnormalities of Cardiac Development
  7. Overview of Vascular Development

These pages are also listed and linked in the yellow boxes at the top of each page. When you have completed the intermediate cardiac module, you can complete the intermediate quiz to test your knowledge. For students who would like either less or more detailed information regarding each step in the developmental process, links throughout the unit will direct you to the corresponding section in the basic level or advanced level respectively. Alternatively, after completing the intermediate module you can proceed to the next advanced module or return to the simpler basic module.


The cardiovascular system is the first major system to function within the embryo, with the heart beginning to function during the fourth week. Congenital heart defects affect 8-10 of every 1000 births in the United States. Hence in both embryological and clinical contexts it is important to consider heart development.


The intermediate section of this module on cardiac embryology is directed at university level students with some previous study of embryology but minimal previous study of cardiac development specifically. This unit takes approximately 30-40 minutes to complete. The intermediate cardiac module contains 7 pages which should be worked through in order.

  1. Primordial Heart Tube
  2. Looping of the Heart Tube
  3. Atrial and Ventricular Septation
  4. Development of the Outflow Tract
  5. Development of Heart Valves
  6. Abnormalities of Cardiac Development
  7. Overview of Vascular Development

These pages are also listed and linked in the yellow boxes at the top of each page. When you have completed the intermediate cardiac module, you can complete the intermediate quiz to test your knowledge. For students who would like either less or more detailed information regarding each step in the developmental process, links throughout the unit will direct you to the corresponding section in the basic level or advanced level respectively. Alternatively, after completing the intermediate module you can proceed to the next advanced module or return to the simpler basic module.

Fetal blood flow 04.jpg Fetal Blood Flow - Proportions of the combined ventricular output

Numbers represent percentage of total input/output flow.

Proportions of the combined ventricular output in the major vessels of the human fetal circulation by phase contrast MRI.

(8 subjects, median gestational age 37 weeks, age range of 30–39 weeks)

  • AAo - Ascending aorta
  • MPA - main pulmonary artery
  • DA - ductus arteriosus
  • PBF - pulmonary blood flow
  • DAo - descending aorta
  • UA - umbilical artery
  • UV - umbilical vein
  • IVC - inferior vena cava
  • SVC - superior vena cava
  • RA - right atrium
  • FO - foramen ovale
  • LA - left atrium
  • RV - right ventricle
  • LV - left ventricle


ANAT2341 Course Timetable  
Week (Mon) Lecture 1 (Mon 1-2pm) Lecture 2 (Tue 3-4pm) Practical (Fri 1-3pm)
Week 2 (1 Aug) Introduction Fertilization Lab 1
Week 3 (8 Aug) Week 1 and 2 Week 3 Lab 2
Week 4 (15 Aug) Mesoderm Ectoderm Lab 3
Week 5 (22 Aug) Early Vascular Placenta Lab 4
Week 6 (29 Aug) Gastrointestinal Respiratory Lab 5
Week 7 (5 Sep) Head Neural Crest Lab 6
Week 8 (12 Sep) Musculoskeletal Limb Development Lab 7
Week 9 (19 Sep) Renal Genital Lab 8
Mid-semester break
Week 10 (3 Oct) Public Holiday Stem Cells Lab 9
Week 11 (10 Oct) Integumentary Endocrine Lab 10
Week 12 (17 Oct) Heart Sensory Lab 11
Week 13 (24 Oct) Fetal Birth and Revision Lab 12

ANAT2341 2016: Moodle page | ECHO360 | Textbooks | Students 2016 | Projects 2016

ANAT2341Lectures - Textbook chapters  
Lecture (Timetable) Textbook - The Developing Human Textbook - Larsen's Human Embryology
Embryology Introduction Introduction to the Developing Human
Fertilization First Week of Human Development Gametogenesis, Fertilization, and First Week
Week 1 and 2 Second Week of Human Development Second Week: Becoming Bilaminar and Fully Implanting
Week 3 Third Week of Human Development Third Week: Becoming Trilaminar and Establishing Body Axes
Mesoderm Fourth to Eighth Weeks of Human Development Fourth Week: Forming the Embryo
Ectoderm Nervous System Development of the Central Nervous System
Early Vascular Cardiovascular System Development of the Vasculature
Placenta Placenta and Fetal Membranes Development of the Vasculature
Endoderm - GIT Alimentary System Development of the Gastrointestinal Tract
Respiratory Respiratory System Development of the Respiratory System and Body Cavities
Head Pharyngeal Apparatus, Face, and Neck Development of the Pharyngeal Apparatus and Face
Neural Crest Nervous System Development of the Peripheral Nervous System
Musculoskeletal Muscular System Development of the Musculoskeletal System
Limb Development of Limbs Development of the Limbs
Renal Urogenital System Development of the Urinary System
Genital Urogenital System Development of the Urinary System
Stem Cells
Integumentary Integumentary System Development of the Skin and Its Derivatives
Endocrine Covered through various chapters (see also alternate text), read head and neck, neural crest and renal chapters.
Endocrinology Textbook - Chapter Titles  
Nussey S. and Whitehead S. Endocrinology: An Integrated Approach (2001) Oxford: BIOS Scientific Publishers; ISBN-10: 1-85996-252-1.

Full Table of Contents

Heart Cardiovascular System Development of the Heart
Sensory Development of Eyes and Ears Development of the Eyes
Fetal Fetal Period Fetal Development and the Fetus as Patient
Birth and Revision
Additional Textbook Content - The following concepts also form part of the theory material covered throughout the course.
  1. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
  2. Common Signaling Pathways Used During Development
  3. Human Birth Defect

Glossary Links

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols

Cite this page: Hill, M.A. 2017 Embryology Lecture - Heart Development. Retrieved September 24, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Lecture_-_Heart_Development

What Links Here?
© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G