Cardiovascular System - Circulation Development
|Embryology - 11 Dec 2023 Expand to Translate|
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The peripheral circulation, both arterial and venous, are extensively remodelled with embryonic and fetal development. The purpose of this current page is to provide a central resource link to this topic of adult circulatory organization from the embryonic vasculature. Due to the extensive developmental remodelling there are a large number of variations in vascular organization and agenesis.
Some Recent Findings
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Search term: Circulation Embryology
Reconstruction of Carnegie Embryo No. 390 arterial system.
- Arise with ascent and inferior branches lost
- Sequential, 25% population have 2 or more renal arteries
- branch of abdominal aorta, divides into 4-5 branches
- each gives off small branches to suprarenal glands, ureter, surrounding cellular tissue and muscles
Note: Frequently a second renal artery (inferior renal) from abdominal aorta at a lower level, supplies lower portion of kidney
See the review describing the variations in adult renal artery and vein organization. of renal vascular anomalies shown in adults using computed tomography. The images below are from that review.
Coronary Arteries Timeline
- Carnegie stage 14 or Carnegie stage 15 - A plexus of blind epicardial capillaries appears on the heart in Carnegie
- Carnegie stage 15, Carnegie stage 16, or Carnegie stage 17 - acquires a coronary sinus connection
- Carnegie stage 18 - connection of the proximal coronary arteries to the aorta.
Mouse Coronary Vessels
Image showing changes in venous (blue) and arterial (red) marker expression during coronary development; black indicates dedifferentiated venous cells.
A recent study, using several species including human, has shown that the caudal cardinal veins are the only contributors to the inferior caval (IVC) and azygos veins.
- Carnegie stage 11 to Carnegie stage 15 - caudal cardinal veins extended caudally from the common cardinal vein.
- Carnegie stage 15 to Carnegie stage 18 - caudal cardinal veins sprout ventrally form the sub cardinal vein plexus .
- then caudal part of the left caudal cardinal vein regresses.
- Inferior vena cava - infrarenal part from the right caudal cardinal vein; renal part from subcardinal veins.
- Azygos veins - from the remaining cranial part or sprouting of the caudal cardinal veins.
See the review describing the variations in adult renal artery and vein organization of renal vascular anomalies shown in adults using computed tomography. The images below are from that review.
- internal carotid artery segmental agenesis - asymptomatic and harmless
- Hikspoors JP, Mekonen HK, Mommen GM, Cornillie P, Köhler SE & Lamers WH. (2016). Infrahepatic inferior caval and azygos vein formation in mammals with different degrees of mesonephric development. J. Anat. , 228, 495-510. PMID: 26659476 DOI.
- Kumar S, Neyaz Z & Gupta A. (2010). The utility of 64 channel multidetector CT angiography for evaluating the renal vascular anatomy and possible variations: a pictorial essay. Korean J Radiol , 11, 346-54. PMID: 20461189 DOI.
- Hutchins GM, Kessler-Hanna A & Moore GW. (1988). Development of the coronary arteries in the embryonic human heart. Circulation , 77, 1250-7. PMID: 3286038
- Red-Horse K, Ueno H, Weissman IL & Krasnow MA. (2010). Coronary arteries form by developmental reprogramming of venous cells. Nature , 464, 549-53. PMID: 20336138 DOI.
- Hikspoors JP, Soffers JH, Mekonen HK, Cornillie P, Köhler SE & Lamers WH. (2015). Development of the human infrahepatic inferior caval and azygos venous systems. J. Anat. , 226, 113-25. PMID: 25496171 DOI.
- Alexandre AM, Visconti E, Schiarelli C, Frassanito P & Pedicelli A. (2016). Bilateral Internal Carotid Artery Segmental Agenesis: Embryology, Common Collateral Pathways, Clinical Presentation, and Clinical Importance of a Rare Condition. World Neurosurg , 95, 620.e9-620.e15. PMID: 27535626 DOI.
Search May 2010
- Cardiovascular System Development All (63457) Review (10735) Free Full Text (15717)
Search Pubmed: Coronary Circulation Development
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Cite this page: Hill, M.A. (2023, December 11) Embryology Cardiovascular System - Circulation Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Circulation_Development
- © Dr Mark Hill 2023, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G