Cardiovascular System Development
|Embryology - 16 Nov 2018 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Textbooks
- 4 Timecourse
- 5 Heart Development Movies
- 6 Animal Models
- 7 Pharyngeal Arch Arteries
- 8 Renal Venous Development
- 9 Fetal Blood Flow
- 10 References
- 11 Additional Images
- 12 External Links
- 13 Glossary Links
Development of the heart and vascular system is often described together as the cardiovascular system, with the heart being the first functional organ that forms in the embryo. Development begins very early in mesoderm both within (embryonic) and outside (extra embryonic, yolk sac and placental) the embryo. Vascular development therefore occurs in many places, the most obvious though is the early forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo. The cardiovascular system is extensively remodelled throughout development, this current page only introduces topic.
The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.
Throughout the mesoderm, small regions differentiate into "blood islands" which contribute both blood vessels (walls) and fetal red blood cells.
These "islands" connect together to form the first vessels which connect with the heart tube.
A detailed description of heart development is covered in the Online Heart Tutorial.
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Marco Cirillo The Memory of the Heart. J Cardiovasc Dev Dis: 2018, 5(4); PubMed 30423868
Justyna Niderla-Bielińska, Ewa Jankowska-Steifer, Aleksandra Flaht-Zabost, Grzegorz Gula, Elżbieta Czarnowska, Anna Ratajska Proepicardium: current understanding of its structure, induction, and fate. Anat Rec (Hoboken): 2018; PubMed 30421563
Zsófia Hoyk, Melinda E Tóth, Nikolett Lénárt, Dóra Nagy, Brigitta Dukay, Alexandra Csefová, Ágnes Zvara, György Seprényi, András Kincses, Fruzsina R Walter, Szilvia Veszelka, Judit Vígh, Beáta Barabási, András Harazin, Ágnes Kittel, László G Puskás, Botond Penke, László Vígh, Mária A Deli, Miklós Sántha Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice. Front Cell Neurosci: 2018, 12;380 PubMed 30410436
Xiao He, Meng-Wei Yao, Ming Zhu, Dong-Lan Liang, Wei Guo, Yi Yang, Rong-Seng Zhao, Ting-Ting Ren, Xiang Ao, Wei Wang, Chun-Yu Zeng, Hua-Ping Liang, Dong-Po Jiang, Jian Yu, Xiang Xu Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium. Stem Cell Res Ther: 2018, 9(1);306 PubMed 30409193
Jiarui Liu, Xiaoning Yang, Siwang Yu, Ruimao Zheng The Leptin Resistance. Adv. Exp. Med. Biol.: 2018, 1090;145-163 PubMed 30390289
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.|
- Human Embryology (2nd ed.) Larson Ch7 p151-188 Heart, Ch8 p189-228 Vasculature
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Ch14: p304-349
- Before we Are Born (5th ed.) Moore and Persaud Ch12; p241-254
- Essentials of Human Embryology Larson Ch7 p97-122 Heart, Ch8 p123-146 Vasculature
- Human Embryology Fitzgerald and Fitzgerald Ch13-17: p77-111
|Begin Basic||Primitive Heart Tube||Embryonic Heart Divisions||Vascular Heart Connections|
|Begin Intermediate:||Primordial Heart Tube||Heart Tube Looping||Atrial Ventricular Septation||Outflow Tract||Heart Valves||Cardiac Abnormalities||Vascular Overview|
|Begin Advanced||Heart Fields||Heart Tubes||Cardiac Looping||Cardiac Septation||Outflow Tract||Valve Development||Cardiac Conduction||Cardiac Abnormalities||Molecular Development|
|The Human Heart from day 10 to 25 (scanning electron micrograph)|
- Forms initially in splanchnic mesoderm of prechordal plate region - cardiogenic region
- growth and folding of the embryo moves heart ventrally and downward into anatomical position
- Day 22 - 23, begins to beat in humans
- heart tube connects to blood vessels forming in splanchnic and extraembryonic mesoderm
- Week 2 - 3 pair of thin-walled tubes
- Week 3 paired heart tubes fuse, truncus arteriosus outflow, heart contracting
- Week 4 heart tube continues to elongate, curving to form S shape
- Week 5 Septation starts]], atrial and ventricular
- Septation continues, atrial septa remains open, foramen ovale
- Week 37-38 At birth, pressure difference closes foramen ovale leaving a fossa ovalis
|Conotruncal septum; atria|
|Closure primum foramen|
|Fusion atrioventricular cushions|
|Septum secundum and foramen ovale|
|Closure secondary interventricular foramen|
|Colour Coding:||beginning to appear||present||Table data Links: heart | Madrid Collection|
Heart Development Movies
Animations showing aspects of heart development.
Pages within the online Cardiac tutorial.
Historic animations including audio descriptions. Some of these descriptions may be currently inaccurate, the transfer is from an old class film and the audio track is of very poor quality.
|About Historic Animations|
The sound quality is quite poor and some of the information is now out of date, most general concepts are still correct.
Please note the relatively large size (Mb) of each excerpt will effect download and viewing.
Ventricular septation rotation models.
Amphibians and reptiles have a three-chambered heart with a single ventricle. Blood leaves the heart ventricle through either the pulmonary artery to the lungs or the aorta to supply the body. The pulmonary artery in amphibians also supplies the skin.
Mammals and birds have a four-chambered heart with a two ventricles. The right ventricle supplies the pulmonary artery to the lungs, the left ventricle supplies the aorta to the body.
Chicken Heart Development
Pharyngeal Arch Arteries
In the head region of the embryo, each pharyngeal arch initially has paired arch arteries. These are extensively remodelled through development and give rise to a range of different arterial structures, as shown in the list below.
- Arch 1 - mainly lost, form part of maxillary artery.
- Arch 2 - stapedial arteries.
- Arch 3 - common carotid arteries, internal carotid arteries.
- Arch 4 - left forms part of aortic arch, right forms part right subclavian artery.
- Arch 6 - left forms part of left pulmonary artery , right forms part of right pulmonary artery.
- Links: Head Development
Renal Venous Development
The renal arterial and venous systems are also reorganised extensively throughout development with changing kidney position.
|Embryo renal venous||Adult renal venous|
- Links: Renal Development
Fetal Blood Flow
Mean Late Fetal Blood Flows
(8 subjects) in the major vessels of the human fetal circulation by phase contrast MRI. (median gestational age 37 weeks, age range of 30–39 weeks)
|(left) Mean flows in ml/kg/min||(right) Proportions of the combined ventricular output in the major vessels of the human fetal circulation by phase contrast MRI.|
- Cardiovascular Links: Fetal Blood Flow values | Mean Fetal Blood Flow | Proportions Ventricular Output | Ventricular Output (colour) | heart | blood | cardiovascular
- Anderson RH, Mori S, Spicer DE, Brown NA & Mohun TJ. (2016). Development and Morphology of the Ventricular Outflow Tracts. World J Pediatr Congenit Heart Surg , 7, 561-77. PMID: 27587491 DOI.
- Krishnan A, Samtani R, Dhanantwari P, Lee E, Yamada S, Shiota K, Donofrio MT, Leatherbury L & Lo CW. (2014). A detailed comparison of mouse and human cardiac development. Pediatr. Res. , 76, 500-7. PMID: 25167202 DOI.
- Vreeker A, van Stuijvenberg L, Hund TJ, Mohler PJ, Nikkels PG & van Veen TA. (2014). Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart. PLoS ONE , 9, e94722. PMID: 24733085 DOI.
- Ishii Y, Langberg J, Rosborough K & Mikawa T. (2009). Endothelial cell lineages of the heart. Cell Tissue Res. , 335, 67-73. PMID: 18682987 DOI.
- Arráez-Aybar LA, Turrero-Nogués A & Marantos-Gamarra DG. (2008). Embryonic cardiac morphometry in Carnegie stages 15-23, from the Complutense University of Madrid Institute of Embryology Human Embryo Collection. Cells Tissues Organs (Print) , 187, 211-20. PMID: 18057862 DOI.
- van den Berg G & Moorman AF. (2011). Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview. PLoS ONE , 6, e22055. PMID: 21779373 DOI.
- Seed M, van Amerom JF, Yoo SJ, Al Nafisi B, Grosse-Wortmann L, Jaeggi E, Jansz MS & Macgowan CK. (2012). Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson , 14, 79. PMID: 23181717 DOI.
Tchirikov M, Schröder HJ & Hecher K. (2006). Ductus venosus shunting in the fetal venous circulation: regulatory mechanisms, diagnostic methods and medical importance. Ultrasound Obstet Gynecol , 27, 452-61. PMID: 16565980 DOI.
Cammarato A, Ahrens CH, Alayari NN, Qeli E, Rucker J, Reedy MC, Zmasek CM, Gucek M, Cole RN, Van Eyk JE, Bodmer R, O'Rourke B, Bernstein SI & Foster DB. (2011). A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS ONE , 6, e18497. PMID: 21541028 DOI.
Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon J, Maeng YS, Rho SS, Shim S, Chai JH, Koo BK, Hong HJ, Yun CO, Choi C, Kim YM, Hwang KC & Kwon YG. (2011). The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. J. Clin. Invest. , 121, 1882-93. PMID: 21540552 DOI.
Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A & Li X. (2011). A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J. Clin. Invest. , 121, 1585-95. PMID: 21364285 DOI.
Arráez-Aybar LA, Turrero-Nogués A & Marantos-Gamarra DG. (2008). Embryonic cardiac morphometry in Carnegie stages 15-23, from the Complutense University of Madrid Institute of Embryology Human Embryo Collection. Cells Tissues Organs (Print) , 187, 211-20. PMID: 18057862 DOI.
Search Pubmed: Cardiovascular System Development
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- Australia Heart Foundation
- USA National Heart, Lung, and Blood Institute - Congenital Heart Defects | Heart and Vascular Information
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Cite this page: Hill, M.A. (2018, November 16) Embryology Cardiovascular System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_Development
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G