Placenta - Abnormalities
|Embryology - 7 Feb 2016 Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Placenta Shape
- 4 Placenta Weight
- 5 Placenta Accreta
- 6 Placenta Increta
- 7 Placenta Percreta
- 8 Placenta Previa
- 9 Vasa Previa
- 10 Abruptio Placenta
- 11 Placenta Variants
- 12 Chronic Intervillositis
- 13 Placental Mesenchymal Dysplasia
- 14 Pre-eclampsia
- 15 Diabetic Placenta
- 16 Placental Chorioangioma
- 17 Hydatidiform Mole
- 18 Cord Abnormalities
- 19 Fetal Erythroblastosis
- 20 Placental Infections
- 21 Placental Membranes
- 22 Placental Pathology
- 23 International Classification of Diseases
- 24 References
- 25 External Links
- 26 Glossary Links
The placenta is a mateno-fetal organ which begins developing at implantation of the blastocyst and is delivered with the fetus at birth. As the fetus relies on the placenta for not only nutrition, but many other developmentally essential functions, the correct development of the placenta is important to correct embryonic and fetal development.
Abnormalities can range from anatomical associated with degree or site of inplantation, structure (as with twinning), to placental function, placento-maternal effects (pre-eclampsia, fetal erythroblastosis) and finally mechanical abnormalities associated with the placental (umbilical) cord.
A 2009 longitudinal Norwegian study suggests an association between large placenta relative to fetal size "disproportionately large placenta relative to birth weight was associated with increased risk of (adult) cardiovascular disease death." See also the DOHAD hypothesis.
This current page lists some abnormalities associated with the placenta and also provides links to other resources. (See also Week 2 Abnormalities - Hydatidiform mole)
- Placenta Links: Introduction | Lecture - Placenta | Practical - Placenta | Implantation | Villi Development | Trophoblast | Maternal Decidua | Endocrine | Cord | Membranes | Abnormalities | Stage 13 | Stage 22 | Histology | Vascular Beds | Blood Vessel Development | Stem Cells | Category:Placenta
Some Recent Findings
|More recent papers|
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Svetlana Bivol, Suzzanne J Owen, Roselyn B Rose'Meyer Glucocorticoid-induced changes in glucocorticoid receptor mRNA and protein expression in the human placenta as a potential factor for altering fetal growth and development. Reprod. Fertil. Dev.: 2016; PubMed 26844822
Neha Sharma, Caroline Kubaczka, Stephanie Kaiser, Daniel Nettersheim, Sadaf S Mughal, Stefanie Riesenberg, Michael Hölzel, Elke Winterhager, Hubert Schorle Tpbpa mediated deletion of Tfap2c leads to deregulation of MAPK, P21, AKT and subsequent placental growth arrest. Development: 2016; PubMed 26811378
Melonie Heron Deaths: Leading Causes for 2012. Natl Vital Stat Rep: 2015, 64(10);1-93 PubMed 26759854
P Lewitowicz, A Wincewicz, D Koziel, J Matykiewicz, A Horecka-Lewitowicz, M Koda, L Kanczuga-Koda, S Gluszek, S Sulkowski Acardius acephalus fetus--report of distinctive anatomical anomalies with regards to pathophysiology of TRAP sequence. Clin Exp Obstet Gynecol: 2015, 42(6);814-8 PubMed 26753494
Peta L Grigsby Animal Models to Study Placental Development and Function throughout Normal and Dysfunctional Human Pregnancy. Semin. Reprod. Med.: 2016; PubMed 26752715
Jiabi B Qin, Hua Wang, Xiaoqi Sheng, Qiong Xie, Shiyou Gao Assisted reproductive technology and risk of adverse obstetric outcomes in dichorionic twin pregnancies: a systematic review and meta-analysis. Fertil. Steril.: 2016; PubMed 26801066
Cağlar Yildiz, Ozlem Bozoklu Akkar, Savaş Karakuş, Ali Cetin, Ali Yanik Hypogastric artery ligation for obstetrical hemorrhage: clinical experience in a tertiary care center. Turk J Med Sci: 2015, 45(6);1312-6 PubMed 26775388
Bhawna Satija, Sanyal Kumar, Leena Wadhwa, Taru Gupta, Supreethi Kohli, Rajkumar Chandoke, Pratibha Gupta Utility of ultrasound and magnetic resonance imaging in prenatal diagnosis of placenta accreta: A prospective study. Indian J Radiol Imaging: 2016, 25(4);464-470 PubMed 26752827
Hao Ying, Yi Lu, Yi-Nuo Dong, De-Fen Wang Effect of Placenta Previa on Preeclampsia. PLoS ONE: 2016, 11(1);e0146126 PubMed 26731265
Fabio Parazzini, Luca Tozzi, Stefano Bianchi Pregnancy outcome and uterine fibroids. Best Pract Res Clin Obstet Gynaecol: 2015; PubMed 26723475
Placentas are generally round or oval in shape and can also be "irregular" (multilobate, "star") shapes. These irregular shaped placentas have been associated with lower birth weight for placental weight suggesting an altered function. 
Embryo Virtual Slides
|Circumvallate placenta is an abnormally shaped placenta where the chorionic membranes are not inserted at the edge of the placenta, but are located inward from the margins toward the placental cord. The membranes are described as "doubled back" over the fetal surface of the placenta.|
A recent Canadian study of 87,600 singleton births has identified a number of risk factors for both high and low placental weight. Some factors are associated either before, after or both accounting for birthweight.
Low placental weight
- chronic hypertension (before and after accounting for birthweight).
- pre-eclampsia (before, but not after adjustment for birthweight).
High placental weight
- anaemia (before and after adjustment for birthweight).
- gestational diabetes (before and after adjustment for birthweight).
- smoking (after adjustment for birthweight).
- Placental and cord determinants include chorioamnionitis, chorangioma/chorangiosis, circumvallate placenta and marginal cord insertion.
Abnormal adherence, with absence of decidua basalis. The incidence of placenta accreta also significantly increases in women with previous cesarean section compared to those without a prior surgical delivery.
- Deficiency of retroplacental sonolucent zone
- Vascular lacunae
- Myometrial thinning
- Interruption of bladder line
| Placenta Increta occurs when the placenta attaches deep into the uterine wall and penetrates into the uterine muscle, but does not penetrate the uterine serosa.
Placenta Increta and Previa
|Placenta Percreta MRI|| Surgical photograph|
Showing the placenta extending through uterine wall (+) and covered by
thin serosal layer (arrow), no features of bladder invasion.
| Placental villi penetrate myometrium and through to uterine serosa.
See clinical article on the laparoscopic management of placenta percreta. 
Placenta Percreta Histopathology
Historically, Paul Portal (1630-1703), a French physician, was the first to describe in 1685 a case of placenta previa in his "The Compleat Practice of Men and Women Midwives".
In this placental abnormality, the placenta overlies internal cervical os of uterus, essentially covering the birth canal. This condition occurs in approximately 1 in 200 to 250 pregnancies and risk factors include prior cesarean delivery, pregnancy termination, intrauterine surgery, smoking, multifetal gestation, increasing parity, and maternal age. A retrospective study of from 59,149 women of 724 pregnancies (1.2%) diagnosed with a complete or partial previa, identified no associated with fetal growth restriction.
In the third trimester and at term, abnormal bleeding can require caesarian delivery and can also lead to Abruptio Placenta.
Ultrasound screening programs during 1st and early 2nd trimester pregnancies now include placental localization. Diagnosis can also be made by transvaginal ultrasound.
Placenta previa MRI
Ultrasound Placenta Previa
|Anterior placenta position (upper arrow) in relation to cervix os (lower arrow).||Posterior placenta position (arrow) in relation to cervix os (triangle).|
- Links: Ultrasound
Vasa previa (vasa praevia) placental abnormality where the fetal vessels lie within the membranes close too or crossing the inner cervical os (opening) and generally diagnosed (98%) by ultrasound. This occurs normally in 1:2500-5000 pregnancies and leads to complications similar too those for placenta previa. Approximately 28% of prenatally diagnosis cases result in emergent preterm delivery.
Type II is defined as the condition where the fetal vessels are found crossing over the internal os connecting either a bilobed placenta or a succenturiate lobe with the main placental mass.
There are suggestions that colour doppler ultrasound can be used to visualise the blood vessels in high-risk cases and if required elective caesarean performed at 35–36 weeks in cases diagnosed as vasa praevia.
Two main associations:
- velamentous insertions (25–62%)
- vessels crossing between lobes in succenturiate or bilobate placentas (33–75%)
Some recent evidence of successful in utero laser ablation of type II vasa previa at 22.5 weeks of gestation.
Management of vasa previa
The following text is from a recent paper identifying the Canadian guidelines for the management of vasa previa.
- If the placenta is found to be low lying at the routine second trimester ultrasound examination, further evaluation for placental cord insertion should be performed. (II-2B)
- Transvaginal ultrasound may be considered for all women at high risk for vasa previa, including those with low or velamentous insertion of the cord, bilobate or succenturiate placenta, or for those having vaginal bleeding, in order to evaluate the internal cervical os. (II-2B)
- If vasa previa is suspected, transvaginal ultrasound colour Doppler may be used to facilitate the diagnosis. Even with the use of transvaginal ultrasound colour Doppler, vasa previa may be missed. (II-2B)
- When vasa previa is diagnosed antenatally, an elective Caesarean section should be offered prior to the onset of labour. (II-1A)
- In cases of vasa previa, premature delivery is most likely; therefore, consideration should be given to administration of corticosteroids at 28 to 32 weeks to promote fetal lung maturation and to hospitalization at about 30 to 32 weeks. (II-2B)
- In a woman with an antenatal diagnosis of vasa previa, when there has been bleeding or premature rupture of membranes, the woman should be offered delivery in a birthing unit with continuous electronic fetal heart rate monitoring and, if time permits, a rapid biochemical test for fetal hemoglobin, to be done as soon as possible; if any of the above tests are abnormal, an urgent Caesarean section should be performed. (III-B
- Women admitted with diagnosed vasa previa should ideally be transferred for delivery in a tertiary facility where a pediatrician and blood for neonatal transfusion are immediately available in case aggressive resuscitation of the neonate is necessary. (II-3B)
- Women admitted to a tertiary care unit with a diagnosis of vasa previa should have this diagnosis clearly identified on the chart, and all health care providers should be made aware of the potential need for immediate delivery by Caesarean section if vaginal bleeding occurs. (III-B).
Represents interruption of the placenta by partial or complete separation, retroplacental blood clot formation and abnormal hemorrhage prior to delivery. There is significant perinatal mortality associated with abruptio placenta.
Placenta with two equal-sized lobes connected by a thin bridge. No identified risks of this structure.
Chorionic plate smaller than basal plate, edges rolled. Placental abruption and haemorrhage risks.
A rare placental abnormality where either all (diffuse placenta membranacea) or part (partial placenta membranacea) is covered by chorionic villi (placental cotyledons). Clinically the abnormality presents with vaginal bleeding, in the second or third trimester or during labor, due to an associated placenta previa. Ultrasound has been used to detect this condition.
Additional lobule separate from the main part of placenta. Risk of vessel rupture and placenta retention.
- Links: Ultrasound
(massive chronicintervillositis, chronic histiocytic intervillositis) Rare placental abnormality and pathology defined by inflammatory placental lesions, mainly in the intervillous space (IVS), with a maternal infiltrate of mononuclear cells (monocytes, lymphocytes, histiocytes) and intervillous fibrinoid deposition.
Chronic intervillositis of the placenta. Jacques SM, Qureshi F. Arch Pathol Lab Med. 1993 Oct;117(10):1032-5.
Placental Mesenchymal Dysplasia
Due to a similar "grape-like" placental appearance, this rare disorder placental mesenchymal stem villous hyperplasia has been mistaken both clinically and macroscopically for a partial hydatidiform molar pregnancy. The disorder also has a high incidence of both intrauterine growth restriction (IUGR) and fetal death. The placental abnormality may be detected, but difficult to diagnose, by ultrasound.
Current research suggests that placental cells may be originated from a mixed population of androgenetic (paternal-derived genome only) and biparental cells. This means that chorionic villus sampling can provide a differential diagnosis between this and a partial mole.
This condition is also known as gestational proteinuric hypertension and occurs in occurs in approximately 2 to 4% of all pregnancies. The pathogenesis of eclamptic convulsions remains unknown and women with a history of eclampsia are at increased risk of eclampsia (1-2%) and preeclampsia (22-35%) in subsequent pregnancies. "Magnesium sulfate is the drug of choice for reducing the rate of eclampsia developing intrapartum and immediately postpartum."(see Sibai BM. 2005).
Recent research using a large population study in Norway has shown a strong generational association such that daughters of women who had pre-eclampsia during pregnancy had more than twice the risk of pre-eclampsia themselves. The paper concludes "Maternal genes and fetal genes from either the mother or father may trigger pre-eclampsia. The maternal association is stronger than the fetal association. The familial association predicts more severe pre-eclampsia."
Maternal Type 1 diabetes can alter placental vascular development. Effects may be due to either maternal hyperglycaemia or fatal hyperinsulinaemia with high glucose and insulin shown in other systems to alter vascularity, increasing vascular endothelial growth factor (VEGF), nitric oxide (NO) and protein kinase C (PKC).
Features of the placental vessels include:
- Increased angiogenesis
- altered junctional maturity and molecular occupancy
- increased leakiness
The placental terminal villi also show vascularity changes including both hypovascularity and hypervascularity. A recent study of the normal and diabetic placenta, shows the diabetic placenta terminal villi were:
- hypovascular villi - had a smaller diameter and a wavy course
- hypervascular villi - had numerous capillaries, reduced stroma and were large in diameter.
Specific changes included:
- villous stroma - collagen envelope around capillaries looked thinner and the network of collagen fibers seemed less dense.
- stromal cells - loss of desmin filaments.
- villous capillaries - were more branched.
- Links: Maternal Diabetes
Chorioangiomas occur in approximately 1 percent of all placentas and are benign haemangiomas. Small chorioangiomas are generally not clinically significant, while large chorioangiomas have been associated with a range of fetal conditions (fetal anemia, thrombocytopenia, hydrops, hydramnios, intrauterine growth retardation) including prematurity and stillbirth.
|Placental Chorioangioma Ultrasound|
|Ultrasound scan placenta and chorioangioma||Ultrasound blood flow in chorioangioma|
Example of a placental chorioangioma forming a yellowish, well-circumscribed firm mass (5 cm × 5 cm) connected by two vessels to the placenta. Histopathologic examination revealed a placental disc 15 cm × 17 cm × 13 cm, with a three-vessel umbilical cord that was attached peripherally and measured 9 cm × 1.5 cm. The weight of the placenta was 530 g. The tumor was confirmed to be a chorioangioma.
Another type of abnormality is when only the conceptus trophoblast layers proliferates and not the embryoblast, no embryo develops, this is called a "hydatidiform mole" (HM), which is due to the continuing presence of the trophoblastic layer, this abnormal conceptus can also implant in the uterus. The trophoblast cells will secrete human chorionic gonadotropin (hCG), as in a normal pregnancy, and may appear maternally and by pregnancy test to be "normal". Prenatal diagnosis by ultrasound analysis demonstrates the absence of a embryo.
There are several forms of hydatidiform mole: partial mole, complete mole and persistent gestational trophoblastic tumor. Many of these tumours arise from a haploid sperm fertilizing an egg without a female pronucleus (the alternative form, an embryo without sperm contribution, is called parthenogenesis). The tumour has a "grape-like" placental appearance without enclosed embryo formation. Following a first molar pregnancy, there is approximately a 1% risk of a second molar pregnancy.
- The incidence of hydatidiform mole varies between ethnic groups, and typically occurs in 1 in every 1500 pregnancies.
- All hydatidiform mole cases are sporadic, except for extremely rare familial cases.
- A maternal gene has been identified for recurrent hydatidiform mole (chromosome 19q13.3-13.4 in a 15.2 cM interval flanked by D19S924 and D19S890).
Complete mole - chromosomal genetic material from the ovum (egg) is lost, by an unknown process. Fertilization then occurs with one or two sperm and an androgenic (from the male only) conceptus (fertilized egg) is formed. With this conceptus the embryo (fetus, baby) does not develop at all but the placenta does grow but it is abnormal and forms lots of cysts and has no blood vessels. These cysts look like a cluster of grapes and that is why it is called a hydatidiform mole (grape like). A hydatidiform mole miscarries by about 16 to 18 weeks gestational age. Since the diagnosis can be made by ultrasound before that time, it is better for you to have an evacuation of the uterus (D & C) so that there is no undue bleeding and no infection. Human chorionic gonadotropin (hCG) will assist in making the diagnosis.
Partial mole - three sets of chromosomes instead of the usual two and this is called triploidy. With such a pregnancy the chromosomal (genetic) material from the ovum (egg) is retained and the egg is fertilized by one or two sperm. Since with partial mole there are maternal chromosomes there is a fetus but because of the three sets of chromosomes this fetus is always grossly abnormal and will not survive. (Text modified from: International Society for the Study of Trophoblastic Diseases,see also JRM Gestational Trophoblastic Disease)
Like any tumour, unless removed there is a risk of progression:
- Stage I: Tumor confined to uterus (non-metastatic)
- Stage II: Tumor involving pelvic organs and/or vagina
- Stage III: Tumor involving lungs, with or without involving pelvic structures and/or vagina
- Stage IV: Tumor involving distant organs
Placental Mesenchymal Dysplasia
Due to a similar "grape-like" placental appearance, this rare disorder has been mistaken both clinically and macroscopically for a partial hydatidiform molar pregnancy. This disorder also has a high incidence of intrauterine growth restriction (IUGR) and fetal death.
Twin Pregnancy Mole
Hydatidiform mole and co-existent healthy fetus is a very rare condition with only 30 cases documented in detail in the literature.
- Links: International Society for the Study of Trophoblastic Diseases | Sydney Gynaecological Oncology Group Gestational Trophoblastic Disease | The Journal of Reproductive Medicine Gestational Trophoblastic Disease (1998) | Dana-Farber Cancer Institute Gynecologic Oncology Program
Velamentous Cord Insertion
(velamentous insertion) Clinical term for describing a placental abnormality where the placental cord inserts into the chorion laeve (placental membranes) away from the edge of the placenta. The placental vessels can also diverge as they traverse between the amnion and chorion before reaching the placenta.The placental vessels are therefore unprotected by Wharton's jelly where they traverse the membranes before they come together into the umbilical cord. This can cause hemorrhage if the vessels are damaged when the membranes are ruptured prior to birth. The condition is more common in monozygotic twins (15%) and triplets.
Velamentous cord insertion, with a low uterine body implantation site, has also been shown to affect fetal heart rate.
A bilobed placenta with velamentous cord insertion.
Cord Vessel Number
|Cord with one artery and one vein|
Persistent Right Umbilical Vein
A fairly rare anomaly, a study of 15,237 obstetric ultrasound examinations performed after 15 weeks' gestation identified only 33 cases of persistent right umbilical vein. Some studies have identified associated fetal anomalies with this condition, including cardiac abnormalities.
| There are few abnormalities associated with umbilical cord development, other that abnormally short or long cords, which in most cases do not cause difficulties.
In some cases though, long cords can wrap around limbs or the fetus neck, which can then restrict blood flow or lead to tissue or nerve damage, and therefore effect develoment.
Cord knotting can also occur (1%) in most cases these knots have no effect, in some cases of severe knotting this can prevents the passage of placental blood.
Umbilical cord torsion
|Rare umbilical cord torsion, even without knot formation can also affect placental blood flow, even leading to fetal demise.|
Refers to the separation of placental vessels before their attachment into the placenta.
This disease is also called Haemolytic Disease of the Newborn, an immune problem from fetus Rh+ /maternal Rh-, leakage from fetus causes anti-Rh antibodies, which is then dangerous for a 2nd child.
RHESUS BLOOD GROUP
Several infective agents may cross into the placenta from the maternal circulation, as well as enter the embry/fetal circulation. The variety of bacterial infections that can occur during pregnancy is as variable as the potential developmental effects, from virtually insignificant to a major developmental, abortive or fatal in outcome.
Pregnant women have an increased susceptibility to malaria infection. Malarial infection of the placenta by sequestration of the infected red blood cells leading to low birth weight and other effects. There are four types of malaria caused by the protozoan parasite Plasmodium falciparum (main), Plasmodium vivax, Plasmodium ovale, Plasmodium malariae). This condition is common in regions where malaria is endemic with women carrying their first pregnancy (primigravida).
A recent paper has identified using an in vitro model that human herpesvirus 8 (HHV-8) can infect the placenta
Clinical term for the cytomegalovirus infection of the placenta.
A earlier histological study identified fixed connective tissue cells predominantly infected cell type in placental tissue. In addition, endothelial cells, macrophages and in some cases trophoblast infection. While a more recent in vitro study suggests that all villi cell types are likely to be infected.
There are few documented abnormalities associated with feral membranes (chorion, amnion). Ultrasound measurement of abnormal yolk sac size/shape in early embryonic development has been suggested as an indicator of early gestational loss. The most common literature described abnormalities are those associated with abnormal vasularization of the chorion.
The best known environmental effect is infection of chorion and/or amnion referred to as chorioamnionitis.
Chronic Chorioamnionitis Histology
- Stage 1 ((a, b) inflammation showing infiltration of lymphocytes limited to the chorionic trophoblast layer (a). CD3 immunostaining demonstrates that the majority of these cells are T cells (b).
- Stage 2 (c, d) inflammation is characterized by infiltration of lymphocytes into the chorioamniotic connective tissue layer ((Stain - Haematoxylin Eosin), c), which are largely CD3+ T cells (d).
The following pathology information from.
This condition can occur following placental infection leading to maternal inflammation of the villous stroma, often with associated intervillositis. The inflammation can lead to disruption of blood flow and necrotic cell death.
Massive Chronic Intervillositis
(MCI) The maternal blood-filled space is filled with CD68-positive histiocytes and an increase in fibrin, occuring more commonly in the first trimester.
The prolonged meconium exposure leads to toxic death of myocytes of placental vessels (umbilical cord or chorionic plate).
A fetal malignancy that leads to an enlarged placenta, with tumor cells in the fetal circulation and rarely in the chorionic villi.
(protein C or S deficiency, factor V Leiden, sickle cell disease, antiphospholipid antibody) This condition can generate an increased fibrin/fibrinoid deposition in the maternal or intervillous space, this can trap and kill villi.
International Classification of Diseases
O12 Gestational oedema and proteinuria without hypertension
- O12.0 Gestational oedema
- O12.1 Gestational proteinuria
- O12.2 Gestational oedema with proteinuria
O13 Gestational hypertension without significant proteinuria
Incl.: Gestational hypertension NOS Mild pre-eclampsia
O14 Gestational hypertension with significant proteinuria
[pregnancy-induced] Excl.: superimposed pre-eclampsia (O11)
- O14.0 Moderate pre-eclampsia
- O14.1 Severe pre-eclampsia
- O14.2 HELLP syndrome Combination of hemolysis, elevated liver enzymes and low platelet count
- O14.9 Pre-eclampsia, unspecified
Incl.: convulsions following conditions in O10-O14 and O16 eclampsia with pregnancy-induced or pre-existing hypertension
- O15.0 Eclampsia in pregnancy
- O15.1 Eclampsia in labour
- O15.2 Eclampsia in the puerperium
- O15.9 Eclampsia, unspecified as to time period Eclampsia NOS
- Abruptio placentae (641.2)
- Placenta previa (641.0, 641.1)
- Postpartum hemorrhage (666.0–666.2)
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Cite this page: Hill, M.A. (2016) Embryology Placenta - Abnormalities. Retrieved February 7, 2016, from https://embryology.med.unsw.edu.au/embryology/index.php/Placenta_-_Abnormalities
- © Dr Mark Hill 2016, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G