Abnormal Development - Maternal Inflammation

Historic Embryology - Viral
1941 Rubella Cataracts \| 1944 Rubella Defects

Some Recent Findings

Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.^[1] "Cellular uptake of proteins from the cerebrospinal fluid was observed in brains from lipopolysaccharide-treated animals in radial progenitor cells. However, the foetal blood-brain barrier to plasma proteins remained intact. Together, these results indicate that maternal inflammation can disrupt the ventricular surface and lead to decreased cellular proliferation. Changes in cell density in Layers IV and V at post-natal Day 8 show that these initial changes have prolonged effects on cortical organization. The possible shift in the fate of progeny and the resulting alterations in the relative cell numbers in the cerebral cortex following a maternal inflammatory response shown here will require further investigation to determine the long-term consequences of inflammation on the development of neuronal circuitry and behaviour."

Search Pubmed: Maternal Inflammation

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Cite this page: Hill, M.A. (2026, March 13) Embryology Abnormal Development - Maternal Inflammation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Maternal_Inflammation