Abnormal Development - Maternal Inflammation

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Introduction

Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | Zoonotic Infection | Toxoplasmosis | Malaria | Maternal Diabetes | Maternal Hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | Hypoxia | Biological Toxins | Chemicals | heavy metals | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis
Viral Links: viral infection | TORCH | cytomegalovirus | Hepatitis Virus | HIV | Parvovirus | Polio Virus | rubella virus | Chickenpox | Lymphocytic Choriomeningitis Virus | Zika Virus | rotavirus | vaccination | Environmental
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects

Some Recent Findings

  • Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.[1] "Cellular uptake of proteins from the cerebrospinal fluid was observed in brains from lipopolysaccharide-treated animals in radial progenitor cells. However, the foetal blood-brain barrier to plasma proteins remained intact. Together, these results indicate that maternal inflammation can disrupt the ventricular surface and lead to decreased cellular proliferation. Changes in cell density in Layers IV and V at post-natal Day 8 show that these initial changes have prolonged effects on cortical organization. The possible shift in the fate of progeny and the resulting alterations in the relative cell numbers in the cerebral cortex following a maternal inflammatory response shown here will require further investigation to determine the long-term consequences of inflammation on the development of neuronal circuitry and behaviour."
  • Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice[2] "These results demonstrate that systemic maternal inflammation combined with neonatal hyperoxia exposure induces alterations in cardiac structure and function leading to cardiac failure in adulthood and supports the importance of the intrauterine and neonatal milieu on adult health."
More recent papers  
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Search term: Maternal Inflammation

Angela M Fowler, William W Tang, Matthew P Young, Anila Mamidi, Karla M Viramontes, Melanie D McCauley, Aaron F Carlin, Robert T Schooley, Jesica Swanstrom, Ralph S Baric, Jennifer Govero, Michael S Diamond, Sujan Shresta Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice. Cell Host Microbe: 2018, 24(5);743-750.e5 PubMed 30439343

Jessica L Irwin, Alison J Yeates, Maria S Mulhern, Emeir M McSorley, J J Strain, Gene E Watson, Katherine Grzesik, Sally W Thurston, Tanzy M Love, Tristram H Smith, Daniel W Mruzek, Conrad F Shamlaye, Catriona Monthy, Gary J Myers, Philip W Davidson, Edwin van Wijngaarden Maternal Gestational Immune Response and Autism Spectrum Disorder Phenotypes at 7 Years of Age in the Seychelles Child Development Study. Mol. Neurobiol.: 2018; PubMed 30430410

Elizabeth Q Littauer, Ioanna Skountzou Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy. Front Immunol: 2018, 9;2455 PubMed 30420854

Carmen Monthé-Drèze, Sheryl L Rifas-Shiman, Diane R Gold, Emily Oken, Sen Sarbattama Maternal obesity and offspring cognition: the role of inflammation. Pediatr. Res.: 2018; PubMed 30420706

References

  1. Velten M, Hutchinson KR, Gorr MW, Wold LE, Lucchesi PA & Rogers LK. (2011). Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice. PLoS ONE , 6, e24544. PMID: 21935422 DOI.
  2. Stolp HB, Turnquist C, Dziegielewska KM, Saunders NR, Anthony DC & Molnár Z. (2011). Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse. Brain , 134, 3236-48. PMID: 21964917 DOI.


Reviews

Articles

Unal ER, Cierny JT, Roedner C, Newman R & Goetzl L. (2011). Maternal inflammation in spontaneous term labor. Am. J. Obstet. Gynecol. , 204, 223.e1-5. PMID: 21376162 DOI.

Williams CL, Teeling JL, Perry VH & Fleming TP. (2011). Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biol. , 9, 49. PMID: 21771319 DOI.

Hava G, Vered L, Yael M, Mordechai H & Mahoud H. (2006). Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy. Dev Psychobiol , 48, 162-8. PMID: 16489598 DOI.

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Cite this page: Hill, M.A. (2018, November 16) Embryology Abnormal Development - Maternal Inflammation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Maternal_Inflammation

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