Abnormal Development - Maternal Inflammation

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Some Recent Findings

  • Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.[1] "Cellular uptake of proteins from the cerebrospinal fluid was observed in brains from lipopolysaccharide-treated animals in radial progenitor cells. However, the foetal blood-brain barrier to plasma proteins remained intact. Together, these results indicate that maternal inflammation can disrupt the ventricular surface and lead to decreased cellular proliferation. Changes in cell density in Layers IV and V at post-natal Day 8 show that these initial changes have prolonged effects on cortical organization. The possible shift in the fate of progeny and the resulting alterations in the relative cell numbers in the cerebral cortex following a maternal inflammatory response shown here will require further investigation to determine the long-term consequences of inflammation on the development of neuronal circuitry and behaviour."
  • Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice[2] "These results demonstrate that systemic maternal inflammation combined with neonatal hyperoxia exposure induces alterations in cardiac structure and function leading to cardiac failure in adulthood and supports the importance of the intrauterine and neonatal milieu on adult health."
More recent papers  
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Search term: Maternal Inflammation

Zhi Zhang, Shilpa Narayan, Lilly Su, Hanaa Al-Alawyat, Jinhuan Liu, Sujatha Kannan Cerebellar injury and impaired function in a rabbit model of maternal inflammation induced neonatal brain injury. Neurobiol Learn Mem: 2018; PubMed 30016703

Hongyan Chen, Yingli Tang, Hanyan Wang, Weibing Chen, Hong Jiang Curcumin alleviates lipopolysaccharide-induced neuroinflammation in fetal mouse brain. Restor. Neurol. Neurosci.: 2018; PubMed 30010156

Jorge Valencia-Ortega, Arturo Zárate, Renata Saucedo, Marcelino Hernández-Valencia, José G Cruz, Edgardo Puello Placental Proinflammatory State and Maternal Endothelial Dysfunction in Preeclampsia. Gynecol. Obstet. Invest.: 2018;1-8 PubMed 30007972

Jennifer A Salati, Victoria H J Roberts, Matthias C Schabel, Jamie O Lo, Christopher D Kroenke, Katherine S Lewandowski, Jonathan R Lindner, Kevin L Grove, Antonio E Frias Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity. Int J Obes (Lond): 2018; PubMed 30006583

María Florencia Zacarías, María Carmen Collado, Carlos Gómez-Gallego, Heini Flinck, Janne Aittoniemi, Erika Isolauri, Seppo Salminen Pregestational overweight and obesity are associated with differences in gut microbiota composition and systemic inflammation in the third trimester. PLoS ONE: 2018, 13(7);e0200305 PubMed 30005082


  1. Velten M, Hutchinson KR, Gorr MW, Wold LE, Lucchesi PA & Rogers LK. (2011). Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice. PLoS ONE , 6, e24544. PMID: 21935422 DOI.
  2. Stolp HB, Turnquist C, Dziegielewska KM, Saunders NR, Anthony DC & Molnár Z. (2011). Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse. Brain , 134, 3236-48. PMID: 21964917 DOI.



Unal ER, Cierny JT, Roedner C, Newman R & Goetzl L. (2011). Maternal inflammation in spontaneous term labor. Am. J. Obstet. Gynecol. , 204, 223.e1-5. PMID: 21376162 DOI.

Williams CL, Teeling JL, Perry VH & Fleming TP. (2011). Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biol. , 9, 49. PMID: 21771319 DOI.

Hava G, Vered L, Yael M, Mordechai H & Mahoud H. (2006). Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy. Dev Psychobiol , 48, 162-8. PMID: 16489598 DOI.

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Cite this page: Hill, M.A. (2018, July 18) Embryology Abnormal Development - Maternal Inflammation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Maternal_Inflammation

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G