Abnormal Development - Maternal Inflammation

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Some Recent Findings

  • Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.[1] "Cellular uptake of proteins from the cerebrospinal fluid was observed in brains from lipopolysaccharide-treated animals in radial progenitor cells. However, the foetal blood-brain barrier to plasma proteins remained intact. Together, these results indicate that maternal inflammation can disrupt the ventricular surface and lead to decreased cellular proliferation. Changes in cell density in Layers IV and V at post-natal Day 8 show that these initial changes have prolonged effects on cortical organization. The possible shift in the fate of progeny and the resulting alterations in the relative cell numbers in the cerebral cortex following a maternal inflammatory response shown here will require further investigation to determine the long-term consequences of inflammation on the development of neuronal circuitry and behaviour."
  • Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice[2] "These results demonstrate that systemic maternal inflammation combined with neonatal hyperoxia exposure induces alterations in cardiac structure and function leading to cardiac failure in adulthood and supports the importance of the intrauterine and neonatal milieu on adult health."
More recent papers  
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Search term: Maternal Inflammation

Ajibola I Abioye, Sangshin Park, Kelsey Ripp, Emily A McDonald, Jonathan D Kurtis, Hannah Wu, Sunthorn Pond-Tor, Surendra Sharma, Jan Ernerudh, Palmera Baltazar, Luz P Acosta, Remigio M Olveda, Veronica Tallo, Jennifer F Friedman Anemia of Inflammation during Human Pregnancy Does Not Affect Newborn Iron Endowment. J. Nutr.: 2018, 148(3);427-436 PubMed 29546300

Simon B Chen, Satoru Kudose, Hannah R Krigman Decidual granulomatous reaction in a placenta from a preeclamptic pregnancy: a case report and review of the literature. Virchows Arch.: 2018; PubMed 29541857

J R Roche, C R Burke, M A Crookenden, A Heiser, J L Loor, S Meier, M D Mitchell, C V C Phyn, S-A Turner Fertility and the transition dairy cow. Reprod. Fertil. Dev.: 2017, 30(1);85-100 PubMed 29539306

S Offenbacher, E L Riché, S P Barros, Y A Bobetsis, D Lin, J D Beck Effects of Maternal Campylobacter rectus Infection on Murine Placenta, Fetal and Neonatal Survival, and Brain Development. J. Periodontol.: 2005, 76 Suppl 11S;2133-2143 PubMed 29539052

Huan Yan, Hong Li, Linlin Zhu, Junjun Gao, Pengyun Li, Zhan Zhang Increased TLR4 and TREM-1 expression on monocytes and neutrophils in preterm birth: further evidence of a proinflammatory state. J. Matern. Fetal. Neonatal. Med.: 2018;1-11 PubMed 29534643


  1. Velten M, Hutchinson KR, Gorr MW, Wold LE, Lucchesi PA & Rogers LK. (2011). Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice. PLoS ONE , 6, e24544. PMID: 21935422 DOI.
  2. Stolp HB, Turnquist C, Dziegielewska KM, Saunders NR, Anthony DC & Molnár Z. (2011). Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse. Brain , 134, 3236-48. PMID: 21964917 DOI.



Unal ER, Cierny JT, Roedner C, Newman R & Goetzl L. (2011). Maternal inflammation in spontaneous term labor. Am. J. Obstet. Gynecol. , 204, 223.e1-5. PMID: 21376162 DOI.

Williams CL, Teeling JL, Perry VH & Fleming TP. (2011). Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biol. , 9, 49. PMID: 21771319 DOI.

Hava G, Vered L, Yael M, Mordechai H & Mahoud H. (2006). Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy. Dev Psychobiol , 48, 162-8. PMID: 16489598 DOI.

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Cite this page: Hill, M.A. (2018, March 19) Embryology Abnormal Development - Maternal Inflammation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Maternal_Inflammation

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G