Abnormal Development - Maternal Inflammation: Difference between revisions

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Embryology - 27 Feb 2026 Expand to Translate
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Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.

Introduction

Historic Embryology - Viral
1941 Rubella Cataracts \| 1944 Rubella Defects

Some Recent Findings

Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.^[1] "Cellular uptake of proteins from the cerebrospinal fluid was observed in brains from lipopolysaccharide-treated animals in radial progenitor cells. However, the foetal blood-brain barrier to plasma proteins remained intact. Together, these results indicate that maternal inflammation can disrupt the ventricular surface and lead to decreased cellular proliferation. Changes in cell density in Layers IV and V at post-natal Day 8 show that these initial changes have prolonged effects on cortical organization. The possible shift in the fate of progeny and the resulting alterations in the relative cell numbers in the cerebral cortex following a maternal inflammatory response shown here will require further investigation to determine the long-term consequences of inflammation on the development of neuronal circuitry and behaviour."
Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice^[2] "These results demonstrate that systemic maternal inflammation combined with neonatal hyperoxia exposure induces alterations in cardiac structure and function leading to cardiac failure in adulthood and supports the importance of the intrauterine and neonatal milieu on adult health."

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Maternal Inflammation <pubmed limit=5>Maternal Inflammation</pubmed>

References

↑ <pubmed>21935422</pubmed>
↑ <pubmed>21964917</pubmed>

Reviews

Articles

Search Pubmed

Search Pubmed: Maternal Inflammation

External Links

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Glossary Links

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Cite this page: Hill, M.A. (2026, February 27) Embryology Abnormal Development - Maternal Inflammation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Maternal_Inflammation

What Links Here?

[1] <pubmed>21935422</pubmed>

[2] <pubmed>21964917</pubmed>

[1]

[2]

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 * '''Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice'''<ref><pubmed>21964917</pubmed></ref> "These results demonstrate that systemic maternal inflammation combined with neonatal hyperoxia exposure induces alterations in cardiac structure and function leading to cardiac failure in adulthood and supports the importance of the intrauterine and neonatal milieu on adult health."
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+Search term: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Maternal%20Inflammation ''Maternal Inflammation'']
+<pubmed limit=5>Maternal Inflammation</pubmed>
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 [[Category:Abnormal Development]] [[Category:Environmental Abnormalities]]