Carnegie stage 13: Difference between revisions
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== Introduction == | == Introduction == | ||
{| | {| | ||
| [[File:Stage13 sem1.jpg|left|400px]] | | valign=top|[[File:Stage13 sem1.jpg|left|400px]] | ||
| | | | ||
===Facts=== | ===Facts=== | ||
[[week 4]] to [[week 5]], 28 - 32 days. | [[week 4]] to [[week 5]], 28 - 32 days. | ||
The embryos have a crown rump length (CRL) of 4 - 6 mm and somite number 30 pairs. | The embryos have a crown rump length ({{CRL}}) of 4 - 6 mm and somite number 30 pairs. | ||
Gestational Age {{GA}} - end week 6 beginning week 7 | Gestational Age {{GA}} - end week 6 beginning week 7 | ||
===Summary=== | ===Summary=== | ||
* Ectoderm: Neural tube continues to close, Caudal neuropore closes, forebrain | * {{Ectoderm}}: Neural tube continues to close, Caudal neuropore closes, forebrain | ||
* Mesoderm: continued segmentation of paraxial mesoderm (21 - 29 somite pairs), heart prominence | * {{Mesoderm}}: continued segmentation of paraxial mesoderm (21 - 29 somite pairs), heart prominence | ||
* Head: 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum | * {{Head}}: 1st, 2nd and 3rd pharyngeal arch, forebrain, site of {{lens placode}}, site of {{otic placode}}, stomodeum | ||
* Body: heart, liver, umbilical, early upper limb bulge | * Body: {{heart}}, {{liver}}, umbilical, early upper {{limb}} bulge | ||
See also [[Carnegie stage 13#Events|'''Carnegie stage 13 Events''']] | |||
|- | |||
| colspan=2| | |||
===Features=== | ===Features=== | ||
* 30 somites, forebrain, site of lens placode, site of otic placode , stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somites | * 30 somites, forebrain, site of lens placode, site of otic placode , stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somites | ||
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| {{SlideStage13bf04}} | | {{SlideStage13bf04}} | ||
| | | | ||
{{Carnegie stage 13 links}} | |||
<br> | |||
{{Stage13movie3D}} | {{Stage13movie3D}} | ||
|} | |} | ||
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{{Embryo5mm}} | {{Embryo5mm}} | ||
===Embryo Virtual Slide=== | ===Embryo Virtual Slide=== | ||
{{SlideStage13bf04}} | {{SlideStage13bf04}} | ||
==Scanning EM== | ==Scanning EM== | ||
[[File:Stage13 sem1.jpg|300px]][[File:Stage13 sem2.jpg|300px]][[File:Stage13 sem3.jpg|300px]] | |||
{{Necker SEM}} | |||
==Kyoto Collection== | ==Kyoto Collection== | ||
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| Oral cavity floor. Scale bar 0.5 mm. | | Oral cavity floor. Scale bar 0.5 mm. | ||
|- | |- | ||
| [[File:Stage 13 EFIC01.jpg|200px]] | | [[File:Stage 13 EFIC01.jpg|200px]] | ||
| [[File:Stage13 oral cavity floor02.jpg|200px]] | | [[File:Stage13 oral cavity floor02.jpg|200px]] | ||
|} | |} | ||
===Movies=== | |||
{| | |||
| valign="bottom"|{{Stage 13 MRI movie 3}} | |||
| valign="bottom"|{{Stage 13 MRI movie 2}} | |||
| valign="bottom"|{{Stage 13 MRI movie 1}} | |||
| valign="bottom"|{{Stage 13 EFIC movie 1}} | |||
|} | |||
{{Kyoto collection}} | {{Kyoto collection}} | ||
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{{Carnegie Embryo iBook table}} | {{Carnegie Embryo iBook table}} | ||
==Hill Collection== | ==Hill Collection== | ||
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:'''Links:''' [[Hill Collection]] | :'''Links:''' [[Hill Collection]] | ||
==Hinrichsen Collection== | |||
[[File:ME18 001.jpg|400px]] | |||
Hinrichsen collection Human Embryo ME18 ([[Carnegie stage 13|stage13]]). | |||
Note the developing pharyngeal arches in this ventral view of the embryo head. | |||
{{Hinrichsen collection}} | |||
==Perry-Arey-Milligan Collection== | |||
{| | |||
|- | |||
! width=40px|Count | |||
! width=60px|Rec. | |||
! width=100px|Cat Number | |||
! width=100px|Stage (est) | |||
! width=100px|Age (days) | |||
! width=100px|Cat Number | |||
! width=80px|Size<br>(CRL mm) | |||
! width=50px|Sex | |||
! width=100px|Section | |||
! width=50px|Quality | |||
! width=150px|Comment | |||
|- | |||
| 1 | |||
| | |||
| 1246-2 | |||
| {{CS13}} | |||
| 23 est | |||
| 1246-2 | |||
| 5 | |||
| | |||
| entire | |||
| fair | |||
| | |||
|- | |||
| 2 | |||
| | |||
| 25 | |||
| {{CS13}} | |||
| 23 est | |||
| 25 | |||
| 5 | |||
| | |||
| | |||
| | |||
| 29-24 all in | |||
|- | |||
| 3 | |||
| | |||
| 26 | |||
| {{CS13}} | |||
| 23 est | |||
| 26 | |||
| 5 | |||
| | |||
| | |||
| | |||
| 25-26 one box | |||
|- | |||
| 4 | |||
| | |||
| 51 | |||
| {{CS13}} | |||
| 23 est | |||
| 51 | |||
| 5 | |||
| | |||
| {{Sagittal}} | |||
| fair | |||
| | |||
|- | |||
| 5 | |||
| | |||
| 14 | |||
| {{CS13}} | |||
| 23 est | |||
| 14 | |||
| 5 | |||
| | |||
| | |||
| good | |||
| 1 of 2 @ 5mm | |||
|- | |||
| | |||
| | |||
| 14 | |||
| {{CS13}} | |||
| 23 est | |||
| 14 | |||
| 5 | |||
| | |||
| | |||
| good | |||
| 2 of 2 @ 5mm | |||
|} | |||
{{Perry-Arey-Milligan collection collapsible table}} | |||
==Stage 13 Serial Section Images== | ==Stage 13 Serial Section Images== | ||
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{{Stage13ULicon120}} | {{Stage13ULicon120}} | ||
==Stage 13 Movies== | ==Stage 13 Reconstruction Movies== | ||
{{Embryo stage 13 movies}} | {{Embryo stage 13 movies}} | ||
==Events== | ==Events== | ||
* | * '''{{Hearing}}''' - otic vesicle closes from surface and endolymphatic appendage apparent. A capillary network forms around the otic vesicle with esoderm becomes condensed as the otic capsule.<ref name=Streeter1945>{{Ref-Streeter1945}}</ref> | ||
* | ** {{Inner ear}} | ||
*** Vestibulocochlear ganglion (vestibular part) and vestibular nerve fibres present. | |||
*** miR-183 MicroRNA family are differentially expressed in cochleovestibular ganglion in the human inner ear{{#pmid:29373586|PMID29373586}} | |||
* '''{{Vision}}''' | |||
** By the end of the fourth week the optic vesicle lies close to the surface ectoderm. Optic evagination differentiation allows identification of optic part of retina, future pigmented layer of retina, and optic stalk. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.<ref name=“Pearson1980”>{{Ref-Pearson1980}}</ref> | |||
* '''{{Cardiovascular}}''' | |||
** [[Neural - Vascular Development|Cerebral Artery]] - hindbrain (i.e., future posterior fossa) is supplied by two parallel neural arteries (or channels). These arteries obtain their blood supply from carotid-vertebrobasilar anastomoses given by the trigeminal artery, the otic artery, hypoglossal artery, and the pre-atlantal artery.{{#pmid:26060802|PMID26060802}} | |||
* '''{{Endocrine}}'''<ref name=O'Rahilly1983a>{{Ref-O'Rahilly1983a}}</ref> | |||
** {{pituitary}} - basement membranes of the craniopharyngeal pouch and the brain are clearly in contact (O'Rahilly 1973). | |||
** {{thymus}} - Weller (1933) recognized already a thymic primordium "of considerable size" on the ventral part of the third pharyngeal pouch, whereas Norris (1938) considered this stage to be "preprimordial" | |||
** {{thyroid}} - median thyroid is now bilobed and is connected to the pharynx by a hollow pedicle.<ref name=Weller1933>{{Ref-Weller1933}}</ref> The telopharyngeal body has been regarded by some<ref name=Weller1933>{{Ref-Weller1933}}</ref> as a "lateral thyroid component". | |||
** {{Pancreas}} - ventral pancreas may perhaps be distinguishable.<ref name=Politzer1952>{{Ref-Politzer1952}}</ref> | |||
* [[Neural_-_Meninges_Development|'''Meninges''']] ({{Spinal cord}}) - [[Carnegie stage 13|xiii]] and [[Carnegie stage 14|xiv]] (embryos of 4 to 8 mm), advances are particularly evident in the vertebral rudiments and in the spinal ganglia, with the latter starting their migration ventrad. The vascularization of the tissues directly adjacent to the neural tube has continued, and endothelium-lined channels are beginning to form in the older embryos.<ref name=Sensenig1951>{{Ref-Sensenig1951}}</ref> | |||
* '''{{genital}}''' -{{primordial germ cell}}s are migrating into the mesonephric ridges.<ref name=Witschi1948>{{Ref-Witschi1948}}</ref> | |||
* '''{{limb}}''' - {{neural}} upper limb nerves (C5-T1) extended from the {{spinal cord}}.<ref name=ShinoharaTanaka1990>{{Ref-ShinoharaTanaka1990}}</ref> | |||
===References=== | ===References=== | ||
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File:Human_Carnegie_stage_13_SOX11_MAZ_GJA1_expression.jpg|Cross-section showing neural tube, notochord, limb bud | File:Human_Carnegie_stage_13_SOX11_MAZ_GJA1_expression.jpg|Cross-section showing neural tube, notochord, limb bud | ||
File:Human Carnegie stage 13 GJA1 expression 2.jpg|Selected image of above cross-section showing neural tube, notochord, limb bud | File:Human Carnegie stage 13 GJA1 expression 2.jpg|Selected image of above cross-section showing neural tube, notochord, limb bud | ||
File:Anderson2016-fig37.jpg|Fig. 37. Human Heart Reconstruction | |||
</gallery> | </gallery> | ||
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File:Bailey087.jpg|Historic - Human embryo with twenty-seven primitive segments (7 mm., 26 days) | File:Bailey087.jpg|Historic - Human embryo with twenty-seven primitive segments (7 mm., 26 days) | ||
File:Bailey088.jpg|Historic - Human embryo with 28 primitive segments (7.5 mm) | File:Bailey088.jpg|Historic - Human embryo with 28 primitive segments (7.5 mm) | ||
Pohlman1911 plate1B.jpg|1911 Cloaca model | Pohlman1911 plate1B.jpg|1911 Cloaca model Carnegie Embryo {{CE186}} | ||
File:Congdon1922-32.jpg|Arch arteries Carnegie Embryo {{CE836}} | |||
</gallery> | </gallery> | ||
Latest revision as of 17:55, 16 March 2020
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Introduction
Factsweek 4 to week 5, 28 - 32 days. The embryos have a crown rump length (CRL) of 4 - 6 mm and somite number 30 pairs. Gestational Age GA - end week 6 beginning week 7 Summary
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Features
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Week: | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Carnegie stage: | 1 2 3 4 | 5 6 | 7 8 9 | 10 11 12 13 | 14 15 | 16 17 | 18 19 | 20 21 22 23 |
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Bright Field
- Embryo Links: Embryo and Placenta | Embryo | Embryo (label) | Embryo (animated) | Embryo (animated large) | Head region | Head region (label) | Body region | Body region (label) | Carnegie stage 13
Embryo Virtual Slide
Stage 13 - Left Ventrolateral View |
Stage 13 | Embryo Slides |
Scanning EM
Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.
Kyoto Collection
Upper half of embryo shown in median sagittal plane. Scale bar 1 mm. | |
Upper half of embryo shown in ventral view. Scale bar 0.5 mm. | Oral cavity floor. Scale bar 0.5 mm. |
Movies
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Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.
Carnegie Collection
- Carnegie stage 13: 6473 left | 6473 dorsal | 6473 right | 6469 right | 8066 dorsal | 8066 left | 8119 left | 7433 right | 7433 ventral
Carnegie Collection Embryos - Stage 13 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Serial No. | Size (mm) | Grade | Fixative | Embedding Medium | Plane | Thinness (µm) | Stain | Year | Notes | |
1 | E.,4.5 Ch., 30x30 | Poor | Salicylic acid | P | Transverse | 10 | Hemat. | 1887 | Obtained by Mall while student | |
19 | E., 5.5 Ch., 18x14 | Poor | p | ? | Transverse | 20 | Al. coch. | 1895 | ||
98 | E., 4 Ch., 24x16x9 | Poor | p | P | Transverse | 20 | Al. coch. | 1896 | ||
76 | E., 4.5 Ch., 22x20 | Poor | Alc. | P | Transverse | 20 | Al. coch. | 1897 | ||
112 | E., 4 | Poor | p | P | Sagittal | 10 | Al. coch. | p | ||
116 | E., 5 | Poor | p | ? | Sagittal | 10 | Al. coch. | 1898 | ||
148 | E.,4.3 Ch., 17x14x10 | Poor | Alc. | P | Coronal | 10 | (Stain - Haematoxylin Eosin) | 1899 | Abnormal. Nasal discs fused | |
186 | E.,3.5 Ch., 25x20x15 | Poor | Alc. | P | Transverse | 20 | Al. coch. | 1901 | ||
239 | E., 3.0 | Poor | Formalin | P | Transverse | 10 | (Stain - Haematoxylin Eosin) | 1903 | ||
248 | E., 4.5 Ch., 30x23x15 | Poor | p | ? | Coronal | 50 | Al. coch. | 1904 | ||
407 | E.,4 Ch., 14x13X7 | Poor | Formalin | ? | Transverse | 40 | Al. coch. | 1907 | ||
463 | E., 3.9 Ch., 17x12x7 | Good | Formalin | P | Coronal | 10 | Al. coch. | 1910 | ||
523 | E., 5 Ch., 25x25x15 | Fair | Formalin | P | Transverse | p | Al. coch. | 1911 | ||
588 | E., 4.0 Ch., 19x15x8 | Good | Corros. acetic | P | Coronal | 15 | (Stain - Haematoxylin Eosin) | 1912 | Advanced | |
786 | E., 4.5 Ch., 19x10x10 | Poor | Alc. | P | Sagittal | 15 | Al. coch. | 1913 | ||
800 | E., 6.0 | Good | Corros. acetic | P | Transverse | 10 | H | 1913 | Curettage. Anencephaly | |
808 | E.,4.0 | Poor | Corros. acetic | P | Transverse | 15 | Al. coch. | 1914 | Tubal Incomplete | |
826 | E., 5.0 Ch., 13x13x9 | Good | Formalin | P | Transverse | 20 | Al. coch. | 1914 | Shrunken | |
836 | E.,4.0 Ch., 22x18x11 | Exc. | Corros. acetic | P | Transverse | 15 | Al. coch. | 1914 | Less advanced | |
963 | E.,4.0 Ch., 23x18x16 | Good | Formalin | P | Coronal | 20 | Al. coch. | 1914 | ||
1075 | E.,6.0 Ch., 46x32x20 | Exc. | Corros. acetic | P | Coronal | 20 | (Stain - Haematoxylin Eosin) or. G. | 1915 | Most advanced in group | |
3956 | E., 4.0 | Poor | Formalin | P | Transverse | 20 | Al. coch. | 1922 | Tubal Incomplete | |
4046 | E.,5 Ch., 22x20x20 | Poor | Formalin | P | Transverse | 50 | Al. coch. | 1922 | ||
5541 | E., 6.0 Ch., 35x30x20 | Good | Formalin | P | Transverse | 10 | Al. coch., eosin | 1927 | ||
5682 | E., 5.3 Ch., 29x25x13 | Poor | Formalin | P | Coronal | 20 | Al. coch. | 1928 | ||
5874 | E., 4.8 | Exc. | Bouin | P | Transverse | 10 | (Stain - Haematoxylin Eosin) | 1929 | Hysterotomy. Bromides only | |
6032 | E., 5.8 Ch., 30x24x13 | Poor | Formalin | P | P | ? | p | 1929 | Not good enough to cut | |
6469 | E., 5.0 Ch., 25x18x18 | Poor | Formalin | P | P | P | P | 1932 | Fragmented on cutting. Not saved | |
6473 | E., 5.0 Ch, 30x30x15 | Exc. | Formalin | C-P | Coronal | 6 | Al. coch. | 1932 | Less advanced. Ag added | |
7433 | E., 5.2 Ch., 15x13x13 | Exc. | Formalin | C-P | Coronal | 8 | (Stain - Haematoxylin Eosin) | 1937 | Tubal | |
7618 | E, 48 Ch, 18x15x15 | Exc. | Bouin | C-P | Coronal | 10 | (Stain - Haematoxylin Eosin) | 1939 | Hystereaomy. Advanced. Ag added | |
7669 | E, 5.0 Ch., 23x16x14 | Good | Formalin | C-P | Coronal | 6 | (Stain - Haematoxylin Eosin) | 1939 | Hysterectomy. Least advanced in group, Ag added | |
7889 | E, 4.2 | Exc. | Bouin | C-P | Coronal | 6 | (Stain - Haematoxylin Eosin) | 1941 | Hysterectomy | |
8066 | E,53 Ch , 20x18xI8 | Exc. | Bouin | C-P | Transverse | 8 | (Stain - Haematoxylin Eosin) | 1942 | Hysterectomy. Ag added to slide 2 | |
8119 | E., 5.3 Ch., 32x28x6.5 | Exc. | Bouin | C-P | Transverse | 8 | (Stain - Haematoxylin Eosin) | 1943 | Hysterectomy | |
8147 | E., 5.2 Ch., 27x21x19 | Poor | Formalin | ? | ? | p | p | 1943 | Tubal Not cut | |
8239 | E., 4.3 | Exc. | Bouin | C-P | Sagittal | 8 | H. phlox. | 1944 | ||
8372 | E., 5.6 | Exc. | Alc.& Bouin | P | Transverse | 10 | Azan | 1946 | ||
8581 | E., 4.8 | Good | Kaiserling | C-P | Sagittal | 8 | Azan | 1948 | Most-advanced third | |
8967 | E., 5.7 | Exc. | Acetic Zenker | C-P | Transverse | 6 | (Stain - Haematoxylin Eosin) | 1931 | Head injured. Univ. Chicago No. H1426 | |
9296 | E,4.5 | Exc. | C-P | Coronal | 8 | Azan | 1955 | |||
9297 | E., 4.5 | Exc. | C-P | Sagittal | 8 | Azan | 1955 | |||
9697 | E., 5.5 | Bouin | 1956 | not cut | ||||||
Abbreviations
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iBook - Carnegie Embryos | |
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Hill Collection
Hill HH145 | |
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- Links: Hill Collection
Hinrichsen Collection
Hinrichsen collection Human Embryo ME18 (stage13).
Note the developing pharyngeal arches in this ventral view of the embryo head.
Image source: The Hinrichsen Collection images are reproduced with the permission of Prof. Beate Brand-Saberi, Head, Department of Anatomy and Molecular Embryology, Ruhr-Universität Bochum. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.
Perry-Arey-Milligan Collection
Count | Rec. | Cat Number | Stage (est) | Age (days) | Cat Number | Size (CRL mm) |
Sex | Section | Quality | Comment |
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1 | 1246-2 | 13 | 23 est | 1246-2 | 5 | entire | fair | |||
2 | 25 | 13 | 23 est | 25 | 5 | 29-24 all in | ||||
3 | 26 | 13 | 23 est | 26 | 5 | 25-26 one box | ||||
4 | 51 | 13 | 23 est | 51 | 5 | Sagittal | fair | |||
5 | 14 | 13 | 23 est | 14 | 5 | good | 1 of 2 @ 5mm | |||
14 | 13 | 23 est | 14 | 5 | good | 2 of 2 @ 5mm |
Perry-Arey-Milligan Collection | |||||||||||
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Count | Rec. | Cat Number | Stage (est) | Age (days) | Cat Number | Size (CRL mm) |
Sex | Section | Quality | Comment | |
1 | 1246-2 | 13 | 23 est | 1246-2 | 5 | entire | fair | ||||
2 | 25 | 13 | 23 est | 25 | 5 | 29-24 all in | |||||
3 | 26 | 13 | 23 est | 26 | 5 | 25-26 one box | |||||
4 | 51 | 13 | 23 est | 51 | 5 | Sagittal | fair | ||||
5 | 14 | 13 | 23 est | 14 | 5 | good | 1 of 2 @ 5mm | ||||
14 | 13 | 23 est | 14 | 5 | good | 2 of 2 @ 5mm | |||||
6 | K | 15 | 37 est | K | 7 | Coronal | poor | ||||
7 | 29 | 15 | 37 est | 29 | 7 | #36 & #37 in 1 box | |||||
8 | 24 | 15 | 24 | 7 | |||||||
9 | 14 | 15 | 37 est | 14 | 7 | good | 1 of 2 @ 7mm | ||||
14 | 15 | 37 est | 14 | 7 | good | 2 of 2 @ 7mm | |||||
10 | 8 | 15 | 37 est | 8 | 8 | longt.sec | Fair-good | entire embryo | |||
11 | 60 | 16 | 38 est | 60 | 10 | Coronal | good | ||||
12 | 87 | 16 | 38 est | 87 | 11 | Male | Coronal | good | |||
13 | 85 | 17 | 39 est | 85 | 12 | Male | Coronal | good | |||
14 | A | 17 | 39 est | A | 13 | entire | good | ||||
15 | 6 | 17 | 39 est | 6 | 15 | Coronal | good | ||||
16 | 6C | 17 | 39 est | 6C | 13 | Transverse | good | pollack | |||
17 | 65 | 18 | 41 est | 65 | 18 | Coronal | good | ||||
18 | 36 | 18 | 41 est | 36 | 17 | good | |||||
19 | 10 | 18 | 41 est | 10 | 18 | good | |||||
20 | 1 | 18 | 41 est | 1 | 18 | Sagittal | good | ||||
1(2) | 18 | 41 est | 1(2) | 70 | Sagittal | good | 18mm head | ||||
21 | 37 | 18 | 41 est | 37 | 70 | good | 18mm head | ||||
22 | 88 | 18 | 41 est | 88 | 18 | Male | Coronal | good | |||
23 | 2 | 19 | 45 est | 2 | 20 | good | |||||
24 | 5 | 19 | 45 est | 5 | 20 | Coronal | fair | ||||
25 | 56 | 19 | 45 est | 56 | 20 | Coronal | good | ||||
26 | 86 | 19 | 45 est | 86 | 20 | Male | Coronal | good | |||
27 | 67 | 19 | 45 est | 67 | 20 | Male | Coronal | good | |||
28 | A-3 | 19 | 45 est | A-3 | 20 | Male | Coronal | good | |||
21 | 48 est | 25 | fair | ||||||||
29 | 62 | 21 | 48 est | 62 | 25 | Coronal | fair | ||||
30 | 78(1) | 21 | 48 est | 78(1) | 25 | Male | Coronal | good | |||
78(2) | 78(2) | 25 | Male | Coronal | good | ||||||
31 | 103 | 22 | 50 | 103 | 28 | Male | good | ||||
32 | 97 | 22 | 50 | 97 | 28 | Male | Coronal | good | |||
?? | B-3 (Box 2) | 23 | B-3 (Box 2) | 30 | Coronal | good | |||||
33 | 98 | 23 | 98 | 30 | Female | Coronal | good | ||||
1 | B(1) | 8 wk | B(1) | 32 | Female | Coronal | good | ||||
B(1) | 8 wk | B(1) | 32 | Female | Coronal | good | |||||
2 | 101 | 8 wk | 101 | 33 | Male | good | |||||
3 | D-3 (Box 2) | 8 wk | D-3 (Box 2) | 33 | Coronal | good | |||||
4 | 94 | 8 wk | 94 | 35 | Female | Coronal | good | ||||
5 | E-3(1) | 8 wk | E-3(1) | 35 | Male | Coronal | good | ||||
E-3(2) | 8 wk | E-3(2) | 35 | Male | Coronal | good | |||||
6 | 127 | 8 wk | 127 | 36 | Sagittal | good | |||||
7 | 38 | 8 wk | 38 | 38 | Sagittal | good | |||||
8 | 126.1 | 8 wk | 126.1 | 38 | Sagittal | good | |||||
126.2 | 8 wk | 126.2 | 38 | Sagittal | good | ||||||
9 | A5(1) | 9 wk | A5(1) | 45 | Coronal | good | |||||
A5(2) | 9 wk | A5(2) | 45 | Coronal | good | ||||||
10 | 68 | 9 wk | 68 | 45 | Coronal | good | |||||
11 | 73 | 9 wk | 73 | 45 | Sagittal | good | |||||
12 | 55A(1) | 9 wk | 55A(1) | 47 | Coronal | good | |||||
55A(2) | 9 wk | 55A(2) | 47 | Coronal | good | ||||||
13 | 89A | 10 wk | 89A | 59 | Male | Coronal | good | ||||
89B(1) | 10 wk | 89B(1) | 59 | Male | Coronal | good | |||||
89B(2) | 10 wk | 89B(2) | 59 | Male | Coronal | good | |||||
14 | 83A | 10 wk | 83A | 60 | Male | Coronal | good | ||||
83B | 10 wk | 83B | 60 | Male | Sagittal | good | |||||
15 | 17(1) | 10 wk | 17(1) | 60 | Sagittal | good | |||||
17(2) | 10 wk | 17(2) | 60 | Coronal | good | ||||||
16 | 1372(1) | 10 wk | 1372(1) | 64 | Sagittal | good | |||||
1372(2) | 10 wk | 1372(2) | 64 | Coronal | good | ||||||
17 | 58A(1) | 10 wk | 58A(1) | 65 | Coronal | good | |||||
58A(2) | 10 wk | 58A(2) | 65 | Coronal | good | ||||||
18 | 52 | 10 wk | 52 | 65 | Female | Sagittal | good | ||||
19 | 19 | 10 wk | 19 | 66 | Sagittal | good | |||||
20 | 15(1) | 10 wk | 73 | 15(1) | 67 | Coronal | good | ||||
15(2) | 10 wk | 73 | 15(2) | 67 | Coronal | good | |||||
21 | 90B | 11 wk | 75 | 90B | 70 | Male | Sagittal | good | |||
22 | 14(1) | 11 wk | 75 | 14(1) | 70 | Coronal | good | ||||
22 | 14(2) | 11 wk | 75 | 14(2) | 70 | Coronal | good | ||||
22 | 14(3) | 11 wk | 75 | 14(3) | 70 | Sagittal | good | ||||
23 | 2001Dec | 39.2 | 11 wk | 75 | 39 | 70 | Coronal | good | 39 box 1= Sagittal | ||
24 | 2001Dec | 90A(1) | 11 wk | 75 | 90A(1) | 70 | Male | Coronal | good | ||
24 | 2001Dec | 90A(2) | 11 wk | 75 | 90A(2) | 70 | Male | Coronal | good | ||
25 | 54A(1) | 11 wk | 77 | 54A(1) | 72 | Male | |||||
25 | 54A(2) | 11 wk | 77 | 54A(2) | 72 | Male | |||||
26 | 91#1 | 11 wk | 77 | 91#1 | 75 | Male | Coronal | good | |||
26 | 91#2 | 11 wk | 77 | 91#2 | 75 | Male | Coronal | good | |||
28 | 66B{1} | 11 wk | 77 | 66B{1} | 75 | Male | Coronal | good | |||
28 | 66B{2} | 11 wk | 77 | 66B{2} | 75 | Male | Coronal | good | |||
29 | 69B{1} | 11 wk | 77 | 69B{1} | 75 | Male | Sagittal | good | |||
29 | 69B{2} | 11 wk | 77 | 69B{2} | 75 | Male | Sagittal | good | |||
30 | 79A{1) | 11 wk | 77 | 79A{1) | 75 | Male | Coronal | good | |||
30 | 79A{2) | 11 wk | 77 | 79A{2) | 75 | Male | Sagittal | good | |||
30 | 79B | 11 wk | 77 | 79B | 75 | Male | Sagittal | good | |||
31 | 1246(1) | 11 wk | 79 | 1246(1) | 78 | Coronal | good | ||||
31 | 1246(2) | 11 wk | 79 | 1246(2) | 78 | Coronal | good | ||||
32 | 2001Dec | 80A(1) | 11 wk | 79 | 80A(1) | 78 | Male | Coronal | good | ||
32 | 2001Dec | 80A(2) | 11 wk | 79 | 80A(2) | 78 | Male | Coronal | good | ||
32 | 2001Dec | 80B | 11 wk | 79 | 80B | 78 | Male | Sagittal | good | ||
33 | 22 | 11 wk | 79 | 22 | 78 | Sagittal | good | ||||
34 | 20{1} | 11 wk | 80 | 20{1} | Coronal | good | |||||
34 | 20{2} | 11 wk | 80 | 20{2} | Coronal | good | |||||
35 | 2001Dec | 74(1) | 11 wk | 80 | 74(1) | 80 | Male | Coronal | good | ||
35 | 2001Dec | 74(1) | 11 wk | 80 | 74(1) | 80 | Male | Coronal | good | ||
36 | 2001Dec | 57B(1} | 11 wk | 80 | 57B(1} | 80 | Male | Sagittal | good | ||
36 | 2001Dec | 57B(2} | 11 wk | 80 | 57B(2} | 80 | Male | Sagittal | good | ||
36 | 2001Dec | 57A(1} | 11 wk | 80 | 57A(1} | 80 | Male | Coronal | good | ||
36 | 2001Dec | 57A(2} | 11 wk | 80 | 57A(2} | 80 | Male | Coronal | good | ||
36 | 2001Dec | 57A(3} | 11 wk | 80 | 57A(3} | 80 | Male | Coronal | good | ||
37 | 2001Dec | 53A(1} | 11 wk | 80 | 53A(1} | 80 | Male | Coronal | good | ||
37 | 2001Dec | 53A(2} | 11 wk | 80 | 53A(2} | 80 | Male | Coronal | good | ||
37 | 2001Dec | 53B(1} | 11 wk | 80 | 53B(1} | 80 | Male | Sagittal | good | ||
37 | 2001Dec | 53B(2} | 11 wk | 80 | 53B(2} | 80 | Male | Sagittal | good | ||
38 | 2001Dec | 74B(1} | 11 wk | 80 | 74B(1} | 80 | Male | Sagittal | good | ||
38 | 2001Dec | 74B(2} | 11 wk | 80 | 74B(2} | 80 | Male | Sagittal | good | ||
39 | 2001Dec | 1819(1} | 11 wk | 81 | 1819(1} | 81 | Transverse | good | |||
39 | 2001Dec | 1819(2} | 11 wk | 81 | 1819(2} | 81 | Transverse | good | |||
40 | 2001Dec | 77B{1} | 11 wk | 82 | 77B{1} | 82 | Male | Sagittal | good | ||
40 | 2001Dec | 77B{2} | 11 wk | 82 | 77B{2} | 82 | Male | Sagittal | good | ||
41 | 2001Dec | 81B{1} | 11 wk | 82 | 81B{1} | 82 | Male | Sagittal | good | ||
41 | 2001Dec | 81B{2} | 11 wk | 82 | 81B{2} | 82 | Male | Sagittal | good | ||
41 | 2001Dec | 81A{1} | 11 wk | 82 | 81A{1} | 82 | Male | Coronal | good | ||
41 | 2001Dec | 81A{2} | 11 wk | 82 | 81A{2} | 82 | Male | Coronal | good | ||
42 | 2001Dec | 75A | 11 wk | 82 | 75A | 82.5 | Male | Coronal | good | ||
43 | 16 | 11 wk | 83 | 16 | 85 | Coronal | |||||
44 | 2001Dec | 93A (1) | 11 wk | 83 | 93A (1) | 85 | Male | Coronal | good | ||
44 | 2001Dec | 93A (2) | 11 wk | 83 | 93A (2) | 85 | Male | Coronal | good | ||
45 | 2001Dec | 12 (1) | 11 wk | 83 | 12 (1) | 85 | Male | Coronal | good | ||
45 | 2001Dec | 12 (2) | 11 wk | 83 | 12 (2) | 85 | Male | Coronal | good | ||
45 | 2001Dec | 12 (3) | 11 wk | 83 | 12 (3) | 85 | Male | Coronal | good | ||
45 | 2001Dec | 12 (4) | 11 wk | 83 | 12 (4) | 85 | Male | Coronal | good | ||
46 | 2001Dec | 92 (1) | 11 wk | 83 | 92 (1) | 85 | Male | Sagittal | good | ||
46 | 2001Dec | 92 (2) | 11 wk | 83 | 92 (2) | 85 | Male | Sagittal | good | ||
47 | 2001Dec | 82B (1) | 12 wk | 84 | 82B (1) | 90 | Female | Sagittal | good | ||
47 | 2001Dec | 82B (2) | 12 wk | 84 | 82B (2) | 90 | Female | Sagittal | good | ||
48 | 2001Dec | 8 | 12 wk | 84 | 8 | 90 | Coronal | ||||
48 | 2001Dec | 8 | 12 wk | 84 | 8 | 90 | Coronal | ||||
49 | 2001Dec | 82A(1) | 12 wk | 84 | 82A(1) | 90 | Female | Coronal | good | ||
49 | 2001Dec | 82A(2) | 12 wk | 84 | 82A(2) | 90 | Female | Coronal | good | ||
50 | 2001Dec | 49 | 12 wk | 88 | 49 | 96 | coronal | fair | |||
51 | 2001Dec | 14151.1 | 12 wk | 88 | 14151.1 | 97 | |||||
51 | 2001Dec | 14151.2 | 12 wk | 88 | 14151.2 | 97 | |||||
51 | 2001Dec | 14151.3 | 12 wk | 88 | 14151.3 | 97 | |||||
52 | 2001Nov | 11.1 | 12 wk | 90 | 11.1 | 100 | Male | Coronal | Exc | whole head-MTC | |
52 | 2001Nov | 11.2 | 12 wk | 90 | 11.2 | 100 | Male | Coronal | Exc | whole head-MTC | |
52 | 2001Nov | 11.3 | 12 wk | 90 | 11.3 | 100 | Male | Coronal | good | whole head-MTC | |
53 | 2001Nov | 4C | 13 wk | 96 | 4C | 112 | Coronal | pollack sta | |||
54 | 2001Nov | 1862 | 13 wk | 97 | 1862 | 113 | |||||
55 | 2001Nov | 1741 | 13 wk | 100 | 1741 | 120 | Coronal | good | |||
56 | 2001Nov | 5C(1) | 14 wk | 103 | 5C(1) | 124 | Coronal | good | |||
56 | 2001Nov | 5C(2) | 14 wk | 103 | 5C(2) | 124 | Coronal | good | pollack sta | ||
57 | 2001Nov | 6C | 15 wk | 106 | 6C | 130 | Transverse | good | pollack sta | ||
58 | 2001Nov | 7C(1) | 17 wk | 122 | 7C(1) | 160 | Transverse | good | pollack | ||
58 | 2001Nov | 7C(2) | 17 wk | 122 | 7C(2) | 160 | Transverse | good | pollack | ||
59 | 2001Nov | 1123 | 21 wk | 1123 | 206 | Coronal | good | pollack | |||
60 | 2001Nov | 1683 | wk | 1683 | 227 | Transverse | good | ||||
61 | 2001Nov | 1731 | wk | 1731 | 246 | Coronal | good | pollack | |||
62 | 2001Nov | 1777 | 26 wk | 1777 | 255 | Coronal | good | pollack | |||
1A(2) | 1A(2) | no CRL | Coronal | good | |||||||
1A(3) | 1A(3) | no CRL | Coronal | good | |||||||
13 | 13 | good | 4 different embryos | ||||||||
28 | 28 | 10mm ? | good | label on box says 4.5 mm | |||||||
5.1 | 5.1 | 10mm ? | Coronal | good | head = 7mm | ||||||
5.2 | 5.2 | good | head = 7mm | ||||||||
23 | 23 | Female | Coronal | good | head measure to 13 | ||||||
18 | 18 | Coronal | good | head measure to 19 | |||||||
70 | 11 wk est | 70 | head 27mm | Coronal | good | ||||||
2001Nov | 100(1) | 100(1) | head 27mm | Sagittal | good | No CR notes | |||||
2001Nov | 100(2) | 100(2) | head 27mm | Sagittal | good | No CR notes | |||||
75A | 75A | ? | Male | Coronal | good | No CR notes |
Stage 13 Serial Section Images
These are the original serial images prepared from embryo sections for Embryology practical classes and transferred online in 1996. This embryo shows some features present on the later Stage 14 embryo.
- Links: Carnegie stage 13 - serial sections | Carnegie stage 22 - serial sections | Carnegie stage 22
Labeled Sections
A1L | A2L | A3L | A4L | A5L | A6L | A7L |
B1L | B2L | B3L | B4L | B5L | B6L | B7L |
C1L | C2L | C3L | C4L | C5L | C6L | C7L |
D1L | D2L | D3L | D4L | D5L | D6L | D7L |
E1L | E2L | E3L | E4L | E5L | E6L | E7L |
F1L | F2L | F3L | F4L | F5L | F6L | F7L |
G1L | G2L | G3L | G4L | G5L | G6L | G7L |
Unlabeled Sections
A1 | A2 | A3 | A4 | A5 | A6 | A7 |
B1 | B2 | B3 | B4 | B5 | B6 | B7 |
C1 | C2 | C3 | C4 | C5 | C6 | C7 |
D1 | D2 | D3 | D4 | D5 | D6 | D7 |
E1 | E2 | E3 | E4 | E5 | E6 | E7 |
F1 | F2 | F3 | F4 | F5 | F6 | F7 |
G1 | G2 | G3 | G4 | G5 | G6 | G7 |
Stage 13 Reconstruction Movies
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Events
- hearing - otic vesicle closes from surface and endolymphatic appendage apparent. A capillary network forms around the otic vesicle with esoderm becomes condensed as the otic capsule.[1]
- vision
- By the end of the fourth week the optic vesicle lies close to the surface ectoderm. Optic evagination differentiation allows identification of optic part of retina, future pigmented layer of retina, and optic stalk. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.[3]
- cardiovascular
- Cerebral Artery - hindbrain (i.e., future posterior fossa) is supplied by two parallel neural arteries (or channels). These arteries obtain their blood supply from carotid-vertebrobasilar anastomoses given by the trigeminal artery, the otic artery, hypoglossal artery, and the pre-atlantal artery.[4]
- endocrine[5]
- pituitary - basement membranes of the craniopharyngeal pouch and the brain are clearly in contact (O'Rahilly 1973).
- thymus - Weller (1933) recognized already a thymic primordium "of considerable size" on the ventral part of the third pharyngeal pouch, whereas Norris (1938) considered this stage to be "preprimordial"
- thyroid - median thyroid is now bilobed and is connected to the pharynx by a hollow pedicle.[6] The telopharyngeal body has been regarded by some[6] as a "lateral thyroid component".
- pancreas - ventral pancreas may perhaps be distinguishable.[7]
- Meninges (spinal cord) - xiii and xiv (embryos of 4 to 8 mm), advances are particularly evident in the vertebral rudiments and in the spinal ganglia, with the latter starting their migration ventrad. The vascularization of the tissues directly adjacent to the neural tube has continued, and endothelium-lined channels are beginning to form in the older embryos.[8]
- genital -primordial germ cells are migrating into the mesonephric ridges.[9]
- limb - neural upper limb nerves (C5-T1) extended from the spinal cord.[10]
References
- ↑ Streeter GL. Developmental horizons in human embryos. Description of age group XIII, embryos about 4 or 5 millimeters long, and age group XIV, period of indentation of the lens vesicle. (1945) Carnegie Instn. Wash. Publ. 557, Contrib. Embryol., Carnegie Inst. Wash., 31: 27-63.
- ↑ Chadly DM, Best J, Ran C, Bruska M, Woźniak W, Kempisty B, Schwartz M, LaFleur B, Kerns BJ, Kessler JA & Matsuoka AJ. (2018). Developmental profiling of microRNAs in the human embryonic inner ear. PLoS ONE , 13, e0191452. PMID: 29373586 DOI.
- ↑ Pearson AA. The development of the eyelids. Part I. External features. (1980) J. Anat.: 130(1): 33-42. PMID 7364662 PDF
- ↑ Menshawi K, Mohr JP & Gutierrez J. (2015). A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply. J Stroke , 17, 144-58. PMID: 26060802 DOI.
- ↑ O'Rahilly R. The timing and sequence of events in the development of the human endocrine system during the embryonic period proper. (1983) Anat. Embryol., 166: 439-451. PMID 6869855
- ↑ 6.0 6.1 Weller GL. Development of the thyroid, parathyroid and thymus glands in man. (1933) Contrib. Embryol., Carnegie Inst. Wash. 24: 93-139.
- ↑ Politzer G. Zur Abgrenzung des Anlagebegriffes, er6rtert an der Friihentwicklung von Parathyreoidea, Pancreas und Thyreoidea (Delineation of the development of the parathyroids, the pancreas, and the thyroid gland). (1952) Acta Anat 15:68-84.
- ↑ Sensenig EC. The early development of the meninges of the spinal cord in human embryos. (1951) Contrib. Embryol., Carnegie Inst. Wash. Publ. 611.
- ↑ Witschi E. Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. (1948) Carnegie Instn. Wash. Publ. 575, Contrib. Embryol., 32: 67-80.
- ↑ Shinohara H. Naora H. Hashimoto R. Hatta T. and Tanaka O. Development of the innervation pattern in the upper limb of staged human embryos. (1990) Acta Anat (Basel) 138: 265-269. PMID 2389673
Additional Images
Historic
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Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.
Cite this page: Hill, M.A. (2024, June 16) Embryology Carnegie stage 13. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_13
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G