Carnegie stage 13

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Introduction

Stage13 sem1.jpg

Facts

week 4 to week 5, 28 - 32 days.

The embryos have a crown rump length (CRL) of 4 - 6 mm and somite number 30 pairs.

Gestational Age GA - end week 6 beginning week 7

Summary

  • ectoderm: Neural tube continues to close, Caudal neuropore closes, forebrain
  • mesoderm: continued segmentation of paraxial mesoderm (21 - 29 somite pairs), heart prominence
  • head: 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum
  • Body: heart, liver, umbilical, early upper limb bulge


See also Carnegie stage 13 Events

Features

  • 30 somites, forebrain, site of lens placode, site of otic placode , stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somites
  • Identify: forebrain, site of lens placode, site of otic placode, stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somite
Stage 13 - Left Ventrolateral View

Stage13 bf4.jpg

 ‎‎Mobile | Desktop | Original

Stage 13 | Embryo Slides
Stage 13 Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Movies | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 13 | Next Stage 14
  Historic Papers: 1905 Embryo 148 | 1926 Precervical Sinus | 1945 | 1955


Carnegie Stage 13 Movies: Gastrointestinal Tract | Cardiovascular | Central Nervous System | Carnegie Stage 13 | Stage 22 Movies | Movies

The original animations were part of the UNSW Independent Learning Project (ILP) prepared by Aashish Kumar (2006).
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Bright Field

Embryo and placenta

Stage13 bf5.gif

Stage13 bf5.jpg Stage13 bf6.jpg

Stage13 bf7.jpg Stage13 bf8.jpg

Stage13 bf9.jpg Stage13 bf10.jpg

Stage13 bf11.jpg Stage13 bf12.jpg

Stage13 bf1.jpg Stage13 bf3.jpg

Embryo Links: Embryo and Placenta | Embryo | Embryo (label) | Embryo (animated) | Embryo (animated large) | Head region | Head region (label) | Body region | Body region (label) | Carnegie stage 13
Stage 13 Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Movies | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 13 | Next Stage 14
  Historic Papers: 1905 Embryo 148 | 1926 Precervical Sinus | 1945 | 1955


Embryo Virtual Slide

Stage 13 - Left Ventrolateral View

Stage13 bf4.jpg

 ‎‎Mobile | Desktop | Original

Stage 13 | Embryo Slides


Scanning EM

Stage13 sem1.jpgStage13 sem2.jpgStage13 sem3.jpg

Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.


Kyoto Collection

Stage13 bf2.jpg

Human Stage13 sagittal upper half01.jpg Human Stage13 sagittal upper half02.jpg
Upper half of embryo shown in median sagittal plane. Scale bar 1 mm.
Stage13 face ventral view01.jpg Stage13 oral cavity floor01.jpg
Upper half of embryo shown in ventral view. Scale bar 0.5 mm. Oral cavity floor. Scale bar 0.5 mm.
Stage 13 EFIC01.jpg Stage13 oral cavity floor02.jpg


Movies

Stage13 MRI 3D03 icon.jpg
 ‎‎Embryo Stage 13
Page | Play
Stage13 MRI 3D02 icon.jpg
 ‎‎Embryo CNS
Page | Play
Stage 13 MRI S01.jpg
 ‎‎Heart Sag MRI
Page | Play
Stage 13 EFIC01.jpg
 ‎‎Sagittal EFIC
Page | Play

Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Stage13 bf13.jpg Stage13 bf14.jpg Stage13 bf15.jpg Stage13 bf16.jpg Stage13 bf17.jpg Stage13 bf18.jpg Stage13 bf19.jpg Stage13 bf20.jpg Stage13 bf21.jpg

Carnegie stage 13: 6473 left | 6473 dorsal | 6473 right | 6469 right | 8066 dorsal | 8066 left | 8119 left | 7433 right | 7433 ventral
Carnegie Collection Embryos - Stage 13 
Serial No. Size (mm) Grade Fixative Embedding Medium Plane Thinness (µm) Stain Year Notes
1 E.,4.5 Ch., 30x30 Poor Salicylic acid P Transverse 10 Hemat. 1887 Obtained by Mall while student
19 E., 5.5 Ch., 18x14 Poor p ? Transverse 20 Al. coch. 1895
98 E., 4 Ch., 24x16x9 Poor p P Transverse 20 Al. coch. 1896
76 E., 4.5 Ch., 22x20 Poor Alc. P Transverse 20 Al. coch. 1897
112 E., 4 Poor p P Sagittal 10 Al. coch. p
116 E., 5 Poor p ? Sagittal 10 Al. coch. 1898
148 E.,4.3 Ch., 17x14x10 Poor Alc. P Coronal 10 (Stain - Haematoxylin Eosin) 1899 Abnormal. Nasal discs fused
186 E.,3.5 Ch., 25x20x15 Poor Alc. P Transverse 20 Al. coch. 1901
239 E., 3.0 Poor Formalin P Transverse 10 (Stain - Haematoxylin Eosin) 1903
248 E., 4.5 Ch., 30x23x15 Poor p ? Coronal 50 Al. coch. 1904
407 E.,4 Ch., 14x13X7 Poor Formalin ? Transverse 40 Al. coch. 1907
463 E., 3.9 Ch., 17x12x7 Good Formalin P Coronal 10 Al. coch. 1910
523 E., 5 Ch., 25x25x15 Fair Formalin P Transverse p Al. coch. 1911
588 E., 4.0 Ch., 19x15x8 Good Corros. acetic P Coronal 15 (Stain - Haematoxylin Eosin) 1912 Advanced
786 E., 4.5 Ch., 19x10x10 Poor Alc. P Sagittal 15 Al. coch. 1913
800 E., 6.0 Good Corros. acetic P Transverse 10 H 1913 Curettage. Anencephaly
808 E.,4.0 Poor Corros. acetic P Transverse 15 Al. coch. 1914 Tubal Incomplete
826 E., 5.0 Ch., 13x13x9 Good Formalin P Transverse 20 Al. coch. 1914 Shrunken
836 E.,4.0 Ch., 22x18x11 Exc. Corros. acetic P Transverse 15 Al. coch. 1914 Less advanced
963 E.,4.0 Ch., 23x18x16 Good Formalin P Coronal 20 Al. coch. 1914
1075 E.,6.0 Ch., 46x32x20 Exc. Corros. acetic P Coronal 20 (Stain - Haematoxylin Eosin) or. G. 1915 Most advanced in group
3956 E., 4.0 Poor Formalin P Transverse 20 Al. coch. 1922 Tubal Incomplete
4046 E.,5 Ch., 22x20x20 Poor Formalin P Transverse 50 Al. coch. 1922
5541 E., 6.0 Ch., 35x30x20 Good Formalin P Transverse 10 Al. coch., eosin 1927
5682 E., 5.3 Ch., 29x25x13 Poor Formalin P Coronal 20 Al. coch. 1928
5874 E., 4.8 Exc. Bouin P Transverse 10 (Stain - Haematoxylin Eosin) 1929 Hysterotomy. Bromides only
6032 E., 5.8 Ch., 30x24x13 Poor Formalin P P ? p 1929 Not good enough to cut
6469 E., 5.0 Ch., 25x18x18 Poor Formalin P P P P 1932 Fragmented on cutting. Not saved
6473 E., 5.0 Ch, 30x30x15 Exc. Formalin C-P Coronal 6 Al. coch. 1932 Less advanced. Ag added
7433 E., 5.2 Ch., 15x13x13 Exc. Formalin C-P Coronal 8 (Stain - Haematoxylin Eosin) 1937 Tubal
7618 E, 48 Ch, 18x15x15 Exc. Bouin C-P Coronal 10 (Stain - Haematoxylin Eosin) 1939 Hystereaomy. Advanced. Ag added
7669 E, 5.0 Ch., 23x16x14 Good Formalin C-P Coronal 6 (Stain - Haematoxylin Eosin) 1939 Hysterectomy. Least advanced in group, Ag added
7889 E, 4.2 Exc. Bouin C-P Coronal 6 (Stain - Haematoxylin Eosin) 1941 Hysterectomy
8066 E,53 Ch , 20x18xI8 Exc. Bouin C-P Transverse 8 (Stain - Haematoxylin Eosin) 1942 Hysterectomy. Ag added to slide 2
8119 E., 5.3 Ch., 32x28x6.5 Exc. Bouin C-P Transverse 8 (Stain - Haematoxylin Eosin) 1943 Hysterectomy
8147 E., 5.2 Ch., 27x21x19 Poor Formalin ? ? p p 1943 Tubal Not cut
8239 E., 4.3 Exc. Bouin C-P Sagittal 8 H. phlox. 1944
8372 E., 5.6 Exc. Alc.& Bouin P Transverse 10 Azan 1946
8581 E., 4.8 Good Kaiserling C-P Sagittal 8 Azan 1948 Most-advanced third
8967 E., 5.7 Exc. Acetic Zenker C-P Transverse 6 (Stain - Haematoxylin Eosin) 1931 Head injured. Univ. Chicago No. H1426
9296 E,4.5 Exc. C-P Coronal 8 Azan 1955
9297 E., 4.5 Exc. C-P Sagittal 8 Azan 1955
9697 E., 5.5 Bouin 1956 not cut
Abbreviations
  • Size - E. is the greatest length of the embryo and Ch. is the mean diameter of the chorion.
  • Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections.
  • Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P).
  • Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution)
  • Stain -
  • ? - unknown or not determined.


iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).


Hill Collection

Hill HH145
HillH145 Stage 13 bf01.jpg HillH145 Stage 13 bf02.jpg
HillH145 Stage 13 bf03.jpg HillH145 Stage 13 bf04.jpg
HillH145 Stage 13 bf05.jpg HillH145 Stage 13 bf06.jpg
HillH145 Stage 13 bf07.jpg HillH145 Stage 13 bf08.jpg
Links: Hill Collection

Hinrichsen Collection

ME18 001.jpg

Hinrichsen collection Human Embryo ME18 (stage13).

Note the developing pharyngeal arches in this ventral view of the embryo head.

Image source: The Hinrichsen Collection images are reproduced with the permission of Prof. Beate Brand-Saberi, Head, Department of Anatomy and Molecular Embryology, Ruhr-Universität Bochum. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Perry-Arey-Milligan Collection

Count Rec. Cat Number Stage (est) Age (days) Cat Number Size
(CRL mm)
Sex Section Quality Comment
1 1246-2 13 23 est 1246-2 5 entire fair
2 25 13 23 est 25 5 29-24 all in
3 26 13 23 est 26 5 25-26 one box
4 51 13 23 est 51 5 Sagittal fair
5 14 13 23 est 14 5 good 1 of 2 @ 5mm
14 13 23 est 14 5 good 2 of 2 @ 5mm
Perry-Arey-Milligan Collection  
Count Rec. Cat Number Stage (est) Age (days) Cat Number Size
(CRL mm)
Sex Section Quality Comment
1 1246-2 13 23 est 1246-2 5 entire fair
2 25 13 23 est 25 5 29-24 all in
3 26 13 23 est 26 5 25-26 one box
4 51 13 23 est 51 5 Sagittal fair
5 14 13 23 est 14 5 good 1 of 2 @ 5mm
14 13 23 est 14 5 good 2 of 2 @ 5mm
6 K 15 37 est K 7 Coronal poor
7 29 15 37 est 29 7 #36 & #37 in 1 box
8 24 15 24 7
9 14 15 37 est 14 7 good 1 of 2 @ 7mm
14 15 37 est 14 7 good 2 of 2 @ 7mm
10 8 15 37 est 8 8 longt.sec Fair-good entire embryo
11 60 16 38 est 60 10 Coronal good
12 87 16 38 est 87 11 Male Coronal good
13 85 17 39 est 85 12 Male Coronal good
14 A 17 39 est A 13 entire good
15 6 17 39 est 6 15 Coronal good
16 6C 17 39 est 6C 13 Transverse good pollack
17 65 18 41 est 65 18 Coronal good
18 36 18 41 est 36 17 good
19 10 18 41 est 10 18 good
20 1 18 41 est 1 18 Sagittal good
1(2) 18 41 est 1(2) 70 Sagittal good 18mm head
21 37 18 41 est 37 70 good 18mm head
22 88 18 41 est 88 18 Male Coronal good
23 2 19 45 est 2 20 good
24 5 19 45 est 5 20 Coronal fair
25 56 19 45 est 56 20 Coronal good
26 86 19 45 est 86 20 Male Coronal good
27 67 19 45 est 67 20 Male Coronal good
28 A-3 19 45 est A-3 20 Male Coronal good
21 48 est 25 fair
29 62 21 48 est 62 25 Coronal fair
30 78(1) 21 48 est 78(1) 25 Male Coronal good
78(2) 78(2) 25 Male Coronal good
31 103 22 50 103 28 Male good
32 97 22 50 97 28 Male Coronal good
?? B-3 (Box 2) 23 B-3 (Box 2) 30 Coronal good
33 98 23 98 30 Female Coronal good
1 B(1) 8 wk B(1) 32 Female Coronal good
B(1) 8 wk B(1) 32 Female Coronal good
2 101 8 wk 101 33 Male good
3 D-3 (Box 2) 8 wk D-3 (Box 2) 33 Coronal good
4 94 8 wk 94 35 Female Coronal good
5 E-3(1) 8 wk E-3(1) 35 Male Coronal good
E-3(2) 8 wk E-3(2) 35 Male Coronal good
6 127 8 wk 127 36 Sagittal good
7 38 8 wk 38 38 Sagittal good
8 126.1 8 wk 126.1 38 Sagittal good
126.2 8 wk 126.2 38 Sagittal good
9 A5(1) 9 wk A5(1) 45 Coronal good
A5(2) 9 wk A5(2) 45 Coronal good
10 68 9 wk 68 45 Coronal good
11 73 9 wk 73 45 Sagittal good
12 55A(1) 9 wk 55A(1) 47 Coronal good
55A(2) 9 wk 55A(2) 47 Coronal good
13 89A 10 wk 89A 59 Male Coronal good
89B(1) 10 wk 89B(1) 59 Male Coronal good
89B(2) 10 wk 89B(2) 59 Male Coronal good
14 83A 10 wk 83A 60 Male Coronal good
83B 10 wk 83B 60 Male Sagittal good
15 17(1) 10 wk 17(1) 60 Sagittal good
17(2) 10 wk 17(2) 60 Coronal good
16 1372(1) 10 wk 1372(1) 64 Sagittal good
1372(2) 10 wk 1372(2) 64 Coronal good
17 58A(1) 10 wk 58A(1) 65 Coronal good
58A(2) 10 wk 58A(2) 65 Coronal good
18 52 10 wk 52 65 Female Sagittal good
19 19 10 wk 19 66 Sagittal good
20 15(1) 10 wk 73 15(1) 67 Coronal good
15(2) 10 wk 73 15(2) 67 Coronal good
21 90B 11 wk 75 90B 70 Male Sagittal good
22 14(1) 11 wk 75 14(1) 70 Coronal good
22 14(2) 11 wk 75 14(2) 70 Coronal good
22 14(3) 11 wk 75 14(3) 70 Sagittal good
23 2001Dec 39.2 11 wk 75 39 70 Coronal good 39 box 1= Sagittal
24 2001Dec 90A(1) 11 wk 75 90A(1) 70 Male Coronal good
24 2001Dec 90A(2) 11 wk 75 90A(2) 70 Male Coronal good
25 54A(1) 11 wk 77 54A(1) 72 Male
25 54A(2) 11 wk 77 54A(2) 72 Male
26 91#1 11 wk 77 91#1 75 Male Coronal good
26 91#2 11 wk 77 91#2 75 Male Coronal good
28 66B{1} 11 wk 77 66B{1} 75 Male Coronal good
28 66B{2} 11 wk 77 66B{2} 75 Male Coronal good
29 69B{1} 11 wk 77 69B{1} 75 Male Sagittal good
29 69B{2} 11 wk 77 69B{2} 75 Male Sagittal good
30 79A{1) 11 wk 77 79A{1) 75 Male Coronal good
30 79A{2) 11 wk 77 79A{2) 75 Male Sagittal good
30 79B 11 wk 77 79B 75 Male Sagittal good
31 1246(1) 11 wk 79 1246(1) 78 Coronal good
31 1246(2) 11 wk 79 1246(2) 78 Coronal good
32 2001Dec 80A(1) 11 wk 79 80A(1) 78 Male Coronal good
32 2001Dec 80A(2) 11 wk 79 80A(2) 78 Male Coronal good
32 2001Dec 80B 11 wk 79 80B 78 Male Sagittal good
33 22 11 wk 79 22 78 Sagittal good
34 20{1} 11 wk 80 20{1} Coronal good
34 20{2} 11 wk 80 20{2} Coronal good
35 2001Dec 74(1) 11 wk 80 74(1) 80 Male Coronal good
35 2001Dec 74(1) 11 wk 80 74(1) 80 Male Coronal good
36 2001Dec 57B(1} 11 wk 80 57B(1} 80 Male Sagittal good
36 2001Dec 57B(2} 11 wk 80 57B(2} 80 Male Sagittal good
36 2001Dec 57A(1} 11 wk 80 57A(1} 80 Male Coronal good
36 2001Dec 57A(2} 11 wk 80 57A(2} 80 Male Coronal good
36 2001Dec 57A(3} 11 wk 80 57A(3} 80 Male Coronal good
37 2001Dec 53A(1} 11 wk 80 53A(1} 80 Male Coronal good
37 2001Dec 53A(2} 11 wk 80 53A(2} 80 Male Coronal good
37 2001Dec 53B(1} 11 wk 80 53B(1} 80 Male Sagittal good
37 2001Dec 53B(2} 11 wk 80 53B(2} 80 Male Sagittal good
38 2001Dec 74B(1} 11 wk 80 74B(1} 80 Male Sagittal good
38 2001Dec 74B(2} 11 wk 80 74B(2} 80 Male Sagittal good
39 2001Dec 1819(1} 11 wk 81 1819(1} 81 Transverse good
39 2001Dec 1819(2} 11 wk 81 1819(2} 81 Transverse good
40 2001Dec 77B{1} 11 wk 82 77B{1} 82 Male Sagittal good
40 2001Dec 77B{2} 11 wk 82 77B{2} 82 Male Sagittal good
41 2001Dec 81B{1} 11 wk 82 81B{1} 82 Male Sagittal good
41 2001Dec 81B{2} 11 wk 82 81B{2} 82 Male Sagittal good
41 2001Dec 81A{1} 11 wk 82 81A{1} 82 Male Coronal good
41 2001Dec 81A{2} 11 wk 82 81A{2} 82 Male Coronal good
42 2001Dec 75A 11 wk 82 75A 82.5 Male Coronal good
43 16 11 wk 83 16 85 Coronal
44 2001Dec 93A (1) 11 wk 83 93A (1) 85 Male Coronal good
44 2001Dec 93A (2) 11 wk 83 93A (2) 85 Male Coronal good
45 2001Dec 12 (1) 11 wk 83 12 (1) 85 Male Coronal good
45 2001Dec 12 (2) 11 wk 83 12 (2) 85 Male Coronal good
45 2001Dec 12 (3) 11 wk 83 12 (3) 85 Male Coronal good
45 2001Dec 12 (4) 11 wk 83 12 (4) 85 Male Coronal good
46 2001Dec 92 (1) 11 wk 83 92 (1) 85 Male Sagittal good
46 2001Dec 92 (2) 11 wk 83 92 (2) 85 Male Sagittal good
47 2001Dec 82B (1) 12 wk 84 82B (1) 90 Female Sagittal good
47 2001Dec 82B (2) 12 wk 84 82B (2) 90 Female Sagittal good
48 2001Dec 8 12 wk 84 8 90 Coronal
48 2001Dec 8 12 wk 84 8 90 Coronal
49 2001Dec 82A(1) 12 wk 84 82A(1) 90 Female Coronal good
49 2001Dec 82A(2) 12 wk 84 82A(2) 90 Female Coronal good
50 2001Dec 49 12 wk 88 49 96 coronal fair
51 2001Dec 14151.1 12 wk 88 14151.1 97
51 2001Dec 14151.2 12 wk 88 14151.2 97
51 2001Dec 14151.3 12 wk 88 14151.3 97
52 2001Nov 11.1 12 wk 90 11.1 100 Male Coronal Exc whole head-MTC
52 2001Nov 11.2 12 wk 90 11.2 100 Male Coronal Exc whole head-MTC
52 2001Nov 11.3 12 wk 90 11.3 100 Male Coronal good whole head-MTC
53 2001Nov 4C 13 wk 96 4C 112 Coronal pollack sta
54 2001Nov 1862 13 wk 97 1862 113
55 2001Nov 1741 13 wk 100 1741 120 Coronal good
56 2001Nov 5C(1) 14 wk 103 5C(1) 124 Coronal good
56 2001Nov 5C(2) 14 wk 103 5C(2) 124 Coronal good pollack sta
57 2001Nov 6C 15 wk 106 6C 130 Transverse good pollack sta
58 2001Nov 7C(1) 17 wk 122 7C(1) 160 Transverse good pollack
58 2001Nov 7C(2) 17 wk 122 7C(2) 160 Transverse good pollack
59 2001Nov 1123 21 wk 1123 206 Coronal good pollack
60 2001Nov 1683 wk 1683 227 Transverse good
61 2001Nov 1731 wk 1731 246 Coronal good pollack
62 2001Nov 1777 26 wk 1777 255 Coronal good pollack
1A(2) 1A(2) no CRL Coronal good
1A(3) 1A(3) no CRL Coronal good
13 13 good 4 different embryos
28 28 10mm ? good label on box says 4.5 mm
5.1 5.1 10mm ? Coronal good head = 7mm
5.2 5.2 good head = 7mm
23 23 Female Coronal good head measure to 13
18 18 Coronal good head measure to 19
70 11 wk est 70 head 27mm Coronal good
2001Nov 100(1) 100(1) head 27mm Sagittal good No CR notes
2001Nov 100(2) 100(2) head 27mm Sagittal good No CR notes
75A 75A ? Male Coronal good No CR notes

Stage 13 Serial Section Images

These are the original serial images prepared from embryo sections for Embryology practical classes and transferred online in 1996. This embryo shows some features present on the later Stage 14 embryo.

Links: Carnegie stage 13 - serial sections | Carnegie stage 22 - serial sections | Carnegie stage 22

Labeled Sections

Stage 13 serial labeled images
Stage 13 image 050.jpg Stage 13 image 051.jpg Stage 13 image 052.jpg Stage 13 image 053.jpg Stage 13 image 054.jpg Stage 13 image 055.jpg Stage 13 image 056.jpg
A1L A2L A3L A4L A5L A6L A7L
Stage 13 image 057.jpg Stage 13 image 058.jpg Stage 13 image 059.jpg Stage 13 image 060.jpg Stage 13 image 061.jpg Stage 13 image 062.jpg Stage 13 image 063.jpg
B1L B2L B3L B4L B5L B6L B7L
Stage 13 image 064.jpg Stage 13 image 065.jpg Stage 13 image 066.jpg Stage 13 image 067.jpg Stage 13 image 068.jpg Stage 13 image 069.jpg Stage 13 image 070.jpg
C1L C2L C3L C4L C5L C6L C7L
Stage 13 image 071.jpg Stage 13 image 072.jpg Stage 13 image 073.jpg Stage 13 image 074.jpg Stage 13 image 075.jpg Stage 13 image 076.jpg Stage 13 image 077.jpg
D1L D2L D3L D4L D5L D6L D7L
Stage 13 image 078.jpg Stage 13 image 079.jpg Stage 13 image 080.jpg Stage 13 image 081.jpg Stage 13 image 082.jpg Stage 13 image 083.jpg Stage 13 image 084.jpg
E1L E2L E3L E4L E5L E6L E7L
Stage 13 image 085.jpg Stage 13 image 086.jpg Stage 13 image 087.jpg Stage 13 image 088.jpg Stage 13 image 089.jpg Stage 13 image 090.jpg Stage 13 image 091.jpg
F1L F2L F3L F4L F5L F6L F7L
Stage 13 image 092.jpg Stage 13 image 093.jpg Stage 13 image 094.jpg Stage 13 image 095.jpg Stage 13 image 096.jpg Stage 13 image 097.jpg Stage 13 image 098.jpg
G1L G2L G3L G4L G5L G6L G7L


Unlabeled Sections

Stage 13 serial unlabeled images
Stage 13 image 001.jpg Stage 13 image 002.jpg Stage 13 image 003.jpg Stage 13 image 004.jpg Stage 13 image 005.jpg Stage 13 image 006.jpg Stage 13 image 007.jpg
A1 A2 A3 A4 A5 A6 A7
Stage 13 image 008.jpg Stage 13 image 009.jpg Stage 13 image 010.jpg Stage 13 image 011.jpg Stage 13 image 012.jpg Stage 13 image 013.jpg Stage 13 image 014.jpg
B1 B2 B3 B4 B5 B6 B7
Stage 13 image 015.jpg Stage 13 image 016.jpg Stage 13 image 017.jpg Stage 13 image 018.jpg Stage 13 image 019.jpg Stage 13 image 020.jpg Stage 13 image 021.jpg
C1 C2 C3 C4 C5 C6 C7
Stage 13 image 022.jpg Stage 13 image 023.jpg Stage 13 image 024.jpg Stage 13 image 025.jpg Stage 13 image 026.jpg Stage 13 image 027.jpg Stage 13 image 028.jpg
D1 D2 D3 D4 D5 D6 D7
Stage 13 image 029.jpg Stage 13 image 030.jpg Stage 13 image 031.jpg Stage 13 image 032.jpg Stage 13 image 033.jpg Stage 13 image 034.jpg Stage 13 image 035.jpg
E1 E2 E3 E4 E5 E6 E7
Stage 13 image 036.jpg Stage 13 image 037.jpg Stage 13 image 038.jpg Stage 13 image 039.jpg Stage 13 image 040.jpg Stage 13 image 041.jpg Stage 13 image 042.jpg
F1 F2 F3 F4 F5 F6 F7
Stage 13 image 043.jpg Stage 13 image 044.jpg Stage 13 image 045.jpg Stage 13 image 046.jpg Stage 13 image 047.jpg Stage 13 image 048.jpg Stage 13 image 049.jpg
G1 G2 G3 G4 G5 G6 G7


Stage 13 Reconstruction Movies

Stage13-ALL-icon.jpg
 ‎‎Systems
Page | Play
Stage13-GIT-icon.jpg
 ‎‎GIT Stage 13
Page | Play
Stage13-CVS-icon.jpg
 ‎‎Cardiovascular
Page | Play
Stage13-CNS-icon.jpg
 ‎‎Stage 13 Neural
Page | Play

Events

  • hearing - otic vesicle closes from surface and endolymphatic appendage apparent. A capillary network forms around the otic vesicle with esoderm becomes condensed as the otic capsule.[1]
    • inner ear
      • Vestibulocochlear ganglion (vestibular part) and vestibular nerve fibres present.
      • miR-183 MicroRNA family are differentially expressed in cochleovestibular ganglion in the human inner ear[2]
  • vision
    • By the end of the fourth week the optic vesicle lies close to the surface ectoderm. Optic evagination differentiation allows identification of optic part of retina, future pigmented layer of retina, and optic stalk. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.[3]
  • cardiovascular
    • Cerebral Artery - hindbrain (i.e., future posterior fossa) is supplied by two parallel neural arteries (or channels). These arteries obtain their blood supply from carotid-vertebrobasilar anastomoses given by the trigeminal artery, the otic artery, hypoglossal artery, and the pre-atlantal artery.[4]
  • endocrine[5]
    • pituitary - basement membranes of the craniopharyngeal pouch and the brain are clearly in contact (O'Rahilly 1973).
    • thymus - Weller (1933) recognized already a thymic primordium "of considerable size" on the ventral part of the third pharyngeal pouch, whereas Norris (1938) considered this stage to be "preprimordial"
    • thyroid - median thyroid is now bilobed and is connected to the pharynx by a hollow pedicle.[6] The telopharyngeal body has been regarded by some[6] as a "lateral thyroid component".
    • pancreas - ventral pancreas may perhaps be distinguishable.[7]
  • Meninges (spinal cord) - xiii and xiv (embryos of 4 to 8 mm), advances are particularly evident in the vertebral rudiments and in the spinal ganglia, with the latter starting their migration ventrad. The vascularization of the tissues directly adjacent to the neural tube has continued, and endothelium-lined channels are beginning to form in the older embryos.[8]
  • genital -primordial germ cells are migrating into the mesonephric ridges.[9]

References

  1. Streeter GL. Developmental horizons in human embryos. Description of age group XIII, embryos about 4 or 5 millimeters long, and age group XIV, period of indentation of the lens vesicle. (1945) Carnegie Instn. Wash. Publ. 557, Contrib. Embryol., Carnegie Inst. Wash., 31: 27-63.
  2. Chadly DM, Best J, Ran C, Bruska M, Woźniak W, Kempisty B, Schwartz M, LaFleur B, Kerns BJ, Kessler JA & Matsuoka AJ. (2018). Developmental profiling of microRNAs in the human embryonic inner ear. PLoS ONE , 13, e0191452. PMID: 29373586 DOI.
  3. Pearson AA. The development of the eyelids. Part I. External features. (1980) J. Anat.: 130(1): 33-42. PMID 7364662 PDF
  4. Menshawi K, Mohr JP & Gutierrez J. (2015). A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply. J Stroke , 17, 144-58. PMID: 26060802 DOI.
  5. O'Rahilly R. The timing and sequence of events in the development of the human endocrine system during the embryonic period proper. (1983) Anat. Embryol., 166: 439-451. PMID 6869855
  6. 6.0 6.1 Weller GL. Development of the thyroid, parathyroid and thymus glands in man. (1933) Contrib. Embryol., Carnegie Inst. Wash. 24: 93-139.
  7. Politzer G. Zur Abgrenzung des Anlagebegriffes, er6rtert an der Friihentwicklung von Parathyreoidea, Pancreas und Thyreoidea (Delineation of the development of the parathyroids, the pancreas, and the thyroid gland). (1952) Acta Anat 15:68-84.
  8. Sensenig EC. The early development of the meninges of the spinal cord in human embryos. (1951) Contrib. Embryol., Carnegie Inst. Wash. Publ. 611.
  9. Witschi E. Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. (1948) Carnegie Instn. Wash. Publ. 575, Contrib. Embryol., 32: 67-80.
  10. Shinohara H. Naora H. Hashimoto R. Hatta T. and Tanaka O. Development of the innervation pattern in the upper limb of staged human embryos. (1990) Acta Anat (Basel) 138: 265-269. PMID 2389673

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Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Embryonic Development



Cite this page: Hill, M.A. (2024, March 19) Embryology Carnegie stage 13. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_13

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