Week 5

Embryology - 5 Dec 2023 Expand to Translate
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Key Events of Human Development during the fifth week (week 5) following fertilization or clinical gestational age GA week 7 (LMP).

Carnegie Stages: 14 | 15

Carnegie Stages

Week:	1	2	3	4	5	6	7	8
Carnegie stage:	1 2 3 4	5 6	7 8 9	10 11 12 13	14 15	16 17	18 19	20 21 22 23

Historic Carnegie Stages 14 and 15.

Historic Papers: 1918 | 1926 Precervical Sinus | 1956 | 1959

Historic Papers: 1891 | 1905 Cranial and Spinal Nerves | 1914 | 1926 Precervical Sinus | 1948 stages 15-18

Timeline

Week 5 - Human Embryo Stages and Events (GA week 7)
Embryo Week: Week 1 \| Week 2 \| Week 3 \| Week 4 \| Week 5 \| Week 6 \| Week 7 \| Week 8 \| Week 9
Day	Stage	Event
29		pituitary - Week 5 elongation, contacts infundibulum, diverticulum of diencephalon heart - Week 5 septation starts, atrial and ventricular respiratory - Week 5 left and right lung buds push into the pericardioperitoneal canals (primordia of pleural cavity) respiratory - Week 5 to 17 lung histology - pseudoglandular hearing - Week 5 cochlear part of otic vesicle elongates (humans 2.5 turns)
30
31
32	Stage 14	ectoderm - sensory placodes, lens pit, otocyst, nasal placode, primary/secondary vesicles, fourth ventricle of brain mesoderm - continued segmentation of paraxial mesoderm (somite pairs), heart prominence Head - 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum Body - heart, liver, umbilical cord, mesonephric ridge visible externally as bulges. Limb - upper and lower limb buds growing neural - first appearance of the future cerebral hemispheres. Cerebellar plate differentiated to an intermediate layer, and future rhombic lip identifiable^[1] liver hepatic gland and its vascular channels enlarge, hematopoietic function appears^[2]
33	Stage 15	neural - cranial nerves (except olfactory and optic) are identifiable in more advanced embryos^[3]
34
35		vision - 35 to 37 days retinal pigment present
Note - the day timing of stages is only approximate, system names link to first page of that specific system, and events are based upon the literature cited below.
References ↑ Müller F & O'Rahilly R. (1988). The first appearance of the future cerebral hemispheres in the human embryo at stage 14. Anat. Embryol. , 177, 495-511. PMID: 3377191 ↑ Godlewski G, Gaubert-Cristol R, Rouy S & Prudhomme M. (1997). Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23). Microsc. Res. Tech. , 39, 314-27. PMID: 9407542 <314::AID-JEMT2>3.0.CO;2-H DOI. ↑ Müller F & O'Rahilly R. (1988). The development of the human brain, including the longitudinal zoning in the diencephalon at stage 15. Anat. Embryol. , 179, 55-71. PMID: 3213956

Day	Stage	Event
29		Pituitary - Week 5 elongation, contacts infundibulum, diverticulum of diencephalon Heart - Week 5 septation starts, atrial and ventricular Respire - Week 5 left and right lung buds push into the pericardioperitoneal canals (primordia of pleural cavity) Respire - Week 5 to 17 lung histology - pseudoglandular Hearing - Week 5 cochlear part of otic vesicle elongates (humans 2.5 turns)
30
31
32	Stage 14	Ectoderm - sensory placodes, lens pit, otocyst, nasal placode, primary/secondary vesicles, fourth ventricle of brain Mesoderm - continued segmentation of paraxial mesoderm (somite pairs), heart prominence Head - 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum Body - heart, liver, umbilical cord, mesonephric ridge visible externally as bulges. Limb - upper and lower limb buds growing Neural - first appearance of the future cerebral hemispheres. Cerebellar plate differentiated to an intermediate layer, and future rhombic lip identifiable^[1] Liver hepatic gland and its vascular channels enlarge, hematopoietic function appears^[2]
33	Stage 15	Neural - cranial nerves (except olfactory and optic) are identifiable in more advanced embryos^[3]
34
35		Eye - 35 to 37 days retinal pigment present

References

↑ <pubmed>3377191</pubmed>
↑ <pubmed>9407542</pubmed>
↑ <pubmed>3213956</pubmed>

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2023, December 5) Embryology Week 5. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Week_5

What Links Here?

[PMID3377191-1] Müller F & O'Rahilly R. (1988). The first appearance of the future cerebral hemispheres in the human embryo at stage 14. Anat. Embryol. , 177, 495-511. PMID: 3377191

[PMID9407542-2] Godlewski G, Gaubert-Cristol R, Rouy S & Prudhomme M. (1997). Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23). Microsc. Res. Tech. , 39, 314-27. PMID: 9407542 <314::AID-JEMT2>3.0.CO;2-H DOI.

[PMID3213956-3] Müller F & O'Rahilly R. (1988). The development of the human brain, including the longitudinal zoning in the diencephalon at stage 15. Anat. Embryol. , 179, 55-71. PMID: 3213956

[4] <pubmed>3377191</pubmed>

[5] <pubmed>9407542</pubmed>

[6] <pubmed>3213956</pubmed>

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