Carnegie stage table

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Carnegie Institute of Washington

Introduction

Carnegie stages are named after the famous US Institute which began collecting and classifying embryos in the early 1900's. Stages are based on the external and/or internal morphological development of the embryo, and are not directly dependent on either age or size. The human embryonic period proper is divided into 23 Carnegie stages covering the first 8 weeks post-ovulation.


Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9
Links: Embryo Virtual Slides | Human Embryo Collections

Carnegie Stage Table

Weeks shown in the table below are embryonic post ovulation age, for clinical Gestational Age (GA) measured from last menstrual period, add 2 weeks.

Stage
Days (approx)
Size
(mm)
Images
(not to scale)
Events
1
1
(week 1)
0.1 - 0.15
Human zygote two pronuclei 02.jpg
fertilized oocyte, zygote, pronuclei
2
2 - 3
0.1 - 0.2
Human embryo day 3.jpg
morula cell division with reduction in cytoplasmic volume, blastocyst formation of inner and outer cell mass
3
4 - 5
0.1 - 0.2
Human embryo day 5.jpg
loss of zona pellucida, free blastocyst
4
5 - 6
0.1 - 0.2
Week2 001 icon.jpg
attaching blastocyst
5
7 - 12
(week 2)
0.1 - 0.2
Stage5 bf11L.jpg
implantation
6
13 - 15
0.2
Stage6 bf03.jpg
extraembryonic mesoderm, primitive streak, gastrulation
7
15 - 17
(week 3)
0.4
Stage7 features.jpg
gastrulation, notochordal process
8
17 - 19
1.0 - 1.5
Stage8 bf4.jpg
primitive pit, notochordal canal
9
19 - 21
1.5 - 2.5
Stage9 dorsal.jpg
Somitogenesis Somite Number 1 - 3 neural folds, cardiac primordium, head fold
10
22 - 23
(week 4)
2 - 3.5
Stage10 bf4b.jpg
Somite Number 4 - 12 neural fold fuses
11
23 - 26
2.5 - 4.5
Stage11 bf7b.jpg
Somite Number 13 - 20 rostral neuropore closes
12
26 - 30
3 - 5
Stage12 bf5b.jpg
Somite Number 21 - 29 caudal neuropore closes
13
28 - 32
(week 5)
4 - 6
Stage13 bf2c.jpg
Somite Number 30 leg buds, lens placode, pharyngeal arches
Stage 13/14 shown in serial embryo sections series of Embryology Program
14
31 - 35
5 - 7
Stage14 bf2c.jpg
lens pit, optic cup
15
35 - 38
7 - 9
Stage15 bf1c.jpg
lens vesicle, nasal pit, hand plate
16
37 - 42
(week 6)
8 - 11
Link=Carnegie_stage_16
nasal pits moved ventrally, auricular hillocks, foot plate
17
42 - 44
11 - 14
Stage17 bf1c.jpg
finger rays
18
44 - 48
(week 7)
13 - 17
Stage18 bf1c.jpg
ossification commences
19
48 - 51
16 - 18
Stage19 bf1c.jpg
straightening of trunk
20
51 - 53
(week 8)
18 - 22
Stage20 bf1c.jpg
upper limbs longer and bent at elbow
21
53 - 54
22 - 24
Stage21 bf1c.jpg
hands and feet turned inward
Stage 22 shown in serial embryo sections series of Embryology Program
22
54 - 56
23 - 28
Stage22 bf1c.jpg
eyelids, external ears
23
56 - 60
27 - 31
Stage23 bf1c.jpg
rounded head, body and limbs
Following this stage Fetal Development occurs until birth (approx 37 weeks)

The embryos shown in the table are from the Kyoto and Carnegie collection and other sources.


References

Stage 11-12

Streeter GL. Developmental horizons in human embryos. Description of age group XI, 13 to 20 somites, and age group XII, 21 to 29 somites. (1942) Contrib. Embryol., Carnegie Inst. Wash. Publ. 541, 30: 211-245.

Stage 13-14

Streeter GL. Developmental horizons in human embryos. Description of age group XIII, embryos about 4 or 5 millimeters long, and age group XIV, period of indentation of the lens vesicle. (1945) Carnegie Instn. Wash. Publ. 557, Contrib. Embryol., Carnegie Inst. Wash., 31: 27-63.

Stage 15-18

Streeter GL. Developmental horizons in human embryos. Description of age groups XV, XVI, XVII, and XVIII, being the third issue of a survey of the Carnegie collection. (1948) Contrib. Embryol., Carnegie Inst. Wash. 575, 32: 133-203.

Stage 11-23

Streeter GL. Developmental horizons in human embryos. Age groups XI to XXIII. (1951) Carnegie Institution of Washington, Washington, D. C.

Stage 19-23

Streeter GL. Developmental Horizons In Human Embryos Description Or Age Groups XIX, XX, XXI, XXII, And XXIII, Being The Fifth Issue Of A Survey Of The Carnegie Collection. (1957) Carnegie Instn. Wash. Publ. 611, Contrib. Embryol., 36: 167-196.


Historic Stages

Historic Disclaimer - information about historic embryology pages 
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Pages where the terms "Historic Textbook" and "Historic Embryology" appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms and interpretations may not reflect our current scientific understanding.     (More? Embryology History | Historic Embryology Papers)

His's Normentafel

Keibel and Elze Normentafel (1908)


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Cite this page: Hill, M.A. 2017 Embryology Carnegie stage table. Retrieved November 17, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_table

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© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G