Carnegie stage 22

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Introduction

Stage22 bf1c.jpg

Facts

Week 8, 54 - 56 days, 23 - 28 mm

Gestational age GA week 10

Summary

  • Ectoderm:
  • Mesoderm: heart prominence, ossification continues
  • Head: nose, eye, external acoustic meatus
  • Body: straightening of trunk, heart, liver, umbilical cord
  • Limb: upper limbs longer and bent at elbow, foot plate with webbed digits, wrist, hand plate with separated digits


See also Carnegie stage 22 Events

Features

  • Identify: straightening of trunk, pigmented eye, eyelid, nose, external acoustic meatus, ear auricle, scalp vascular plexus, separated digits (fingers), thigh, ankle, umbilical cord
  • hearing - cochlea continues spiral growth.


Stage 22 Links: Week 8 | System Development | Lecture - Limb | Lecture - Head Development | Lecture - Sensory | Science Practical - Head | Science Practical - Sensory | Science Practical - Urogenital | Historic - Skull Development | Carnegie Embryos | Madrid Embryos | Category:Carnegie Stage 22 | Next Stage 23
  Historic Papers: 1914 | 1954 Stage 19-23


Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Kyoto Collection

Stage22 bf1a.jpg

Lateral view. Amniotic membrane removed.


Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Image source: Embryology page Created: 19.03.1999

Carnegie Collection

Stage22 bf3.jpg Stage22 bf5.jpg Stage22 bf4.jpg

Stage22 bf6.jpg Stage22 bf8.jpg Stage22 bf7.jpg



Carnegie Collection - Stage 22 
Serial No. Size (mm) Grade Fixative Embedding Medium Plane Thinness (µm) Stain Point Score Sex Year Notes
392 E., 23 Ch., 45x45x25 Poor ... P Sag. 50 Al. coch. 42 M 1907 Brödel Collection. Injected
405 E., 26 Good Formol C Sag. 40 Carmine 42.5 M 1907
464 E.,26 Ch., 45x40x30 Good Formol? alc? P Sag. 100 Al. coch. 44.5 F 1910
584A E.,25 Ch., 50x42x40 Poor Formol P Sag. 50 Al. coch. 41  ? 1913
630 E., 25 Poor Formol P Trans. 100 Al. coch. 46 F 1913
840 E, 24.8 Good Formol P Trans. 50 Al. coch. 44.5 M 1914
875 E, 27 Ch., 40x28x22 Good Formol P Sag. 40 Al. coch. 45 F 1914
895 E., 26 Ch., 67x62x54 Good Formol P Trans. 25 Al. coch. 46.5 M 1914
1315 E.,25 Good Formol P Sag. 50 Al. coch. 40.5 M 1915 Spina bifida and anencephaly
1458 E., 27.5 Ch, 45x45x30 Exc. Formol C Sag. 50 (Stain - Haematoxylin Eosin) aur, or. G. 45.5 F 1916
1894 E, 24.6 Good Formol c Sag. 40,80 (Stain - Haematoxylin Eosin) aur, or. G. 41 M 1917
2206 E, 27 Ch, 50x30x18 Poor Formol p Trans. 40 (Stain - Haematoxylin Eosin) 44.5 F 1918
3681 E, 26.3 Ch, 36x36x34 Good Formol p Trans. 25 Al. coch. 44.5 F 1921
4304 E,25 Ch, 66x45x45 Good Bouin p Trans. 20 (Stain - Haematoxylin Eosin) 44.5 M 1923 Injected
4339 E, 24.5 Good Formol p Trans. 15 Al. coch, Mallory 46,5 M 1923
4476 E., 26.2 Good Bouin p Trans. 40 (Stain - Haematoxylin Eosin) 46 M 1923 Tubal
4638 E, 23.4 Exc. Bouin p Trans. 15,20 Al. coch, or. G. 41.5  ?? 1924
6701 E, 24 Poor Formol p Cor. 20 (Stain - Haematoxylin Eosin) 41 M 1933
6832 E, 25.8 Exc. Bouin C-P Cor. 20 (Stain - Haematoxylin Eosin) 42 M 1934
8394 E, 25.3 Ch, 48x50x34 Exc. Bouin C-P Trans. 20 (Stain - Haematoxylin Eosin), Masson 44.5 M 1946
8948 E, 26.7 Ch, 61x51x50 Poor Formol-Zenker p Trans. 15 Ag p . 7 1952
Abbreviations
  • Size - E. is the greatest length of the embryo and Ch. is the mean diameter of the chorion.
  • Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections.
  • Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P).
  • Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution)
  • Stain -
  •  ? - unknown or not determined.


iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Hinrichsen Collection

ME31 001.jpg

ME 31 Carnegie stage 22

Image source: The Hinrichsen Collection images are reproduced with the permission of Prof. Beate Brand-Saberi, Head, Department of Anatomy and Molecular Embryology, Ruhr-Universität Bochum. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Madrid Collection

Madrid Collection Embryos  
Carnegie
Stage
Embryo Days CRL (mm) Section
thickness
Staining Section plane
22 RX 53 23.5 10 (Stain - Haematoxylin Eosin) transverse
22 H7 54 24 10 (Stain - Haematoxylin Eosin) transverse
22 R3 55 25 10 (Stain - Haematoxylin Eosin) frontal
22 Eo2 55 26 10 (Stain - Haematoxylin Eosin)-trichrome transverse


Stage 22 Movies

Movies - Embryo Carnegie stage 22 - These are rotating embryo animations based upon reconstruction of serial slice images.

Stage22 ALL3d.jpg
 ‎‎Systems
Page | Play
Stage22-GIT-icon.jpg
 ‎‎Gastrointestinal
Page | Play
Stage22-CVS-icon.jpg
 ‎‎Cardiovascular
Page | Play
Stage22-CNS-icon.jpg
 ‎‎Stage 22 Neural
Page | Play
Stage22-CNS-icon.jpg
 ‎‎Urogenital
Page | Play
Stage22-CNS-icon.jpg
 ‎‎Skeletal
Page | Play

These 3d movies were part of the UNSW Medical degree Independent Learning Project (ILP) prepared by Aashish Kumar (2006).


Stage 22 Serial Section Images

Virtual Slides

Stage 22 image 099 icon.jpg These are high resolution histological sections (Stain - Haematoxylin Eosin) through regions of the Stage 22 human embryo from the original serial section set shown below. See also High resolution image extracts.
Stage 22 - Eye and Nose

Stage 22 image 008.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Eye

Stage 22 image 008-eye.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Oral Cavity and Inner Ear

Stage 22 image 011.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Larynx and Medulla

Stage 22 image 015.jpg

 ‎‎Mobile | Original

Stage 22 | Embryo Slides
Stage 22 - Neck

Stage 22 image 017.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Atria and Lungs

Stage 22 image 025.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Liver and Ductus Venosus

Stage 22 image 034.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Pelvis

Stage 22 image 048.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Spinal Cord

Stage 22 image 033-spinal-cord.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides
Stage 22 - Spinal Cord (rotated)

Human Stage22 spinal cord03.jpg

 ‎‎Mobile | Desktop | Original

Stage 22 | Embryo Slides

High Resolution Images

Serial Sections

These are the original serial images prepared from embryo sections for Embryology practical classes and transferred online in 1996.

Links: Carnegie stage 22 - serial sections | Carnegie stage 13 - serial sections | Carnegie stage 13

Labeled

Stage 22L serial labeled images
Stage 22 image 050.jpg Stage 22 image 051.jpg Stage 22 image 052.jpg Stage 22 image 053.jpg Stage 22 image 054.jpg Stage 22 image 055.jpg Stage 22 image 056.jpg
A1L A2L A3L A4L A5L A6L A7L
Stage 22 image 057.jpg Stage 22 image 058.jpg Stage 22 image 059.jpg Stage 22 image 060.jpg Stage 22 image 061.jpg Stage 22 image 062.jpg Stage 22 image 063.jpg
B1L B2L B3L B4L B5L B6L B7L
Stage 22 image 064.jpg Stage 22 image 065.jpg Stage 22 image 066.jpg Stage 22 image 067.jpg Stage 22 image 068.jpg Stage 22 image 069.jpg Stage 22 image 070.jpg
C1L C2L C3L C4L C5L C6L C7L
Stage 22 image 071.jpg Stage 22 image 072.jpg Stage 22 image 073.jpg Stage 22 image 074.jpg Stage 22 image 075.jpg Stage 22 image 076.jpg Stage 22 image 077.jpg
D1L D2L D3L D4L D5L D6L D7L
Stage 22 image 078.jpg Stage 22 image 079.jpg Stage 22 image 080.jpg Stage 22 image 081.jpg Stage 22 image 082.jpg Stage 22 image 083.jpg Stage 22 image 084.jpg
E1L E2L E3L E4L E5L E6L E7L
Stage 22 image 085.jpg Stage 22 image 086.jpg Stage 22 image 087.jpg Stage 22 image 088.jpg Stage 22 image 089.jpg Stage 22 image 090.jpg Stage 22 image 091.jpg
F1L F2L F3L F4L F5L F6L F7L
Stage 22 image 092.jpg Stage 22 image 093.jpg Stage 22 image 094.jpg Stage 22 image 095.jpg Stage 22 image 096.jpg Stage 22 image 097.jpg Stage 22 image 098.jpg
G1L G2L G3L G4L G5L G6L G7L


Unlabeled

Stage 22 serial unlabeled images
Stage 22 image 001.jpg Stage 22 image 002.jpg Stage 22 image 003.jpg Stage 22 image 004.jpg Stage 22 image 005.jpg Stage 22 image 006.jpg Stage 22 image 007.jpg
A1 A2 A3 A4 A5 A6 A7
Stage 22 image 008.jpg Stage 22 image 009.jpg Stage 22 image 010.jpg Stage 22 image 011.jpg Stage 22 image 012.jpg Stage 22 image 013.jpg Stage 22 image 014.jpg
B1 B2 B3 B4 B5 B6 B7
Stage 22 image 015.jpg Stage 22 image 016.jpg Stage 22 image 017.jpg Stage 22 image 018.jpg Stage 22 image 019.jpg Stage 22 image 020.jpg Stage 22 image 021.jpg
C1 C2 C3 C4 C5 C6 C7
Stage 22 image 022.jpg Stage 22 image 023.jpg Stage 22 image 024.jpg Stage 22 image 025.jpg Stage 22 image 026.jpg Stage 22 image 027.jpg Stage 22 image 028.jpg
D1 D2 D3 D4 D5 D6 D7
Stage 22 image 029.jpg Stage 22 image 030.jpg Stage 22 image 031.jpg Stage 22 image 032.jpg Stage 22 image 033.jpg Stage 22 image 034.jpg Stage 22 image 035.jpg
E1 E2 E3 E4 E5 E6 E7
Stage 22 image 036.jpg Stage 22 image 037.jpg Stage 22 image 038.jpg Stage 22 image 039.jpg Stage 22 image 040.jpg Stage 22 image 041.jpg Stage 22 image 042.jpg
F1 F2 F3 F4 F5 F6 F7
Stage 22 image 043.jpg Stage 22 image 044.jpg Stage 22 image 045.jpg Stage 22 image 046.jpg Stage 22 image 047.jpg Stage 22 image 048.jpg Stage 22 image 049.jpg
G1 G2 G3 G4 G5 G6 G7


Stage 22 Selected Serial Section Images

About Stage 22 Embryo Sections - The Carnegie stage 22 human embryo is 27 mm (CRL) in size and approximately equal to day 54 - 56 of development (week 8). These images have been selected to show some key features of late embryo development.

Links: Carnegie stage 22 - selected serial sections‎‎ | Carnegie stage 22 - serial sections | Carnegie stage 22 | Embryo Serial Sections
Stage 22 image 099 icon.jpg
Stage 22 serial unlabeled images

A1   A2   A3   A4   A5   A6   A7

B1   B2   B3   B4   B5   B6   B7

C1   C2   C3   C4   C5   C6   C7

D1   D2   D3   D4   D5   D6   D7

E1   E2   E3   E4   E5   E6   E7

F1   F2   F3   F4   F5   F6   F7

G1   G2   G3   G4   G5   G6   G7

Stage 22 Serial labeled images

A1L  A2L  A3L  A4L  A5L  A6L  A7L

B1L  B2L  B3L  B4L  B4L  B6L  B7L

C1L  C2L  C3L  C4L  C5L  C6L  C7L

D1L  D2L  D3L  D4L  D5L  D6L  D7L

E1L  E2L  E3L  E4L  E5L  E6L  E7L

F1L  F2L  F3L  F4L  F5L  F6L  F7L

G1L  G2L  G3L  G4L  G5L  G6L  G7L


Events

  • Vision - (stage 19 -22) the eyelid folds develop into the eyelids and cover more of the eye as the palpebral fissure takes shape. The upper and the lower eyelids meet at the outer canthus in Stage 19. [2]
  • Endocrine System Development[3]
    • Parathyroids - Parathyroids 4 become detached from the pharyngeal endoderm (Jirfisek 1980).
    • Adrenal Cortex - the C2 cells have changed and resemble fibrocytes.[4]
  • Meninges (Spinal Cord) - cavity formation in the meninx primitiva has progressed, and the rudimentary ventral dura is more distinct. Ventral to the medial edge of the ganglia, this dense dural rudiment is separated from the lateral extremities of the centra and intervertebral disks. Within this space a large longitudinal venous channel is developing. The dura can be identified around the spinal ganglia, which are now shifting into the intervertebral foramina, but becomes less distinct as it passes dorsad. The ventral dura can be followed throughout the cervical, thoracic, and lumbar segments, but in the sacral segments it can be identified only on the dorsal surfaces of the intervertebral disks.[5]


References

  1. Streeter GL. Developmental Horizons In Human Embryos Description Or Age Groups XIX, XX, XXI, XXII, And XXIII, Being The Fifth Issue Of A Survey Of The Carnegie Collection. (1957) Carnegie Instn. Wash. Publ. 611, Contrib. Embryol., 36: 167-196.
  2. Pearson AA. The development of the eyelids. Part I. External features. (1980) J. Anat.: 130(1): 33-42. PMID 7364662 PDF
  3. O'Rahilly R. The timing and sequence of events in the development of the human endocrine system during the embryonic period proper. (1983) Anat. Embryol., 166: 439-451. PMID 6869855
  4. Crowder RE. The development of the adrenal gland in man, with special reference to origin and ultimate location of cell types and evidence in favor of the "cell migration" theory. (1957) Contrib. Embryol., Carnegie Inst. Wash. 36, 193-210.
  5. Sensenig EC. The early development of the meninges of the spinal cord in human embryos. (1951) Contrib. Embryol., Carnegie Inst. Wash. Publ. 611,

Additional Images


Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline



Cite this page: Hill, M.A. 2017 Embryology Carnegie stage 22. Retrieved July 21, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_22

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© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G