Abnormal Development - Cytomegalovirus
|Embryology - 20 Feb 2018 Expand to Translate|
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- 1 P35.1 Congenital cytomegalovirus infection
- 1.1 Introduction
- 1.2 Some Recent Findings
- 1.3 Cytomegalovirus Structure
- 1.4 Cytomegalovirus Detection
- 1.5 Cytomegalovirus History
- 1.6 Cytomegalovirus Musculoskeletal
- 1.7 Cytomegalovirus Placentitis
- 1.8 References
- 1.9 External Links
- 1.10 Glossary Links
P35.1 Congenital cytomegalovirus infection
Human cytomegalovirus (HCMV, Greek, cyto = "cell", megalo = "large") or Human Herpesvirus 5 (HHV-5) is a member of the herpes virus family. A viral infection that causes systemic infection and extensive brain damage and cell death by necrosis. Cytomegalovirus is the leading cause of congenital viral infection, with a range of incidence between 0·5–3% of live births worldwide. Approximately 30% of maternal infections during pregnancy can result in congenital infection. Neonates with congenital or perinatal cytomegalovirus infection can be asymptomatic and infection can also be transmitted postnatally from mother to infant by breastfeeding.
HCMV infection is ranked as one of the most common infections in adults, with the seropositive rates ranging from 60–99% globally. In Western countries, adults with advanced AIDS prior to the introduction of highly active antiretroviral therapy (HAART) this virus also a cause of blindness (CMV retinitis) and death in patients.
Congenital cytomegalovirus infection is also a cause of non-hereditary congenital sensorineural hearing loss.
Some Recent Findings
"Congenital cytomegalovirus (cCMV) infections are the most prevalent intrauterine infections worldwide and are the result of maternal primary or non-primary infections. Early maternal primary infections are thought to carry the highest risk of fetal developmental abnormalities as seen by ultrasound; however, non-primary infections may prove equally detrimental. METHODS/RESULTS: This case series presents 5 cases with fetal abnormalities detected in the second and third trimester, in which cCMV infection was ruled out due to negative maternal CMV-IgM. DISCUSSION: This series highlights the possible pitfalls in serology interpretation and fetal diagnosis necessary for appropriate parental counseling. Once fetal abnormalities have been confirmed and cCMV is suspected, maternal CMV serostatus and fetal infection should be determined. Maternal CMV serology may be ambiguous; therefore, caution should be exercised when interpreting the results."
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Fei Zou, Zhi-Tao Lu, Shuang Wang, Si Wu, Ying-Ying Wu, Zheng-Rong Sun Human cytomegalovirus UL141 protein interacts with CELF5 and affects viral DNA replication. Mol Med Rep: 2018; PubMed 29328469
L M Mikhaleva, M N Boltovskaya, S A Mikhalev, I I Babichenko, R A Vandysheva [Endometrial dysfunction caused by chronic endometritis: сlinical and morphological aspects]. [Kliniko-morfologicheskie aspekty éndometrial'noĭ disfunktsii, obuslovlennoĭ khronicheskim éndometritom.] Arkh. Patol.: 2017, 79(6);22-29 PubMed 29265074
V Larouche, M Tamilia Cytomegalovirus-mononucleosis-induced thyroiditis in an immunocompetent patient. Endocrinol Diabetes Metab Case Rep: 2017, 2017; PubMed 29204277
Cora Alexandra Voekt, Therese Rinderknecht, Hans Hellmuth Hirsch, Annette Blaich, Irene Mathilde Hösli Ultrasound indications for maternal STORCH testing in pregnancy. Swiss Med Wkly: 2017, 147;w14534 PubMed 29185251
Iêda M Orioli, Helen Dolk, Jorge S Lopez-Camelo, Daniel Mattos, Fernando A Poletta, Maria G Dutra, Flavia M Carvalho, Eduardo E Castilla Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study. BMJ: 2017, 359;j5018 PubMed 29162597
- double-stranded linear DNA virus
- 235 Kb in size
Cytomegalovirus infected spermatozoa nucleus
|Full and empty viral capsids||HCMV virions|
Image shows human embryonic lung infected by cytomegalovirus demonstrated by an immunofluorescent technique. Viral infection causes systemic infection and extensive brain damage and cell death by necrosis.
A combination of tests has been used for prenatal diagnosis and there are some less reliable sonographic features to the infection.
- maternal serum - specific immunoglobulin (IgM) antibodies
- amniotic fluid - viral culture and PCR amplification of CMV DNA.
- 1921 - first to suggest that the "cytomegalia" could be due to a viral agent.
- 1950 - demonstrated that infection may occur in utero.
- 1956-57 - several groups independently isolate human CMV strains.
- 1960 - the term "cytomegalovirus" introduced.
|A mouse model of effects of cytomegalovirus infection on development has shown induction of micrognathia and other musculoskeletal abnormalities by impacting on signalling pathways, involving FN, NF-kappaB2, RelA, RelB, and Shh and Smad7 proteins.||
Cytomegalovirus induced micrognathia and abnormal skeletogenesis in mouse model.
Clinical term for the cytomegalovirus infection of the placenta.
A earlier histological study identified fixed connective tissue cells predominantly infected cell type in placental tissue. In addition, endothelial cells, macrophages and in some cases trophoblast infection. While a more recent in vitro study suggests that all villi cell types are likely to be infected.
- Victor A Naumenko, Yurii A Tyulenev, Sergei A Yakovenko, Lubov' F Kurilo, Ludmila V Shileyko, Aleksander S Segal, Larisa E Zavalishina, Regina R Klimova, Anton S Tsibizov, Sergei V Alkhovskii, Alla A Kushch Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture. Herpesviridae: 2011, 2(1);7 PubMed 21711549 | Herpesviridae.
- Natacha Teissier, Anne-Lise Delezoide, Anne-Elisabeth Mas, Suonavy Khung-Savatovsky, Bettina Bessières, Jeannette Nardelli, Christelle Vauloup-Fellous, Olivier Picone, Nadira Houhou, Jean-François Oury, Thierry Van Den Abbeele, Pierre Gressens, Homa Adle-Biassette Inner ear lesions in congenital cytomegalovirus infection of human fetuses. Acta Neuropathol.: 2011, 122(6);763-74 PubMed 22033878
- Magdalena Angelova, Kevin Zwezdaryk, MaryBeth Ferris, Bin Shan, Cindy A Morris, Deborah E Sullivan Human cytomegalovirus infection dysregulates the canonical Wnt/β-catenin signaling pathway. PLoS Pathog.: 2012, 8(10);e1002959 PubMed 23071438 | PLoS Pathog.
- Julia Gunkel, Bloeme J van der Knoop, Joppe Nijman, Linda S de Vries, Gwendolyn T R Manten, Peter G J Nikkels, Jean-Luc Murk, Johanna I P de Vries, Tom F W Wolfs Congenital Cytomegalovirus Infection in the Absence of Maternal Cytomegalovirus-IgM Antibodies. Fetal. Diagn. Ther.: 2017; PubMed 28259882
- M Enders, A Daiminger, S Exler, K Ertan, G Enders, R Bald Prenatal diagnosis of congenital cytomegalovirus infection in 115 cases: a 5 years' single centre experience. Prenat. Diagn.: 2017; PubMed 28207161
- Efraim Bilavsky, Joseph Pardo, Joseph Attias, Itzhak Levy, Jean-François Magny, Yves Ville, Marianne Leruez-Ville, Jacob Amir Clinical Implications for Children Born with Congenital Cytomegalovirus Infection Following a Negative Amniocentesis. Clin. Infect. Dis.: 2016; PubMed 27114380
- Natanja Oosterom, Joppe Nijman, Julia Gunkel, Tom F W Wolfs, Floris Groenendaal, Malgosia A Verboon-Maciolek, Linda S de Vries Neuro-Imaging Findings in Infants with Congenital Cytomegalovirus Infection: Relation to Trimester of Infection. Neonatology: 2015, 107(4);289-296 PubMed 25790782
- Liliana Gabrielli, Maria Paola Bonasoni, Donatella Santini, Giulia Piccirilli, Angela Chiereghin, Brunella Guerra, Maria Paola Landini, Maria Grazia Capretti, Marcello Lanari, Tiziana Lazzarotto Human fetal inner ear involvement in congenital cytomegalovirus infection. Acta Neuropathol Commun: 2013, 1(1);63 PubMed 24252374
- Ennio Polilli, Giustino Parruti, Francesca D'Arcangelo, Elisa Tracanna, Luigi Clerico, Vincenzo Savini, Francesco D'Antonio, Maurizio Rosati, Lamberto Manzoli, Domenico D'Antonio, Giovanni Nigro Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection. Clin. Vaccine Immunol.: 2012, 19(12);1991-3 PubMed 23100477
- T Lazzarotto, B Guerra, L Gabrielli, M Lanari, M P Landini Update on the prevention, diagnosis and management of cytomegalovirus infection during pregnancy. Clin. Microbiol. Infect.: 2011, 17(9);1285-93 PubMed 21631642
- Tina Jaskoll, George Abichaker, Parish P Sedghizadeh, Pablo Bringas, Michael Melnick Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev. Biol.: 2008, 8;33 PubMed 18371224 | BMC Dev Biol.
- C Sinzger, H Müntefering, T Löning, H Stöss, B Plachter, G Jahn Cell types infected in human cytomegalovirus placentitis identified by immunohistochemical double staining. Virchows Arch A Pathol Anat Histopathol: 1993, 423(4);249-56 PubMed 8236822
- Liu Tao, Chen Suhua, Chen Juanjuan, Yin Zongzhi, Xiao Juan, Zhang Dandan In vitro study on human cytomegalovirus affecting early pregnancy villous EVT's invasion function. Virol. J.: 2011, 8;114 PubMed 21392403
- Medical Microbiology. 4th edition. Baron S, editor. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Medical Microbiology- Cytomegalovirus | Search Medical Microbiology "Cytomegalovirus"
- Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Viruses Exploit Host Cell Machinery for All Aspects of Their Multiplication
- Disease Control Priorities in Developing Countries. 2nd edition. Jamison DT, Breman JG, Measham AR, et al., editors. Washington (DC): World Bank; 2006. Chapter 20Vaccine-preventable Diseases
Amanda Carlson, Errol R Norwitz, Robert J Stiller Cytomegalovirus infection in pregnancy: should all women be screened? Rev Obstet Gynecol: 2010, 3(4);172-9 PubMed 21364849
Yoav Yinon, Dan Farine, Mark H Yudin Screening, diagnosis, and management of cytomegalovirus infection in pregnancy. Obstet Gynecol Surv: 2010, 65(11);736-43 PubMed 21375790
F Mosca, L Pugni Cytomegalovirus infection: the state of the art. J Chemother: 2007, 19 Suppl 2;46-8 PubMed 18073181
J Hassan, J Connell Translational mini-review series on infectious disease: congenital cytomegalovirus infection: 50 years on. Clin. Exp. Immunol.: 2007, 149(2);205-10 PubMed 17635529
Shimon Degani Sonographic findings in fetal viral infections: a systematic review. Obstet Gynecol Surv: 2006, 61(5);329-36 PubMed 16635273
Maria Grazia Revello, Giuseppe Gerna Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin. Microbiol. Rev.: 2002, 15(4);680-715 PubMed 12364375
Jessica L Nyholm, Mark R Schleiss Prevention of maternal cytomegalovirus infection: current status and future prospects. Int J Womens Health: 2010, 2;23-35 PubMed 21072294
Suresh B Boppana, Shannon A Ross, Zdenek Novak, Masako Shimamura, Robert W Tolan, April L Palmer, Amina Ahmed, Marian G Michaels, Pablo J Sánchez, David I Bernstein, William J Britt, Karen B Fowler, National Institute on Deafness and Other Communication Disorders CMV and Hearing Multicenter Screening (CHIMES) Study Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. JAMA: 2010, 303(14);1375-82 PubMed 20388893
H D Riley History of the cytomegalovirus. South. Med. J.: 1997, 90(2);184-90 PubMed 9042169
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- Centers for Disease Control and Prevention Cytomegalovirus (CMV) and Congenital CMV Infection | testing-diagnosis | The Congenital Disease Mothers Don't Know About
- PubMed Health Congenital cytomegalovirus
- MedlinePlus Congenital cytomegalovirus
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Cite this page: Hill, M.A. (2018, February 20) Embryology Abnormal Development - Cytomegalovirus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Cytomegalovirus
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