Placodes: Difference between revisions
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* '''An effective assay for high cellular resolution time-lapse imaging of sensory placode formation and morphogenesis'''<ref><pubmed>2155472</pubmed>| [http://www.biomedcentral.com/1471-2202/12/37 BMC Neurosci.]</ref> "This new imaging assay provides a powerful method to analyze directly development of placode-derived sensory neurons and subsequent ganglia formation for the first time in amniotes. Viewing placode development in a head cross-section provides a vantage point from which it is possible to study comprehensive events in placode formation, from differentiation, cell ingression to ganglion assembly. Understanding how placodal neurons form may reveal a new mechanism of neurogenesis distinct from that in the central nervous system and provide new insight into how cells acquire motility from a stationary epithelial cell type." | |||
* '''Epibranchial Placodes'''<ref><pubmed>20460364</pubmed></ref> "The inner ear and the epibranchial ganglia constitute much of the sensory system in the caudal vertebrate head. ...However, recent studies indicate that both systems arise from a morphologically distinct common precursor domain: the posterior placodal area. This review summarises recent studies into the induction, morphogenesis and innervation of these systems and discusses lineage restriction and cell specification in the context of their common origin." | * '''Epibranchial Placodes'''<ref><pubmed>20460364</pubmed></ref> "The inner ear and the epibranchial ganglia constitute much of the sensory system in the caudal vertebrate head. ...However, recent studies indicate that both systems arise from a morphologically distinct common precursor domain: the posterior placodal area. This review summarises recent studies into the induction, morphogenesis and innervation of these systems and discusses lineage restriction and cell specification in the context of their common origin." | ||
* '''Otic Placode'''<ref><pubmed>20171206</pubmed></ref> "The inner ear epithelium, with its complex array of sensory, non-sensory, and neuronal cell types necessary for hearing and balance, is derived from a thickened patch of head ectoderm called the otic placode. ...Collectively, our results suggest that Wnt8a provides the link between FGF-induced formation of the pre-otic field and restriction of the otic placode to ectoderm adjacent to the hindbrain." | * '''Otic Placode'''<ref><pubmed>20171206</pubmed></ref> "The inner ear epithelium, with its complex array of sensory, non-sensory, and neuronal cell types necessary for hearing and balance, is derived from a thickened patch of head ectoderm called the otic placode. ...Collectively, our results suggest that Wnt8a provides the link between FGF-induced formation of the pre-otic field and restriction of the otic placode to ectoderm adjacent to the hindbrain." | ||
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* '''Postotic Placode'''<ref><pubmed>20554875</pubmed></ref> "The (zebrafish) embryonic line originates from a postotic placode that produces both a migrating sensory primordium and afferent neurons. Nothing is known about the origin and innervation of the larval lines. Here we show that a "secondary" placode can be detected at 24 h postfertilization (hpf), shortly after the primary placode has given rise to the embryonic primordium and ganglion." | * '''Postotic Placode'''<ref><pubmed>20554875</pubmed></ref> "The (zebrafish) embryonic line originates from a postotic placode that produces both a migrating sensory primordium and afferent neurons. Nothing is known about the origin and innervation of the larval lines. Here we show that a "secondary" placode can be detected at 24 h postfertilization (hpf), shortly after the primary placode has given rise to the embryonic primordium and ganglion." | ||
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(More? [[Talk:Placodes|Recent References]]) | |||
==Otic Placode== | ==Otic Placode== |
Revision as of 10:19, 26 November 2011
Introduction
Placodes are ectodermal thickenings which have important roles in development of special sensory systems.
In human development, during week 4 a series of thickened surface ectodermal patches form in pairs rostro-caudally in the head region.
Recent research suggests that all sensory placodes may arise from common panplacodal primordium origin around the neural plate, and then differentiate to eventually have different developmental fates. These sensory placodes will later contribute key components of each of our special senses (vision, hearing and smell). Note that their initial postion on the developing head is significantly different to their final position in the future sensory system.
- Adenohypophyseal placode
- Otic placodes - the first placodes visible on the surface of the embryo.
- Olfactory (Nasal) placodes - has 2 components (medial and lateral) and will form the nose olfactory epithelium.
- Optic (Lens) placodes - lies on the surface, adjacent to the outpocketing of the nervous system (which will for the retina) and will form the lens.
- Profundal/trigeminal placodes
Other species have a number of other placodes which form additional sensory structures (fish, lateral line receptor).
- Epibranchial placodes
- Lateral line placodes
- Hypobranchial placodes
- Links: Week 4 | Sensory System Development
Some Recent Findings
|
(More? Recent References)
Otic Placode
The otic placode is the first of the sensory placodes visible on the surface of the developing human embryo. This placode will differentiate to contribute almost entirely the components of the inner ear. The images below show the first appearance on the embryo surface during week 4 and the eventual disappearance from the surface by week 5. This is only the beginning of the complex development of this structure, influenced by the surrounding epidermis, neural tube and neural crest.
Stage 11
The scanning EM of the week 4 human embryo Carnegie stage 11 shown below is a superior dorsal view of the paired otic placodes sinking into the surface at the level of the hindbrain between day 24 and day 25.
Stage 12
By Carnegie stage 12 26 days, only a small opening of the developing otic vesicle (otocyst) remains visible on the embryo surface located behind the second pharyngeal arch.
Stage 13
By week 5 Carnegie stage 13 the otic vesicle (otocyst) is completely formed and is no longer visible on the embryo surface.
Cross-sections of the embryo head at this stage show the otocyst now lies within the embryo as a hollow fluid-filled epithelial "ball", located between the epidermis and the neural tube (hindbrain).
A2L | A3L | A4L | A5L |
- Links: Inner Ear | Hearing and Balance Development
Adenohypophyseal Placode
The hypophysis, or pituitary, is an endocrine gland that links the brain to peripheral endocrine organs and systems of the body through several specific hormones. The developmental origin of the hypophysis is unique, with epithelial origins from neural ectoderm (posterior) and from surface ectoderm (anterior) the adenohypophyseal placode.
In the mouse, gonadotropin-releasing hormone-1 neurones control the release of gonadotropins from the anterior pituitary and were thought to originate from the adenohypophyseal placed. A recent study has shown that they are really associated early with the formation of the nasal placode.[6]
Drosophila and mouse placode similarity[7]
- Links: Pituitary Development
Olfactory Placodes
(Nasal)
Optic Placodes
Optic placodes (Lens) lie on the embryo surface, adjacent to the out-pocketing of the nervous system (forms the retina) and will form the lens.
surface ectoderm -> lens placode -> lens pit -> lens vesicle -> lens fibres -> lens capsule and embryonic/fetal nucleus.
- Links: Lens Development | Vision Development
Trigeminal Placodes
(Profundal)
Sensory System
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
References
- ↑ <pubmed>20885782</pubmed>| PLoS Genet.
- ↑ <pubmed>2155472</pubmed>| BMC Neurosci.
- ↑ <pubmed>20460364</pubmed>
- ↑ <pubmed>20171206</pubmed>
- ↑ <pubmed>20554875</pubmed>
- ↑ <pubmed>20008041</pubmed>
- ↑ <pubmed>18056636</pubmed>| PMC2148390
Online Textbooks
- Colloquium Series on Developmental Biology Induction and Segregation of the Vertebrate Cranial Placodes Park BY, Saint-Jeannet JP. San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
- Developmental Biology (6th ed.) Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000. Chick embryo rhombomere neural crest cells | Some derivatives of the pharyngeal arches | Tissue Architecture of the Central Nervous System | Neuronal Types | Snapshot Summary: Central Nervous System and Epidermis
- Neuroscience Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark. Sunderland (MA): Sinauer Associates, Inc. ; c2001 The Auditory System | The Inner Ear | Early Brain Development
- Clinical Methods 63. Cranial Nerves IX and X: The Glossopharyngeal and Vagus Nerves | The Tongue | 126. The Ear and Auditory System | An Overview of the Head and Neck - Ears and Hearing | Audiometry
- Eurekah Bioscience Collection Cranial Neural Crest and Development of the Head Skeleton
Search Bookshelf placode development
Reviews
pubmed>20801420</pubmed> <pubmed>20460364</pubmed> <pubmed>9927591</pubmed>
Articles
Search Pubmed
June 2010 "placode development" All (852) Review (90) Free Full Text (285)
Search Pubmed placode development | otic placode development | optic placode development | nasal placode development | adenohypophyseal placode development
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
Glossary Links
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Cite this page: Hill, M.A. (2024, May 1) Embryology Placodes. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Placodes
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G