Developmental Signals - Fibroblast Growth Factor: Difference between revisions
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The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the endocrine hormone-like Fgf15/21/23 subfamily (hFGFs), and the paracrine canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. | The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the endocrine hormone-like Fgf15/21/23 subfamily (hFGFs), and the paracrine canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. | ||
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* '''The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle'''{{#pmid:32338604|PMID32338604}} "Recent studies indicate that many developing tissues modify glycolysis to favor lactate synthesis, but how this promotes development is unclear. Using forward and reverse genetics in zebrafish, we show that disrupting the glycolytic gene phosphoglycerate kinase-1 (pgk1) impairs Fgf-dependent development of hair cells and neurons in the otic vesicle and other neurons in the CNS/PNS. Fgf-MAPK signaling underperforms in pgk1-/- mutants even when Fgf is transiently overexpressed. Wild-type embryos treated with drugs that block synthesis or secretion of lactate mimic the pgk1-/- phenotype, whereas pgk1-/- mutants are rescued by treatment with exogenous lactate. Lactate treatment of wild-type embryos elevates expression of Etv5b/Erm even when Fgf signaling is blocked. However, lactate's ability to stimulate neurogenesis is reversed by blocking MAPK. Thus, lactate raises basal levels of MAPK and Etv5b (a critical effector of the Fgf pathway), rendering cells more responsive to dynamic changes in Fgf signaling required by many developing tissues." | |||
* '''ERK Activity Dynamics during {{Zebrafish}} Embryonic Development'''{{#pmid:30597912|PMID30597912}} "During vertebrate development, extracellular signal-regulated kinase (ERK) is activated by growth factors such as fibroblast growth factor (FGF), and it regulates the formation of tissues/organs including eyes, brains, somites, limbs, and inner ears. However, an experimental system to monitor ERK activity dynamics in the entire body of the vertebrate embryo is lacking. We recently studied ERK activity dynamics in the pre-somitic mesoderm of living zebrafish embryos injected with mRNAs encoding a Förster resonance energy transfer (FRET)-based ERK biosensor. ... A spatiotemporal map of ERK activity in the entire body during zebrafish embryogenesis was generated, and previously unidentified activation dynamics and ERK domains were identified." | * '''ERK Activity Dynamics during {{Zebrafish}} Embryonic Development'''{{#pmid:30597912|PMID30597912}} "During vertebrate development, extracellular signal-regulated kinase (ERK) is activated by growth factors such as fibroblast growth factor (FGF), and it regulates the formation of tissues/organs including eyes, brains, somites, limbs, and inner ears. However, an experimental system to monitor ERK activity dynamics in the entire body of the vertebrate embryo is lacking. We recently studied ERK activity dynamics in the pre-somitic mesoderm of living zebrafish embryos injected with mRNAs encoding a Förster resonance energy transfer (FRET)-based ERK biosensor. ... A spatiotemporal map of ERK activity in the entire body during zebrafish embryogenesis was generated, and previously unidentified activation dynamics and ERK domains were identified." | ||
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* '''A review of FGF signaling in {{palate}} development'''{{#pmid:29655165|PMID29655165}} "The fibroblast growth factors ({{FGF}}s) play a critical role during palatogenesis by mediating a variety of cellular responses. Extensive epidemiological and genetic studies over several decades in humans have revealed members of the FGF family function as candidate genes for syndromic and nonsyndromic cleft lip and cleft palate. The findings that FGFs signaling work delicately in the development of palate have been confirmed in mice carrying targeted mutations. Here we try to review recent progress toward a detailed understanding of FGF signaling including FGF7, FGF8, FGF9, FGF10, FGF18 and their receptors FGFR1, FGFR2 in palate development studies and discuss how they interact with other factors on the basis of animal studies regarding {{cleft palate}}." {{palate}} | * '''A review of FGF signaling in {{palate}} development'''{{#pmid:29655165|PMID29655165}} "The fibroblast growth factors ({{FGF}}s) play a critical role during palatogenesis by mediating a variety of cellular responses. Extensive epidemiological and genetic studies over several decades in humans have revealed members of the FGF family function as candidate genes for syndromic and nonsyndromic cleft lip and cleft palate. The findings that FGFs signaling work delicately in the development of palate have been confirmed in mice carrying targeted mutations. Here we try to review recent progress toward a detailed understanding of FGF signaling including FGF7, FGF8, FGF9, FGF10, FGF18 and their receptors FGFR1, FGFR2 in palate development studies and discuss how they interact with other factors on the basis of animal studies regarding {{cleft palate}}." {{palate}} | ||
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| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | | [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | ||
Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fibroblast+Growth+Factor ''Fibroblast Growth Factor''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=FGF ''FGF''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=ERK ''ERK''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fibroblast+Growth+Factor ''Fibroblast Growth Factor''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=FGF ''FGF''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=ERK ''ERK''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fibroblast+Growth+Factor+Receptor ''Fibroblast Growth Factor Receptor''] | ||
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| {{Older papers}} | | {{Older papers}} | ||
* '''FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain'''{{#pmid:29158323|PMID29158323}} "Fibroblast growth factor (FGF) morphogen signalling through the evolutionarily ancient extracellular signalling-regulated kinase/mitogen activated protein kinase (ERK/MAPK) pathway recurs in many neural and non-neural developmental contexts, and understanding the mechanisms that regulate FGF/ERK function are correspondingly important. The glycosaminoglycan heparan sulphate (HS) binds to FGFs and exists in an enormous number of differentially sulphated forms produced by the action of HS modifying enzymes, and so has the potential to present an extremely large amount of information in FGF/ERK signalling. ...We discover that two different HS modifying enzymes, Hs2st and Hs6st1, indeed differentially modulate the properties of emerging Fgf8 protein concentration gradients and the Erk signalling output in response to Fgf8 in living tissue in ex vivo cultures. Both Hs2st and Hs6st1 are required for stable Fgf8 gradients to form as rapidly as they do in wild-type tissue while only Hs6st1 has a significant effect on suppressing the levels of Fgf8 protein in the gradient compared to wild type. Next we show that Hs2st and Hs6st1 act to antagonise and agonise the Erk signalling in response to Fgf8 protein, respectively, in ex vivo cultures of living tissue. Examination of endogenous Fgf8 protein and Erk signalling outputs in Hs2st-/- and Hs6st1-/- embryos suggests that our ex vivo findings have physiological relevance in vivo Our discovery identifies a new class of mechanism to tune Fgf8 function by regulated expression of Hs2st and Hs6st1 that is likely to have broader application to the >200 other signalling proteins that interact with HS and their function in neural development and disease." | |||
* '''Review - The Multiple Roles of FGF Signaling in the Developing Spinal Cord'''{{#pmid:28626748|PMID28626748}} "During vertebrate embryonic development, the {{spinal cord}} is formed by the neural derivatives of a neuromesodermal population that is specified at early stages of development and which develops in concert with the caudal regression of the primitive streak. Several processes related to {{spinal cord}} specification and maturation are coupled to this caudal extension including neurogenesis, ventral patterning and {{neural crest}} specification and all of them seem to be crucially regulated by Fibroblast Growth Factor ({{FGF}}) signaling, which is prominently active in the neuromesodermal region and transiently in its derivatives. Here we review the role of FGF signaling in those processes, trying to separate its different functions and highlighting the interactions with other signaling pathways." {{spinal cord}} | * '''Review - The Multiple Roles of FGF Signaling in the Developing Spinal Cord'''{{#pmid:28626748|PMID28626748}} "During vertebrate embryonic development, the {{spinal cord}} is formed by the neural derivatives of a neuromesodermal population that is specified at early stages of development and which develops in concert with the caudal regression of the primitive streak. Several processes related to {{spinal cord}} specification and maturation are coupled to this caudal extension including neurogenesis, ventral patterning and {{neural crest}} specification and all of them seem to be crucially regulated by Fibroblast Growth Factor ({{FGF}}) signaling, which is prominently active in the neuromesodermal region and transiently in its derivatives. Here we review the role of FGF signaling in those processes, trying to separate its different functions and highlighting the interactions with other signaling pathways." {{spinal cord}} | ||
Revision as of 10:40, 30 April 2020
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Introduction
Fibroblast Growth Factors (FGF) were originally identified by their ability to stimulate fibroblast cell proliferation but have a role in a growing number of different tissues development and differentiation and continue to have a role in the adult.
The first two identified factors were originally given the nomenclature of acidic or basic. We now know there to be at least 22 different human FGFs (Fgf1–Fgf23). These protein growth factors are bound by 4 different cell membrane receptors (FGFR1-4). FGFRs belong to the tyrosine kinase receptor family.
The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the endocrine hormone-like Fgf15/21/23 subfamily (hFGFs), and the paracrine canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Human FGF Family
Table - Human Fibroblast Growth Factor Family FGF | ||||
Approved Symbol |
Approved Name | Previous Symbols |
Synonyms | Chromosome |
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FGF1 | fibroblast growth factor 1 | FGFA | "AFGF, ECGF, ECGFA, ECGFB, HBGF1, ECGF-beta, FGF-alpha, GLIO703" | 5q31.3 |
FGF2 | fibroblast growth factor 2 | FGFB | 4q28.1 | |
FGF4 | fibroblast growth factor 4 | HSTF1 | "K-FGF, HBGF-4, HST, HST-1, KFGF" | 11q13.3 |
FGF5 | fibroblast growth factor 5 | 4q21.21 | ||
FGF6 | fibroblast growth factor 6 | 12p13.32 | ||
FGF7 | fibroblast growth factor 7 | KGF | 15q21.2 | |
FGF8 | fibroblast growth factor 8 | AIGF | 10q24.32 | |
FGF9 | fibroblast growth factor 9 | 13q12.11 | ||
Links: Developmental Signals - Fibroblast Growth Factor | OMIM Fgf1 | HGNC | Bmp Family | Fgf Family | Sox Family | Tbx Family |
Human FGF Family | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein Properties
Human FGF
- ~150–300 amino acids
- have a conserved ~120-residue core with ~30–60% identity
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Fibroblast Growth Factor | FGF | ERK | Fibroblast Growth Factor Receptor |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Ectoderm
neural crest cell migration during early chicken embryo development[14]
- "Fibroblast growth factor (FGF) signalling acts as one of modulators that control neural crest cell (NCC) migration, but how this is achieved is still unclear. In this study, we investigated the effects of FGF signalling on NCC migration by blocking this process. Constructs that were capable of inducing Sprouty2 (Spry2) or dominant-negative FGFR1 (Dn-FGFR1) expression were transfected into the cells making up the neural tubes. Our results revealed that blocking FGF signalling at stage HH10 (neurulation stage) could enhance NCC migration at both the cranial and trunk levels in the developing embryos. It was established that FGF-mediated NCC migration was not due to altering the expression of N-cadherin in the neural tube. Instead, we determined that cyclin D1 was overexpressed in the cranial and trunk levels when Sprouty2 was upregulated in the dorsal neural tube. These results imply that the cell cycle was a target of FGF signalling through which it regulates NCC migration at the neurulation stage."
Endoderm
Chicken antero-posterior endoderm patterning[15]
- Links: Endoderm | Chicken Development
Mesoderm
A Putative Model for the role of Sprouty4 as a mediator that links the mouse segmentation clock to the gradient of FGF signaling.[16]
The FGF signaling may be periodically inhibited by Sprouty4, by which temporal periodicity of Notch segmentation clock may be translated to spatial periodicity of the array of somites.
- In the PSM - FGF signaling establishes a posterior-to-anterior gradient, which is involved in the positioning of presumptive somite boundaries.
- Cyclic Sprouty4
- which is controlled by the Notch segmentation clock, the mechanism of which includes negative feedback loop of Hes7,
- may inhibit the FGF signaling possibly around the anterior border of the FGF signaling positive area
- where the FGF signaling is close to its threshold.
- S - somite
- PS - presumptive somite.
- Links: somitogenesis | Axial Skeleton Development | Notch | FGF
Bone
FGF9 has been shown to induce endochondral ossification in cranial mesenchyme in the mouse model.[17]
Respiration
Lung Buds
Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.
Branching
Fibroblast growth factor 10 (FGF10) and sonic hedgehog (SHH) form a feedback loop for branching
- mesenchyme produced FGF10 signals to the distal epithelium to upregulate SHH expression.
- SHH then feeds back to inhibit Fgf10 expression in the adjacent mesenchyme, dividing in two the Fgf10 expression domain.
- new FGF10 signaling domains serve as two chemoattractant sources, leading to bifurcation of the epithelial tip.
Loop process mediated through FGF-activated transcription factor genes Etv4 and Etv5.[19]
- Links: respiratory
Limb
FGF soaked beads (FGF-1, FGF-2 and FGF-4) are capable of inducing additional limbs in chicken embryos.[20] A later study[21] identified the endogenous signal as Fgf-8 from initially the intermediate mesoderm and then the prelimb field ectoderm for limb initiation and outgrowth, respectively.
Hearing
- fibroblast growth factor 1 - (Fgf-1) a growth factor released from cochlea sensory epithelium which stimulates spiral ganglion neurite branching.
- fibroblast growth factor 8 - (Fgf-8) a growth factor released by inner hair cells which regulates pillar cell number, position and rate of development.
- fibroblast growth factor receptor 3 - (Fgfr-3) a tyrosine kinase receptor with a role in the commitment, differentiation and position of pillar cells in the organ of corti
- Links: hearing
Palate
Fibroblast growth factors are required during palatogenesis and are candidate genes for syndromic and nonsyndromic cleft lip and cleft palate, see the recent review.[6]
FGF7, FGF8, FGF9, FGF10, FGF18 and their receptors FGFR1, FGFR2
- Links: palate | cleft palate
Abnormalities
- FGFR1 mutation has been associated with the relatively milder form of Pfeiffer syndrome type 1.
- FGFR2 and FGFR3 have been associated with the Apert, Crouzon and Pfeiffer syndromes.
FGF10
A recent mouse knock-out study has shown a single-gene deletion of Fgf10 can generate duodenal atresia in this animal model.[22]
(A) Normal gastric, pyloric, and duodenal morphology was demonstrated by wild type embryos. Null Fgf10 embryos universally demonstrated microgastria, but duodenal morphology varied according to presence and type of DA. Null embryos provided examples of: normal continuity and morphology of the duodenum for tm1 (D) and tm2 (E); type 1 DA, tm1 (F) and tm2 (G); type 2 DA, tm1 (H) and tm2 (I); and type 3 DA, tm1 (J) and tm2 (K).
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References
- ↑ Itoh N. (2010). Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. Cell Tissue Res. , 342, 1-11. PMID: 20730630 DOI.
- ↑ 2.0 2.1 Fongang B & Kudlicki A. (2013). The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network. BMC Dev. Biol. , 13, 42. PMID: 24304493 DOI.
- ↑ Kantarci H, Gou Y & Riley BB. (2020). The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle. Elife , 9, . PMID: 32338604 DOI.
- ↑ Wong KL, Akiyama R, Bessho Y & Matsui T. (2018). ERK Activity Dynamics during Zebrafish Embryonic Development. Int J Mol Sci , 20, . PMID: 30597912 DOI.
- ↑ Row RH, Pegg A, Kinney B, Farr GH, Maves L, Lowell S, Wilson V & Martin BL. (2018). BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. Elife , 7, . PMID: 29877796 DOI.
- ↑ 6.0 6.1 Weng M, Chen Z, Xiao Q, Li R & Chen Z. (2018). A review of FGF signaling in palate development. Biomed. Pharmacother. , 103, 240-247. PMID: 29655165 DOI.
- ↑ Chan WK, Price DJ & Pratt T. (2017). FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain. Biol Open , 6, 1933-1942. PMID: 29158323 DOI.
- ↑ Diez Del Corral R & Morales AV. (2017). The Multiple Roles of FGF Signaling in the Developing Spinal Cord. Front Cell Dev Biol , 5, 58. PMID: 28626748 DOI.
- ↑ Atsuta Y & Takahashi Y. (2015). FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis. Development , 142, 2329-37. PMID: 26130757 DOI.
- ↑ Gredler ML, Seifert AW & Cohn MJ. (2015). Tissue-specific roles of Fgfr2 in development of the external genitalia. Development , 142, 2203-12. PMID: 26081573 DOI.
- ↑ Shifley ET, Kenny AP, Rankin SA & Zorn AM. (2012). Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev. Biol. , 12, 27. PMID: 22988910 DOI.
- ↑ Lahti L, Saarimäki-Vire J, Rita H & Partanen J. (2011). FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors. Dev. Biol. , 349, 270-82. PMID: 21074523 DOI.
- ↑ Yu SR, Burkhardt M, Nowak M, Ries J, Petrásek Z, Scholpp S, Schwille P & Brand M. (2009). Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature , 461, 533-6. PMID: 19741606 DOI.
- ↑ Zhang XT, Wang G, Li Y, Chuai M, Lee KKH & Yang X. (2018). Role of FGF signalling in neural crest cell migration during early chick embryo development. Zygote , , 1-8. PMID: 30520400 DOI.
- ↑ Bayha E, Jørgensen MC, Serup P & Grapin-Botton A. (2009). Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS ONE , 4, e5845. PMID: 19516907 DOI.
- ↑ Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T & Bessho Y. (2009). Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PLoS ONE , 4, e5603. PMID: 19440349 DOI.
- ↑ Govindarajan V & Overbeek PA. (2006). FGF9 can induce endochondral ossification in cranial mesenchyme. BMC Dev. Biol. , 6, 7. PMID: 16504022 DOI.
- ↑ Cardoso WV & Kotton DN. (2008). Specification and patterning of the respiratory system. , , . PMID: 20614584 DOI.
- ↑ Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M & Sun X. (2015). FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev. Cell , 35, 322-32. PMID: 26555052 DOI.
- ↑ Cohn MJ, Izpisúa-Belmonte JC, Abud H, Heath JK & Tickle C. (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell , 80, 739-46. PMID: 7889567
- ↑ Vogel A, Rodriguez C & Izpisúa-Belmonte JC. (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development , 122, 1737-50. PMID: 8674413
- ↑ 22.0 22.1 Teague WJ, Jones MLM, Hawkey L, Smyth IM, Catubig A, King SK, Sarila G, Li R & Hutson JM. (2018). FGF10 and the Mystery of Duodenal Atresia in Humans. Front Genet , 9, 530. PMID: 30473704 DOI.
Reviews
Articles
Su N, Xu X, Li C, He Q, Zhao L, Li C, Chen S, Luo F, Yi L, Du X, Huang H, Deng C & Chen L. (2010). Generation of Fgfr3 conditional knockout mice. Int. J. Biol. Sci. , 6, 327-32. PMID: 20582225
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Cite this page: Hill, M.A. (2024, May 3) Embryology Developmental Signals - Fibroblast Growth Factor. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Fibroblast_Growth_Factor
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G