Developmental Signals - Six

Embryology - 2 Dec 2023 Expand to Translate
Google Translate - select your language from the list shown below (this will open a new external page)
العربية \| català \| 中文 \| 中國傳統的 \| français \| Deutsche \| עִברִית \| हिंदी \| bahasa Indonesia \| italiano \| 日本語 \| 한국어 \| မြန်မာ \| Pilipino \| Polskie \| português \| ਪੰਜਾਬੀ ਦੇ \| Română \| русский \| Español \| Swahili \| Svensk \| ไทย \| Türkçe \| اردو \| ייִדיש \| Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)

Introduction

Sine oculis-related homeobox (SIX) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele^[1] "Omphalocele is a human congenital anomaly in ventral body wall closure and may be caused by impaired formation of the primary abdominal wall (PAW) and/or defects in abdominal muscle development. Here, we report that mice doubly deficient in homeobox genes Six4 and Six5 showed the same ventral body wall closure defects as those seen in human omphalocele. SIX4 and SIX5 were localized in surface ectodermal cells and somatic mesoderm-derived mesenchymal and coelomic epithelial cells (CECs) in the PAW." omphalocele

Activation of Six1 Expression in Vertebrate Sensory Neurons^[2] "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Development Six

Transcription Factor

Neural Development

Vision Development

Abnormalities

omphalocele - Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele ^[1]

References

↑ ^1.0 ^1.1 Takahashi M, Tamura M, Sato S & Kawakami K. (2018). Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele. Dis Model Mech , 11, . PMID: 30237319 DOI.
↑ Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

Search Bookshelf Six

Reviews

Articles

Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

Yajima H, Suzuki M, Ochi H, Ikeda K, Sato S, Yamamura K, Ogino H, Ueno N & Kawakami K. (2014). Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates. BMC Biol. , 12, 40. PMID: 24885223 DOI.

Search Pubmed

Search Pubmed Now: Six

http://www.ncbi.nlm.nih.gov/omim

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

OMIM - Six1

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2023, December 2) Embryology Developmental Signals - Six. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Six

What Links Here?

[PMID30237319-1] 1.0 ^1.1 Takahashi M, Tamura M, Sato S & Kawakami K. (2018). Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele. Dis Model Mech , 11, . PMID: 30237319 DOI.

[PMID26313368-2] Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

[1]

[2]