Abnormal Development - Measles Virus: Difference between revisions

Revision as of 13:30, 2 November 2011

Notice - Mark Hill

Currently this page is only a template and will be updated (this notice removed when completed).

Introduction

Measles (rubeola) is a paramyxovirus appearing mainly as a respiratory viral infection, clinically different from Rubella. A single-stranded RNA virus which is highly contagious. Before measles vaccination (USA 1963) more than 90% of children had an infection before puberty and in developing countries it is still a common and often fatal childhood disease. Childhood immunisation and immunity persists in only about 80% of adults.

Pregnancy effects of measles results in a higher risk of premature labor, spontaneous abortion, low-birth-weight, and possibly rare cases of birth defects with no definable pattern of malformation.^[1]

Historic Embryology - Viral
1941 Rubella Cataracts \| 1944 Rubella Defects

Some Recent Findings

The measles virus replication cycle^[2] "This review describes the two interrelated and interdependent processes of transcription and replication for measles virus. First, we concentrate on the ribonucleoprotein (RNP) complex, which contains the negative sense genomic template and in encapsidated in every virion. Second, we examine the viral proteins involved in these processes, placing particular emphasis on their structure, conserved sequence motifs, their interaction partners and the domains which mediate these associations."

Virus Structure

Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Paramyxoviridae; Paramyxovirinae; Morbillivirus; Measles virus

References

↑ <pubmed>12850161</pubmed>
↑ <pubmed>19198563</pubmed>

Textbooks

Medical Microbiology. 4th edition. Baron S, editor. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Medical Microbiology- Measles
Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Viruses Exploit Host Cell Machinery for All Aspects of Their Multiplication
Disease Control Priorities in Developing Countries. 2nd edition. Jamison DT, Breman JG, Measham AR, et al., editors. Washington (DC): World Bank; 2006. Chapter 20Vaccine-preventable Diseases

Reviews

Articles

Search Pubmed

Search Pubmed: Cytomegalovirus Virus | Congenital Cytomegalovirus Syndrome | Congenital Cytomegalovirus Infection

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

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Cite this page: Hill, M.A. (2024, May 8) Embryology Abnormal Development - Measles Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Measles_Virus

What Links Here?

[1] <pubmed>12850161</pubmed>

[2] <pubmed>19198563</pubmed>

[1]

[2]

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+* '''The measles virus replication cycle'''<ref><pubmed>19198563</pubmed></ref> "This review describes the two interrelated and interdependent processes of transcription and replication for measles virus. First, we concentrate on the ribonucleoprotein (RNP) complex, which contains the negative sense genomic template and in encapsidated in every virion. Second, we examine the viral proteins involved in these processes, placing particular emphasis on their structure, conserved sequence motifs, their interaction partners and the domains which mediate these associations."
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