Cardiovascular System - Transposition of the Great Vessels
Embryology - 15 Jun 2024 Expand to Translate |
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Introduction
Characterized by aorta arising from right ventricle and pulmonary artery from the left ventricle and often associated with other cardiac abnormalities (e.g. ventricular septal defect).
- International Classification of Diseases code 745.1
- Australian national rate (1982-1992) 3.6/10,000 births.
- Of 988 infants 4.1% were stillborn and 23.2% liveborn died during neonatal period.
- slightly more common in twin births than singleton.
- Congenital Malformations Australia 1981-1992 P. Lancaster and E. Pedisich ISSN 1321-8352
- Neonates with transposed great arteries die without an arterial switch operation, first carried out in 1975.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Transposition of the Great Vessels <pubmed limit=5>Transposition of the Great Vessels</pubmed> |
Ultrasound
<html5media height="450" width="640">File:US Transposition Great Arteries GA36week.mp4</html5media>
Ultrasound showing Transposition Great Arteries (GA 36 weeks)
- Links: MP4 movie | Transposition of the Great Vessels | Ultrasound | International Classification of Diseases | Movies
History
1833
The morbid anatomy of some of the most important parts of the human body (1833)[3]
- "A very singular Malformation of the Heart, in a child about two months old, came, some time ago, into my possession : the aorta arose out of the right ventricle, and the pulmonary artery out of the left. There was no communication between the one vessel and the other, except through the small remains of the ductus arteriosus, which was just large enough to admit a crow quill. The foramen ovale was a little more closed than in a child newly born. The heart was of the common size for a child of two months old, and, except for the circumstances which have been stated, it had nothing remarkable in its structure. In this child florid blood must have always been circulating between the lungs and the left side of the heart, except for the admixture of the dark blood which passed through the small communication of the foramen ovale ; and dark blood must have been always circulating between the right side of the heart and the general mass of the body, except for the very small quantity of florid blood which passed into the aorta by the remains of the ductus arteriosus. Life must, therefore, have been supported for a very considerable length of time with hardly any florid blood distributed over the body."
1863
- "The aorta arises from the fleshy part of the base of the right ventricle, at its left portion, where it presents itself in front, being quite uncovered by the pulmonary artery, and is situate between this vessel and the right auricle."[2]
Australian Statistics
Number of women who gave birth to babies with transposition of great vessels, Australia, 2002–2003
Year | Number | Rate1 |
2002 | 105 | 4.3 |
2003 | 103 | 4.1 |
2002–2003 | 208 | 4.2 |
1The rate is per 10,000 women who gave birth.
Based upon Table 2.10.4 of Congenital anomalies in Australia 2002–2003.[4]
International Classification of Diseases
The International Classification of Diseases (ICD) World Health Organization's classification used worldwide as the standard diagnostic tool for epidemiology, health management and clinical purposes. This includes the analysis of the general health situation of population groups. It is used to monitor the incidence and prevalence of diseases and other health problems.
ICD11
- LB01 Congenital anomaly of atrioventricular or ventriculo-arterial connections
- LB01.1 Transposition of the great arteries
ICD-11 Structural developmental anomalies of the circulatory system (draft) |
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ICD-11 Beta Draft - NOT FINAL, updated on a daily basis, It is not approved by WHO, NOT TO BE USED for CODING except for agreed FIELD TRIALS.
20 Developmental Anomalies - Structural Developmental Anomalies Beta coding and tree structure for "structural developmental anomalies" within this section are shown in the table below. |
Structural developmental anomalies of the circulatory system |
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CD-11 Beta Draft - NOT FINAL, updated on a daily basis, It is not approved by WHO, NOT TO BE USED for CODING except for agreed FIELD TRIALS.
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ICD10
ICD-10-AM codes: Q20.1, Q20.3, Q20.5
ICD-9-BPA codes: 745.10–745.19
(ICD) The World Health Organization's classification used worldwide to classify the causes of death. The current version is ICD-10 (1990) that is due for replacement by ICD-11 (2011). A modified version, Australian modification of ICD-10 (ICD-10-AM), is used to classify diagnoses in Australian hospitals. Within this classification "congenital malformations, deformations and chromosomal abnormalities" are (Q00-Q99) but excludes "inborn errors of metabolism" (E70-E90).
- Links: WHO
Cardiovascular Abnormalities
Heart defects and preterm birth are the most common causes of neonatal and infant death. The long-term development of the heart combined with extensive remodelling and post-natal changes in circulation lead to an abundance of abnormalities associated with this system.
A UK study literature showed that preterm infants have more than twice as many cardiovascular malformations (5.1 / 1000 term infants and 12.5 / 1000 preterm infants) as do infants born at term and that 16% of all infants with cardiovascular malformations are preterm. (0.4% of live births occur at greater than 28 weeks of gestation, 0.9% at 28 to 31 weeks, and 6% at 32 to 36 weeks. Overall, 7.3% of live-born infants are preterm)[5]
"Baltimore-Washington Infant Study data on live-born cases and controls (1981-1989) was reanalyzed for potential environmental and genetic risk-factor associations in complete atrioventricular septal defects AVSD (n = 213), with separate comparisons to the atrial (n = 75) and the ventricular (n = 32) forms of partial AVSD. ...Maternal diabetes constituted a potentially preventable risk factor for the most severe, complete form of AVSD." [6]
In addition, there are in several congenital abnormalities that exist in adults (bicuspid aortic valve, mitral valve prolapse, and partial anomalous pulmonary venous connection) which may not be clinically recognized.
References
- ↑ <pubmed>20028930</pubmed>
- ↑ 2.0 2.1 <pubmed>20896216</pubmed>| PMC2147784 | PDF
- ↑ Matthew, Baillie The morbid anatomy of some of the most important parts of the human body (1833) Internet Archive
- ↑ Abeywardana S & Sullivan EA 2008. Congenital anomalies in Australia 2002–2003. Birth anomalies series no. 3 Cat. no. PER 41. Sydney: AIHW National Perinatal Statistics Unit. PDF
- ↑ <pubmed>16322141</pubmed>
- ↑ <pubmed>11241431</pubmed>
Reviews
<pubmed>18851735</pubmed> <pubmed>15987628</pubmed>
Articles
<pubmed>15547014</pubmed> <pubmed>2107695</pubmed> <pubmed>3348669</pubmed>
Search Pubmed
Search Pubmed: Transposition of the Great Vessels
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Cite this page: Hill, M.A. (2024, June 15) Embryology Cardiovascular System - Transposition of the Great Vessels. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Transposition_of_the_Great_Vessels
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G