Cardiovascular System - Ventricular Septal Defects
|Embryology - 11 Dec 2018 Expand to Translate|
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- 1 LB21.5 Congenital Ventricular Septal Defects
- 1.1 Introduction
- 1.2 Some Recent Findings
- 1.3 Anatomy
- 1.4 History
- 1.5 Ultrasound
- 1.6 Pulmonary Changes
- 1.7 International Classification of Diseases
- 1.8 Movies
- 1.9 Clinical Classification
- 1.10 Cardiovascular Abnormalities
- 1.11 References
- 1.12 External Links
- 1.13 Terms
- 1.14 Glossary Links
LB21.5 Congenital Ventricular Septal Defects
ICD-11 Beta Draft code: LB21.5. Current ICD-10 code: Q21.0 Ventricular septal defect
|ICD-11 Structural developmental anomalies of the circulatory system (draft)|
| ICD-11 Beta Draft - NOT FINAL, updated on a daily basis, It is not approved by WHO, NOT TO BE USED for CODING except for agreed FIELD TRIALS.
20 Developmental Anomalies - Structural Developmental Anomalies
Beta coding and tree structure for "structural developmental anomalies" within this section are shown in the table below.
|Structural developmental anomalies of the circulatory system|
|CD-11 Beta Draft - NOT FINAL, updated on a daily basis, It is not approved by WHO, NOT TO BE USED for CODING except for agreed FIELD TRIALS.|
The Ventricular Septal Defect (VSD) is the most common form of congenital cardiovascular anomaly, occurring in nearly 50% of all infants with a congenital heart defect. Usually occurs in the membranous (perimembranous) rather than muscular interventricular septum, and is more frequent in males that females. This defect can also contribute to outflow tract (OFT) malformations. See also the recent cardiac development online review section - Normal as opposed to abnormal ventricular septation.
Perimembranous defects are located close to the aortic and tricuspid valves and adjacent to atrioventricular conduction bundle.
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Meiying Cai, Hailong Huang, Linjuan Su, Na Lin, Xiaoqing Wu, Xiaorui Xie, Gang An, Ying Li, Yuan Lin, Liangpu Xu, Hua Cao Chromosomal abnormalities and copy number variations in fetal ventricular septal defects. Mol Cytogenet: 2018, 11;58 PubMed 30519285
Luyao Ma, Qun Gu, Buqing Ni, Haoliang Sun, Xiangxiang Zhen, Shijiang Zhang, Yongfeng Shao Simultaneously surgical management of adult complex coarctation of aorta concomitant with intracardiac abnormality. J Thorac Dis: 2018, 10(10);5842-5849 PubMed 30505492
Lu He, Ge-Sheng Cheng, Yu-Shun Zhang, Xu-Mei He, Xing-Ye Wang, Ya-Juan Du Transcatheter Closure of Perimembranous Ventricular Septal Defects in Children using a Wire-Drifting Technique. Clinics (Sao Paulo): 2018, 73;e371 PubMed 30517278
Taner Kasar, İbrahim Cansaran Tanıdır, Erkut Öztürk, Selman Gökalp, Gülhan Tunca Şahin, Mehmet Akın Topkarcı, Yakup Ergül, Alper Güzeltaş Arrhythmia during diagnostic cardiac catheterization in pediatric patients with congenital heart disease. Turk Kardiyol Dern Ars: 2018, 46(8);675-682 PubMed 30516525
|The image shows a congenitally malformed heart in which both the right and left atrioventricular valves (RAVV, LAVV) are connected with the dominant left ventricle. The right ventricle is incomplete, and is supplied through a ventricular septal defect. Note that, in this heart, the aorta arises from the incomplete right ventricle, and the pulmonary trunk from the dominant left ventricle. This is the arrangement usually described as “transposition”, but better accounted for in terms of discordant ventriculo-arterial connections.||The image shows the lesion known as classical tricuspid atresia. There has been failure of expansion of the atrioventricular junctions, so that the floor of the right is separated from the roof of the right ventricle by the right atrioventricular groove (dashed black lines). Only the dominant left ventricle has an inlet, with the blood entering the incomplete right ventricle through the ventricular septal defect (star).||The image shows a heart dissected to reveal the structure of the incomplete right ventricle. In this heart, as in most example of tricuspid atresia, it gives rise to the pulmonary trunk. The ventricular septal defect (VSD) is restrictive in this heart.
Images from Anderson (2016)
||The first western clinical description of ventricular septal defects was made by Henri Roger in 1879, which later became known as maladie de Roger.
His description was based upon 6 acyanotic patients and autopsy finding of a child with ventricular septal defect.
There is a defect in the ventricular septum adjacent to the atrioventricular valves. Blood flow is seen across the defect on Colour Doppler imaging.
(Heath-Edward grade) A pathological grading system for pulmonary artery structural changes that occur with congenital cardiac septal defects. The classification is named after the two original paper authors Donald HEATH and Jessee EDWARDS and grades from I to VI with increasing severity of the arterial changes.
- Grade I - hypertrophy of the media of small muscular arteries and arterioles.
- Grade II - intimal cellular proliferation in addition to medial hypertrophy.
- Grade III - advanced medial thickening with hypertrophy and hyperplasia including progressive intimal proliferation and concentric fibrosis. Results in an obliteration of the arterioles and small arteries.
- Grade IV - "plexiform lesions" of the muscular pulmonary arteries and arterioles with a plexiform network of capillary-like channels within a dilated segment.
- Grade V - complex plexiform, angiomatous and cavernous lesions and hyalinization of intimal fibrosis.
- Grade VI - necrotizing arteritis.
International Classification of Diseases
The International Classification of Diseases (ICD) World Health Organization's classification used worldwide as the standard diagnostic tool for epidemiology, health management and clinical purposes. This includes the analysis of the general health situation of population groups. It is used to monitor the incidence and prevalence of diseases and other health problems. Within this classification "congenital malformations, deformations and chromosomal abnormalities" are (Q00-Q99) but excludes "inborn errors of metabolism" (E70-E90).
Congenital malformations of the circulatory system (Q20-Q28)
- ICD-10 Code: Q21.0 Ventricular septal defect
Q21 Congenital malformations of cardiac septa
Excl.: acquired cardiac septal defect (I51.0)
- Q21.0 Ventricular septal defect
- Q21.1 Atrial septal defect Coronary sinus defect Patent or persistent: foramen ovale ostium secundum defect (type II) Sinus venosus defect
- Q21.2 Atrioventricular septal defect Common atrioventricular canal Endocardial cushion defect Ostium primum atrial septal defect (type I)
- Q21.3 Tetralogy of Fallot Ventricular septal defect with pulmonary stenosis or atresia, dextroposition of aorta and hypertrophy of right ventricle.
- Q21.4 Aortopulmonary septal defect Aortic septal defect Aortopulmonary window
- Q21.8 Other congenital malformations of cardiac septa Eisenmenger's defect Pentalogy of Fallot Excl.: Eisenmenger's complex (I27.8) syndrome (I27.8)
- Q21.9 Congenital malformation of cardiac septum, unspecified Septal (heart) defect NOS
Number of parameters are considered when classifying:
- Size of the defect.
- Location of the defect.
- Number of defects.
- Presence or absence of a ventricular septal aneurysm.
Heart defects and preterm birth are the most common causes of neonatal and infant death. The long-term development of the heart combined with extensive remodelling and post-natal changes in circulation lead to an abundance of abnormalities associated with this system.
A UK study literature showed that preterm infants have more than twice as many cardiovascular malformations (5.1 / 1000 term infants and 12.5 / 1000 preterm infants) as do infants born at term and that 16% of all infants with cardiovascular malformations are preterm. (0.4% of live births occur at greater than 28 weeks of gestation, 0.9% at 28 to 31 weeks, and 6% at 32 to 36 weeks. Overall, 7.3% of live-born infants are preterm)
"Baltimore-Washington Infant Study data on live-born cases and controls (1981-1989) was reanalyzed for potential environmental and genetic risk-factor associations in complete atrioventricular septal defects AVSD (n = 213), with separate comparisons to the atrial (n = 75) and the ventricular (n = 32) forms of partial AVSD. ...Maternal diabetes constituted a potentially preventable risk factor for the most severe, complete form of AVSD."
In addition, there are in several congenital abnormalities that exist in adults (bicuspid aortic valve, mitral valve prolapse, and partial anomalous pulmonary venous connection) which may not be clinically recognized.
- Fraser CD, Zhou X, Palepu S, Lui C, Suarez-Pierre A, Crawford TC, Magruder JT, Jacobs ML, Cameron DE, Hibino N & Vricella LA. (2018). Tricuspid Valve Detachment in Ventricular Septal Defect Closure Does Not Impact Valve Function. Ann. Thorac. Surg. , , . PMID: 29625102 DOI.
- Lee H, Cho JY & Kim GJ. (2011). Complete Repair of Coarctation of the Aorta and a Ventricular Septal Defect in a 1,480 g Low Birth Weight Neonate. Korean J Thorac Cardiovasc Surg , 44, 183-5. PMID: 22263148 DOI.
- Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)
- Clark Fle G. (1847). Case of cyanosis, with a description of the appearances presented on dissection, illustrated by the preparation, and a drawing, of the heart. Med Chir Trans , 30, 112.2-120. PMID: 20895864
- Allwork SP. (1979). Maladie du Roger 1879: a new translation for the centenary. Am. Heart J. , 98, 307-11. PMID: 382810
- HEATH D & EDWARDS JE. (1958). The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. Circulation , 18, 533-47. PMID: 13573570
- Tanner K, Sabrine N & Wren C. (2005). Cardiovascular malformations among preterm infants. Pediatrics , 116, e833-8. PMID: 16322141 DOI.
- Loffredo CA, Hirata J, Wilson PD, Ferencz C & Lurie IW. (2001). Atrioventricular septal defects: possible etiologic differences between complete and partial defects. Teratology , 63, 87-93. PMID: 11241431 <87::AID-TERA1014>3.0.CO;2-5 DOI.
Ikai A. (2018). Surgical strategies for pulmonary atresia with ventricular septal defect associated with major aortopulmonary collateral arteries. Gen Thorac Cardiovasc Surg , 66, 390-397. PMID: 29802565 DOI.
Ghosh S, Sridhar A, Solomon N & Sivaprakasham M. (2018). Transcatheter closure of ventricular septal defect in aortic valve prolapse and aortic regurgitation. Indian Heart J , 70, 528-532. PMID: 30170648 DOI.
Nishioka M, Fuchigami T, Akashige T & Nagata N. (2018). [Successful Staged Surgical Management for Double Outlet Right Ventricle with Ebstein's Anomaly and Aortic Coarctation;Report of a Case]. Kyobu Geka , 71, 615-621. PMID: 30185760
Lee H, Cho JY & Kim GJ. (2011). Complete Repair of Coarctation of the Aorta and a Ventricular Septal Defect in a 1,480 g Low Birth Weight Neonate. Korean J Thorac Cardiovasc Surg , 44, 183-5. PMID: 22263148 DOI.
Callaghan MA, O'Hare B & Casey W. (2012). What other anomalies? Failure to wean post ventricular septal defect repair secondary to anomalous origin of the left coronary artery from the pulmonary artery. Paediatr Anaesth , 22, 487-9. PMID: 22229525 DOI.
Bian C, Ma J, Wang J, Xu G, Jiang J, Yao S & Liu Y. (2011). Perimembranous ventricular septal defect with aneurysm: two options for transcatheter closure. Tex Heart Inst J , 38, 528-32. PMID: 22163127
Fried R, Falkovsky G, Newburger J, Gorchakova AI, Rabinovitch M, Gordonova MI, Fyler D, Reid L & Burakovsky V. (1986). Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension. Pediatr Cardiol , 7, 147-54. PMID: 3808993 DOI.
Haworth SG. (1986). Pulmonary vascular bed in children with complete atrioventricular septal defect: relation between structural and hemodynamic abnormalities. Am. J. Cardiol. , 57, 833-9. PMID: 2938464
Hoffmeister HM, Fischbach H & Hoffmeister HE. (1981). Pulmonary arterial changes and hemodynamic parameters in isolated ventricular septal defect. Thorac Cardiovasc Surg , 29, 355-8. PMID: 6179217 DOI.
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Cite this page: Hill, M.A. (2018, December 11) Embryology Cardiovascular System - Ventricular Septal Defects. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Ventricular_Septal_Defects
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