Mouse Heart

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Introduction

Mouse.jpg

This page is organised to show day by day heart (cardiac) development features and approximate timing of key events.


Mouse Links: Introduction | Mouse Stages | Mouse Timeline | Mouse Timeline Detailed | Mouse Estrous Cycle | Mouse Heart | Mouse Knockout | Movie - Cephalic Plexus | Movie - Blastocyst Cdx2 | ANAT2341 Project 2009 | Category:Mouse
Mouse Movies 
Mouse Zygote  
Fertilization 001 icon.jpg
 ‎‎Mouse Fertilisation
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Mouse zygote division icon.jpg
 ‎‎Zygote Mitosis
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Mouse zygote division 02 icon.jpg
 ‎‎Early Division
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Parental genome mix 01 icon.jpg
 ‎‎Parental Genomes
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Mouse blastocyst movie icon.jpg
 ‎‎Mouse Blastocyst
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Mouse Various  
Oocyte Meiosis 01 icon.jpg
 ‎‎Oocyte Meiosis
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DNA bead-induced ectopic polar body-icon.jpg
 ‎‎Ectopic Polar Body
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Mouse spermatozoa mito movie icon.jpg
 ‎‎Male Mitochondria
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Mouse spermatozoa mito movie icon.jpg
 ‎‎Male Mitochondria
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Mouse Blastocyst Cdx2 icon.jpg
 ‎‎Blastocyst Cdx2
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Model embryo to 128 cell stage icon.jpg
 ‎‎Blastocyst Model
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Mouse lipid droplets icon.jpg
‎‎Mouse Lipid Drops
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Somitogenesis 01 icon.jpg
 ‎‎Somitogenesis
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Mouse-melanoblast migration icon.jpg
 ‎‎Mouse Melanoblast
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Mouse limb gene expression icon.jpg
 ‎‎Limb Genes
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Mouse microCT  
Mouse CT E11.5 movie-icon.jpg
 ‎‎Mouse E11.5 CT
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Mouse CT E12.5 sagittal movie.jpg
 ‎‎Mouse E12.5 CT
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Mouse CT E12.5 coronal movie.jpg
 ‎‎Mouse E12.5 CT
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Mouse CT E12.5 axial movie.jpg
 ‎‎Mouse E12.5 Axial
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Mouse embryo E13 microCT icon.jpg
 ‎‎Mouse E13 microCT
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Mouse embryo E14 microCT icon.jpg
 ‎‎Mouse E14 microCT
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Mouse embryo E14 sectioned microCT icon.jpg
 ‎‎Mouse E14 microCT
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Mouse embryo E15 microCT icon.jpg
 ‎‎Mouse E15 microCT
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Mouse face microCT icon.jpg
 ‎‎Mouse Face
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 ‎‎Mouse Head Plexus
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Historic Embryology - Mouse 
1927 Growth | 1927a Gonads 1 | 1927b Gonads 2 | 1928 Gonads 3 | 1932 Gonads 4 | 1962 Oocyte | 2016 Heart


Mouse Stages: E1 | E2.5 | E3.0 | E3.5 | E4.5 | E5.0 | E5.5 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E18.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 E4.5 E5.0 E6.0 E7.0 E8.0 E9.0 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868
Otis EM and Brent R. Equivalent ages in mouse and human embryos. (1954) Anat Rec. 120(1):33-63. PMID 13207763

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

Timeline Links: human timeline | mouse timeline | mouse detailed timeline | chicken timeline | rat timeline | Medaka | Category:Timeline

Some Recent Findings

  • Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure[1] "These data demonstrate that disruption of normal HA catabolism in Hyal2-/- mice causes increased HA, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells. Excess endothelial-to-mesenchymal transition, resulting in increased mesenchymal cells, is the likely cause of morphological heart abnormalities in both humans and mice. In mice, these abnormalities result in progressive and severe diastolic dysfunction, culminating in heart failure."
More recent papers  
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More? References | Discussion Page | Journal Searches | 2019 References

Search term: Mouse Heart Development

<pubmed limit=5>Mouse Heart Development</pubmed>

<pubmed limit=5>Mouse Cardiac Development</pubmed>

Normal Images

The following images of normal heart development are arranged in timed sequence and are from a recent review.[2]

References

  1. Chowdhury B, Xiang B, Liu M, Hemming R, Dolinsky VW & Triggs-Raine B. (2017). Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure. Circ Cardiovasc Genet , 10, . PMID: 28196902 DOI.
  2. Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)

External Links

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Cite this page: Hill, M.A. (2019, July 19) Embryology Mouse Heart. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Heart

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G