Mouse Spermatozoa Mitochondria Movie

Embryology - 11 Dec 2023 Expand to Translate
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<html5media height="545" width="500">File:Spermatozoa_mitochondria_PMID23878233.mp4</html5media>

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Spermatozoa Mitochondria in Early Mouse Embryos

original figure images.

Male mammalian spermatozoa mitochondrial DNA (mtDNA) is generally eliminated before oocyte fertilisation, leaving only the maternal mtDNA to be inherited by the embryo.

This experiment shows that the distribution of spermatozoa mitochondria up to the morula stage of development in mice. These mitochondria do not appear to be eliminated by lysosomes and autophagy.

This animation shows live cell fluorescence imaging of sperm mitochondria (red) in early embryos.

Sperm mitochondria disaggregated and became restricted to only one blastomere during one-cell to four-cell stages.

Sperm mitochondria distributed in several cells after the eight-cell stage and could be detected until morula stages.

Scale bars: 20 µm.

1 Cell Stage

2 Cell Stage

4 Cell Stage

8 Cell Stage

Morula Stage

Reference

Luo SM, Ge ZJ, Wang ZW, Jiang ZZ, Wang ZB, Ouyang YC, Hou Y, Schatten H & Sun QY. (2013). Unique insights into maternal mitochondrial inheritance in mice. Proc. Natl. Acad. Sci. U.S.A. , 110, 13038-43. PMID: 23878233 DOI.

Copyright

Proceedings National Academy of Sciences (PNAS) Liberalization of PNAS copyright policy: Noncommercial use freely allowed Note original Author should be contacted for permission to reuse for Educational purposes. See also PNAS Author Rights and Permission FAQs

Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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Fig. 2. http://www.pnas.org/content/110/32/13038/F2.expansion.html Original figure images, cropped resized, relabeled and animated in photoshop.

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Cite this page: Hill, M.A. (2023, December 11) Embryology Mouse Spermatozoa Mitochondria Movie. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mouse_Spermatozoa_Mitochondria_Movie

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