|Embryology - 24 Nov 2017 Expand to Translate|
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- 1 Introduction
- 2 Sample Publications
- 3 Sample Embryos
- 4 Related Images
- 5 References
- 6 Glossary Links
|Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Japan.
Prof. Kohei Shiota, Dr Mark Hill, Prof. Shigehito Yamada and Prof. Mineo Yasuda
40th Anniversary Commemoration Symposium (2015) (Kyoto University, Japan)
|iBook - Kyoto Embryo Collection|
- Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period. "The pelvic skeleton is formed via endochondral ossification. However, it is not known how the normal cartilage is formed before ossification occurs. Furthermore, the overall timeline of cartilage formation and the morphology of the cartilage in the pelvis are unclear. In this study, cartilage formation in the pelvic skeletons of 25 human fetuses (crown-rump length [CRL] = 11.9-75.0 mm) was observed using phase-contrast computed tomography and 7T magnetic resonance imaging. The chondrification center of the ilium, ischium, and pubis first appeared simultaneously at Carnegie stage (CS) 18, was located around the acetabulum, and grew radially in the later stage. The iliac crest formed at CS20 while the iliac body's central part remained chondrified. The iliac body formed a discoid at CS22. The growth rate was greater in the ilium than in the sacrum-coccyx, pubis, and ischium. Connection and articulation formed in a limited period, while the sacroiliac joint formed at CS21. The articulation of the pubic symphysis, connection of the articular column in the sacrum, and Y-shape connection of the three parts of the hip bones to the acetabulum were observed at CS23; the connection of the ischium and pubic ramus was observed at the early-fetal stage. Furthermore, the degree of connection at the center of the sacrum varied among samples. Most of the pelvimetry data showed a high correlation with CRL. The transverse and antero-posterior lengths of the pelvic inlet of the lesser pelvis varied among samples (R2 = 0.11). The subpubic angle also varied (65-90°) and was not correlated with CRL (R2 = 0.22). Moreover, cartilaginous structure formation appeared to influence bone structure. This study provides valuable information regarding the morphogenesis of the pelvic structure."
- A detailed comparison of mouse and human cardiac development "Episcopic fluorescence image capture (EFIC) was performed on 66 wild-type mouse embryos from embryonic day (E) 9.5 to birth; 2-dimensional and 3-dimensional datasets were compared with EFIC and magnetic resonance images from a study of 52 human fetuses (Carnegie stage 13-23). Time course of atrial, ventricular, and outflow septation were outlined and followed a similar sequence in both species. Bilateral venae cavae and prominent atrial appendages were seen in the mouse fetus; in human fetuses, atrial appendages were small, and a single right superior vena cava was present. In contrast to humans with separate pulmonary vein orifices, a pulmonary venous confluence with one orifice enters the left atrium in mice. The cardiac developmental sequences observed in mouse and human fetuses are comparable, with minor differences in atrial and venous morphology. These comparisons of mouse and human cardiac development strongly support that mouse morphogenesis is a good model for human development."
- Morphogenesis of the spleen during the human embryonic period "Between Carnegie stages (CSs) 14 and 17, the spleen was usually recognized as a bulge in the dorsal mesogastrium (DM), and after CS 20, the spleen became apparent. Intrasplenic folds were observed later. A high-density area was first recognized in 6 of the 58 cases at CS 16 and in all cases examined after CS 18. The spleen was recognized neither as a bulge nor as a high-density area at CS 13. The mesothelium was pseudostratified until CS 16 and was replaced with high columnar cells and then with low columnar cells. The basement membrane was obvious after CS 17. The mesenchymal cells differentiated from cells in the DM, and sinus formation started at CS 20. Hematopoietic cells were detected after CS 18. The vessels were observed at CS 14 in the DM. Hilus formation was observed after CS 20. The parallel entries of the arteries and veins were observed at CS 23. The rate of increase in spleen length in relation to that of stomach length along the cranial-caudal direction was 0.51 ± 0.11, which remained constant during CSs 19 and 23, indicating that their growths were similar."
- Human embryo imaging with a super-parallel magnetic resonance (MR) microscope
- Polydactyly in human embryos "129 embryos with polydactyly in 36,380 human conceptuses obtained through induced abortion during the period from 1962 to 1974."
Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.
|Kyoto Specimens (Last Updated - April 7, 2014) Specimens 23,813|
|Carnegie stage:||1 2 3 4||5 6||7 8 9||10 11 12 13||14 15||16 17||18 19||20 21 22 23|
- Link: Carnegie stage 7
- Link: Carnegie stage 8
- Link: Carnegie stage 9
- Link: Carnegie stage 10
- Link: Carnegie stage 12
- Link: Carnegie stage 13
- Link: Carnegie stage 14
- Link: Carnegie stage 15
- Link: Carnegie stage 16
- Link: Carnegie stage 17
- Kyoto 25783 Links: right+yolk | left+yolk | left | ventral | right | dorsal | Kyoto Collection | Carnegie stage 18
- Link: Carnegie stage 18
- Link: Carnegie stage 19
- Link: Carnegie stage 20
- Link: Carnegie stage 21
- Link: Carnegie stage 22
- Link: Carnegie stage 23
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Limb Development (week 8)
External ear stages
- Misaki Okumura, Aoi Ishikawa, Tomoki Aoyama, Shigehito Yamada, Chigako Uwabe, Hirohiko Imai, Tetsuya Matsuda, Akio Yoneyama, Tohoru Takeda, Tetsuya Takakuwa Cartilage formation in the pelvic skeleton during the embryonic and early-fetal period. PLoS ONE: 2017, 12(4);e0173852 PubMed 28384153
- Anita Krishnan, Rajeev Samtani, Preeta Dhanantwari, Elaine Lee, Shigehito Yamada, Kohei Shiota, Mary T Donofrio, Linda Leatherbury, Cecilia W Lo A detailed comparison of mouse and human cardiac development. Pediatr. Res.: 2014; PubMed 25167202
- Aya Endo, Saki Ueno, Shigehito Yamada, Chigako Uwabe, Tetsuya Takakuwa Morphogenesis of the spleen during the human embryonic period. Anat Rec (Hoboken): 2014; PubMed 25403423
- Yoshimasa Matsuda, Shinya Ono, Yosuke Otake, Shinya Handa, Katsumi Kose, Tomoyuki Haishi, Shigeto Yamada, Chikako Uwabe, Kohei Shiota Imaging of a large collection of human embryo using a super-parallel MR microscope. Magn Reson Med Sci: 2007, 6(3);139-46 PubMed 18037794
- < K Shiota, E Matsunaga A genetic and epidemiologic study of polydactyly in human embryos in Japan. Jinrui Idengaku Zasshi: 1978, 23(2);173-92 PubMed 691840
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Cite this page: Hill, M.A. 2017 Embryology Kyoto Collection. Retrieved November 24, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Kyoto_Collection
- © Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G