Developmental Signals - Nerve Growth Factor
Embryology - 4 May 2024 Expand to Translate |
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Introduction
Nerve Growth Factor (NGF) was first discovered in the 1950's by Rita Levi-Montalcini with Stanley Cohen and Viktor Hamburger.[1][2] See review Levi-Montalcini review 30 years later.[3]
For which Rita Levi-Montalcini and Stanley Cohen received the 1986 Nobel Prize in Medicine.[4]
The Nobel Prize in Physiology or Medicine 1986 - Stanley Cohen, Rita Levi-Montalcini "for their discoveries of growth factors"
Draft page - Notice removed when completed.
Historical: Cohen S. Levi-Montalcini R. and Hamburger V. A nerve growth-stimulating factor isolated from sarcomas 37 and 180. (1954) Proc Natl Acad Sci U S A. 40(10):1014-8. PMID: 16589582
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nerve Growth Factor <pubmed limit=5>Nerve Growth Factor</pubmed> |
Structure
Gene
Protein
Function
Neural
- Links: Neural System Development
Signaling Pathway
Receptor
Tyrosine Kinase Receptor A
TRKA
NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors.
- OMIM Links: TRKA
Nerve Growth Factor Receptor
NGFR; p75(NTR)
Receptor binds at low affinity NGF and other neurotrophins: brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4).
Intracellular Signaling
Other Neural Growth Factors
- Brain-derived neurotrophic factor (BDNF)
- Glial cell line-derived neurotrophic factor (GDNF)
- Neurotrophic 3 (NT3)
OMIM
About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM
References
- ↑ <pubmed>14824426</pubmed>
- ↑ Cohen S. Levi-Montalcini R. and Hamburger V. A nerve growth-stimulating factor isolated from sarcomas 37 and 180. (1954) Proc Natl Acad Sci U S A. 40(10):1014-8. PMID: 16589582
- ↑ <pubmed>3301324</pubmed>
- ↑ <pubmed>23389287</pubmed>| PMC3589620
- ↑ <pubmed>24312363</pubmed>
- ↑ <pubmed>23190582</pubmed>
Reviews
3323396 2828509
3301324
Articles
All Rita Levi-Montalcini PMID references
<pubmed>22693607</pubmed>
Online Textbooks
- Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al.New York: Garland Science; 2002.
- Molecular Cell Biology. 4th edition. Lodish H, Berk A, Zipursky SL, et al.New York: W. H. Freeman; 2000.
- Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000.
Search PubMed
- Search PubMed: Nerve Growth Factor
- All Databases: Nerve Growth Factor
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- OMIM - NGF
Glossary Links
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Cite this page: Hill, M.A. (2024, May 4) Embryology Developmental Signals - Nerve Growth Factor. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nerve_Growth_Factor
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G