Difference between revisions of "Detailed Cardiac - Sinus Node"
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The adult node is a mixture of about 10,000 cells distinct
The adult node is a mixture of about 10,000 cells distinct located at the entry of the right superior caval vein (SVC) into the right atrium.
Revision as of 04:29, 19 February 2017
|Embryology - 18 Sep 2021 Expand to Translate|
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|Detailed Cardiac: Systemic Venous Sinus | Pulmonary Vein | Superior Interatrial Fold | Atrioventricular Cushions | Atrioventricular Canal | Interventricular Communication | Subpulmonary Infundibulum | Arterial Roots | Intrapericardial Arterial Trunks | Extrapericardial Arterial Channels | Sinus Node | Atrioventricular Conduction Axis|
Appearance and Remodelling of the Sinus Node
The sinoatrial node (SAN) is the primary pacemaker of the heart that initially develops from part of pro-pacemaking embryonic venous pole that expresses both Hcn4 and the transcriptional factor Shox2. The chicken embryo has been used as a model of SAN development, where early canonical Wnts expression within the right lateral plate mesoderm just posterior of the heart field results in development of these cells.
The adult node is a mixture of about 10,000 cells distinct cardiomyocytes located at the entry of the right superior caval vein (SVC) into the right atrium.
|Cardiovascular Links: cardiovascular | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | 2016 Cardiac Review | heart | coronary circulation | heart valve | heart rate | Circulation | blood | blood vessel | blood vessel histology | heart histology | Lymphatic | ductus venosus | spleen | Stage 22 | cardiovascular abnormalities | OMIM | 2012 ECHO Meeting | Category:Cardiovascular|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Sinus Node Development
<pubmed limit=5>Sinus Node Development</pubmed>
A secreted glycoprotein patterning switch with different roles in different tissues and signaling has generally been divided into the canonical and non-canonical pathways. The name was derived from two drosophila phenotypes wingless and int and the gene was first defined as a protooncogene, int1.
- Wnt binds the surface receptor Frizzled (Fz) and LRP5/6 receptor complex
- Induces the stabilization of beta-catenin (through the DIX and PDZ domains of Dishevelled and other factors including Axin, glycogen synthase kinase 3 and casein kinase 1)
- Beta-catenin translocates into the nucleus
- Beta-catenin complexes with members of the LEF/TCF family of transcription factors.
- Transcriptional induction of target genes.
- Beta-catenin is then exported from the nucleus and degraded via the proteosomal machinery.
Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) gene located at 15q24.1, the 1,203 amino acid protein contains 6 putative transmembrane segments, a pore region, and a cyclic nucleotide-binding domain.
- Links: [OMIM HCN4
Short Stature Homeobox 2 (SHOX2) gene located at 3q25.32, the protein acts as a homeobox transcription factor.
- mouse og12 gene - developmental sinus venosus (aorta), female genitalia, diencephalon, mes- and myelencephalon, nasal capsula, palate, eyelid, and limbs
- Links: OMIM SHOX2
ISL Lim Homeobox 1 (ISL1) gene located at 5q11.1 is a member of the LIM/homeodomain family of transcription factors that binds to the enhancer region of the insulin gene. Functions in survival, proliferation, and function of pacemaker cells throughout development.
- Links: OMIM ISL1
Sinus node dysfunction (SND) or sick sinus syndrome (SSS) can occur in the elderly.
<pubmed>26023305</pubmed> <pubmed>24672485</pubmed> <pubmed></pubmed> <pubmed></pubmed>
<pubmed>27291063</pubmed> <pubmed>26682210</pubmed> <pubmed>26611337</pubmed> <pubmed>26835096</pubmed>
Cite this page: Hill, M.A. (2021, September 18) Embryology Detailed Cardiac - Sinus Node. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Detailed_Cardiac_-_Sinus_Node
- © Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G