Cardiovascular System - Lymphatic Development: Difference between revisions
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'''International Society of Lymphology '''[http://www.u.arizona.edu/~witte/aims.htm ISL] | [http://www.u.arizona.edu/~witte/lymphology.htm Lymphology Journal] | '''International Society of Lymphology '''[http://www.u.arizona.edu/~witte/aims.htm ISL] | [http://www.u.arizona.edu/~witte/lymphology.htm Lymphology Journal] | ||
'''Australian Lymphology Association''' [www.lymphology.asn.au/index.php ALA] | '''Australian Lymphology Association''' [http://www.lymphology.asn.au/index.php ALA] | ||
'''American Society of Lymphology '''[http://www.lymphology.org/page.asp?xqp=aboutus ASL] | '''American Society of Lymphology '''[http://www.lymphology.org/page.asp?xqp=aboutus ASL] |
Revision as of 08:32, 1 November 2010
Introduction
An important part of the cardiovascular system is the lymphatic vasculature, which functions to return interstitial fluid (lymph) to the bloodstream.
This system was first identified by Aselli G. 1627 in a paper "De Lacteibus sive Lacteis Venis", Quarto Vasorum Mesarai corum Genere novo invento. Milan: Mediolani
Some Recent Findings
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Lymphatic Vessels
- Lymph capillaries
- Lymph collecting vessels
- Lymph ducts
Lymphatic Vessel Contraction
Lymphatic vessels undergo spontaneous rhythmic contractions which aid lymph flow. This is most easily demonstrated in models based upon mesentry lymphatics of the gastrointestinal tract. Contractile activity is regulated by physical factors (transmural pressure) and neurological (alpha-adrenergic, histamine, bradykinin) acting on lymphatic smooth muscle. Contractility and receptor expression may also be different in different parts of the lymphatic system.
Alpha-adrenergic - alpha 1- and not alpha 2-adrenoceptors.
Histamine - lymphatic smooth muscle via stimulation of H(1) (and in some vessels H(2)) receptors.
Bradykinin - chronotropic but not inotropic effects on lymphatic pump activity via stimulation of B1 receptors.
Molecular Development
Angiopoietins (Ang1–Ang4)
Notch probably mediates choice of fate between arterial and venous.
Prox1 Prospero-related Homeobox 1 - expressed in a subpopulation of blood endothelial cells that then generate, by both budding and sprouting, cells of the lymphatic vascular system. Triggers the molecular program leading to the formation of the lymphatic system. (OMIM - PROSPERO-RELATED HOMEOBOX 1; PROX1)
Tie (Tie1 and Tie2) tyrosine kinase receptors.
Vascular endothelial growth factor (VEGF) family of proteins and angiopoietin/Tie, Notch, and ephrin/Eph pathways play major roles in eary vessel development.
Abnormalities
Lymphangioma - dysplasia of childhood form lymphatic capillaries or collectors, which form fluid-filled cysts.
lymphatic spaces lined by endothelium smooth muscle fascicles in the septa between the lymphatic spaces lymphoid aggregates in the delicate collagenous stroma
References
Journals
- Lymphology - Journal Homepage
Reviews
<pubmed>18519960</pubmed> <pubmed>17036631</pubmed> <pubmed>16212503</pubmed> <pubmed>15293565</pubmed> <pubmed>14704766</pubmed> <pubmed>12543725</pubmed>
Articles
<pubmed>17202268</pubmed>
<pubmed>16291864</pubmed> <pubmed>16877368</pubmed>
Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity Nicole C. Johnson, Miriam E. Dillard, Peter Baluk, Donald M. McDonald, Natasha L. Harvey, Sharon L. Frase, and Guillermo Oliver Genes Dev. 2008;22 3282-3291
Search Pubmed
Search NLM Bookshelf: lymphatic
Search PubMed: lymphatic development | lymphology
External Links
International Society of Lymphology ISL | Lymphology Journal
Australian Lymphology Association ALA
American Society of Lymphology ASL
British Lymphology Society [www.lymphoedema.org/bls/ BLS]
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 5) Embryology Cardiovascular System - Lymphatic Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Lymphatic_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G