Cardiovascular System - Spleen Development: Difference between revisions
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== Some Recent Findings == | == Some Recent Findings == | ||
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* '''White pulp and marginal zone in human spleen from the 17th to 40th week of gestation'''<ref><pubmed>19255788</pubmed></ref> | * '''White pulp and marginal zone in human spleen from the 17th to 40th week of gestation'''<ref><pubmed>19255788</pubmed></ref> | ||
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* '''Lymphoid organ development'''<ref><pubmed>16550197</pubmed></ref> "... At one end are the 'canonical' secondary lymphoid organs, including lymph nodes and spleen; at the other end are 'ectopic' or tertiary lymphoid organs, which are cellular accumulations arising during chronic inflammation by the process of lymphoid neogenesis." | * '''Lymphoid organ development'''<ref><pubmed>16550197</pubmed></ref> "... At one end are the 'canonical' secondary lymphoid organs, including lymph nodes and spleen; at the other end are 'ectopic' or tertiary lymphoid organs, which are cellular accumulations arising during chronic inflammation by the process of lymphoid neogenesis." | ||
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== Development Overview == | == Development Overview == |
Revision as of 22:17, 18 October 2010
Introduction
The spleen is located on the left side of the abdomen and has a role initially in blood and then immune system development. The spleen's haematopoietic function (blood cell formation) is lost with embryo development and lymphoid precursor cells migrate into the developing organ. Vascularization of the spleen arises initially by branches from the dorsal aorta. Mesoderm within the dorsal mesogastrium form a long strip of cells adjacent to the forming stomach above the developing pancreas.
Immune Links: immune | blood | spleen | thymus | lymphatic | lymph node | Antibody | Med Lecture - Lymphatic Structure | Med Practical | Immune Movies | vaccination | bacterial infection | Abnormalities | Category:Immune | ||
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Some Recent Findings
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Development Overview
The human spleen arises in week 5 within the dorsal mesogastrium as proliferating mesenchyme overlying the dorsal pancreatic endoderm. Cells required for its hemopoietic function arise from the yolk sac wall and near dorsal aorta.
The spleen generates both red and white cells in the 2nd trimester. Note that many embryonic RBCs remain nucleated. | |
D4 Dorsal Mesogastrium (stage 13) |
Human Embryo Stage 22
D4 Dorsal Mesogastrium (stage 13)
F1 Developing Human Spleen (stage 22)
F2 Developing Human Spleen (stage 22)
F3 Developing Human Spleen (stage 22)
Abnormalities
Congenital absence of the spleen is usually accompanied by complex cardiac malformations, malposition and maldevelopment of the abdominal organs, and abnormal lobation of the lungs. (from OMIM)
Connexin-43 involved with abnormal spleen development (cardiac and lung also).
References
Reviews
<pubmed>16550197</pubmed> <pubmed>15738953</pubmed> <pubmed>15530642</pubmed> <pubmed>14966753</pubmed> <pubmed>10676919</pubmed> <pubmed>7728201</pubmed>
Search PubMed
Search NCBI Bookshelf: Spleen Development
Search PubMed: Search August 2006 "Spleen Development" 13,401 reference articles of which 450 were reviews.
Search term = Spleen Development
Glossary Links
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Cite this page: Hill, M.A. (2024, May 23) Embryology Cardiovascular System - Spleen Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Spleen_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G