Sensory - Vision Development
|Embryology - 19 Jan 2018 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Timeline
- 4 Lens
- 5 Stage 22 Eye
- 6 Retinotopic Map
- 7 Neural Crest
- 8 Schlemm's canal
- 9 Extraocular Muscles
- 10 Additional Images
- 11 References
- 12 Terms
- 13 External Links
- 14 Glossary Links
These notes introduce the development of the eye: induction and regional specification of the eye structures, maturation and formation of retina and optic tectum neuronal connections.
The adult eye has contributions from several different embryonic layers eventually forming neuronal, supportive connective tissue, optical structures, and muscular tissues.
There are additional pages shown in the vision links, covering specific topics of vision development.
|Vision Links: Introduction | Lens | Retina | Placodes | Extraocular Muscle | Cornea | Eyelid | Abnormalities | Student project 1 | Student project 2 | Category:Vision|
|Senses Links: Introduction | Placodes | Hearing and Balance | Vision | Smell | Taste | Touch | Stage 22 | Category:Senses|
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
D Ian Flitcroft, James Loughman, Christine F Wildsoet, Cathy Williams, Jeremy A Guggenheim, for the CREAM Consortium Novel Myopia Genes and Pathways Identified From Syndromic Forms of Myopia. Invest. Ophthalmol. Vis. Sci.: 2018, 59(1);338-348 PubMed 29346494
Nabin Paudel Smartphone Applications for Amblyopia Treatment: A Review of Current Apps and Professional Involvement. Telemed J E Health: 2018; PubMed 29346038
Celeste Gilbert, Lisa Keay, Anna Palagyi, Vu Quang Do, Peter McCluskey, Andrew White, Nicole Carnt, Fiona Stapleton, Tracey-Lea Laba Investigation of attributes which guide choice in cataract surgery services in urban Sydney, Australia. Clin Exp Optom: 2018; PubMed 29345003
Yong Cheng, Qingyu Meng, Lvzhen Huang, Xuan Shi, Jing Hou, Xiaoxin Li, Jianhong Liang iTRAQ-based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma. Oncol Lett: 2017, 14(6);8084-8091 PubMed 29344252
Kevin M Broderick, Thomas B Ableman, Eric D Weber, Robert W Enzenauer, Harold J Wain, Keith J Wroblewski Non-organic Vision Loss in the Afghanistan and Iraq Conflicts. Neuroophthalmology: 2017, 41(4);175-181 PubMed 29344055
Vanessa Harrar, Laurent Elkrief, Joseph Bouskila, Ryan Kucera, Anders Fink-Jensen, Jean-François Bouchard, Roberta Palmour, Maurice Ptito Effects of Prenatal Alcohol Exposure on the Visual System of Monkeys Measured at Different Stages of Development. Invest. Ophthalmol. Vis. Sci.: 2017, 58(14);6282-6291 PubMed 29242902
Romain Luscan, Sabrina Mechaussier, Antoine Paul, Guoling Tian, Xavier Gérard, Sabine Defoort-Dellhemmes, Natalie Loundon, Isabelle Audo, Sophie Bonnin, Jean-François LeGargasson, Julien Dumont, Nicolas Goudin, Meriem Garfa-Traoré, Marc Bras, Aurore Pouliet, Bettina Bessières, Nathalie Boddaert, José-Alain Sahel, Stanislas Lyonnet, Josseline Kaplan, Nicholas J Cowan, Jean-Michel Rozet, Sandrine Marlin, Isabelle Perrault Mutations in TUBB4B Cause a Distinctive Sensorineural Disease. Am. J. Hum. Genet.: 2017; PubMed 29198720
Meriem El Bahloul, Fouad Chraïbi, Marrakchi Mohammed, Meriem Abdellaoui, Idriss Benatiya [Unilateral macular coloboma: about a case]. [Colobome maculaire unilatérale: à propos d’un cas.] Pan Afr Med J: 2017, 28;55 PubMed 29184607
Audrey Desgrange, Claire Heliot, Ilya Skovorodkin, Saad U Akram, Janne Heikkilä, Veli-Pekka Ronkainen, Ilkka Miinalainen, Seppo J Vainio, Silvia Cereghini HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis. Development: 2017; PubMed 29158444
Özlem Barut Selver, Ayşe Yağcı, Sait Eğrilmez, Mehmet Gürdal, Melis Palamar, Türker Çavuşoğlu, Utku Ateş, Ali Veral, Çağrı Güven, Jose Mario Wolosin Limbal Stem Cell Deficiency and Treatment with Stem Cell Transplantation. Turk J Ophthalmol: 2017, 47(5);285-291 PubMed 29109898
Carnegie Stages - Eye
| The following data is from a study of human embryonic carnegie stages and other sources.
||Embryo Virtual Slides|
See below the drawings of sections of the whole eye from week 8 of development.
The lens or crystalline lens or aquula (Latin, aquula = a little stream) has a key role in focussing light (with the cornea) upon the neural retina. The lens embryonic origin is from surface ectoderm of the sensory placodes that form in the head region (More? Week 4 - Placodes). The lens focusses by refracting light as it passes through the biconvex lens, which can be altered in shape (accommodation) by surrounding ciliary muscles. These ciliary muscles are activated (contracted) by parasympathetic innervation from the ciliary ganglion itself innervated by the oculomotor nerve (Cranial Nerve III) (More? Cranial Nerves).
surface ectoderm -> lens placode -> lens pit -> lens vesicle -> lens fibres -> lens capsule and embryonic/fetal nucleus.
- Links: Vision - Lens Development
Stage 22 Eye
The images below link to virtual slides of the human developing eye at Carnegie stage 22. Click on the image to open or select specific regions from the regions of interest links.
Virtual Slide - Regions of Interest
Links: Embryo Virtual Slides
This neuroscience term describes how the developing retina is precisely "mapped" onto the visual cortex through a series of signaling and activity dependent mechanisms. This follows from Hubel and Wiesel (1981 Nobel Prize in Physiology or Medicine) key discoveries (1959-70) of how in development system matching occurs in the visual system. The topographic map establishes an ordered neuronal connection between sensory structures and the central nervous system.
The retinotectal map (eye to brain) of birds (lower vertebrates):
- temporal (posterior) retina is connected to the rostral (anterior) part of the contralateral optic tectum
- nasal (anterior) retina to the caudal (posterior) tectum
- ventral retina to the dorsal (medial) tectum
- dorsal ventral (lateral) tectum
Retinal waves a form of coordinated spontaneous activity that occurs in the developing retina. These waves of electrical activity (action potentials) are thought to have a role in establishing the initial retinotopic map by correlating/coordinating the activity of neighbouring retinal ganglion cells.
EphA/ephrin-A molecular signaling also thought to have a role in establishing the initial retinotopic map.
Mouse eye neural crest
Mouse eye TGF-beta model
- Links: Image - Mouse eye neural crest | Image - Mouse eye TGF-beta model | Vision Development | Neural Crest Development | Head Development
Schematic showing the stages of Schlemm's canal development in the postnatal mouse by the novel process of canalogenesis. (Cartoons have been drawn for clarity and are not intended to suggest that most early sprouts arise from the LVP.)
Extraocular muscles are required to move the eye within the orbit. Their embryonic origin requires an interaction between the cranial mesoderm and the migrating neural crest cells.
The following is from a recent paper comparing human to zebrafish muscle development.
- Links: Extraocular Muscles
|Historic Disclaimer - information about historic embryology pages|
|Embryology History | Historic Embryology Papers)|
- Anand Swaroop, Donald J Zack Transcriptome analysis of the retina. Genome Biol.: 2002, 3(8);REVIEWS1022 PubMed 12186651 | Genome Biol.
- Vinicius Toledo Ribas, Bruno Souza Gonçalves, Rafael Linden, Luciana Barreto Chiarini Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells. PLoS ONE: 2012, 7(4);e34483 PubMed 22496813 | PMC4183095 | Front Hum Neurosci.
- Vinicius Toledo Ribas, Bruno Souza Gonçalves, Rafael Linden, Luciana Barreto Chiarini Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells. PLoS ONE: 2012, 7(4);e34483 PubMed 22496813
- Itaru Hayakawa, Hiroshi Kawasaki Rearrangement of retinogeniculate projection patterns after eye-specific segregation in mice. PLoS ONE: 2010, 5(6);e11001 PubMed 20544023 | PLoS ONE
- Nicole A Rapicavoli, Erin M Poth, Seth Blackshaw The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC Dev. Biol.: 2010, 10;49 PubMed 20459797
- A A Pearson The development of the eyelids. Part I. External features. J. Anat.: 1980, 130(Pt 1);33-42 PubMed 7364662
- Streeter GL. Developmental Horizons In Human Embryos Description Or Age Groups XIX, XX, XXI, XXII, And XXIII, Being The Fifth Issue Of A Survey Of The Carnegie Collection. (1957) Carnegie Instn. Wash. Publ. 611, Contrib. Embryol., 36: 167-196.
- Lars M Ittner, Heiko Wurdak, Kerstin Schwerdtfeger, Thomas Kunz, Fabian Ille, Per Leveen, Tord A Hjalt, Ueli Suter, Stefan Karlsson, Farhad Hafezi, Walter Born, Lukas Sommer Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells. J. Biol.: 2005, 4(3);11 PubMed 16403239 | J Biol.
- Krishnakumar Kizhatil, Margaret Ryan, Jeffrey K Marchant, Stephen Henrich, Simon W M John Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol.: 2014, 12(7);e1001912 PubMed 25051267 | PLoS Biol.
- Daniel S Kasprick, Phillip E Kish, Tyler L Junttila, Lindsay A Ward, Brenda L Bohnsack, Alon Kahana Microanatomy of adult zebrafish extraocular muscles. PLoS ONE: 2011, 6(11);e27095 PubMed 22132088 | PLoS One.
- Kolb H, Fernandez E, Nelson R, editors. Webvision: The Organization of the Retina and Visual System [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK11530/
- Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000. Development of the Vertebrate Eye. Available from: https://www.ncbi.nlm.nih.gov/books/NBK10024/
- Evolution of the mammalian middle ear bones from the reptilian jaw | Chick embryo rhombomere neural crest cells | Some derivatives of the pharyngeal arches | Formation of the Neural Tube | Differentiation of the Neural Tube | Tissue Architecture of the Central Nervous System | Neuronal Types | Snapshot Summary: Central Nervous System and Epidermis
- Neuroscience Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark. Sunderland (MA): Sinauer Associates, Inc. ; c2001 The Auditory System | The Inner Ear | The Middle Ear | The External Ear | Early Brain Development | Construction of Neural Circuits | Modification of Brain Circuits as a Result of Experience
- Molecular Biology of the Cell (4th Edn) Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter. New York: Garland Publishing; 2002. Neural Development | The three phases of neural development
- Clinical Methods 63. Cranial Nerves IX and X: The Glossopharyngeal and Vagus Nerves | The Tongue | 126. The Ear and Auditory System | An Overview of the Head and Neck - Ears and Hearing | Audiometry
- Health Services/Technology Assessment Text (HSTAT) Bethesda (MD): National Library of Medicine (US), 2003 Oct. Developmental Disorders Associated with Failure to Thrive
- Eurekah Bioscience Collection Cranial Neural Crest and Development of the Head Skeleton
- Webvision: The Organization of the Retina and Visual System. Kolb H, Fernandez E, Nelson R, editors. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-.
Francis Beby, Thomas Lamonerie The homeobox gene Otx2 in development and disease. Exp. Eye Res.: 2013, 111;9-16 PubMed 23523800
Ching-Hwa Sung, Jen-Zen Chuang The cell biology of vision. J. Cell Biol.: 2010, 190(6);953-63 PubMed 20855501
The International Journal of Developmental Biology Vol. 48 Nos. 8/9 (2004) Eye Development
L B Paquette, H A Jackson, C J Tavaré, D A Miller, A Panigrahy In utero eye development documented by fetal MR imaging. AJNR Am J Neuroradiol: 2009, 30(9);1787-91 PubMed 19541779
Bookshelf vision development
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Cite this page: Hill, M.A. 2018 Embryology Sensory - Vision Development. Retrieved January 19, 2018, from https://embryology.med.unsw.edu.au/embryology/index.php/Sensory_-_Vision_Development
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