Neural System - Molecular

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Introduction

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Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular


Mechanism Links: mitosis | cell migration | epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular


Molecular System Links: Heart | Neural | Renal | Respiratory | Mechanisms | Factors | Molecular


Neural Links: ectoderm | neural | neural crest | ventricular | sensory | Stage 22 | gliogenesis | neural fetal | Medicine Lecture - Neural | Lecture - Ectoderm | Lecture - Neural Crest | Lab - Early Neural | neural abnormalities | folic acid | iodine deficiency | Fetal Alcohol Syndrome | Postnatal | Postnatal - Neural Examination | Histology | Historic Neural | Category:Neural

Some Recent Findings

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Search term: Notch

<pubmed limit=5>Notch</pubmed>

Notch

Developmental Signals - Notch

Spinal Cord

Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.[1]
  • Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1.
  • Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition.
  • Upregulation of Delta-1 in single NP cells which signal (blue arrows) and activate NOTCH signalling in adjacent cells, which as a consequence express Hes5 and are maintained in a proliferating state.
  • Delta-1 expressing NP cell divides into two cells that express Tis21.
  • Double Delta-1/Tis21 labelled NP down regulate the expression of Delta-1 as they reach the NZ and begin to divide in a neurogenic manner.
  • One of the daughter cells upregulates Delta-1 expression and differentiates as a neuron while the other one, which receives NOTCH signalling (blue arrows), remains as neurogenic NP. Hensen node (HN), neural tube (NT), neurogenic zone (NZ), proliferation to neurogenesis transition zone (PNTZ), presomitic territory (PS), somite (S).
Spinal cord delta notch model.png

Hypothalamus

Hypothalamus gene interaction model.jpg

Hypothalamus Development Gene Interaction Model[2]

Links: Hypothalamus Development


References

  1. Hämmerle B & Tejedor FJ. (2007). A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS ONE , 2, e1169. PMID: 18000541 DOI.
  2. Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V & Dupé V. (2013). Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev , 8, 25. PMID: 24360028 DOI.


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Cite this page: Hill, M.A. (2019, June 16) Embryology Neural System - Molecular. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_-_Molecular

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G