Abnormal Development - Parvovirus

From Embryology
Embryology - 15 Dec 2018    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)

Introduction

Parvovirus H-1 virions.

Human parvovirus B19 (Latin, parvo = poor), infection is also called "fifth disease" and occurs mainly in children. Pets (dogs and cats) have their own animal parvoviruses that do not infect humans.

Parvovirus B19 (B19V) is the only member of the Parvoviridae family known to cause disease in humans and is a single-strand 5,594 nucleotide DNA Class II virus. The virions have a diameter of 22-25 nm and are transmitted by respiratory secretions between humans and can also cross the placenta. Virus replication requires help from either host cells or other viruses.


Viral Links: viral infection | TORCH | cytomegalovirus | Hepatitis Virus | HIV | Parvovirus | Polio Virus | rubella virus | Chickenpox | Lymphocytic Choriomeningitis Virus | Zika Virus | rotavirus | vaccination | Environmental
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects

Some Recent Findings

  • Parvovirus B19 infection in pregnancy: new insights and management.[1] "In this article, we review the virology, pathology, epidemiology and clinical spectrum of intrauterine human parvovirus B19 (B19V) infection, including intrauterine fetal death, non-immune hydrops fetalis, thrombocytopenia and neurological manifestations such as pediatric stroke and perivascular calcifications. In addition, we discuss the new insights into the neurodevelopmental outcome of intrauterine B19V infection. Current diagnosis and management of B19V infection is summarized, including a diagnostic and follow-up flowchart for practical clinical use."

Fifth Disease

Childhood parvovirus infection (erythema infectious) hand rash. (Image CDC)

Historic terminology referring to the fifth in a group of once-common childhood diseases (the other four are measles, rubella, scarlet fever and Dukes' disease) that all have similar rashes.

  1. First disease - measles
  2. Second disease - scarlet fever (Streptococcus pyogenes)
  3. Third disease - rubella
  4. Fourth disease - Dukes' disease is also a historic term for a febrile disease of childhood (suggested as Staphylococcus aureus)
  5. Fifth disease - Parvovirus

B19

Yvonne Cossart

Professor Yvonne Cossart (University of Sydney, Bosch Professor of Infectious Diseases)

Yvonne Cossart coined the nomenclature "B19", from the well on a microtitre (microtiter) plate where the virus antigen was first discovered in blood.[2] Microtitre plates are generally organised by rows (alphabetically) and columns (numerically).

"A parvovirus-like antigen has been found in sera of nine healthy blood-donors and two patients. Its pathogenicity is unknown, but 30% of adults possess specific antibody. The new agent can be confused with hepatitis-B antigen both morphologically and serologically."

Hydrops Fetalis

The following information is based on infection in a pregnant woman followed by transplacental transmission to the fetus.[3]

  • Most parvovirus B19 infections during pregnancy do not lead to loss of the fetes.
    • estimated 30% risk of transplacental infection among women who are infected with parvovirus B19 during pregnancy
  • Transmission to the fetus can lead to miscarriage or hydrops fetalis.
    • estimated 5 to 9 % risk of fetal loss.
  • Infection during the second trimester poses the greatest risk of hydrops fetalis.
  • Parvovirus infects the fetal liver that is involved with early erythrocyte production.
  • Seroprevalence data indicate that about half of pregnant women are susceptible to parvovirus infection.

References

  1. E P de Jong, F J Walther, A C M Kroes, D Oepkes Parvovirus B19 infection in pregnancy: new insights and management. Prenat. Diagn.: 2011, 31(5);419-25 PubMed 21351281
  2. Y E Cossart, A M Field, B Cant, D Widdows Parvovirus-like particles in human sera. Lancet: 1975, 1(7898);72-3 PubMed 46024
  3. Neal S Young, Kevin E Brown Parvovirus B19. N. Engl. J. Med.: 2004, 350(6);586-97 PubMed 14762186

Reviews

R F Lamont, J D Sobel, E Vaisbuch, J P Kusanovic, S Mazaki-Tovi, S K Kim, N Uldbjerg, R Romero Parvovirus B19 infection in human pregnancy. BJOG: 2011, 118(2);175-86 PubMed 21040396


Articles

Monika Schiesser, Consolato Sergi, Martin Enders, Holger Maul, Paul Schnitzler Discordant outcomes in a case of parvovirus b19 transmission into both dichorionic twins. Twin Res Hum Genet: 2009, 12(2);175-9 PubMed 19335188

R A Simms, R E Liebling, R R Patel, M L Denbow, S A Abdel-Fattah, P W Soothill, T G Overton Management and outcome of pregnancies with parvovirus B19 infection over seven years in a tertiary fetal medicine unit. Fetal. Diagn. Ther.: 2009, 25(4);373-8 PubMed 19786782

Richard H Beigi, Harold C Wiesenfeld, Daniel V Landers, Hyagriv N Simhan High rate of severe fetal outcomes associated with maternal parvovirus b19 infection in pregnancy. Infect Dis Obstet Gynecol: 2008, 2008;524601 PubMed 18464909

A Kempe, B Rösing, C Berg, D Kamil, A Heep, U Gembruch, A Geipel First-trimester treatment of fetal anemia secondary to parvovirus B19 infection. Ultrasound Obstet Gynecol: 2007, 29(2);226-8 PubMed 17252527

Jin Xu, Thomas C Raff, Nabil S Muallem, A George Neubert Hydrops fetalis secondary to parvovirus B19 infections. J Am Board Fam Pract: 2003, 16(1);63-8 PubMed 12583652

N Yaegashi Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection. Tohoku J. Exp. Med.: 2000, 190(2);65-82 PubMed 10770616

A D Cameron, S Swain, W J Patrick Human parvovirus B19 infection associated with hydrops fetalis. Aust N Z J Obstet Gynaecol: 1997, 37(3);316-9 PubMed 9325515


Search Pubmed

June 2010

Search Pubmed: Parvovirus B19 | fifth disease | Parvovirus



Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | Zoonotic Infection | Toxoplasmosis | Malaria | Maternal Diabetes | Maternal Hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | Hypoxia | Biological Toxins | Chemicals | heavy metals | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.


Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link



Cite this page: Hill, M.A. (2018, December 15) Embryology Abnormal Development - Parvovirus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Parvovirus

What Links Here?
© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G