Abnormal Development - Lymphocytic Choriomeningitis Virus
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Lymphocytic choriomeningitis virus (LCMV) is carried by wild mice (Mus musculus). Laboratory rodents and pet rodents, such as rats, mice, hamsters and guinea pigs, can become infected with LCMV from contact with wild mice. This can happen in a breeding facility, in a laboratory facility, in a pet store, or in the home if wild mice are present. Humans can be infected through exposure to rodent excreta. In the rat animal model, the virus appears to selectively infect mitotically active neuronal precursors, while glial cells may also have a role in the initial entry, replication, and dispersion.
Maternal infection can be transferred placental to fetus and can result in either loss or birth defects (hydrocephalus, chorioretinitis or deafness). Since LCMV infection was first identified, more than 50 babies have been reported with LCMV infection worldwide.
Some Recent Findings
Lineage: Viruses; ssRNA negative-strand viruses; Arenaviridae; Arenavirus; Old world arenaviruses; Lymphocytic choriomeningitis virus
- Lymphocytic choriomeningitis virus (strain Armstrong)
- Lymphocytic choriomeningitis virus (strain Pasteur)
- Lymphocytic choriomeningitis virus (strain Traub)
- Lymphocytic choriomeningitis virus (strain WE)
- Links: Genome
Diagnosis of congenital LCMV infection can be confirmed in infants by immunofluorescence antibody (IFA), enzyme-linked immunosorbent assays (ELISAs) or quantitative polymerase chain reaction (QPCR, or real time PCR (rtPCR)).
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- Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Viruses Exploit Host Cell Machinery for All Aspects of Their Multiplication
- Disease Control Priorities in Developing Countries. 2nd edition. Jamison DT, Breman JG, Measham AR, et al., editors. Washington (DC): World Bank; 2006. Chapter 20Vaccine-preventable Diseases
Wright R, Johnson D, Neumann M, Ksiazek TG, Rollin P, Keech RV, Bonthius DJ, Hitchon P, Grose CF, Bell WE & Bale JF. (1997). Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection. Pediatrics , 100, E9. PMID: 9200383
Kotturi MF, Peters B, Buendia-Laysa F, Sidney J, Oseroff C, Botten J, Grey H, Buchmeier MJ & Sette A. (2007). The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J. Virol. , 81, 4928-40. PMID: 17329346 DOI.
Barton LL, Mets MB & Beauchamp CL. (2002). Lymphocytic choriomeningitis virus: emerging fetal teratogen. Am. J. Obstet. Gynecol. , 187, 1715-6. PMID: 12501090
Search Pubmed: Lymphocytic choriomeningitis virus
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Cite this page: Hill, M.A. (2020, August 11) Embryology Abnormal Development - Lymphocytic Choriomeningitis Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Lymphocytic_Choriomeningitis_Virus
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