Abnormal Development - Lymphocytic Choriomeningitis Virus

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Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.

Introduction

Infected infant head CT scan[1]

Lymphocytic choriomeningitis virus (LCMV) is carried by wild mice (Mus musculus). Laboratory rodents and pet rodents, such as rats, mice, hamsters and guinea pigs, can become infected with LCMV from contact with wild mice. This can happen in a breeding facility, in a laboratory facility, in a pet store, or in the home if wild mice are present. Humans can be infected through exposure to rodent excreta. In the rat animal model, the virus appears to selectively infect mitotically active neuronal precursors, while glial cells may also have a role in the initial entry, replication, and dispersion.

Maternal infection can be transferred placental to fetus and can result in either loss or birth defects (hydrocephalus, chorioretinitis or deafness). Since LCMV infection was first identified, more than 50 babies have been reported with LCMV infection worldwide.


Viral Links: viral infection | TORCH | cytomegalovirus | hepatitis | HIV | parvovirus | polio | rubella virus | chickenpox | Lymphocytic Choriomeningitis Virus | Zika virus | human papillomavirus | rotavirus | vaccination | environment
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects

Some Recent Findings

  • A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis.[2]

Virus Structure

Lineage: Viruses; ssRNA negative-strand viruses; Arenaviridae; Arenavirus; Old world arenaviruses; Lymphocytic choriomeningitis virus

  • Lymphocytic choriomeningitis virus (strain Armstrong)
  • Lymphocytic choriomeningitis virus (strain Pasteur)
  • Lymphocytic choriomeningitis virus (strain Traub)
  • Lymphocytic choriomeningitis virus (strain WE)


Links: Genome

Virus Detection

Diagnosis of congenital LCMV infection can be confirmed in infants by immunofluorescence antibody (IFA)[3], enzyme-linked immunosorbent assays (ELISAs) or quantitative polymerase chain reaction (QPCR, or real time PCR (rtPCR)).[4]

References

  1. <pubmed>18052527</pubmed>| PLoS Pathog.
  2. <pubmed>19253314</pubmed>
  3. <pubmed>1100673</pubmed>
  4. <pubmed>17920702</pubmed>

Textbooks

Reviews

<pubmed>16731068</pubmed> <pubmed>9200383</pubmed>

Articles

<pubmed>17920702</pubmed> <pubmed>17329346</pubmed> <pubmed>12501090</pubmed> <pubmed>11438904</pubmed> <pubmed>8903188</pubmed>| PDF

Search Pubmed

Search Pubmed: Lymphocytic choriomeningitis virus


Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | zoonotic infection | toxoplasmosis | Malaria | maternal diabetes | maternal hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | hypoxia | biological toxins | chemicals | heavy metals | air pollution | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis

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Cite this page: Hill, M.A. (2019, July 16) Embryology Abnormal Development - Lymphocytic Choriomeningitis Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Lymphocytic_Choriomeningitis_Virus

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G