Abnormal Development - Lymphocytic Choriomeningitis Virus

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Infected infant head CT scan[1]

Lymphocytic choriomeningitis virus (LCMV) is carried by wild mice (Mus musculus). Laboratory rodents and pet rodents, such as rats, mice, hamsters and guinea pigs, can become infected with LCMV from contact with wild mice. This can happen in a breeding facility, in a laboratory facility, in a pet store, or in the home if wild mice are present. Humans can be infected through exposure to rodent excreta. In the rat animal model, the virus appears to selectively infect mitotically active neuronal precursors, while glial cells may also have a role in the initial entry, replication, and dispersion.

Maternal infection can be transferred placental to fetus and can result in either loss or birth defects (hydrocephalus, chorioretinitis or deafness). Since LCMV infection was first identified, more than 50 babies have been reported with LCMV infection worldwide.

Viral Links: viral infection | TORCH | cytomegalovirus | hepatitis | HIV | parvovirus | polio | rubella virus | chickenpox | Lymphocytic Choriomeningitis Virus | Zika virus | human papillomavirus | rotavirus | vaccination | environment
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects

Some Recent Findings

  • A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis.[2]

Virus Structure

Lineage: Viruses; ssRNA negative-strand viruses; Arenaviridae; Arenavirus; Old world arenaviruses; Lymphocytic choriomeningitis virus

  • Lymphocytic choriomeningitis virus (strain Armstrong)
  • Lymphocytic choriomeningitis virus (strain Pasteur)
  • Lymphocytic choriomeningitis virus (strain Traub)
  • Lymphocytic choriomeningitis virus (strain WE)

Links: Genome

Virus Detection

Diagnosis of congenital LCMV infection can be confirmed in infants by immunofluorescence antibody (IFA)[3], enzyme-linked immunosorbent assays (ELISAs) or quantitative polymerase chain reaction (QPCR, or real time PCR (rtPCR)).[4]


  1. <pubmed>18052527</pubmed>| PLoS Pathog.
  2. <pubmed>19253314</pubmed>
  3. <pubmed>1100673</pubmed>
  4. <pubmed>17920702</pubmed>



<pubmed>16731068</pubmed> <pubmed>9200383</pubmed>


<pubmed>17920702</pubmed> <pubmed>17329346</pubmed> <pubmed>12501090</pubmed> <pubmed>11438904</pubmed> <pubmed>8903188</pubmed>| PDF

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Search Pubmed: Lymphocytic choriomeningitis virus

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Cite this page: Hill, M.A. (2019, July 16) Embryology Abnormal Development - Lymphocytic Choriomeningitis Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Lymphocytic_Choriomeningitis_Virus

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G