2010 Lecture 21
- 1 Introduction
- 2 Lecture Objectives
- 3 Textbook references
- 4 Heart Development
- 5 Separation of the Atria from the Venticles
- 6 Atrial Septation
- 7 Ventricular Septation
- 8 Outflow Tract Septation
- 9 Vascular Remodeling
- 10 Birth Changes
- 11 Abnormalities
- 12 Movies
- 13 Glossary Links
- 14 Course Content 2010
In lecture 7 - Early Vascular Development, the early development of the cardiovascular system was discussed. This second lecture will now focus on the extensive remodeling that occurs in both the heart and vascular system during later development. In addition, there will be discussion on the major cardiovascular abnormalities. The laboratory this week will also give you the opportunity to work through some of these concepts using a new online teaching module.
Dr Nalini Pather - Lecture 21 - Printable version
This material is also presented in an online Cardiac Embryology tutorial.
- Describe the development of primary and secondary atrial septa and the ventricular septum.
- Explain the changes occurring in the bulbis cordis and truncus arteriosus in its transformation from a single to a double tube.
- Describe the development of the aortic arches on the right and left sides from the fetus to the adult.
- Describe the development of arteries and veins.
- Describe the major cardiovascular developmental abnormalities.
- Human Embryology (3rd ed.) Larson Chapter 7 p151-188 Heart, Chapter 8 p189-228 Vasculature
- The Developing Human: Clinically Oriented Embryology (6th ed.) Chapter 14: p304-349
- Before we Are Born (5th ed.) Moore and Persaud Chapter 12; p241-254
- Essentials of Human Embryology Larson Chapter 7 p97-122 Heart, Chapter 8 p123-146 Vasculature
- Human Embryology Fitzgerald and Fitzgerald Chapter 13-17: p77-111
- Yutzey KE, Kirby ML. Wherefore heart thou? Embryonic origins of cardiogenic mesoderm. Dev Dyn. 2002 Mar;223(3):307-20. Review. PMID: 11891982
- Three-dimensional reconstruction of gene expression patterns during cardiac development. Soufan AT, Ruijter JM, van den Hoff MJ, de Boer PA, Hagoort J, Moorman AF. Physiol Genomics. 2003 May 13;13(3):187-95. Review. PMID: 12746463
- Moorman A, Webb S, Brown NA, Lamers W, Anderson RH. Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart. 2003 Jul;89(7):806-14. PMID: 12807866
- Bruneau BG. Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res. 2002 Mar 22;90(5):509-19. Review. PMID: 11909814
- endocardial tube in pericardial cavity
- dorsal mesentry (mesocardial) attachment lost
- attached at cranial (arterial) and caudal (venous) ends
- tube elongation - bending and series of expansions
- refers to the outflow tract in early embryo
- 3 parts
|Fetal Structure||Adult Structure|
|Conus arteriosus||right ventricle - smooth part|
|Primitive ventricle||right ventricle - trabecular part
left ventricle - trabecular part
|Primitive atrium||right atrium - trabecular part
left atrium - trabecular part
|Sinus venosus||right atrium - smooth part (sinus venarum)
coronary sinus oblique vein of left atrium
- pericardium - covers the heart, formed by 3 layers consisting of a fibrous pericardium and a double layered serous pericardium (parietal layer and visceral epicardium layer).
- myocardium - muscular wall of the heart, thickest layer formed by spirally arranged cardiac muscle cells.
- endocardium - lines the heart, epithelial (endothelial) tissue lining the inner surface of heart chambers and valves.
Embryonic Heart Rate
- Stage 9-10 2 mm embryo (gestational sac diameter of 20 mm) EHR at least 75 beats / minute
- Stage 11-12 5 mm embryo (gestational sac diameter of 30 mm) EHR at least 100 beats / minute
- Stage 16 10 mm embryo EHR at least 120 beats / minute
- Stage 18 15 mm embryo EHR at least 130 beats / minute
Separation of the Atria from the Venticles
- form initial division of atria and ventricles
- form on dorsal and ventral wall of atrioventcular canals
- grow into canal - meet and fuse to separate atrioventricular canal into right and left channels
- anterior and posterior cushions fuse; lateral cushions remain unfused
Through all development blood shunts from right to left atrium (bypass lungs)
- dorso-cranial wall, crescentric-shaped membranous extension
- grows downward towards endocardial cushions
- opening is foramen primum (ostium primum)- serves as a shunt
- a series of perforations develop in cranial end - coalesce to form foramen secundum (ostium secundum)
- septum primum fuses with endocardial cushions - obliterates foramen primum
- crescentric septum secundum begins to form to the right of septum primum
- grows as septum primum downwards, does not fuse with endocardial cushion, opening is foramen ovale
- arrangement of the two septa facilitates a one-way valve
- with heart looping and formation of interatrial septa, the sinus venosus shifts completely to right atrium
- right sinus horn incorporates into dorsal wall of right atrium
- left sinus horn becomes the coronary sinus
- sinoatrial opening - has 2 flaps, left fuses with septum secundum, right forms valve to inferior vena cava and coronary sinus. Stage 13 - right venous valve Stage 22 - right venous valve
- posterior wall - outgrowth forms single pulmonary vein, divided into 4 branches
- incorporation into the wall leads to 4 openings in posterior wall
- later moves to the right aligns with atrioventricular canal.
- 2 separate components - superior membranous, inferior muscular
- growth of inferior wall
- fusion of 3 components - right and left bulbar ridges and dorsal endocardial cushion
- above the muscular septum, fusion continuous with septation of the outflow tract
Outflow Tract Septation
- in early development, outflow tract is a single tube, bulbus cordis
- elongates to form proximal conus arteriosus and distal truncus arteriosus
- 2 growths from wall in spiral pattern, inferior upwards - separate tract into 2 channels Stage 13 truncus arteriousus
- mesenchyme and neural crest contribute to this septation process
- fusion of outgrowths separate aortic and pulmonary outflow
|Normal Heart||Abnormal Heart||Abnormal Heart 2|
- Aortic sac - remodels forming 2 horns, R forms brachiocephalic artery, L forms common carotid artery
Pharyngeal arch arteries
- pharyngeal arch artery 1 and 2 regress
- pharyngeal arch artery 3 and the associated dorsal aorta form the paired internal carotid arteries, these in turn generate the external carotids
- Left pharyngeal arch artery 4 – forms the aortic arch
- paraxial mesoderm forms paired dorsal aorta
- head mesenchyme forms aortic arches
- connecting stalk contains unbilical (placental) arteries
- dorsal aortas give rise to
- vitelline arteries which connect to capillaries on yolk sac
- intersegmental arteries between somites
Cardinal veins contribute nearly all systemic venous system.
common cardinal veins - ducts of Cuvier
hepatic veins - drain de-oxygenated blood from the liver into the inferior vena cava.
internal iliac vein - hypogastric vein
At birth, cutting the umbilical cord and changes in the lungs after the first breaths trigger major functional adaptations in the fetal circulatory system.
- blood flow through ductus venosus is eliminated
- pulmonary circulation bed expands - reducing blood flow through ductus arteriosus
- physiological closure of interatrial shunt
- closure of ductus venosus in liver is prolonged
|Fetal Structure||Adult Structure|
|foramen ovale||fossa ovalis|
|umbilical vein (intra-abdominal part)||ligamentum teres|
|ductus venosus||ligamentum venosum|
|umbilical arteries||distal part -lateral umbilical ligaments; proximal part - superior vesical artery (supplies bladder)|
|ductus arteriosus||ligamentum arteriosum|
There are many different cardiac abnormalities, some more common than others, and only a few will be described in this lecture.
Major Abnormalities: Aortic Stenosis, Atrial Septal Defects, Coarctation of Aorta, Dextrocardia, Hypoplastic Left Heart, Long QT Syndrome, Patent Ductus Arteriosus, Pulmonary Atresia, Pulmonary Stenosis, Tetralogy of Fallot, Transposition of Great Vessels, Tricuspid Atresia, Total Anomalous Pulmonary Venous Connection, Ventricular Septal Defect, Abnormalities of Conducting System.
Atrial Septal Defects
Ventricular Septal Defects
Patent Ductus Arteriosus
Tetralogy of Fallot
|Heart Looping||Heart Realign||Heart Atrial Septation||Heart Outflow Septation|
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Course Content 2010
Embryology Introduction | Cell Division/Fertilization | Lab 1 | Week 1&2 Development | Week 3 Development | Lab 2 | Mesoderm Development | Ectoderm, Early Neural, Neural Crest | Lab 3 | Early Vascular Development | Placenta | Lab 4 | Endoderm, Early Gastrointestinal | Respiratory Development | Lab 5 | Head Development | Neural Crest Development | Lab 6 | Musculoskeletal Development | Limb Development | Lab 7 | Kidney | Genital | Lab 8 | Sensory | Stem Cells | Stem Cells | Endocrine | Lab 10 | Late Vascular Development | Integumentary | Lab 11 | Birth, Postnatal | Revision | Lab 12 | Lecture Audio | Course Timetable
Cite this page: Hill, M.A. (2019, May 20) Embryology 2010 Lecture 21. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2010_Lecture_21
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G