File:NOTCH-endothelial-cartoon.jpg

From Embryology

Original file(1,280 × 888 pixels, file size: 92 KB, MIME type: image/jpeg)

NOTCH Signaling in the Endothelium

(a) A vascular sprout is characterized by a leading ‘tip’ cell followed by ‘stalk’ cells. Tip cells express high levels of DLL4 that activate NOTCH1 in the stalk cells to promote NOTCH signaling and impose differential gene expression. Increase of DLL4 in tip cells is achieved by both endothelial and non-endothelial derived VEGF to activate VEGFR2. In stalk cells, activation of the receptor results in generation of NICD that translocates to the nucleus where it binds to RBPJ and regulates gene expression. A consequence of NOTCH activation is to increase PTEN levels that suppress proliferation and to upregulate SMAD6 that titrates the signaling mediated by BMPs.


(b) Regulation of new sprouting during vascular expansion depends on integration of BMP signaling, NOTCH signaling and VEGF signaling. Differential expression patterns (illustrated by the different colors in the schema) of the NOTCH, VEGF, and BMP pathways are required to enable sprouting of new vessels. In contrast, synchronized fluctuations of the pathways favor vessel enlargement and disfavor branching.

(c) In adult vessels, NOTCH is responsible for maintaining endothelial quiescence and junctional integrity. BMPs, bone morphogenetic proteins; DLL4, delta-like 4; NICD, NOTCH ICD; PTEN, phosphatase and tensin homolog; RBPJ, recombination signal-binding protein for immunoglobulin kappa J; SMAD, mothers against decapentaplegic; VEGF, vascular endothelial growth factor; VEGFR2, vascular endothelial growth factor receptor 2.

Links: Notch
Cardiovascular Links: cardiovascular | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | 2016 Cardiac Review | heart | coronary circulation | heart valve | heart rate | Circulation | blood | blood vessel | blood vessel histology | heart histology | Lymphatic | ductus venosus | spleen | Stage 22 | cardiovascular abnormalities | OMIM | 2012 ECHO Meeting | Category:Cardiovascular
Historic Embryology - Cardiovascular 
1902 Vena cava inferior | 1905 Brain Blood Vessels | 1909 Cervical Veins | 1909 Dorsal aorta and umbilical veins | 1912 Heart | 1912 Human Heart | 1914 Earliest Blood-Vessels | 1915 Congenital Cardiac Disease | 1915 Dura Venous Sinuses | 1916 Blood cell origin | 1916 Pars Membranacea Septi | 1919 Lower Limb Arteries | 1921 Human Brain Vascular | 1921 Spleen | 1922 Aortic-Arch System | 1922 Pig Forelimb Arteries | 1922 Chicken Pulmonary | 1923 Head Subcutaneous Plexus | 1923 Ductus Venosus | 1925 Venous Development | 1927 Stage 11 Heart | 1928 Heart Blood Flow | 1935 Aorta | 1935 Venous valves | 1938 Pars Membranacea Septi | 1938 Foramen Ovale | 1939 Atrio-Ventricular Valves | 1940 Vena cava inferior | 1940 Early Hematopoiesis | 1941 Blood Formation | 1942 Truncus and Conus Partitioning | Ziegler Heart Models | 1951 Heart Movie | 1954 Week 9 Heart | 1957 Cranial venous system | 1959 Brain Arterial Anastomoses | Historic Embryology Papers | 2012 ECHO Meeting | 2016 Cardiac Review | Historic Disclaimer

Reference

Mack JJ & Iruela-Arispe ML. (2018). NOTCH regulation of the endothelial cell phenotype. Curr. Opin. Hematol. , , . PMID: 29547401 DOI.

Copyright

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distri- bution, and reproduction in any medium, provided the original work is properly cited.


Cite this page: Hill, M.A. (2024, May 29) Embryology NOTCH-endothelial-cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:NOTCH-endothelial-cartoon.jpg

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current20:42, 21 March 2018Thumbnail for version as of 20:42, 21 March 20181,280 × 888 (92 KB)Z8600021 (talk | contribs)
20:41, 21 March 2018Thumbnail for version as of 20:41, 21 March 20182,136 × 1,983 (365 KB)Z8600021 (talk | contribs)===Reference=== {{#pmid:29547401}} ====Copyright==== This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distri- bution, and reproduction in any medium, provided the ori...

The following page uses this file: