Developmental Signals - Retinoic acid

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Some Recent Findings

Visualization of an endogenous retinoic acid gradient across embryonic development "In vertebrate development, the body plan is determined by primordial morphogen gradients that suffuse the embryo. Retinoic acid (RA) is an important morphogen involved in patterning the anterior-posterior axis of structures, including the hindbrain and paraxial mesoderm. RA diffuses over long distances, and its activity is spatially restricted by synthesizing and degrading enzymes. ...Live imaging of endogenous concentration gradients across embryonic development will allow the precise assignment of molecular mechanisms to developmental dynamics and will accelerate the application of approaches based on morphogen gradients to tissue engineering and regenerative medicine." Zebrafish Development

Recent References | References

Fetal Gonad

Immunohistochemical localisation of retinoid receptor expression in the human fetal gonad

Neural

Model retinoic acid extracellular signal-regulated kinase and Wnt pathway interactions

RA Is Not Required for Radial Expansion of the Embryonic Cortex

References

Articles

<pubmed>21673209</pubmed>| Can Fam Physician

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Cite this page: Hill, M.A. (2024, June 16) Embryology Developmental Signals - Retinoic acid. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Retinoic_acid

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G