Gastrointestinal Tract - Mesentery Development: Difference between revisions
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::[[ | ::[[Historic_Embryology_Papers|'''Historic Embryology''']]: [[Paper - The development of the great omentum and transverse mesocolon|1884 great omentum and transverse mesocolon]] | [[Book_-_Manual_of_Human_Embryology_17-5|1912 Small Intestine]] | [[Book_-_Manual_of_Human_Embryology_17-6|1912 large Intestine]] | [[Paper - On the factors concerned in causing rotation of the intestine in man|1915 Intestinal Rotation]] | ||
==Some Recent Findings== | ==Some Recent Findings== | ||
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* mesosigmoid | * mesosigmoid | ||
* mesorectum | * mesorectum | ||
==Dorsal Mesogastrium== | |||
Greater Omentum | |||
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| width=500px|<html5media height="520" width="490">File:Greater omentum 001.mp4</html5media> | |||
[[Media:Greater omentum 001.mp4|'''Click Here''' to play on mobile device]] | |||
| [[File:Greater omentum 001 icon.jpg|100px|right]]This animation shows the development of the [[G#greater omentum|greater omentum]] associated with the greater curvature of the stomach. | |||
The [[G#greater omentum|greater omentum]] begins as an extended fold of the [[D#dorsal mesogastrium|dorsal mesogastrium]] that continues to grow and extend down into the peritoneal cavity and eventually lies anterior to the small intestines. This fold of mesentery will also fuse to form a single sheet. | |||
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* <font color=darkorange>'''liver'''</font> | |||
* <font color=palegoldenrod>'''gastrointestinal tract'''</font> | |||
* <font color=lightpink>'''mesentery'''</font> | |||
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==Small Intestine== | ==Small Intestine== | ||
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Latest revision as of 09:49, 3 May 2020
Embryology - 16 Jun 2024 Expand to Translate |
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Introduction
The adult gastrointestinal tract (GIT) is attached along its length by a dorsal mesentery between the stomach (oesophagogastric) and anus (anorectal junctions) arising from splanchnic mesoderm. This differentiates into a mesothelium, an epithelium derived from mesoderm. The majority of the ventral mesentery is developmentally lost at the level of the midgut and only the dorsal mesentery remains in the adult, through which blood vessels, nerves and lymph connects to the gastrointestinal wall.
Recently mouse mesentery has been used as a transplantation site for human intestinal organoid study.[1]
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Mesentery Embryology | Mesentery Development | |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Movies
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Regions
The following are anatomical sub-regions of the continuous mesentery.
- dorsal mesogastrium
- mesoduodenum
- mesenteric root region
- small intestine region
- right mesocolon
- left mesocolon
- mesosigmoid
- mesorectum
Dorsal Mesogastrium
Greater Omentum
<html5media height="520" width="490">File:Greater omentum 001.mp4</html5media> | This animation shows the development of the greater omentum associated with the greater curvature of the stomach.
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Small Intestine
Intestinal Functions
Small Intestine
- absorption of nutrients and minerals found in food
- Duodenum -principal site for iron absorption
Colon
- absorbs fluid, water and salts, from solid wastes
Embryonic Development
Week 4
Colour code:
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Week 7
Human embryo small intestine secondary loops (week 7 to 8).[7]
Week 8
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Late embryonic small intestine commencing at the duodenum, continuing as ventrally herniated and returning to join the colon.
Small intestine tertiary loops week 8.[7]
- Links: Carnegie stage 22 | Week 8
Rotation
A recent 3 dimensional study[7] has suggested a modified “en-bloc rotation” of the small intestine, compared the the earlier simplified description of 270 degree rotation.
Fetal Intestine Length
Fetal small Intestine length growth | Fetal Large Intestine length growth |
Data from[5]
Small Intestine Length
Small intestine growth in length is initially linear (first half pregnancy to 32 cm CRL), followed by rapid growth in the last 15 weeks doubling the overall length. Growth continues postnatally but after 1 year slows again to a linear increase to adulthood.[10]
Age (weeks GA gestational age) | Average Length (cm) |
20 | 125 |
30 | 200 |
term | 275 |
1 year postnatal | 380 |
5 years | 450 |
10 years | 500 |
20 years | 575 |
Table data based upon 8 published reports of necropsy measurement of 1010 guts.[10] |
Hindgut
Anatomically the distal third of the transverse colon and the splenic flexure, the descending colon, sigmoid colon and rectum. The developmental timing of the anus and rectum formation[11] in human embryos of the Carnegie Collection has been previously carried out (1974). A more recent study[12] has also been made of the Kyoto Collection embryos.
There has been some recent controversy over the "anal membrane" formation.
A recent study hindgut and anorectum development in human embryos shows that WNT5a is active in this region prior to anus formation, when it is down-regulated.[13]
Other studies - [14][15][16][17][18] (rat)
Abnormalities
Intestinal malrotation[19]
Midgut Volvulus[20]
Molecular Factors
Histology
The adult mesentery consists of loose irregular connective tissue, areolar connective tissue, collagen fibres, elastic fibres. There are also numerous mast cells (granulocytes) containing histamine and other substances released during inflammatory and allergic reactions.
Low power (x10) | High power (x40) |
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References
- ↑ Cortez AR, Poling HM, Brown NE, Singh A, Mahe MM & Helmrath MA. (2018). Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site. Surgery , 164, 643-650. PMID: 30072255 DOI.
- ↑ Isaza-Restrepo A, Martin-Saavedra JS, Velez-Leal JL, Vargas-Barato F & Riveros-Dueñas R. (2018). The Peritoneum: Beyond the Tissue - A Review. Front Physiol , 9, 738. PMID: 29962968 DOI.
- ↑ Hikspoors JPJM, Kruepunga N, Mommen GMC, Peeters JPWU, Hülsman CJM, Eleonore Köhler S & Lamers WH. (2018). The development of the dorsal mesentery in human embryos and fetuses. Semin. Cell Dev. Biol. , , . PMID: 30142441 DOI.
- ↑ Ueno S, Yamada S, Uwabe C, Männer J, Shiraki N & Takakuwa T. (2016). The Digestive Tract and Derived Primordia Differentiate by Following a Precise Timeline in Human Embryos Between Carnegie Stages 11 and 13. Anat Rec (Hoboken) , 299, 439-49. PMID: 26995337 DOI.
- ↑ 5.0 5.1 Ben-Nun MS, Ben-Shlush A & Raviv Zilka L. (2018). Growth of the colon and rectum throughout gestation: evaluation with fetal MRI. Acta Radiol Open , 7, 2058460118761206. PMID: 29531795 DOI.
- ↑ Wells JM & Spence JR. (2014). How to make an intestine. Development , 141, 752-60. PMID: 24496613 DOI.
- ↑ 7.0 7.1 7.2 Soffers JH, Hikspoors JP, Mekonen HK, Koehler SE & Lamers WH. (2015). The growth pattern of the human intestine and its mesentery. BMC Dev. Biol. , 15, 31. PMID: 26297675 DOI.
- ↑ FitzSimmons J, Chinn A & Shepard TH. (1988). Normal length of the human fetal gastrointestinal tract. Pediatr Pathol , 8, 633-41. PMID: 3244599
- ↑ Archie JG, Collins JS & Lebel RR. (2006). Quantitative standards for fetal and neonatal autopsy. Am. J. Clin. Pathol. , 126, 256-65. PMID: 16891202 DOI.
- ↑ 10.0 10.1 Weaver LT, Austin S & Cole TJ. (1991). Small intestinal length: a factor essential for gut adaptation. Gut , 32, 1321-3. PMID: 1752463
- ↑ de Vries PA. and Friedland GW. The staged sequential development of the anus and rectum in human embryos and fetuses. (1974) J. Pediatr. Surg., 9(5): 755-69 PMID 4424274
- ↑ Hashimoto R. (2013). Development of the human tail bud and splanchnic mesenchyme. Congenit Anom (Kyoto) , 53, 27-33. PMID: 23480355 DOI.
- ↑ Li FF, Zhang T, Bai YZ, Yuan ZW & Wang WL. (2011). Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos. Int J Colorectal Dis , 26, 983-8. PMID: 21431850 DOI.
- ↑ van der Putte SC. (2009). The development of the human anorectum. Anat Rec (Hoboken) , 292, 951-4. PMID: 19496155 DOI.
- ↑ Kromer P. (1999). Further study of the urorectal septum in staged human embryos. Folia Morphol. (Warsz) , 58, 53-63. PMID: 10504783
- ↑ Nievelstein RA, van der Werff JF, Verbeek FJ, Valk J & Vermeij-Keers C. (1998). Normal and abnormal embryonic development of the anorectum in human embryos. Teratology , 57, 70-8. PMID: 9562679 <70::AID-TERA5>3.0.CO;2-A DOI.
- ↑ Kromer P. (1996). Development of the urorectal septum and differentiation of the urogenital sinus in human embryos of stages 13 to 19. Folia Morphol. (Warsz) , 55, 362-3. PMID: 9243909
- ↑ Kluth D, Fiegel HC & Metzger R. (2011). Embryology of the hindgut. Semin. Pediatr. Surg. , 20, 152-60. PMID: 21708335 DOI.
- ↑ Ezer SS, Oguzkurt P, Temiz A, Ince E, Gezer HO, Demir S & Hicsonmez A. (2016). Intestinal malrotation needs immediate consideration and investigation. Pediatr Int , 58, 1200-1204. PMID: 27353636 DOI.
- ↑ Coste AH & Bhimji SS. (2018). Midgut Volvulus. , , . PMID: 28722991
Reviews
Byrnes KG, Walsh D, Lewton-Brain P, McDermott K & Coffey JC. (2019). Anatomy of the mesentery: Historical development and recent advances. Semin. Cell Dev. Biol. , 92, 4-11. PMID: 30316830 DOI.
Byrnes KG, McDermott KW & Coffey JC. (2019). Mesenteric organogenesis. Semin. Cell Dev. Biol. , 92, 1-3. PMID: 30336281 DOI.
Byrnes KG, Walsh D, Lewton-Brain P, McDermott K & Coffey JC. (2019). Anatomy of the mesentery: Historical development and recent advances. Semin. Cell Dev. Biol. , 92, 4-11. PMID: 30316830 DOI.
Yoshino T & Saito D. (2019). Epithelial-to-mesenchymal transition-based morphogenesis of dorsal mesentery and gonad. Semin. Cell Dev. Biol. , 92, 105-112. PMID: 30193994 DOI.
Hen G & Sela-Donenfeld D. (2019). "A narrow bridge home": The dorsal mesentery in primordial germ cell migration. Semin. Cell Dev. Biol. , 92, 97-104. PMID: 30153479 DOI.
Hikspoors JPJM, Kruepunga N, Mommen GMC, Peeters JPWU, Hülsman CJM, Eleonore Köhler S & Lamers WH. (2018). The development of the dorsal mesentery in human embryos and fetuses. Semin. Cell Dev. Biol. , , . PMID: 30142441 DOI.
Byrnes KG, McDermott K & Coffey JC. (2018). Development of mesenteric tissues. Semin. Cell Dev. Biol. , , . PMID: 30347243 DOI.
Byrnes KG, Walsh D, Dockery P, McDermott K & Coffey JC. (2018). Anatomy of the mesentery: Current understanding and mechanisms of attachment. Semin. Cell Dev. Biol. , , . PMID: 30316831 DOI.
Isaza-Restrepo A, Martin-Saavedra JS, Velez-Leal JL, Vargas-Barato F & Riveros-Dueñas R. (2018). The Peritoneum: Beyond the Tissue - A Review. Front Physiol , 9, 738. PMID: 29962968 DOI.
Wells JM & Spence JR. (2014). How to make an intestine. Development , 141, 752-60. PMID: 24496613 DOI.
Noah TK, Donahue B & Shroyer NF. (2011). Intestinal development and differentiation. Exp. Cell Res. , 317, 2702-10. PMID: 21978911 DOI.
Burns AJ, Roberts RR, Bornstein JC & Young HM. (2009). Development of the enteric nervous system and its role in intestinal motility during fetal and early postnatal stages. Semin. Pediatr. Surg. , 18, 196-205. PMID: 19782301 DOI.
Articles
Wozniak S, Florjanski J, Kordecki H, Podhorska-Okolow M & Domagala Z. (2018). Fetal sigmoid colon mesentery - In relevance in fetal ultrasound application. A pilot study. Ann. Anat. , 216, 152-158. PMID: 29292173 DOI.
Cho BH, Kim JH, Jin ZW, Wilting J, Rodríguez-Vázquez JF & Murakami G. (2018). Topographical anatomy of the intestines during in utero physiological herniation. Clin Anat , 31, 583-592. PMID: 29044646 DOI.
Nerurkar NL, Mahadevan L & Tabin CJ. (2017). BMP signaling controls buckling forces to modulate looping morphogenesis of the gut. Proc. Natl. Acad. Sci. U.S.A. , 114, 2277-2282. PMID: 28193855 DOI.
Soffers JH, Hikspoors JP, Mekonen HK, Koehler SE & Lamers WH. (2015). The growth pattern of the human intestine and its mesentery. BMC Dev. Biol. , 15, 31. PMID: 26297675 DOI.
Coffey JC, Culligan K, Walsh LG, Sehgal R, Dunne C, McGrath D, Walsh D, Moore M, Staunton M, Scanlon T, Dewhurst C, Kenny B, O'Riordan C, O'Brien JM, Quondamatteo F & Dockery P. (2016). An appraisal of the computed axial tomographic appearance of the human mesentery based on mesenteric contiguity from the duodenojejunal flexure to the mesorectal level. Eur Radiol , 26, 714-21. PMID: 26186959 DOI.
Davis NM, Kurpios NA, Sun X, Gros J, Martin JF & Tabin CJ. (2008). The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery. Dev. Cell , 15, 134-45. PMID: 18606147 DOI.
Cascio S, Tien AS, Agarwal P & Tan HL. (2006). Dorsal mesenteric agenesis without small bowel atresia: a rare cause of midgut volvulus in children. J. Pediatr. Surg. , 41, E5-7. PMID: 16952580 DOI.
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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History | Historic Embryology Papers) |
Frazer JE. and Robbins RH. On the factors concerned in causing rotation of the intestine in man. (1915) J Anat. 50(1): 75-110. PMID 17233053
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Cite this page: Hill, M.A. (2024, June 16) Embryology Gastrointestinal Tract - Mesentery Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Gastrointestinal_Tract_-_Mesentery_Development
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