Cardiovascular System - Coronary Circulation Development: Difference between revisions
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Image showing changes in venous (blue) and arterial (red) marker expression during coronary development; black indicates dedifferentiated venous cells.<ref name="PMID20336138" /> | Image showing changes in venous (blue) and arterial (red) marker expression during coronary development; black indicates dedifferentiated venous cells.<ref name="PMID20336138" /> | ||
==Abnormalities== | |||
===Anomalous Left Coronary Artery from the Pulmonary Artery=== | |||
Anomalous origin of left coronary artery from pulmonary artery (ALCAPA) is a rare malformation (incidence of 0.25–0.50% )in children with abnormal cardiac development leading to a mortality rate of 90% in unoperated infants.<ref><pubmed>7949665</pubmed></ref> There are a variety of surgical repair techniques including: direct aortic implantation, a modified tubular extension technique, and an intrapulmonary baffling technique.<ref><pubmed>19808708</pubmed>| [http://icvts.ctsnetjournals.org/cgi/content/full/10/1/70 Interact Cardiovasc Thorac Surg.]</ref> | |||
==References== | ==References== |
Revision as of 10:26, 16 October 2010
Introduction
The coronary circulation provides the blood supply to the heart required for the normal muscular function. From recent mouse studies, the origin of this specialised vasculature is from the sinus venosus.
Development of the heart and vascular system begins very early in mesoderm both within (embryonic) and outside (extra embryonic) the embryo. Vascular development therefore occurs in many places, the most obvious though is the inflow and outflow in the forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo.
The coronary circulation an important medical topic postnatally. Blockage and failure of this system leads initially to angina, continued ischemia leads to hypoxic death of cardiac muscle and myocardial infarction, a heart attack.
For general information about blood vessel development, see Blood Vessel Development and note that blood vessels also occurs outside the embryo in the extra-embryonic mesoderm of the yolk sac (vitelline) and in the villi of the placenta.
Some Recent Findings
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(More? recent references)
Mouse Coronary Vessel Development
Image showing changes in venous (blue) and arterial (red) marker expression during coronary development; black indicates dedifferentiated venous cells.[1]
Abnormalities
Anomalous Left Coronary Artery from the Pulmonary Artery
Anomalous origin of left coronary artery from pulmonary artery (ALCAPA) is a rare malformation (incidence of 0.25–0.50% )in children with abnormal cardiac development leading to a mortality rate of 90% in unoperated infants.[3] There are a variety of surgical repair techniques including: direct aortic implantation, a modified tubular extension technique, and an intrapulmonary baffling technique.[4]
References
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See also Category:Heart ILP and Category:Heart
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Cite this page: Hill, M.A. (2024, June 20) Embryology Cardiovascular System - Coronary Circulation Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Coronary_Circulation_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G